Ronald Weigel, MD, PhD, MBA

Portrait
Associate Vice President for UI Health Alliance
EA Crowell, Jr Professor and Chair of Surgery
Professor of Molecular Physiology and Biophysics
Professor of Surgery - Surgical Oncology and Endocrine Surgery
Professor of Biochemistry
Professor of Anatomy and Cell Biology

Contact Information

Primary Office
1509 JCP
Iowa City, IA 52242
319-353-7474

Education

MS, Chemical Engineering, Massachusetts Institute of Technology
MD, Yale University School of Medicine
PhD, Molecular Biophysics and Biochemistry, Yale University Graduate School
MBA, The Wharton School, University of Pennsylvania
Internship, Duke University Medical Center
Postdoctoral Fellow, Fellowship, Department Microbiology/ Immunology, Duke University Medical Center
Chief Resident, Duke University Medical Center

Licensure and Certifications

Iowa Medical License - Iowa Board of Medicine
Pennsylvania Medical License
Board Certified - American Board of Surgery
California Medical License
North Carolina Medical License

Education/Training Program Affiliations

Department of Biochemistry PhD, Medical Scientist Training Program

Research Summary

The Weigel laboratory has had a long-standing interest in determining mechanisms of hormone response in breast cancer. Our work has identified transcriptional mechanisms that regulate the expression of estrogen receptor- alpha in breast carcinomas. Other areas of investigation have sought to identify genes that are related to hormone response and additional mechanisms of gene regulation that are responsive to estrogen. Current Projects Regulation of ER by AP2 . We identified the AP2? transcription factor as a key regulator of hormone response in breast cancer. We are now examining mechanisms of gene regulation that involve this transcription factor. Chromatin Effects Altering AP2 Activity. We have shown that epigenetic chromatin alterations can influence activity of AP2 at certain promoters. The mechanism appears to involve altered binding of AP2 mediated through chromatin structure. Studies to determine how chromatin structure alters AP2 activity are being pursued. Interaction of AP2 and p53. We demonstrated a direct interaction between AP2 factors and the p53 tumor suppressor. The interaction of p53 and AP2 has functional effects on these two factors that appear to alter hormone response in breast cancer and cell growth in other cancer types. We are investigating the details of this interaction and the functional effects on gene regulation and cell physiology.

Publications

Liu, Q., Kulak, M. V., Borcherding, N., Maina, P. K., Zhang, W., Weigel, R. J. & Qi, H. H. (2018). A novel HER2 gene body enhancer contributes to HER2 expression. Oncogene, 37(5), 687-694. PMID: 29035388.

Arshava, E. V., Marchigiani, R. J., Gerke, H., El Abiad, R., Weigel, R. J., Parekh, K. R. & Keech, J. (2018). Per oral endoscopic myotomy: early experience and safety of a multispecialty approach. Surgical endoscopy. PMID: 29349541.

De Andrade, J. P., Lorenzen, A. W., Wu, V. T., Bogachek, M. V., Park, J. M., Gu, V. W., Sevenich, C. M., Cassady, V. C., Beck, A. C., Kulak, M. V., Robinson, R. A., Lal, G. & Weigel, R. J. (2017). Targeting the SUMO pathway as a novel treatment for anaplastic thyroid cancer. Oncotarget, 8(70), 114801-114815. PMID: 29383121.

Thomas, A., Weigel, R. J., Lynch, C. F., Spanheimer, P. M., Breitbach, E. K. & Schroeder, M. C. (2017). Incidence, characteristics, and management of recently diagnosed, microscopically invasive breast cancer by receptor status: Iowa SEER 2000 to 2013. American journal of surgery, 214(2), 323-328. PMID: 27692792.

Wu, V. T., Lorenzen, A. W., Beck, A. C., Reid, V. J., Sugg, S. L., Howe, J. R., Pollard, J. H., Lal, G. & Weigel, R. J. (2017). Comparative analysis of radioactive iodine versus thyroidectomy for definitive treatment of Graves disease. Surgery, 161(1), 147-155. PMID: 27863789.

Gómez-Contreras, P., Ramiro-Díaz, J. M., Sierra, A., Stipp, C., Domann, F. E., Weigel, R. J. & Lal, G. (2017). Extracellular matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells in part via S100A4 and Rho-family GTPases. Clinical & experimental metastasis, 34(1), 37-49. PMID: 27770373.

Bogachek, M. V., Park, J. M., De Andrade, J. P., Lorenzen, A. W., Kulak, M. V., White, J. R., Gu, V. W., Wu, V. T. & Weigel, R. J. (2016). Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas. Stem cell reports, 7(6), 1140-1151. PMID: 27916539.

Bogachek, M. V., Park, J. M., DeAndrade, J. P., Lorenzen, A. W., Kulak, M. V., White, J. R., Gu, V. W., Wu, V. T. & Weigel, R. J. (In Press). Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas. Stem Cell Reports, pii: S2213-6711 (16)30263-6.

