FOEDRC member Dr. Vitor Lira is awarded AHA Scientist Development Grant

Dr. Vitor Lira, Assistant Professor in Health and Human Physiology and member of the Fraternal Order of Eagles Diabetes Center and the Obesity Research and Education Initiative at the University of Iowa, has received the American Heart Association (AHA) Scientist Development Grant.

His three -year project is entitled “Molecular insights into the exercise-mediated protection against diabetic cardiomyopathy”. The $308,000 award, will study an important mechanism for heart failure in diabetes called diabetic cardiomyopathy. This condition, affects more than 40% of patients with type 2 diabetes, leads to heart failure and lacks effective therapy. Exercise protects the diabetic heart, at least in part, by stimulating the pathway of autophagy, which degrades malfunctioning proteins and cellular structures. The goal of this project is to elucidate the role of the protein kinases ULK1/2 and the transcription factor ATF4 in the exercise-mediated regulation of cardiac autophagy in obesity and type 2 diabetes. Determining the molecular regulation of cardiac autophagy by exercise in obesity and type 2 diabetes, might reveal alternative targets for therapy.

Monday, August 1, 2016