Next Generation Sequencing Interest Group

Genomic Analysis of Chronic Staphylococcus Aureus Infections in Cystic Fibrosis

Speaker: Anthony Fischer, MD, PhD, Assistant Professor of Pediatrics - Pulmonary Medicine, University of Iowa

Using whole genome sequencing to analyze isolates of Staphylococcus aureus cultured from patients with cystic fibrosis, we have learned that children and adults with cystic fibrosis are often infected with different strains of S. aureus, accessory gene content varies significantly between strains of S. aureus, and some accessory genes are associated with long term persistence of S. aureus in the cystic fibrosis airway.