Wu, V. T., Lorenzen, A. W., Beck, A. C., Reid, V. J., Sugg, S. L., Howe, J. R., Pollard, J. H., Lal, G. & Weigel, R. J. (In Press). Comparative Analysis of RAI vs. Thyroidectomy for Definitive Treatment of Graves' Disease. Surgery, pii: S0039-6060(16)30522-0.

Lal, G., Gomez-Contreras, P., Ramiro-Diaz, J. M., Sierra, A., Stipp, C., Domann, F. & Weigel, R. J. (In Press). Extracellular Matrix 1 (ECM1) regulates the actin cytoskeletal architecture of aggressive breast cancer cells via S100A4 and Rho-family GTPases. Clinical and Experimental Metastasis.

De Andrade, J. P., Park, J. M., Gu, V. W., Woodfield, G. W., Kulak, M. V., Lorenzen, A. W., Wu, V. T., Van Dorin, S. E., Spanheimer, P. M. & Weigel, R. J. (2016). EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib. Molecular cancer therapeutics, 15(3), 503-11. PMID: 26832794.

Weigel, R. J., Upchurch, Jr, G. R., Eberlein, T. J. & Lucas, C. E. (2015). Presidential Forum Discussion: Development of Surgical Scientists. Annals of surgery, 262(4), 555-62. PMID: 26366534.

Lizarraga, I. M., Weigel, R. J. (2015). Axillary lymph node dissection for breast cancer: Primum non nocere. (Vols. 41). (8), pp. 955-7. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. PMID: 26071786.

Weigel, R. J. (2015). 2015 Presidential Address-Society of Surgical Oncology: The Next 75 Years. Annals of surgical oncology. PMID: 26033181.

Borcherding, N., Kusner, D., Kolb, R., Xie, Q., Li, W., Yuan, F., Velez, G., Askeland, R., Weigel, R. J. & Zhang, W. (2015). Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells. Cancer research, 75(10), 1972-82. PMID: 25769722.

Spanheimer, P. M., Lorenzen, A. W., De Andrade, J. P., Kulak, M. V., Carr, J. C., Woodfield, G. W., Sugg, S. L. & Weigel, R. J. (2015). Receptor Tyrosine Kinase Expression Predicts Response to Sunitinib in Breast Cancer. Annals of surgical oncology. PMID: 25971960.

Lizarraga, I., Schroeder, M. C., Weigel, R. J. & Thomas, A. (2015). Surgical Management of Breast Cancer in 2010-2011 SEER Registries by Hormone and HER2 Receptor Status. Annals of surgical oncology. PMID: 25956579.

Park, J. M., Wu, T., Cyr, A. R., Woodfield, G. W., De Andrade, J. P., Spanheimer, P. M., Li, T., Sugg, S. L., Lal, G., Domann, F. E., Zhang, W. & Weigel, R. J. (2015). The role of Tcfap2c in tumorigenesis and cancer growth in an activated Neu model of mammary carcinogenesis. Oncogene. PMID: 25772240.

Bogachek, M. V., Park, J. M., De Andrade, J. P., Kulak, M. V., White, J. R., Wu, T., Spanheimer, P. M., Bair, T. B., Olivier, A. K. & Weigel, R. J. (2015). A novel animal model for locally advanced breast cancer. Annals of surgical oncology, 22(3), 866-73. PMID: 25326397.

Cyr, A. R., Kulak, M. V., Park, J. M., Bogachek, M. V., Spanheimer, P. M., Woodfield, G. W., White-Baer, L. S., O'Malley, Y. Q., Sugg, S. L., Olivier, A. K., Zhang, W., Domann, F. E. & Weigel, R. J. (2015). TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis. Oncogene, 34(4), 436-44. PMID: 24469049.

Bogachek, M. V., De Andrade, J. P. & Weigel, R. J. (2015). Regulation of epithelial-mesenchymal transition through SUMOylation of transcription factors. Cancer research, 75(1), 11-5. PMID: 25524900.

Xia, C., Schroeder, M. C., Weigel, R. J., Sugg, S. L. & Thomas, A. (2014). Rate of contralateral prophylactic mastectomy is influenced by preoperative MRI recommendations. Annals of surgical oncology, 21(13), 4133-8. PMID: 24934585.

Berman, R. S., Weigel, R. J. (2014). Training and certification of the surgical oncologist. Chinese clinical oncology, 3(4), 45. PMID: 25841526.

Bhama, A. R., Smith, R. J., Robinson, R. A., Weigel, R. J., Sugg, S. L., Howe, J. R. & Lal, G. (2014). Preoperative evaluation of thyroglossal duct cysts: children versus adults--is there a difference?. American journal of surgery, 207(6), 902-6. PMID: 24246260.

Bogachek, M., Chen, Y., Kulak, M. V., Woodfield, G. W., Cyr, A. R., Spanheimer, P. M., Li, Y., Li, T. & Weigel, R. J. (2014). Sumoylation Pathway Is Required to Maintain the Basal Breast Cancer Subtype. Cancer Cell, 25, 748-761.

Spanheimer, P. M., Cyr, A. R., Gillum, M. P., Woodfield, G. W., Askeland, R. W. & Weigel, R. J. (2014). Distinct Pathways Regulated by RET and ER in Luminal Breast Cancer Demonstrates the Biologic Basis for Combination Therapy. Annals of Surgery, 259, 793-799.

