Assistant Professor of Epidemiology
Assistant Professor of Epidemiologykelli-ryckman@uiowa.edu
(319) 384-1546
Biography
Dr. Ryckman is an Assistant Professor in the Department of Epidemiology, College of Public Health. Dr. Ryckman received her bachelors’ degree in Biochemistry from Iowa State University. She attended graduate school at Vanderbilt University and received her Masters’ in Applied Statistics and her PhD in Human Genetics. She has a strong background in statistical genetics with specific emphasis on reproductive immunology, metabolomics, maternal-fetal medicine and genetics. Her focus is on the analysis of complex data and developing analytical techniques to examine disease-related associations by examining genetic, demographic and metabolic factors in large population databases. Dr. Ryckman is currently funded by a K99/R00 award from the National Institute of Child Health and Development entitled “Integrated Genomic and Metabolomic Profiles in Newborn Infants.” Other research interests include: metabolomic predictors of adverse pregnancy outcomes, low birth weight as a risk factor for later-life disease and infant metabolic consequences of morbidly obese pregnancies.
Research Interest(s)
Dr. Ryckman's interests include identifying genetic and metabolic mechanisms associated with adverse pregnancy outcomes such as preeclampsia, preterm birth and low birth weight and with complications of prematurity such as patent ductus arteriosus and respiratory distress syndrome. She is interested in how current prenatal and newborn screening, which is universally used to detect mainly rare and inherited disorders, can be used to identify subgroups of women (for prenatal screening) or newborns (for newborn screening) at risk for adverse birth outcomes such as preterm birth and complications of prematurity.
Selected Publications
Ryckman KK, Simhan HN, Krohn MJ, Williams SM. Cervical cytokine network patterns during pregnancy: the role of bacterial vaginosis and geographic ancestry. J. Reprod. Immunol. 2009: 79: 174-82.
PMCID: PMC2688465
Ryckman KK, Williams SM, Krohn MJ, Simhan HN. Genetic association of toll-like receptor 4 with cervical cytokine concentrations during pregnancy. Genes Immun. 2009: 10: 636-40.
PMCID: PMC3164507
Ryckman KK, Morken NH, White MJ, Velez DR, Menon R, Fortunato SJ, Magnus P, Williams SM, Jacobsson B. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. PLoS One. 2010; 5:e9040.
PMCID: PMC2815792
Ryckman KK, Fielding K, Hill AV, Mendy M, Rayco-Solon P, Sirugo G, van der Sande MA, Waight P, Whittle HC, Hall AJ, Williams SM, Hennig BJ. Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis. PLos One. 2010; 5:e12273.
PMCID:PMC2923624
Ryckman KK, Dagle JM, Kelsey K, Momany AM, Murray JC. Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates. Pediatr Res. 2011; 70: 90-5.
PMCID: PMC3117229
Ryckman KK, Dagle JM, Kelsey K, Momany AM, Murray JC. Genetic associations of surfactant protein D and angiotensin-coverting enzyme with lung disease in preterm infants. J Perinatol. 2012: 32: 349-355.
PMCID: PMC3370386
Ryckman KK, Feenstra B, Shaffer JR, Bream ENA, Geller F, Feingold E, Weeks DE, Gadow E, Cosentino V, Saleme C, Simhan HN, Merrill D, Fong C, Busch T, Berends SK, Comas B, Camelo JL, Boyd H, Laurie C, Crosslin D, Zhang Q, Doheny KF, Pugh E, Melbye M, Marazita ML, Dagle JM, Murray JC. Replication of a Genome-Wide Association Study of Birth Weight in Preterm Neonates. J Pediatr. 2011: 160: 19-24.
PMCID: PMC3237813
Ryckman KK, Cook DE, Berberich SL, Shchelochkov OA, Copeland S, Berends SK, Busch T, Dagle JM, Murray JC. Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns. J Pediatr Endocrinol Metab. 2012: 25: 301-5.
PubMed - in process
Alul FY, Cook DE, Shchelochkov OA, Berberich SL, Murray JC, Ryckman KK. The Heritability of Metabolic Profiles in Newborn Twins. Heredity. 2012, in press.
PubMed - in process
Ryckman KK, Berberich SL, Shchelochkov OA, Cook DE, Murray JC. Clinical and Environmental Influences on Metabolic Biomarkers Collected for Newborn Screening. Clinical Biochemistry. 2012, in press.
PubMed - in process