Contact Information:

Office: 629 MRC
Phone: 319-335-8958
Faculty Profile

Brief description of current research:

Dr. Chapleau's research focuses on mechanisms of autonomic regulation in health and disease including effects of aging, hypertension, hypercholesterolemia, cardiomyopathy, myocardial infarction (MI), heart failure, and muscular dystrophy. Key hypotheses involve the roles of acid-sensing ion channels in sensory transduction, reactive oxygen species and angiotensin in sensory and sympathetic signaling, and oxidative stress in autonomic dysregulation. Experimental approaches include assessment of the cellular and molecular basis of sensory transduction and neuronal excitability in baroreceptor and sympathetic neurons using patch-clamp, imaging, and molecular techniques; recording of baroreceptor and sympathetic nerve activity in vivo; and assessment of cardiovascular and autonomic function in conscious mice using radiotelemetry.

3 most influential diabetes/obesity/metabolism 
publications:

• Lu Y, Ma X, Sabharwal R, Snitsarev V, Morgan D, Rahmouni K, Drummond HA, Whiteis CA, Costa V, Price M, Benson C, Welsh MJ,Chapleau MW, Abboud FM.  The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation.  Neuron, 64: 885-897, 2009. *Contributed equally to this paper.Contributed equally to this paper. PMC2807410.
• Sabharwal R, Zhang Z, Lu Y, Abboud FM, Russo AF, Chapleau MW.  Receptor activity-modifying protein-1 increases baroreflex sensitivity and attenuates angiotensin-induced hypertension.  Hypertension, 55: 627-635, 2010. PMC20100989.
• Sabharwal R, Cicha MZ, Sinisterra RDM, de Sousa FB, Santos RA,Chapleau MW.  Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy. Clin. Sci. (Lond), 127: 101-109, 2014. PMCID: PMC4318348.