Spanheimer, P. M., Park, J. M., Askeland, R. w., Kulak, M. V., Cyr, A. R., Woodfield, G. W., Sugg, S. L., Thomas, A. & Weigel, R. J. (2014). Inhibition of RET Increases the Efficacy of Antiestrogen and Is a Novel Treatment Strategy for Luminal Breast Cancer. Clinical Cancer Research, 20, 2115-2125. PMID: 24526731.

Lizarraga, I. M., Scott-Conner, C. E., Muzahir, S., Weigel, R. J., Graham, M. M. & Sugg, S. L. (2013). Management of contralateral axillary sentinel lymph nodes detected on lymphoscintigraphy for breast cancer. Annals of surgical oncology, 20(10), 3317-22. PMID: 23975295.

Lal, G., Gomez-Contreras, P., Kulak, M., Woodfield, G., Bair, T., Domann, F. E. & Weigel, R. J. (2013). Human melanoma cells over-express Extracellular Matrix 1 (ECM1) which is regulated by TFAP2C. (Vols. 8). pp. e73953. PLOS ONE.

Weigel, R. J. (2013). Molecular Biology. The SCORE Portal.

Weigel, R. J. (2013). Clinical Trials on Cancer. The SCORE Portal.

Weigel, R. J. (2013). Eccrine Tumor. The SCORE Portal.

Weigel, R. J. (2013). Screening and Biomarkers. The SCORE Portal.

Spanheimer, P. M., Carr, J. C., Thomas, A., Sugg, S. L., Scott-Conner, C. E., Liao, J. & Weigel, R. J. (2013). The response to neoadjuvant chemotherapy predicts clinical outcome and increases breast conservation in advanced breast cancer. American journal of surgery, 206(1), 2-7. PMID: 23375759.

Carr, J. C., Spanheimer, P. M., Dahdaleh, F. S., Lal, G., Weigel, R. J., Sugg, S. L., Liao, J. & Howe, R. J. (2013). Discriminating Pheochromocytomas from Other Adrenal Lesions: The Dilemma of Elevated Catecholamines. (20), pp. 3855-61. Annals of Surgical Oncology .

Spanheimer, P. M., Stoltze, A. J., Howe, J. R., Sugg, S. L., Lal, G. & Weigel, R. J. (2013). Do Giant Parathyroid Adenomas Represent a Distinct Clinical Entity?. In Surgery. (Vols. 154). (714-718)

Spanheimer, P. M., Askeland, R. W., Wu, T. & Weigel, R. J. (2013). High TFAP2C/Low CD44 Expression is Associated with an Increased Rate of Pathologic Complete Response Following Neoadjuvant Chemotherapy in Breast Cancer. (184), pp. 519-525. Journal of Surgical Research.

Kulak, M. V., Cyr, A. R., Woodfield, G. W., Bogachek, M., Li, T., Price, D. H., Domann, F. E. & Weigel, R. J. (2012). Transcriptional Regulation of the GPX1 Gene by TFAP2C and Aberrant CpG Methylation in Human Breast Cancer. (Vols. 32). pp. 4043-4051. Oncogene.

Spanheimer, P. M., Woodfield, G. W., Cyr, A. R., Kulak, M. V., White-Baer, L. S., Bair, T. B. & Weigel, R. J. (2012). Expression of the RET Proto-oncogene is Regulated by TFAP2C in Breast Cancer Independent of the Estrogen Receptor. Annals of Surgical Oncology, 20, 2204-2212.

O’Malley, Y., Lal, G., Howe, J. R., Weigel, R. J., Komorowski, R. A., Shilyansky, J. & Sugg, S. L. (2012). Invasion in Follicular Thyroid Cancer Cell Lines is Mediated by EphA2 and pAkt. (Vols. 152). pp. 1218-24. Surgery.

Spanheimer, P. M., Weigel, R. J. (2012). Concepts in Thyroid, Parathyroid and Adrenal Surgery. In , C. E. Scott-Conner (Eds.) Chassin’s Operative Strategy in General Surgery. Springer, New York.

Spanheimer, P. M., Weigel, R. J. (2012). Management of Patients with Primary Hyperparathyroidism and Concurrent Thyroid Disease: An Evolving Field. Annals of Surgical Oncology, 19, 1428-9.

Bhama, A. R., Smith, R. J., Robinson, R. A., Weigel, R. J., Sugg, S. L., Howe, J. R. & Lal, G. (2012). Preoperative Evaluation of Thyroglossal Duct Cysts: Children versus Adults – Is there a Difference?. (207), pp. 902-6. American Journal of Surgery.

Lal, G., Groff, M., Howe, J. R., Weigel, R. J., Sugg, S. L. & Lynch, C. F. (2012). Risk of Subsequent Primary Thyroid Cancer Following Another Malignancy: Latency Trends in a Population-based Study. (Vols. 19). pp. 1887-96. Annals of Surgical Oncology.

