David H. Price, PhD

Portrait
Professor of Biochemistry

Contact Information

Primary Office: 260 EMRB
Iowa City, IA 52242
319-335-7910

Education

BS, Dept of Chemistry, North Carolina State University
PhD, Dept of Chemistry, Florida State University

Post Doctoral Fellow, Dept of Biology, Caltech
Post Doctoral Fellow, Dept of Chemistry, Caltech

Education/Training Program Affiliations

Department of Biochemistry PhD, Interdisciplinary Graduate Program in Molecular and Cellular Biology, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

Understanding how mRNA levels are controlled in eukaryotes requires dissection of the intricate pathways responsible for the synthesis and processing of mRNA. Previously, we uncovered evidence for a regulatory process in higher eukaryotes that controls the fraction of initiated RNA polymerase II (Pol II) molecules able to produce full-length mRNAs. We then discovered P-TEFb, a cyclin dependent kinase that plays a key role in this elongation control process. The kinase activity of P-TEFb is generally required for eukaryotic gene expression and thus P-TEFb function is highly regulated. We are currently engaged in projects to more fully understand the mechanisms utilized in Pol II elongation control. In this regard we continue to employ viruses that infect human cells because they reveal unexpected ways to exploit elongation control. For example, the AIDS retrovirus, HIV, encodes a protein, Tat, that enables the virus to take over the control of P-TEFb. We have begun to work with Jeff Meier (Internal Medicine) to examine the transcriptional life cycle of the human cytomegalovirus (HCMV). Transcription and RNA processing are temporally and mechanistically intertwined and we persist in investigating how the two processes affect each other. We are also collaborating with Donal Luse (Cleveland Clinic) concerning the interplay of the elongation control machinery and chromatin. We employ in vitro assays in which the function of specific factors can be evaluated and have recently taken advantage of isolated nuclei to accurately report on transcription and RNA processing in cells. Using CRISPR genome editing technology and small molecules that inhibit or degrade specific proteins we can manipulate cells and follow up with nucleotide-resolution bioinformatics analysis of the pattern of transcription in the isolated nuclei. These and other innovative techniques provide us with unique opportunities to advance our understanding of the molecular mechanisms that control gene expression. The studies are useful in the development of therapies for viral infections and cancer.

Publications

Bosque, A., Nilson, K., Macedo, A., Spivak, A., Archin, N., Van Wagoner, R., Martins, L., Novis, C., Szaniawski, M., Ireland, C., Margolis, D., Price, D. & Planelles, V. (2017). Benzotriazoles reactive latent HIV-1 through inactivation of STAT5 SUMOylation. Cell Reports, 18, 1324-1334.

Tan, J. L., Fogley, R. D., Flynn, R. A., Ablain, J., Yang, S., Saint-André, V., Fan, Z. P., Do, B. T., Laga, A. C., Fujinaga, K., Santoriello, C., Greer, C. B., Kim, Y. J., Clohessy, J. G., Bothmer, A., Pandell, N., Avagyan, S., Brogie, J. E., van Rooijen, E., Hagedorn, E. J., Shyh-Chang, N., White, R. M., Price, D. H., Pandolfi, P. P., Peterlin, B. M., Zhou, Y., Kim, T. H., Asara, J. M., Chang, H. Y., Young, R. A. & Zon, L. I. (2016). Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Molecular cell, 62(1), 34-46. PMID: 27058786.

Nilson, K. A., Guo, J., Turek, M. E., Brogie, J. E., Delaney, E., Luse, D. S. & Price, D. H. (2015). THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. Molecular cell, 59(4), 576-87. PMID: 26257281.

Guo, J., Li, T., Schipper, J., Nilson, K., Fordjour, F., Cooper, J., Gordân, R. & Price, D. (2014). Sequence specificity incompletely defines the genome-wide occupancy of Myc. Genome Biol, 15(10), 482. PMID: 25287278.

Gu, J., Babayeva, N. D., Suwa, Y., Baranovsky, A. G., Price, D. H. & Tahirov, T. H. (2014). Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4. Cell Cycle.

Fowler, T., Ghatak, P., Price, D. H., Conaway, R., Conaway, J., Chiang, C. M., Bradner, J. E., Shilatifard, A. & Roy, A. L. (2014). Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells. PLoS One, 9, e87003. PMID: 24466310.

