Brandon S. Davies, PhD

Portrait
Assistant Professor of Biochemistry

Contact Information

Office
3326 PBDB
169 Newton Dr.
Iowa City, IA 52242
319-335-3225

Lab
3326 PBDB
169 Newton Dr.
Iowa City, IA 52242
319-335-3228

Fax
319-335-9570

Education

BA, Biology and English, University of Utah
PhD, Molecular and Cell Biology, University of California, Berkeley
Postdoctoral Fellow, Cardiology, University of California, Los Angeles

Education/Training Program Affiliations

Department of Biochemistry PhD, Interdisciplinary Graduate Program in Molecular Medicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Fraternal Order of Eagles Diabetes Research Center, UI Obesity Research and Education Initiative

Research Summary

The primary focus of my laboratory is on the regulation of triglyceride-rich lipoprotein metabolism and fatty acid partitioning. Lipoprotein lipase (LPL) is the primary enzyme responsible for hydrolyzing lipoprotein triglycerides for the delivery of fatty acids to tissues. To become functional LPL must be trafficked across endothelial cells. As a postdoctoral fellow I identified the endothelial cell protein GPIHBP1 as the transporter responsible for trafficking LPL across capillary endothelial cells. My current research program is investigating how this trafficking, and subsequent LPL-mediated triglyceride clearance, is regulated and how it may become misregulated in metabolic disease.

Visit Google Scholar for all of Dr. Brandon Davies's publications.

Publications

Chi, X., Britt, E., Shows, H., Hjelmaas, A., Shetty, S., Cushing, E., Li, W., Dou, A., Zhang, R. & Davies, B. (2017). ANGPTL8 promotes the ability of the ANGPTL3 to bind and inhibit lipoprotein lipase. Molecular Metabolism, 6(10), 1137–1149. PMID: 29031715.

Cushing, E., Chi, X., Sylvers, K., Shetty, S., Potthoff, M. & Davies, B. (2017). Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting. Molecular Metabolism, 6(8), 809-818. PMID: 28752045.

Chi, X., Shetty, S. K., Shows, H. W., Hjelmaas, A. J., Malcolm, E. K. & Davies, B. S. (2015). Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1. The Journal of Biological Chemistry, 290(19), 11865-77. PMID: 25809481.

Beigneux, A. P., Fong, L. G., Bensadoun, A., Davies, B. S., Oberer, M., Gårdsvoll, H., Ploug, M. & Young, S. G. (2014). GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding. Circulation Research, 116(4), 624-632. PMID: 25387803.

Young, S. G., Yang, S. H., Davies, B. S., Jung, H. J. & Fong, L. G. (2013). Targeting protein prenylation in progeria. Science translational medicine, 5(171), 171ps3. PMID: 23390246.

Davies, B. S., Goulbourne, C. N., Barnes, R. H., Turlo, K. A., Gin, P., Vaughan, S., Vaux, D. J., Bensadoun, A., Beigneux, A. P., Fong, L. G. & Young, S. G. (2012). Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. Journal of lipid research, 53(12), 2690-7. PMID: 23008484.

Gin, P., Goulbourne, C. N., Adeyo, O., Beigneux, A. P., Davies, B. S., Tat, S., Voss, C. V., Bensadoun, A., Fong, L. G. & Young, S. G. (2012). Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1. Human molecular genetics, 21(13), 2961-72. PMID: 22493000.

Davies, B. S., Beigneux, A. P., Fong, L. G. & Young, S. G. (2012). New wrinkles in lipoprotein lipase biology. Current opinion in lipidology, 23(1), 35-42. PMID: 22123668.

Weinstein, M. M., Goulbourne, C. N., Davies, B. S., Tu, Y., Barnes, R. H., Watkins, S. M., Davis, R., Reue, K., Tontonoz, P., Beigneux, A. P., Fong, L. G. & Young, S. G. (2012). Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arteriosclerosis, thrombosis, and vascular biology, 32(2), 230-5. PMID: 22173228.

Jung, H. J., Coffinier, C., Choe, Y., Beigneux, A. P., Davies, B. S., Yang, S. H., Barnes, R. H., Hong, J., Sun, T., Pleasure, S. J., Young, S. G. & Fong, L. G. (2012). Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proceedings of the National Academy of Sciences of the United States of America, 109(7), E423-31. PMID: 22308344.

Young, S. G., Davies, B. S., Voss, C. V., Gin, P., Weinstein, M. M., Tontonoz, P., Reue, K., Bensadoun, A., Fong, L. G. & Beigneux, A. P. (2011). GPIHBP1, an endothelial cell transporter for lipoprotein lipase. Journal of lipid research, 52(11), 1869-84. PMID: 21844202.