Larrieux, G., Cupp, J. A., Liao, J., Scott-Conner, C. E. & Weigel, R. J. (2012). The Effect of Introducing Hematoma Ultrasound Guided (HUG) Lumpectomy in a Surgical Practice. (Vols. 215). pp. 237-243. Journal of the American College of Surgeons.

(2012). The Response to Neoadjuvant Chemotherapy Predicts Clinical Outcome and Increases Breast Conservation in Advanced Breast Cancer. American Journal of Surgery.

Guidroz, J. A., Larrieux, G., Liao, J., Sugg, S. L., Scott-Conner, C. E. & Weigel, R. (2011). Sampling of secondary margins decreases the need for re-excision after partial mastectomy. Surgery, 150(4), 802-9. PMID: 22000194.

Spanheimer, P. M., Sugg, S. L., Lal, G., Howe, J. R. & Weigel, R. (2011). Surveillance and intervention after thyroid lobectomy. Ann Surg Oncol, 18(6), 1729-33. PMID: 21246403.

Calva-Cerqueira, D., Dahdaleh, F., Woodfield, G., Weigel, R. J., Carr, J., Chinnathambi, S. & Howe, J. R. (2011). Discovery of SMAD4 Promoters, Transcription Factor Binding Sites, and Deletions in Juvenile Polyposis Patients. Nucleic Acids Research, 39, 5369-5378.

Royer, N., Miron, J., Kirby, P., Weigel, R. J. & Lal, G. (2011). Incidental Finding of Composite Pheochromocytoma-Ganglioneuroma: Successful Management after Emergent Appendectomy and Review of the Literature. (Vols. 3). pp. 39-44. World Journal of Endocrine Surgery.

Guidroz, J. A., Scott-Conner, C. E. & Weigel, R. J. (2011). Management of Pregnant Women with Breast Cancer. (Vols. 103). pp. 337-340. Journal of Surgical Oncology.

Spanheimer, P. M., Weigel, R. J. (2011). Reply to comment on "Surveillance and intervention after thyroid lobectomy". Annals of Surgical Oncology, 18, S309.

Guidroz, J. A., Weigel, R. J. (2011). The Biology of Breast Cancer. In , C. E. Scott-Conner , F. M. Dirbas (Eds.) Breast Surgical Techniques and Interdisciplinary Management. Springer, New York.

Calva-Cerqueira, D., Dahdaleh, F. S., Woodfield, G., Chinnathambi, S., Nagy, P. L., Larsen-Haidle, J., Weigel, R. & Howe, J. R. (2010). Discovery of the BMPR1A promoter and germline mutations that cause juvenile polyposis. Hum Mol Genet, 19(23), 4654-62. PMID: 20843829.

Lal, G., Fairchild, T., Howe, J. R., Weigel, R., Sugg, S. L. & Menda, Y. (2010). PET-CT scans in recurrent or persistent differentiated thyroid cancer: is there added utility beyond conventional imaging?. Surgery, 148(6), 1082-9; discussion 1089-90. PMID: 21134537.

Woodfield, G. W., Chen, Y., Bair, T. B., Domann, F. E. & Weigel, R. (2010). Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer, 49(10), 948-62. PMID: 20629094.

Gollapalli, V., Liao, J., Dudakovic, A., Sugg, S. L., Scott-Conner, C. E. & Weigel, R. (2010). Risk factors for development and recurrence of primary breast abscesses. J Am Coll Surg, 211(1), 41-8. PMID: 20610247.

Guidroz, J. A., Johnson, M. T., Scott-Conner, C. E., Deyoung, B. & Weigel, R. (2010). The use of touch preparation for the evaluation of sentinel lymph nodes in breast cancer. Am J Surg, 199(6), 792-6. PMID: 19954770.

Fang, S. H., Guidroz, J. A., O'Malley, Y., Lal, G., Sugg, S. L., Howe, J. R., Jensen, C. S. & Weigel, R. (2010). Expansion of a cell population expressing stem cell markers in parathyroid glands from patients with hyperparathyroidism. Ann Surg, 251(1), 107-13. PMID: 20009751.

Lal, G., Nowell, A. G., Liao, J., Sugg, S. L., Weigel, R. & Howe, J. R. (2009). Determinants of survival in patients with calciphylaxis: a multivariate analysis. Surgery, 146(6), 1028-34. PMID: 19958929.

Fang, S. H., Chen, Y. & Weigel, R. (2009). GATA-3 as a marker of hormone response in breast cancer. J Surg Res, 157(2), 290-5. PMID: 19059610.

Johnson, M. T., Guidroz, J. A., Smith, B. J., Graham, M. M., Scott-Conner, C. E., Sugg, S. L. & Weigel, R. (2009). A single institutional experience of factors affecting successful identification of sentinel lymph node in breast cancer patients. Surgery, 146(4), 671-6; discussion 676-7. PMID: 19789026.

Woodfield, G. W., Hitchler, M. J., Chen, Y., Domann, F. E. & Weigel, R. (2009). Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure. Clin Cancer Res, 15(11), 3672-9. PMID: 19458056.