Liu, P., Xiang, Y., Fujinaga, K., Bartholomeeusen, K., Nilson, K., Price, D. H. & Peterlin, B. M. (2014). Release of P-TEFb from 7SK snRNP activates HEXIM1 transcription. J Biol Chem, [Epub ahead of print]. PMID: 24515107.

Davis, M. A., Guo, J., Price, D. H. & Luse, D. S. (2014). Functional interactions of the RNA polymerase II-interacting proteins Gdown1 and TFIIF. J Biol Chem, [Epub ahead of print]. PMID: 24596085.

Guo, J., Turek, M. E. & Price, D. H. (2014). Regulation of RNA polymerase II termination by phosphorylation of Gdown1. J Biol Chem, [Epub ahead of print]. PMID: 24634214.

Guo, J., Price, D. H. (2013). RNA polymerase II transcription elongation control. Chem Rev, 113(11), 8583-603. PMID: 23919563.

Van Duyne, R., Guendel, I., Jaworski, E., Sampey, G., Klase, Z., Chen, H., Zeng, C., Kovalskyy, D., El Kouni, M. H., Lepene, B., Patanarut, A., Nekhai, S., Price, D. H. & Kashanchi, F. (2013). Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription. Journal of molecular biology, 425(4), 812-29. PMID: 23247501.

Guo, J., Li, T. & Price, D. H. (2013). Runaway transcription. Genome Biol, 19(9), 133. PMID: 24079702.

Li, T., Price, D. H. (2012). Gdown1 - making a link between Mediator and RNA polymerase II elongation control. Transcription, 3, 1-3.

Zhou, Q., Li, T. & Price, D. H. (2012). RNA polymerase II elongation control. Annual review of biochemistry, 81, 119-43. PMID: 22404626.

Cheng, B., Li, T., Rahl, P. B., Adamson, T. E., Loudas, N. B., Guo, J., Varzavand, K., Cooper, J. J., Hu, X., Gnatt, A., Young, R. A. & Price, D. H. (2012). Functional association of Gdown1 with RNA polymerase II poised on human genes. Molecular cell, 45(1), 38-50. PMID: 22244331.

Fujinaga, K., Barboric, M., Li, Q., Luo, Z., Price, D. H. & Peterlin, B. M. (2012). PKC phosphorylates HEXIM1 and regulates P-TEFb activity. Nucleic acids research, 40(18), 9160-70. PMID: 22821562.

Peterlin, B. M., Brogie, J. E. & Price, D. H. (2012). 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription. Wiley interdisciplinary reviews. RNA, 3(1), 92-103. PMID: 21853533.

Kulak, M. V., Cyr, A. R., Woodfield, G. W., Bogachek, M., Spanheimer, P. M., Li, T., Price, D. H., Domann, F. E. & Weigel, R. J. (2012). Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer. Oncogene. PMID: 22964634.

Nguyen, D., Krueger, B. J., Sedore, S. C., Brogie, J. E., Rogers, J. T., Rajendra, T. K., Saunders, A., Matera, A. G., Lis, J. T., Uguen, P. & Price, D. H. (2012). The Drosophila 7SK snRNP and the essential role of dHEXIM in development. Nucleic acids research, 40(12), 5283-97. PMID: 22379134.

Nilson, K. A., Price, D. H. (2011). The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency. Genetics research international, 2011, Article ID. 726901. PMID: 22567366.

Cojocaru, M., Bouchard, A., Cloutier, P., Cooper, J. J., Varzavand, K., Price, D. H. & Coulombe, B. (2011). Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B. The Journal of biological chemistry, 286(7), 5012-22. PMID: 21127351.

Krueger, B. J., Varzavand, K., Cooper, J. J. & Price, D. H. (2010). The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK. PloS one, 5(8), e12335. PMID: 20808803.

Bartkowiak, B., Liu, P., Phatnani, H. P., Fuda, N. J., Cooper, J. J., Price, D. H., Adelman, K., Lis, J. T. & Greenleaf, A. L. (2010). CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes & development, 24(20), 2303-16. PMID: 20952539.

Price, D. H. (2010). Regulation of RNA polymerase II elongation by c-Myc. Cell, 141(3), 399-400. PMID: 20434979.

Tahirov, T. H., Babayeva, N. D., Varzavand, K., Cooper, J. J., Sedore, S. C. & Price, D. H. (2010). Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature, 465(7299), 747-51. PMID: 20535204.

