Allyn Mark, MD

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Faculty Profile

Brief description of current research:

Dr. Mark's research addresses brain control of the sympathetic nervous system and its role in physiologic and pathologic states, including obesity and the metabolic syndrome.  His research focuses on mechanisms of obesity-induced hypertension, including the sympathetic actions of leptin and the concept introduced in his laboratory of selective leptin resistance in obese states.  With Dr. Robin Davisson at Weill Cornell Medical College, his recent research is addressing the role of brain endoplasmic reticulum stress in promoting sympathetic activation and increases in arterial pressured in mouse models of obesity and hypertension.  In 2011, Dr. Mark and Dr. Charles Brenner founded and now co-direct the UI Obesity Research and Education Initiative that interacts and partners extensively with the FOEDRC.

3 most influential diabetes/obesity/metabolism publications:

  • Ribeiro AC,* Ceccarini G,* Dupre C, Friedman JM, Pfaff DW, Mark AL.  Contrasting Effects of Leptin on Food Anticipatory and Total Locomotor Activity.  PLoS One 6: e23364, 2011.  (*Ribeiro and Ceccarini are co-first authors). PMC3154408
  • Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, GrobeJL, Rahmouni K, Sigmund CD, Mark AL.  A Brain Leptin-Renin Angiotensin System Interaction in the Regula-tion of Sympathetic Nerve Activity.  Am J Physiol: Heart Circ Physiol, 303:H197-H206,2012.    (Featured article in this issue.)  PMC3404702
  • Mark AL.  Selective Leptin Resistance Revisited.  Carl Ludwig Distinguished Lectureship Award 2011.  Am J Physiol: Regul Integr Comp Physiol. 2013; 305: R566-R581.