Lal, G., Hashimi, S., Smith, B. J., Lynch, C. F., Zhang, L., Robinson, R. A. & Weigel, R. J. (2009). Extracellular Matrix 1 (ECM1) expression is a novel prognostic marker for poor long-term survival in breast cancer – a hospital-based cohort study in Iowa. (Vols. 16). pp. 2280-7. Annals of Surgical Oncology.

Spanheimer, P. M., Graham, M. M., Sugg, S. L., Scott-Conner, C. E. & Weigel, R. J. (2009). Measurement of Uterine Radiation Exposure from Lymphoscintigraphy Indicates Safety of Sentinel Lymph Node Biopsy during Pregnancy. (Vols. 16). pp. 1143-7. Annals of Surgical Oncology.

Weigel, R. J. (2009). Textbook of Surgical Oncology. American Journal of Surgery, 197, 828.

Calva, D., O’Dorisio, T. M., O’Dorisio, M. S., Lal, G., Sugg, S. L., Weigel, R. J. & Howe, J. R. (2009). When Is Prophylactic Thyroidectomy Indicated For Patients With The RET C609Y Mutation?. (Vols. 16). pp. 2237-44. Annals of Surgical Oncology.

Lal, G., O’Dorisio, T., McDougall, I. R. & Weigel, R. J. (2008). Cancer of the Endocrine System. In , M. D. Abeloff , J. O. Armitage & J. E. Niederhuber , M. B. Kastan , W. G. McKenna (Eds.) Clinical Oncology. (4) Elsevier, Philadelphia.

Hoballah, J. J., Liao, J., Salameh, M. & Weigel, R. J. (2008). Physician Reimbursement for General Surgical Procedures in the Last Century: 1906-2006. (206), pp. 670-7. Journal of the American College of Surgeons.

Woodfield, G. W., Horan, A. D., Chen, Y. & Weigel, R. (2007). TFAP2C controls hormone response in breast cancer cells through multiple pathways of estrogen signaling. Cancer Res, 67(18), 8439-43. PMID: 17875680.

McPherson, L. A., Woodfield, G. W. & Weigel, R. (2007). AP2 transcription factors regulate expression of CRABPII in hormone responsive breast carcinoma. J Surg Res, 138(1), 71-8. PMID: 17187826.

Kairys, J. C., Daskalakis, C. & Weigel, R. (2006). Surgeon-performed ultrasound for preoperative localization of abnormal parathyroid glands in patients with primary hyperparathyroidism. World J Surg, 30(9), 1658-63; discussion 1664. PMID: 16855801.

Stabach, P. R., Thiyagarajan, M. M., Woodfield, G. W. & Weigel, R. (2006). AP2alpha alters the transcriptional activity and stability of p53. Oncogene, 25(15), 2148-59. PMID: 16288208.

Boland, G. M., Weigel, R. J. (2006). Formation and Prevention of Postoperative Abdominal Adhesions. (Vols. 132). pp. 3-12. Journal of Surgical Research.

Weigel, R. J., McDougall, I. R. (2006). The Role of Radioactive Iodine in the Treatment of Well-differentiated Thyroid Cancer. (Vols. 15). pp. 625-38. Surgical Oncology Clinics of North America.

Weigel, R. J. (2006). Variability in the Adoption of Breast MRI Among Surgeons. (Vols. 93). pp. 343-4. Journal of Surgical Oncology.

Stabach, P. R., Thiyagarajan, M. M. & Weigel, R. (2005). Expression of ZER6 in ERalpha-positive breast cancer. J Surg Res, 126(1), 86-91; discussion 1-2. PMID: 15916980.

Weigel, R. J., Silverberg, L. I. (2005). Effect of Parathyroidectomy on Polycythemia Vera. (Vols. 137). pp. 102-3. Surgery.

Parikh, P., Palazzo, J. P., Rose, L. J., Daskalakis, C. & Weigel, R. J. (2005). GATA-3 Expression as a Predictor of Hormone Response in Breast Cancer. (200), pp. 705-710. Journal of the American College of Surgeons.

Radomski, J. S., Cohn, H. E. & Weigel, R. J. (2005). Multiple Endocrine Neoplasia and Tumors of the Endocrine Pancreas. In , B. E. Jarrell & R. A. Carabasi (Eds.) NMS Surgery. (5) Lippincott Williams & Wilkins, Philadelphia.

Vernick, J. J., Weigel, R. J. (2005). Pancreas. In , B. E. Jarrell , R. A. Carabasi (Eds.) NMS Surgery. (5) Lippincott Williams & Wilkins, Philadelphia.

Weigel, R. J. (2005). Thyroid. In , J. A. Norton , R. R. Bollinger , A. E. Chang , S. F. Lowry , S. J. Mulvihill , H. I. Pass , R. W. Thompson (Eds.) Surgery: Scientific Basis and Current Evidence. (2) Springer-Verlag, New York.

Aqeilan, R. I., Palamarchuk, A., Weigel, R., Herrero, J. J., Pekarsky, Y. & Croce, C. M. (2004). Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor. Cancer Res, 64(22), 8256-61. PMID: 15548692.

Weigel, R. J., Macdonald, J. S., Haller, D. & McDougall, I. R. (2004). Cancer of the Endocrine System. In , M. D. Abeloff , J. O. Armitage & J. E. Niederhuber , M. B. Kastan , W. G. McKenna (Eds.) Clinical Oncology. (3) Elsevier, Philadelphia.

