Computational Biology Seminar Series

Thursday, December 12, 2019, 12:00pm to 1:00pm
Carver Biomedical Research Building , Kelch Conference Room - 1289 CBRB
285 Newton Road, Iowa City, IA 52246
Realizing the potential of full-length transcriptome sequencingVisiting Speaker - Chris Vollmers, PhD, UC - Santa Cruz Over the last decade, the analysis of transcriptomes using RNA-seq has become an integral part of biomedical research. However, because RNA-seq requires the fragmentation of transcripts, a lot of information on the analyzed transcriptome is lost in the process. Sequencing full-length transcripts using long-read sequencers like the ONT MinION could overcome this limitation but faces its own set of challenges. Dr. Vollmers will talk about how my lab has started to address these challenges using both molecular and computational biology. Finally, Dr. Vollmers will present full-length transcriptome data of human immune cells on the bulk and single-cell level to show the types of information we can now extract from this type of data. Lunch will be provided