New Grant Award to FOEDRC Member Ryan Boudreau, PhD

FOE Diabetes Research Center member Dr. Ryan Boudreau, received the 2016 Carver Trust Young Investigator's award. Below is a summary of his grant proposal.

 Systematic characterization of post-transcriptional gene regulatory networks in cardiac disease.

Our genomes encode thousands of unique proteins needed for our cellular make-up and function. Each protein-coding gene is first transcribed into individual messenger RNAs (mRNAs) that are then precisely regulated to control when and where they are translated into proteins. This regulation, in part, is mediated by a complex network of hundreds of RNA-binding proteins (RBPs) that recognize specific sequence codes within the mRNAs. In the heart, these processes remain largely understudied, and here, we propose high-throughput and innovative wet-lab and computational approaches to expand our knowledge of how cardiac cells regulate their mRNAs and how these processes are disrupted in heart disease. The resulting data will provide critical information and resources to advance our understanding of the biological- and disease-relevance of cardiac mRNA regulation. In addition, this work will support our future efforts to identify genetic risk factors contributing to heart failure and to assess whether therapeutic targeting of RNA regulatory pathways can improve disease outcomes.

Monday, May 2, 2016