Weigel, R. J., Dracon, G., Radhakrishnan, R., Rho, Y., Sevgen, F. & Dafoe, D. C. (2004). Incentive Systems For Academic Productivity in a Department of Surgery. (Vols. 199). pp. 300-307. Journal of the American College of Surgeons.

Kulkarni, K., Kim, S. M. & Weigel, R. J. (2004). Utility of Very Delayed Parathyroid MIBI SPECT for Localization of Parathyroid Adenoma. (Vols. 29). pp. 727-729. Clinical Nuclear Medicine.

Chan, B. K., Desser, T. S., McDougall, I. R., Weigel, R. & Jeffrey, R. B. (2003). Common and uncommon sonographic features of papillary thyroid carcinoma. (Vols. 22). pp. 1083-90. Journal of Ultrasound in Medicine.

Yu, S. J., Asa, S. L., Weigel, R. & Ezzat, S. (2003). Pituitary Tumor AP-2a Recognizes A Cryptic Promoter in Intron 4 of Fibroblast Growth Factor Receptor 4. (Vols. 278). pp. 19597-602. Journal of Biological Chemistry.

Lal, T. G., Kaulback, K. R., Bombonati, A., Palazzo, J. P., Jeffrey, R. B. & Weigel, R. J. (2003). Surgical Management of Adrenal Cysts. (Vols. 69). pp. 812-4. American Surgeon.

McFadden, D. W., Ferguson, M. K., Weigel, R. J., Garrison, N. R., Stelzner, M. G., Brophy, C. M., Dionne, D. & Souba, W. W. (2003). The Journal of surgical research increases its science citation index: what's the impact?. Journal of Surgical Research, 114, 107-9.

McPherson, L. A., Loktev, A. V. & Weigel, R. (2002). Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53. J Biol Chem, 277(47), 45028-33. PMID: 12226108.

Conroy, A. T., Sharma, M., Holtz, A. E., Wu, C., Sun, Z. & Weigel, R. (2002). A Novel Zinc Finger Transcription Factor with Two Isoforms that are Differentially Repressed by Estrogen Receptor-a. (Vols. 277). pp. 9326-34. Journal of Biological Chemistry.

Karwowski, J. K., Jeffrey, R. B., McDougall, I. R. & Weigel, R. (2002). Intraoperative ultrasonograpy improves identification of recurrent thyroid cancer. (Vols. 132). pp. 924-9. Surgery.

Karwowski, J. K., Nowels, K. W., McDougall, I. R. & Weigel, R. (2002). Needle Track Seeding of Papillary Thyroid Carcinoma from Fine Needle Aspiration Biopsy. (Vols. 46). pp. 591-595. Acta Cytologica.

Reeder, S. B., Desser, T. S., Weigel, R. & Jeffrey, R. B. (2002). Sonography in Primary Hyperparathyroidism: Review With Emphasis on Scanning Technique. (Vols. 21). pp. 539-552. Journal of Ultrasound in Medicine.

Schuur, E. R., Loktev, A. V., Sharma, M., Sun, Z., Roth, R. A. & Weigel, R. (2001). Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family. J Biol Chem, 276(36), 33554-60. PMID: 11435445.

Yang, G. P., Levine, S. & Weigel, R. (2001). A spike in parathyroid hormone during neck exploration may cause a false-negative intraoperative assay result. Arch Surg, 136(8), 945-9. PMID: 11485536.

Wong, P., Carmeci, C., Jeffrey, R. B. & Weigel, R. (2001). Parathyroid crisis in a 20 year old--an unusual cause of hypercalcaemic crisis. Postgrad Med J, 77(909), 468-70. PMID: 11423601.

Schuur, E. R., McPherson, L. A., Yang, G. P. & Weigel, R. (2001). Genomic structure of the promoters of the human estrogen receptor-alpha gene demonstrate changes in chromatin structure induced by AP2gamma. J Biol Chem, 276(18), 15519-26. PMID: 11278455.

Desai, D., McPherson, L. A., Higgins, J. P. & Weigel, R. (2001). Genetic analysis of a papillary thyroid carcinoma in a patient with MEN1. Ann Surg Oncol, 8(4), 342-6. PMID: 11352308.

Desai, D., Jeffrey, R. B., McDougall, I. R. & Weigel, R. (2001). Intraoperative ultrasonography for localization of recurrent thyroid cancer. Surgery, 129(4), 498-500. PMID: 11283542.

Weigel, R. J. (2001). Non-operative management of hyperparathyroidism—present and future. (Vols. 13). pp. 33-38. Current Opinion in Oncology.

McDougall, I. R., Weigel, R. (2001). Recombinant human thyrotropin in the management of thyroid cancer. Curr Opin Oncol, 13(1), 39-43. PMID: 11148684.

Weigel, R. J. (2001). Thyroid. In , J. A. Norton , R. R. Bollinger , A. E. Chang , S. F. Lowry , S. J. Mulvihill , H. I. Pass , R. W. Thompson (Eds.) Surgery: Scientific Basis and Current Evidence. pp. 879-896. Springer-Verlag, New York.