Nagy, P. L., Price, D. H. (2009). Formaldehyde-assisted isolation of regulatory elements. Wiley interdisciplinary reviews. Systems biology and medicine, 1(3), 400-6. PMID: 20046543.

Cheng, B., Price, D. H. (2009). Isolation and functional analysis of RNA polymerase II elongation complexes. Methods (San Diego, Calif.), 48(4), 346-52. PMID: 19409997.

Price, D. H. (2009). Guest Editor's Introduction. Controlling which genes are transcriptionally expressed is key to the generation and maintenance of the repertoire of cell types needed to support the mammalian lifestyle. Methods (San Diego, Calif.), 48(4), 321-2. PMID: 19654069.

Gurumurthy, M., Tan, C. H., Ng, R., Zeiger, L., Lau, J., Lee, J., Dey, A., Philp, R., Li, Q., Lim, T. M., Price, D. H., Lane, D. P. & Chao, S. H. (2008). Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription. Journal of molecular biology, 378(2), 302-17. PMID: 18371977.

Price, D. H. (2008). Poised polymerases: on your mark...get set...go!. Molecular cell, 30(1), 7-10. PMID: 18406322.

Krueger, B. J., Jeronimo, C., Roy, B. B., Bouchard, A., Barrandon, C., Byers, S. A., Searcey, C. E., Cooper, J. J., Bensaude, O., Cohen, E. A., Coulombe, B. & Price, D. H. (2008). LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. Nucleic acids research, 36(7), 2219-29. PMID: 18281698.

Cheng, B., Price, D. H. (2008). Analysis of factor interactions with RNA polymerase II elongation complexes using a new electrophoretic mobility shift assay. Nucleic acids research, 36(20), e135. PMID: 18832375.

Sedore, S. C., Byers, S. A., Biglione, S., Price, J. P., Maury, W. J. & Price, D. H. (2007). Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR. Nucleic acids research, 35(13), 4347-58. PMID: 17576689.

Biglione, S., Byers, S. A., Price, J. P., Nguyen, V. T., Bensaude, O., Price, D. H. & Maury, W. (2007). Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex. Retrovirology, 4, 47. PMID: 17625008.

Cheng, B., Price, D. H. (2007). Properties of RNA polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. The Journal of biological chemistry, 282(30), 21901-12. PMID: 17548348.

Jeronimo, C., Forget, D., Bouchard, A., Li, Q., Chua, G., Poitras, C., Thérien, C., Bergeron, D., Bourassa, S., Greenblatt, J., Chabot, B., Poirier, G. G., Hughes, T. R., Blanchette, M., Price, D. H. & Coulombe, B. (2007). Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Molecular cell, 27(2), 262-74. PMID: 17643375.

Li, Q., Cooper, J. J., Altwerger, G. H., Feldkamp, M. D., Shea, M. A. & Price, D. H. (2007). HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells. Nucleic acids research, 35(8), 2503-12. PMID: 17395637.

Price, D. H. (2006). Small interfering RNAs (siRNA). Encyclopedia of Science and Technology, McGraw-Hill.

Peterlin, B. M., Price, D. H. (2006). Controlling the elongation phase of transcription with P-TEFb. Molecular cell, 23(3), 297-305. PMID: 16885020.

Byers, S. A., Price, J. P., Cooper, J. J., Li, Q. & Price, D. H. (2005). HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. The Journal of biological chemistry, 280(16), 16360-7. PMID: 15713662.

Price, D. H., Tracy, C. S. & Upshur, R. E. (2005). Chaperone use during intimate examinations in primary care: postal survey of family physicians. BMC family practice, 6, 52. PMID: 16371153.

Shore, S. M., Byers, S. A., Dent, P. & Price, D. H. (2005). Characterization of Cdk9(55) and differential regulation of two Cdk9 isoforms. Gene, 350(1), 51-8. PMID: 15780980.

Palangat, M., Renner, D. B., Price, D. H. & Landick, R. (2005). A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. Proceedings of the National Academy of Sciences of the United States of America, 102(42), 15036-41. PMID: 16214896.

Byers, S. A., Schafer, B., Sappal, D. S., Brown, J. & Price, D. H. (2005). The antiproliferative agent MLN944 preferentially inhibits transcription. Molecular cancer therapeutics, 4(8), 1260-7. PMID: 16093442.

Barboric, M., Kohoutek, J., Price, J. P., Blazek, D., Price, D. H. & Peterlin, B. M. (2005). Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb. The EMBO journal, 24(24), 4291-303. PMID: 16362050.