Beigneux, A. P., Davies, B. S., Tat, S., Chen, J., Gin, P., Voss, C. V., Weinstein, M. M., Bensadoun, A., Pullinger, C. R., Fong, L. G. & Young, S. G. (2011). Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase. The Journal of biological chemistry, 286(22), 19735-43. PMID: 21478160.

Voss, C. V., Davies, B. S., Tat, S., Gin, P., Fong, L. G., Pelletier, C., Mottler, C. D., Bensadoun, A., Beigneux, A. P. & Young, S. G. (2011). Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Proceedings of the National Academy of Sciences of the United States of America, 108(19), 7980-4. PMID: 21518912.

Gin, P., Beigneux, A. P., Voss, C., Davies, B. S., Beckstead, J. A., Ryan, R. O., Bensadoun, A., Fong, L. G. & Young, S. G. (2011). Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 31(1), 176-82. PMID: 20966398.

Davies, B. S., Coffinier, C., Yang, S. H., barnes, R. H., Jung, H. J. & young, S. G. (2011). Investigating the purpose of prelamin a processing. Nucleus, 2, 9-Apr.

Davies, B. S., Coffinier, C., Yang, S. H., Jung, H. J., Fong, L. G. & young, S. G. (2011). Posttranslational processing of nuclear lamins. pp. 21-41. Protein prenylation part a, Academic Press.

Olafsen, T., Young, S. G., Davies, B. S., Beigneux, A. P., Kenanova, V. E., Voss, C., Young, G., Wong, K. P., Barnes, R. H., Tu, Y., Weinstein, M. M., Nobumori, C., Huang, S. C., Goldberg, I. J., Bensadoun, A. & Wu, A. M. (2010). Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. The Journal of biological chemistry, 285(50), 39239-48. PMID: 20889497.

Weinstein, M. M., Tu, Y., Beigneux, A. P., Davies, B. S., Gin, P., Voss, C., Walzem, R. L., Reue, K., Tontonoz, P., Bensadoun, A., Fong, L. G. & Young, S. G. (2010). Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arteriosclerosis, thrombosis, and vascular biology, 30(11), 2106-13. PMID: 20814015.

Davies, B. S., Barnes, R. H., Tu, Y., Ren, S., Andres, D. A., Spielmann, H. P., Lammerding, J., Wang, Y., Young, S. G. & Fong, L. G. (2010). An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Human molecular genetics, 19(13), 2682-94. PMID: 20421363.

Coffinier, C., Jung, H. J., Li, Z., Nobumori, C., Yun, U. J., Farber, E. A., Davies, B. S., Weinstein, M. M., Yang, S. H., Lammerding, J., Farahani, J. N., Bentolila, L. A., Fong, L. G. & Young, S. G. (2010). Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. The Journal of biological chemistry, 285(27), 20818-26. PMID: 20439468.

Davies, B. S., Beigneux, A. P., Barnes, R. H., Tu, Y., Gin, P., Weinstein, M. M., Nobumori, C., Nyrén, R., Goldberg, I., Olivecrona, G., Bensadoun, A., Young, S. G. & Fong, L. G. (2010). GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell metabolism, 12(1), 42-52. PMID: 20620994.

Olivecrona, G., Ehrenborg, E., Semb, H., Makoveichuk, E., Lindberg, A., Hayden, M. R., Gin, P., Davies, B. S., Weinstein, M. M., Fong, L. G., Beigneux, A. P., Young, S. G., Olivecrona, T. & Hernell, O. (2010). Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. Journal of lipid research, 51(6), 1535-45. PMID: 20026666.

Lee, R., Chang, S. Y., Trinh, H., Tu, Y., White, A. C., Davies, B. S., Bergo, M. O., Fong, L. G., Lowry, W. E. & Young, S. G. (2010). Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Human molecular genetics, 19(8), 1603-17. PMID: 20106865.

Chan, L. N., Hart, C., Guo, L., Nyberg, T., Davies, B. S., Fong, L. G., Young, S. G., Agnew, B. J. & Tamanoi, F. (2009). A novel approach to tag and identify geranylgeranylated proteins. Electrophoresis, 30(20), 3598-606. PMID: 19784953.

Beigneux, A. P., Gin, P., Davies, B. S., Weinstein, M. M., Bensadoun, A., Fong, L. G. & Young, S. G. (2009). Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. The Journal of biological chemistry, 284(44), 30240-7. PMID: 19726683.