Yang, G. P., Weigel, R. J. (2001). Transcription. In , W. W. Souba , D. Wilmore (Eds.) Surgical Research. pp. 233-251. Academic Press, San Diego.

Ghosh, M. G., Thompson, D. A. & Weigel, R. (2000). PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer. Cancer Res, 60(22), 6367-75. PMID: 11103799.

Schuur, E. R., Weigel, R. (2000). Monoallelic amplification of estrogen receptor-alpha expression in breast cancer. Cancer Res, 60(10), 2598-601. PMID: 10825128.

Macdonald, J. S., Haller, D., McDougall, I. R. & Weigel, R. J. (2000). Endocrine system. In , M. D. Abeloff , J. O. Armitage & A. S. Lichter , J. E. Niederhuber (Eds.) Clinical Oncolog. (2), pp. 1360-1397. Churchill, Livingstone, New York.

Durski, J. M., Weigel, R. & McDougall, I. R. (2000). Recombinant Human Thyrotropin (rhTSH) in the Management of Differentiated Thyroid Cancer. (Vols. 21). pp. 521-528. Nuclear Medicine Communications.

McPherson, L. A., Weigel, R. (1999). AP2alpha and AP2gamma: a comparison of binding site specificity and trans-activation of the estrogen receptor promoter and single site promoter constructs. Nucleic Acids Res, 27(20), 4040-9. PMID: 10497269.

Nakatani, K., Thompson, D. A., Barthel, A., Sakaue, H., Liu, W., Weigel, R. & Roth, R. A. (1999). Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem, 274(31), 21528-32. PMID: 10419456.

Nakatani, K., Sakaue, H., Thompson, D. A., Weigel, R. & Roth, R. A. (1999). Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. Biochem Biophys Res Commun, 257(3), 906-10. PMID: 10208883.

Yang, G. P., Ross, D. T., Kuang, W. W., Brown, P. O. & Weigel, R. (1999). Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res, 27(6), 1517-23. PMID: 10037815.

Hoch, R. V., Thompson, D. A., Baker, R. J. & Weigel, R. (1999). GATA-3 is expressed in association with estrogen receptor in breast cancer. (Vols. 84). pp. 122-128. International Journal of Cancer.

Purcell, G. P., Dirbas, F. M., Jeffrey, R. B., Lane, M. J., Desser, T., McDougall, I. R. & Weigel, R. (1999). Parathyroid localization with high resolution ultrasound and technetium 99m-sestamibi. (Vols. 134). pp. 824-828. Archives of Surgery.

Carmeci, C., Thompson, D. A., Kuang, W. W., Lightdale, N., Furthmayr, H. & Weigel, R. (1998). Moesin expression is associated with the estrogen receptor-negative breast cancer phenotype. Surgery, 124(2), 211-7. PMID: 9706140.

Carmeci, C., Jeffrey, R. B., McDougall, I. R., Nowels, K. W. & Weigel, R. (1998). Ultrasound-guided fine-needle aspiration biopsy of thyroid masses. Thyroid, 8(4), 283-9. PMID: 9588492.

Thompson, D. A., Weigel, R. (1998). Characterization of a gene that is inversely correlated with estrogen receptor expression (ICERE-1) in breast carcinomas. Eur J Biochem, 252(1), 169-77. PMID: 9523727.

Kuang, W. W., Thompson, D. A., Hoch, R. V. & Weigel, R. (1998). Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line. Nucleic Acids Res, 26(4), 1116-23. PMID: 9461476.

Weigel, R. J. (1998). Cancer biology. In , J. E. Niederhuber (Eds.) Fundamentals of Surgery. pp. 227-231. Appleton & Lange, Stamford, CT.

Thompson, D. A., Weigel, R. (1998). hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is co-expressed with estrogen receptor in breast cancer cell lines. (Vols. 251). pp. 111-116. Biochemical and Biophysical Research Communications.

Thompson, D. A., Carmeci, C. & Weigel, R. J. (1998). RT-PCR using formalin-fixed, paraffin-embedded (FFPE) archival tumour specimens. In , Siebert & Larrick (Eds.) Gene Cloning and Analysis by RT-PCR. pp. 3-17. BioTechniques Books, Natick, MA.

Weigel, R. J. (1998). The endocrine system. In , J. E. Niederhuber (Eds.) Fundamentals of Surgery. pp. 425-439. Appleton & Lange, Stamford, CT.

Lane, M., Desser, T., Weigel, R. & Jeffrey, R. B. (1998). Use of color and power Doppler sonography to identify feeding arteries associated with parathyroid adenomas. (Vols. 171). pp. 819-823. American Journal of Roentgenology.

Carmeci, C., Thompson, D. A., Ring, H. Z., Francke, U. & Weigel, R. (1997). Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics, 45(3), 607-17. PMID: 9367686.

Thompson, D. A., McPherson, L. A., Carmeci, C., deConinck, E. C. & Weigel, R. (1997). Identification of two estrogen receptor transcripts with novel 5' exons isolated from a MCF7 cDNA library. J Steroid Biochem Mol Biol, 62(2-3), 143-53. PMID: 9393949.

