Contact Information

Office: 4-370 BSB
Phone: 319-335-7907
Faculty Profile

A brief description of current research:

 The focus of the Sindler Laboratory is to investigate how aging and other age-related disorders such as diabetes, obesity, and chronic kidney disease worsen cardiovascular (endothelial function and arterial stiffness) and renal function. We are working on identifying novel mechanisms that contribute to functional decline and the efficacy of therapeutic interventions on improving physiological decline with aging with the goal of translating into human clinical studies and improving overall health and quality of life. Pathways of interest include: nitric oxide bioavailability, oxidative stress, nicotinamide adenine dinucleotide (NAD+) bioavailability, Sirtuin signaling, and mitochondrial function.

3 most influential diabetes/obesity/metabolism publications:

Sindler AL, Fleenor BS, DeVan AE, Seals DR. Inorganic Nitrite Supplementation for Healthy Arterial Aging. J Appl Physiol, (1985) 2014 Mar;116(5):463-77. doi: 10.1152/japplphysiol.01100.2013. PMID: 24408999

Sindler AL, Cox-York KA, Reese LR, Bryan NS, Seals DR, Gentile CL. Oral Nitrite Therapy Improves Vascular Function in Diabetic Mice. Diab Vasc Dis Res. 2015 May;12(3):221-4. doi: 10.1177/1479164114565628. PMID: 25696116

DeVan AE, Johnson LC, Brooks FA, Evans TD, Justice JN, Cruickshank-Quinn C, Reisdorph N, Bryan NS, McQueen MB, Santos-Parker JR, Chonchol MB, Bassett CJ, Sindler AL, Giordano T, Seals DR. Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults. J Appl Physiol (1985). 2016 Feb 15;120(4):416-25. doi: 10.1152/japplphysiol.00879.2015.

de Picciotto NE, Gano LB, Sindler AL, Johnson LC, Martens CR, Imai S, Seals DR. Nicotinamide mononuceotide supplementation reverses vascular dysfunction with aging in mice. Aging Cell. 2016 Jun;15(3):522-30. doi: 10.1111/acel.12461.