Randy Kardon, MD, PhD

Contact Information

Office: 11290D  PFP 
Phone: 319-356-2260 
Faculty Profile


Brief description of current research:

My diabetes related research focuses on 3 areas:

1) Assessment of diabetic peripheral and autonomic neuropathy in human and animal models using advanced imaging of the structure and function of corneal nerves and the dynamics of iris movement that occur during the pupil light reflex.

2) Assessment of mitochondrial function in human corneal endothelial layer preparations from diabetic and non-diabetic donors prior to transplantation into recipients. The effect of mitochondrial function on the survival of transplantable tissue is being studied and pharmacological strategies for improving viability of tissue prior to transplant.

3) Application of a new metabolic imaging device of human retina for assessing the dynamics of mitochondrial oxygen metabolism across the retina in response to retinal stimulation in eyes with and without diabetic retinopathy. This will provide a new understanding of how mitochondrial oxidative metabolism is affected by diabetes and development of strategies to restore normal retinal metabolism in order to prevent vision loss from diabetes.

3 most influential diabetes/obesity/metabolism publications:

  • Schallek J, Kardon R, Kwon Y, Abramoff M, Soliz P, Ts’o D. Stimulus-evoked intrinsic optical signals in the retina: Pharmacologic dissection reveals outer retinal origins. Invest Ophthalmol Vis Sci 2009;50(10):4873-4880.
  • Kardon R, Anderson SC, Damarjian TG, Grace EM, Stone E, Kawasaki A. Chromatic pupil responses: preferential activation of the melanopsin-mediated versus outer photoreceptor-mediated pupil light reflex. Ophthalmology 2009;116(8):1564-1573.
  • Kardon RH. Role of the macular optical coherence tomography scan in neuro-ophthalmology. J Neuroophthalmol. 2011 Dec;31(4):353-61. Review. PubMed PMID: 22089499; PubMed Central PMCID: PMC3226727.

Quote:

“I am exploring how we can use the structure and function of the nerves in the human eye as an accessible means for early detection, monitoring and assessing new treatments of diabetes”