Carmeci, C., deConinck, E. C., Lawton, T., Bloch, D. A. & Weigel, R. (1997). Analysis of estrogen receptor messenger RNA in breast carcinomas from archival specimens is predictive of tumor biology. Am J Pathol, 150(5), 1563-70. PMID: 9137083.

McPherson, L. A., Baichwal, V. R. & Weigel, R. (1997). Identification of ERF-1 as a member of the AP2 transcription factor family. Proc Natl Acad Sci U S A, 94(9), 4342-7. PMID: 9113991.

Weigel, R. J. (1996). Advances in the diagnosis and management of thyroid cancers. (Vols. 8). pp. 37-43. Current Opinion in Oncology.

Weigel, R., Ikeda, D. M. & Nowels, K. W. (1996). Primary squamous cell carcinoma of the breast. (Vols. 89). pp. 511-515. Southern Medical Journal.

Macdonald, J. S., Haller, D. & Weigel, R. J. (1995). Endocrine system. In , M. D. Abeloff & J. O. Armitage , A. S. Lichter , J. E. Niederhuber (Eds.) Clinical Oncology. Livingstone, New York.

Weigel, R. J. (1995). Inherited cancer. In , M. D. Abeloff , J. O. Armitage , A. S. Lichter (Eds.) Clinical Oncology. pp. 167-186. Livingstone, New York.

Weigel, R., Crooks, D. L., Iglehart, J. D. & deConinck, E. C. (1995). Quantitative analysis of the transcriptional start sites of estrogen receptor in breast carcinoma. (Vols. 6). pp. 707-711. Cell Growth and Differentiation.

deConinck, E. C., McPherson, L. A. & Weigel, R. (1995). Transcriptional regulation of estrogen receptor in breast carcinoma. (Vols. 15). pp. 2191-2196. Molecular and Cellular Biology.

Weigel, R., Wells, S. A., Gunnells, J. C. & Leight, G. S. (1994). Surgical treatment of primary hyperaldosteronism. (Vols. 219). pp. 347-352. Annals of Surgery.

Weigel, R., deConinck, E. C. (1993). Transcriptional control of estrogen receptor in estrogen receptor-negative breast carcinoma. (Vols. 53). pp. 3472-3474. Cancer Research.

Weigel, R. J., Boyle, T. J. & Kirk, A. D. (1992). Infections. In , H. K. Lyerly & J. W. Gaynor (Eds.) The Handbook of Surgical Intensive Care. pp. 653-705. Mosby Year Book, St. Louis, MO.

Weigel, R. J. (1992). Wound healing: biologic and clinic features. In , D. C. Sabiston , H. K. Lyerly (Eds.) Textbook of Surgery Pocket Companion. pp. 80-85. W.B. Saunders Company, Philadelphia, PA.

Weigel, R., Nevins, J. R. (1990). Adenovirus infection of differentiated F9 cells results in a global shut-off of differentiation-induced gene expression. (Vols. 18). pp. 6107-6112. Nucleic Acids Research.

Weigel, R., Devoto, S. H. & Nevins, J. R. (1990). The adenovirus 12S E1A gene represses differentiation of F9 teratocarcinoma cells. (Vols. 87). pp. 9878-9882. Proceedings of the National Academy of Sciences USA.

Young, K. S., Weigel, R., Hiebert, S. & Nevins, J. R. (1989). Adenovirus E1A-mediated negative control of genes activated during F9 differentiation. (Vols. 9). pp. 3109-3113. Molecular and Cellular Biology.

Weigel, R. (1986). Gene expression during the latent and replicative states of the Epstein-Barr virus. In Yale University Ph.D. Thesis.

Weigel, R., Fischer, D., Heston, L. & Miller, G. (1985). Constitutive expression of Epstein-Barr virus-encoded RNAs and nuclear antigen during latency and after induction of Epstein-Barr virus replication. (Vols. 53). pp. 254-259. Journal of Virology.

Weigel, R., Miller, G. (1985). Latent and viral replicative transcription in vivo from the Bam K fragment of Epstein-Barr virus DNA. (Vols. 54). pp. 501-508. Journal of Virology.

Robert, M., Shedd, D., Weigel, R., Fischer, D. & Miller, G. (1984). Expression of COS-1 cells of Epstein-Barr virus and nuclear antigen from a complete gene and a deleted gene. (Vols. 50). pp. 822-831. Journal of Virology.

Weigel, R., Miller, G. (1983). Major EB virus-specific cytoplasmic transcripts in a cellular clone of the HR-1 Burkitt lymphoma line during latency and after induction of viral replicative cycle by phorbol esters. (Vols. 125). pp. 287-298. Virology.

Weigel, R. J. (1981). Comments on static linear and non-linear elastic properties of normal and arterialized venous tissue in dog and man. In Letter to the Editor, Circulation Research. (Vols. 49). pp. 1363-1364.

Weigel, R. J. (1980). Covalent binding of biologically active molecules to synthetic polymers: a study of blood compatible surfaces. In M.I.T. Master's Thesis.