Contact Information
Office: 3186 ML
Phone: 319-335-7712
Faculty Profile
Brief description of current research:
Dr. Dayal’s primary research interest is in studying the mechanisms of vascular dysfunction and thrombosis related to risk factors such as hyperhomocysteinemia, aging, and cancer. To pursue her research efforts in obesity and insulin resistance associated thrombosis, she is collaborating with Dr. Dale Abel on several projects. Her research work over the years has been supported through several funding’s from American Heart Association and National Institute of Aging (NIA), NIH. She is currently funded through a R01 mechanism from NIA, NIH to study role of peroxide mediated platelet activation in aging. In addition, she has received administrative supplement through NIA, NIH to advance her research interests towards Alzheimers and related dementia, where she will specifically define mechanistic role of oxidative stress. More recently, she has been funded through an Indian Agency (Indo US Joint Network) to establish infrastructure for future homocysteine-lowering trials to prevent or decrease vascular incidents in Indian patients with ischemic stroke. She is extremely excited about this opportunity as this will allow her to translate her basic research findings into human stroke.
3 most influential diabetes/obesity/metabolism publications:
- Dayal S , Wilson KM, Motto DG, Miller FJ Jr, Chauhan AK, Lentz SR. Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis. Circulation. 2013;127(12):1308-16. PMID: 23426106. PMCID: PMC4047166
- Dayal S, Chauhan AK, Jensen M, Leo L, Lynch CM, Faraci FM, Kruger WD, Lentz SR. Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood. 2012;119(13):3176-83. PMCID: PMC3321876
- Dayal S, Gu SX, Hutchins RD, Wilson KM, Wang Y, Fu X, Lentz SR. Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis. Arterioscler Thromb Vasc Biol. 2015;35;1798-804 PMCID:4514539
Quote:
"Never give up: keep trying for the right path to success."