Fong, L. G., Vickers, T. A., Farber, E. A., Choi, C., Yun, U. J., Hu, Y., Yang, S. H., Coffinier, C., Lee, R., Yin, L., Davies, B. S., Andres, D. A., Spielmann, H. P., Bennett, C. F. & Young, S. G. (2009). Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides. Human molecular genetics, 18(13), 2462-71. PMID: 19376814.

Park, K. W., Waki, H., Kim, W. K., Davies, B. S., Young, S. G., Parhami, F. & Tontonoz, P. (2009). The small molecule phenamil induces osteoblast differentiation and mineralization. Molecular and cellular biology, 29(14), 3905-14. PMID: 19433444.

Beigneux, A. P., Franssen, R., Bensadoun, A., Gin, P., Melford, K., Peter, J., Walzem, R. L., Weinstein, M. M., Davies, B. S., Kuivenhoven, J. A., Kastelein, J. J., Fong, L. G., Dallinga-Thie, G. M. & Young, S. G. (2009). Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arteriosclerosis, thrombosis, and vascular biology, 29(6), 956-62. PMID: 19304573.

Beigneux, A. P., Weinstein, M. M., Davies, B. S., Gin, P., Bensadoun, A., Fong, L. G. & Young, S. G. (2009). GPIHBP1 and lipolysis: an update. Current opinion in lipidology, 20(3), 211-6. PMID: 19369870.

Beigneux, A. P., Davies, B. S., Bensadoun, A., Fong, L. G. & Young, S. G. (2009). GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins. Journal of lipid research, 50 Suppl, S57-62. PMID: 18854402.

Davies, B. S., Yang, S. H., Farber, E., Lee, R., Buck, S. B., Andres, D. A., Spielmann, H. P., Agnew, B. J., Tamanoi, F., Fong, L. G. & Young, S. G. (2009). Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. Journal of lipid research, 50(1), 126-34. PMID: 18757838.

Davies, B. S., Fong, L. G., Yang, S. H., Coffinier, C. & Young, S. G. (2009). The posttranslational processing of prelamin A and disease. pp. 153-74. Annual review of genomics and human genetics. PMID: 19453251.

Weinstein, M. M., Yin, L., Beigneux, A. P., Davies, B. S., Gin, P., Estrada, K., Melford, K., Bishop, J. R., Esko, J. D., Dallinga-Thie, G. M., Fong, L. G., Bensadoun, A. & Young, S. G. (2008). Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. The Journal of biological chemistry, 283(50), 34511-8. PMID: 18845532.

Davies, B. S., Waki, H., Beigneux, A. P., Farber, E., Weinstein, M. M., Wilpitz, D. C., Tai, L. J., Evans, R. M., Fong, L. G., Tontonoz, P. & Young, S. G. (2008). The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Molecular endocrinology, 22(11), 2496-504. PMID: 18787041.

Gin, P., Yin, L., Davies, B. S., Weinstein, M. M., Ryan, R. O., Bensadoun, A., Fong, L. G., Young, S. G. & Beigneux, A. P. (2008). The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. The Journal of biological chemistry, 283(43), 29554-62. PMID: 18713736.

Beigneux, A. P., Gin, P., Davies, B. S., Weinstein, M. M., Bensadoun, A., Ryan, R. O., Fong, L. G. & Young, S. G. (2008). Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. Journal of lipid research, 49(6), 1312-21. PMID: 18340083.

Young, S. G., Davies, B. S., Fong, L. G., Gin, P., Weinstein, M. M., Bensadoun, A. & Beigneux, A. P. (2007). GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons. Current opinion in lipidology, 18(4), 389-96. PMID: 17620854.

Beigneux, A. P., Davies, B. S., Gin, P., Weinstein, M. M., Farber, E., Qiao, X., Peale, F., Bunting, S., Walzem, R. L., Wong, J. S., Blaner, W. S., Ding, Z. M., Melford, K., Wongsiriroj, N., Shu, X. & de Sauvage, F. (2007). Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell metabolism, 5(4), 279-91. PMID: 17403372.

Gin, P., Beigneux, A. P., Davies, B. S., Young, M. F., Ryan, R. O., Bensadoun, A., Fong, L. G. & Young, S. G. (2007). Normal binding of lipoprotein lipase, chylomicrons, and apo-av to gpihbp1 containing a g56r amino acid substitution. Biochem Biophys Acts, 1771, 1464-68. PMID: 17997385.

Davies, B. S., Rine, J. (2006). A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae. Genetics, 174(1), 191-201. PMID: 16783004.

Davies, B. S., Wang, H. S. & Rine, J. (2005). Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms. Molecular and cellular biology, 25(16), 7375-85. PMID: 16055745.