Adamson, T. E., Shutt, D. C. & Price, D. H. (2005). Functional coupling of cleavage and polyadenylation with transcription of mRNA. The Journal of biological chemistry, 280(37), 32262-71. PMID: 16041059.

Li, Q., Price, J. P., Byers, S. A., Cheng, D., Peng, J. & Price, D. H. (2005). Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. The Journal of biological chemistry, 280(31), 28819-26. PMID: 15965233.

Price, D. H. (2004). Gene expression in eukaryotes: RNA polymerasse II elongation control. Encyclopedia of Biological Chemistry, Academic Press/Elsevier Science, 3, 766-69.

Michels, A. A., Fraldi, A., Li, Q., Adamson, T. E., Bonnet, F., Nguyen, V. T., Sedore, S. C., Price, J. P., Price, D. H., Lania, L. & Bensaude, O. (2004). Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. The EMBO journal, 23(13), 2608-19. PMID: 15201869.

Jiang, Y., Liu, M., Spencer, C. A. & Price, D. H. (2004). Involvement of transcription termination factor 2 in mitotic repression of transcription elongation. Molecular cell, 14(3), 375-85. PMID: 15125840.

Jiang, Y., Price, D. H. (2004). Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector. Cell cycle (Georgetown, Tex.), 3(9), 1151-3. PMID: 15467445.

Adamson, T. E., Price, D. H. (2003). Cotranscriptional processing of Drosophila histone mRNAs. Molecular and cellular biology, 23(12), 4046-55. PMID: 12773550.

Shore, S. M., Byers, S. A., Maury, W. & Price, D. H. (2003). Identification of a novel isoform of Cdk9. Gene, 307, 175-82. PMID: 12706900.

Adamson, T. E., Shore, S. M. & Price, D. H. (2003). Analysis of RNA polymerase II elongation in vitro. Methods in enzymology, 371, 264-75. PMID: 14712706.

Moteki, S., Price, D. H. (2002). Functional coupling of capping and transcription of mRNA. Molecular Cell, 10, 599-609.

Chao, S. H., Greenleaf, A. L. & Price, D. H. (2001). Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription. Nucleic acids research, 29(3), 767-73. PMID: 11160900.

Chao, S. H., Price, D. H. (2001). Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. The Journal of biological chemistry, 276(34), 31793-9. PMID: 11431468.

Zhou, M., Nekhai, S., Bharucha, D. C., Kumar, A., Ge, H., Price, D. H., Egly, J. M. & Brady, J. N. (2001). TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription. The Journal of biological chemistry, 276(48), 44633-40. PMID: 11572868.

Renner, D. B., Yamaguchi, Y., Wada, T., Handa, H. & Price, D. H. (2001). A highly purified RNA polymerase II elongation control system. The Journal of biological chemistry, 276(45), 42601-9. PMID: 11553615.

Price, D. H. (2000). P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Molecular and cellular biology, 20(8), 2629-34. PMID: 10733565.

Lis, J. T., Mason, P., Peng, J., Price, D. H. & Werner, J. (2000). P-TEFb kinase recruitment and function at heat shock loci. Genes & development, 14(7), 792-803. PMID: 10766736.

Chao, S. H., Fujinaga, K., Marion, J. E., Taube, R., Sausville, E. A., Senderowicz, A. M., Peterlin, B. M. & Price, D. H. (2000). Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. The Journal of biological chemistry, 275(37), 28345-8. PMID: 10906320.

Zhou, M., Halanski, M. A., Radonovich, M. F., Kashanchi, F., Peng, J., Price, D. H. & Brady, J. N. (2000). Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription. Molecular and cellular biology, 20(14), 5077-86. PMID: 10866664.

Suñé, C., Goldstrohm, A. C., Peng, J., Price, D. H. & Garcia-Blanco, M. A. (2000). An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation. Virology, 274(2), 356-66. PMID: 10964778.

Ye, M., Duus, K. M., Peng, J., Price, D. H. & Grose, C. (1999). Varicella-zoster virus Fc receptor component gI is phosphorylated on its endodomain by a cyclin-dependent kinase. Journal of virology, 73(2), 1320-30. PMID: 9882337.

Price, D. H., Gray, M. W. (1999). Confirmation of predicted edits and demonstration of unpredicted edits in Acanthamoeba castellanii mitochondrial tRNAs. Current genetics, 35(1), 23-9. PMID: 10022945.

