5/3/2018 4:00pm CANCELED: Distinguished Biomedical Scholar Lecture - Mitchell Lazar, MD, PhD

This lecture has been canceled. We hope to reschedule it for a future date. 

"The Ups and Downs of Transcriptional Regulation of Metabolism"

Mitchell Lazar, MD, PhD
Willard and Rhonda Ware Professor in Diabetes and Metabolic Diseases
Director, Institute for Diabetes, Obesity and Metabolism
Chief, Division of Endocrinology, Diabetes and Metabolism
University of Pennsylvania Perelman School of Medicine

Faculty host: E. Dale Abel, MD, PhD

The Lazar lab studies the transcriptional regulation of metabolism. Metabolic diseases, including diabetes and obesity, have a strong genetic basis, yet their increasing prevalence has been fueled by an environmental replete with fattening diets, insufficient physical activity, and exposure to light around the clock. The goal of the Lazar lab is to understand the homeostatic mechanisms that control physiological metabolism and how these are overcome by harmful environmental factors. The focus is on nuclear receptors and HDAC3-containing corepressor complexes, whose functions are interrogated using a combination of genomic, proteomic, bioinformatic, and metabolic phenotyping methods. Of particular interest is the circadian nuclear receptor Rev-erbα, a key repressive component of the circadian clock that coordinates biological rhythms of metabolism in liver, adipose, and other tissues. Another focus is on nuclear receptor PPARγ, the master regulator of adipocyte differentiation. Ligands for PPARγ have potent antidiabetic activity, and thus PPARγ represents a key transcriptional link between obesity and diabetes. HDAC3 is also of great interest as an integrator of the activities of nuclear receptors and other transcription factors, with tissue-specific functions that protect from challenges to the circadian, nutritional, and thermal environment.

For more information, please visit his lab website.


The Distinguished Biomedical Scholar Lecture Series features top-tier scientists and physicians performing high-impact research in a variety of areas.

Most lectures, with few exceptions, will be held on the third Thursday of each month during the academic year. The seminars will be of broad interest and are open to the public all University faculty, staff and students. The schedule of current speakers can be found here.

Individuals with disabilities are encouraged to attend all University of Iowa-sponsored events. If you are a person with a disability who requires an accommodation in order to participate in this program, please contact Sonya Housholder in advance at (319) 335-8587 or

Location: 1110A Medical Education Research Facility

5/7/2018 1:00pm Frontiers in Obesity, Diabetes and Metabolism: Anthony Comuzzie, PhD, FTOS

Executive Director of the Obesity Society                                              Silver Spring, MD

Location: 1289 CBRB - Kelch Conference Room Carver Biomedical Research Building

5/14/2018 1:00pm Frontiers in Obesity, Diabetes and Metabolism Seminar: Yong Xu, MD, PhD

Associate Professor of Pediatrics, Nutrition and                      Molecular & Cellular Biology

Baylor College of Medicine - Houston, Texas

Location: 1289 CBRB - Kelch Conference Room Carver Biomedical Research Building

5/21/2018 1:00pm Frontiers in Obesity, Diabetes and Metabolism: Teresa Zimmers, PhD

Adj. Associate Professor, Biochemistry & Molecular Biology          Adj. Associate Professor, Otolaryngology-Head & Neck Surgery Associate Professor, Anatomy & Cell Biology                                    Indiana University School of Medicine

Location: 1289 CBRB - Kelch Conference Room Carver Biomedical Research Building