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Recent Publications
CF airway epithelia display exaggerated host defense responses and prolonged cilia loss during RSV infection
Sunday, February 16, 2025
CONCLUSIONS: These findings further our understanding of innate immune dysfunction in the CF airway epithelium and suggest that virus-induced cilia injury may further compromise host defenses in CF airways.
Profiles of Exosomal microRNAs in Joint Cells and Candidate microRNAs for Cartilage Regeneration
Thursday, February 13, 2025
The activation of chondrogenic progenitor cells (CPCs) in articular cartilage during a traumatic injury is vital for cartilage regeneration. Although our understanding of the mechanisms underlying CPC chondrogenic activation remains incomplete, there is evidence that exosomal microRNAs (miRNAs or miRs) are involved in tissue healing due to their regulating role of posttranscriptional gene expressions. In this study, we profiled enriched and differential expression of miRNAs in exosomes derived...
The oxygen level in air directs airway epithelial cell differentiation by controlling mitochondrial citrate export
Friday, January 24, 2025
Oxygen controls most metazoan metabolism, yet in mammals, tissue O(2) levels vary widely. While extensive research has explored cellular responses to hypoxia, understanding how cells respond to physiologically high O(2) levels remains uncertain. To address this problem, we investigated respiratory epithelia as their contact with air exposes them to some of the highest O(2) levels in the body. We asked how the O(2) level in air controls differentiation of airway basal stem cells into the ciliated...
The Impact of Cell-Intrinsic STAT6 Protein on Donor T Cell-Mediated Graft-Versus-Tumor Effect
Saturday, January 11, 2025
Bone marrow transplantation (BMT) is mainly performed to restore an anti-tumor immune response, called the graft-versus-tumor (GVT) effect, against leukemia, myeloma and lymphoma. This GVT reactivity is driven by donor T cells, and it can also cause lethal graft-versus-host disease (GVHD). We previously demonstrated that the colonization of mice with helminths preserves the GVT response while suppressing GVHD. As the T helper-2 (Th2) pathway is critical to helminthic immune regulation, we asked...
Spatial differences in gene expression across the dorsal raphe nucleus in a model of early Alzheimer's disease
Monday, November 25, 2024
CONCLUSIONS: Map2k3os may serve regulatory roles relevant for tau phosphorylation and warrants further investigation to characterize its interactions. Overall, this report demonstrates the power of large-scale spatial transcriptomics technologies, while underscoring the need for convergent-data validation to overcome their limitations.