Hara, R., Selby, C. P., Liu, M., Price, D. H. & Sancar, A. (1999). Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer. The Journal of biological chemistry, 274(35), 24779-86. PMID: 10455150.

Price, D. H., Gray, M. W. (1999). A novel nucleotide incorporation activity implicated in the editing of mitochondrial transfer RNAs in Acanthamoeba castellanii. RNA (New York, N.Y.), 5(2), 302-17. PMID: 10024181.

Fu, T. J., Peng, J., Lee, G., Price, D. H. & Flores, O. (1999). Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. The Journal of biological chemistry, 274(49), 34527-30. PMID: 10574912.

Wimmer, J., Fujinaga, K., Taube, R., Cujec, T. P., Zhu, Y., Peng, J., Price, D. H. & Peterlin, B. M. (1999). Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. Virology, 255(1), 182-9. PMID: 10049833.

Peng, J., Zhu, Y., Milton, J. T. & Price, D. H. (1998). Identification of multiple cyclin subunits of human P-TEFb. Genes & development, 12(5), 755-62. PMID: 9499409.

Xie, Z., Price, D. H. (1998). Unusual nucleic acid binding properties of factor 2, an RNA polymerase II transcript release factor. The Journal of biological chemistry, 273(6), 3771-7. PMID: 9452510.

Peng, J., Liu, M., Marion, J., Zhu, Y. & Price, D. H. (1998). RNA polymerase II elongation control. Cold Spring Harbor symposia on quantitative biology, 63, 365-70. PMID: 10384301.

Peng, J., Marshall, N. F. & Price, D. H. (1998). Identification of a cyclin subunit required for the function of Drosophila P-TEFb. The Journal of biological chemistry, 273(22), 13855-60. PMID: 9593731.

Fujinaga, K., Cujec, T. P., Peng, J., Garriga, J., Price, D. H., Graña, X. & Peterlin, B. M. (1998). The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. Journal of virology, 72(9), 7154-9. PMID: 9696809.

Garriga, J., Peng, J., Parreño, M., Price, D. H., Henderson, E. E. & Graña, X. (1998). Upregulation of cyclin T1/CDK9 complexes during T cell activation. Oncogene, 17(24), 3093-102. PMID: 9872325.

Liu, M., Xie, Z. & Price, D. H. (1998). A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member. The Journal of biological chemistry, 273(40), 25541-4. PMID: 9748214.

Mancebo, H., Lee, G., Flygare, J., Tomassini, J., Luu, P., Zhu, Y., Peng, J., Blau, C., Hazuda, D. & Price, D. H. (1997). P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes and Development, 11, 2633-2644.

Xie, Z., Price, D. H. (1997). Drosophila factor 2, an RNA polymerase II transcript release factor, has DNA-dependent ATPase activity. The Journal of biological chemistry, 272, 31902-7.

Zhu, Y., Pe'ery, T., Peng, J., Ramanathan, Y., Marshall, N., Marshall, T., Amendt, B., Mathews, M. B. & Price, D. H. (1997). Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. Genes & development, 11(20), 2622-32. PMID: 9334325.

Chen, Y., Chafin, D., Price, D. H. & Greenleaf, A. L. (1996). Drosophila RNA polymerase II mutants that affect transcription elongation. The Journal of biological chemistry, 271(11), 5993-9. PMID: 8626382.

Xie, Z., Price, D. H. (1996). Purification of an RNA polymerase II transcript release factor from Drosophila. The Journal of biological chemistry, 271(19), 11043-6. PMID: 8626643.

Marshall, N. F., Peng, J., Xie, Z. & Price, D. H. (1996). Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. The Journal of biological chemistry, 271(43), 27176-83. PMID: 8900211.

Chafin, D. R., Guo, H. & Price, D. H. (1995). Action of alpha-amanitin during pyrophosphorolysis and elongation by RNA polymerase II. The Journal of biological chemistry, 270(32), 19114-9. PMID: 7642577.

Marshall, N. F., Price, D. H. (1995). Purification of P-TEFb, a transcription factor required for the transition into productive elongation. The Journal of biological chemistry, 270(21), 12335-8. PMID: 7759473.

Kephart, D. D., Wang, B. Q., Burton, Z. F. & Price, D. H. (1994). Functional analysis of Drosophila factor 5 (TFIIF), a general transcription factor. The Journal of biological chemistry, 269(18), 13536-43. PMID: 8175788.

