Postdoctoral Research Fellow

Dept. of Internal Medicine

Email: ofonime-udofot@uiowa.edu

Training Mentor: Paloma Giangrande

​Research Project

Inhibition of Extracellular Histones in Sepsis-Induced Cardiomyopathy

My research interest lies in the fields of nanobiology and drug delivery. My research efforts will address a critical unmet need in the treatment of various critical diseases such as Prostate cancer and hyperproliferative/inflammatory cardiovascular disease. To achieve this, I will seek effective ways in delivering and increasing the bioavailability of RNA bio-drugs with fewer side effects. My goal is to work towards the development of next-generation smart drugs with improved efficacy and reduced toxicity. As a Postdoctoral Research Scholar in Dr. Paloma Giangrande’s laboratory, I will be concentrating on the development and delivery of RNA bio-drugs for the treatment of cardiomyopathy associated with sepsis and also prostate cancer. These studies will evaluate these novel RNA bio-drugs in cells in culture as well as in animal models of inflammation and prostate cancer. Finally, I will evaluate and optimize formulations for enhancing delivery and bioavailability to target the cardiovascular tissues and prostate cancer site.