Sue Bodine, PhD

Contact Information

Office: 1283D CBRB
Phone: 319-335-2553
Faculty Profile

Brief description of current research:

Dr. Bodine is a Neuromuscular Physiologist whose general field of study is Skeletal Muscle Plasticity. My current research program is centered on the study of the neuromuscular system and its response and adaptation to various stressors.  Skeletal muscle is a particularly interesting tissue because it interacts with and responds to numerous systems and signals to control movement, as well as, glucose homeostasis, metabolism, and thermogenesis. The recent focus of my research has been on identifying the cellular and molecular mechanisms that regulate skeletal muscle mass, especially under atrophy inducing conditions.   Skeletal muscle loss occurs as the result of a variety of disparate conditions including: disuse, bed rest, spinal cord injury, neurodegeneration, diabetes, cancer, chronic glucocorticoid treatment and aging; and will affect every individual in their lifetime.  My laboratory is interested in identifying the mechanisms responsible for muscle atrophy and determining strategies for preventing atrophy or accelerating recovery following a period of muscle loss.  In the quest to understand muscle atrophy, we have also investigated the mechanisms that regulate adaptive muscle growth, or hypertrophy, in adult animals.  The mechanisms regulating skeletal muscle growth are of interest since activation of hypertrophy pathways could be beneficial in the treatment of atrophy and also because an inability to respond to growth cues could exacerbate the loss of muscle mass and function that occurs during aging and also as the result of obesity and diabetes.

3 most influential diabetes/obesity/metabolism publications:

  • Gomes, A.V. Waddell, D.S., Siu, R., Stein, M., Dewey, S., Furlow, J.D., and Bodine, S.C.  Upregulation of Proteasome Activity in Muscle Ring Finger-1 Null Mice Following Denervation. FASEB J  26(7) 2986-2999, 2012 (Epub 2012 April 16).
  • Hwee, DT, Baehr, LM, Philp, A., Baar, K and Bodine, SC.  Maintenance of muscle mass and load-induced growth in Muscle Ring Finger 1 null mice with aging.  Aging Cell 13: 92-101, 2014.
  • Bodine, SC and Baehr, LM. Invited Review, Skeletal Muscle Atrophy and the Role of the E3 Ubiquitin Ligases, MuRF1 and MAFbx/Atrogin-1.   AJP: Endo Metab 307: E469-484, 2014
  • Baehr LM, West DWD, Marcotte G, Marshall AG, DeSousa, LG, Baar K, and Bodine SC. Age-related deficits in skeletal muscle recovery following disuse atrophy are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis.  Aging,8: 127-146, 2016.

Quote:

“Skeletal muscle is much more than an end organ…it is one of the most plastic tissues in the body and proper muscle function is a necessity for a healthy life.”