Guo, H., Price, D. H. (1993). Mechanism of DmS-II-mediated pause suppression by Drosophila RNA polymerase II. The Journal of biological chemistry, 268(25), 18762-70. PMID: 7689559.

Kephart, D. D., Price, M. P., Burton, Z. F., Finkelstein, A., Greenblatt, J. & Price, D. H. (1993). Cloning of a Drosophila cDNA with sequence similarity to human transcription factor RAP74. Nucleic acids research, 21(5), 1319. PMID: 8464716.

Kephart, D. D., Marshall, N. F. & Price, D. H. (1992). Stability of Drosophila RNA polymerase II elongation complexes in vitro. Molecular and cellular biology, 12(5), 2067-77. PMID: 1373806.

Marshall, N. F., Price, D. H. (1992). Control of formation of two distinct classes of RNA polymerase II elongation complexes. Molecular and cellular biology, 12(5), 2078-90. PMID: 1569941.

Chafin, D. R., Claussen, T. J. & Price, D. H. (1991). Identification and purification of a yeast protein that affects elongation by RNA polymerase II. The Journal of biological chemistry, 266(14), 9256-62. PMID: 1851172.

Marshall, T. K., Guo, H. & Price, D. H. (1990). Drosophila RNA polymerase II elongation factor DmS-II has homology to mouse S-II and sequence similarity to yeast PPR2. Nucleic acids research, 18(21), 6293-8. PMID: 2243775.

Sluder, A. E., Greenleaf, A. L. & Price, D. H. (1989). Properties of a Drosophila RNA polymerase II elongation factor. The Journal of biological chemistry, 264(15), 8963-9. PMID: 2722810.

Price, D. H., Sluder, A. E. & Greenleaf, A. L. (1989). Dynamic interaction between a Drosophila transcription factor and RNA polymerase II. Molecular and cellular biology, 9(4), 1465-75. PMID: 2725511.

Sluder, A. E., Price, D. H. & Greenleaf, A. L. (1988). Elongation by Drosophila RNA polymerase II. Transcription of 3'-extended DNA templates. The Journal of biological chemistry, 263(20), 9917-25. PMID: 2454924.

Maroni, G., Otto, E., Lastowski-Perry, D. & Price, D. H. (1987). The metallothionein gene of Drosophila. Experientia. Supplementum, 52, 385-92. PMID: 2822463.

Greenleaf, A. L., Jokerst, R. S., Zehring, W. A., Hamilton, B. J., Weeks, J. R., Sluder, A. E. & Price, D. H. (1987). Drosophila RNA polymerase II: genetics and in vitro transcription. RNA Polymerase and the Regulation of Transcription (Elsevier, New York), 459-63.

Sluder, A. E., Price, D. H. & Greenleaf, A. L. (1987). An activity necessary for in vitro transcription is a DNase inhibitor. Biochimie, 69, 1199-205. PMID: 3129025.

Price, D. H., Sluder, A. E. & Greenleaf, A. L. (1987). Fractionation of transcription factors for RNA polymerase II from Drosophila Kc cell nuclear extracts. The Journal of biological chemistry, 262(7), 3244-55. PMID: 3818640.

Morris, G. F., Price, D. H. & Marzluff, W. F. (1986). Synthesis of U1 RNA in a DNA-dependent system from sea urchin embryos. Proceedings of the National Academy of Sciences of the United States of America, 83(11), 3674-8. PMID: 3459149.

Price, D. H., Parker, C. S. (1984). The 3' end of drosophila histone H3 mRNA is produced by a processing activity in vitro. Cell, 38(2), 423-9. PMID: 6432343.

Anderson, D. M., Richter, J. D., Chamberlin, M. E., Price, D. H., Britten, R. J., Smith, L. D. & Davidson, E. H. (1982). Sequence organization of the poly(A) RNA synthesized and accumulated in lampbrush chromosome stage Xenopus laevis oocytes. Journal of molecular biology, 155(3), 281-309. PMID: 6176716.

Thomas, V. G., Lumsden, H. G. & Price, D. H. (1975). Aspects of the winter metabolism of ruffed grouse (Bonasa umbellus) with special reference to energy reserves. Canadian journal of zoology, 53(4), 434-40. PMID: 1131743.

Price, D. H. (1972). A doomwatch for environmental pollution. (c). Pollution of water. Royal Society of Health journal, 92(4), 183-6. PMID: 5080164.