Technologies: 

Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation.  Vanrobaeys Y, Peterson ZJ, Walsh EN, Chatterjee S, Lin LC, Lyons LC, Nickl-Jockschat T, Abel T. Nature Communications, (2023);14(1):7095. doi: 10.1038/s41467-023-42751-z. PMID: 37925446; PMCID: PMC10625558.

DNA methylation effects on Van der Woude Syndrome phenotypic variability. Seaberg A, Awotoye W, Qian F, Dunlay L, Butali A, Murray J, Moreno-Uribe L; Petrin A. Front Dent Med. (2023) ;4:1120948. doi: 10.3389/fdmed.2023.1120948. PMID: 36936396; PMCID: PMC10019782. https://pubmed.ncbi.nlm.nih.gov/36936396/

Gene Expression within a human choroidal neovascular membrane using spatial transcriptomics. Voigt A, Mullin N, Navratil E, Flamme-Wiese M, Lin LC, Scheetz T, Han I, Stone E, Tucker B, and Mullins R. (2023) Investigative Ophthalmology & Visual Science. 64:40. doi:10.1167/iovs.64.13.40. PMID: 37878301. https://doi.org/10.1167/iovs.64.13.40 

Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation. Vanrobeys Y, Mukherjee U, Langmack L, Bahl E, Lin LC, Michaelson JJ, Abel T, Chatterjee S. Nature Communications, 14, 6100 (2023). https://doi.org/10.1038/s41467-023-41715-7

Activity-induced gene expression in the human brain. Snehajyoti Chatterjee, Brian J Park, Yann Vanrobaeys, Shane A Heiney, Ariane E Rhone, Kirill V Nourski, Lucy Langmack, Utsav Mukherjee, Christopher K Kovach, Zsuzsanna Kocsis, Yukiko Kikuchi, Christopher I Petkov, Marco M Hefti, Ethan Bahl, Jacob J Michaelson, Hiroto Kawasaki, Hiroyuki Oya, Matthew A Howard III, Thomas Nickl-Jockschat, Li-Chun Lin, Ted Abel. bioRxiv (2023) .09.21.558812; doi: https://doi.org/10.1101/2023.09.21.558812

Sorafenib inhibits invasion of multicellular organoids that mimic Lymphangioleiomyomatosis nodules.
Sinem Koc-Gunel, Lalit K. Gautam, Ben A. Calvert, Shubha Murthy, Noa C. Harriott, Janna C. Nawroth, Beiyun Zhou, Vera P. Krymskaya, Amy L. Ryan. bioRxiv (2023).06.12.544372; doi: https://doi.org/10.1101/2023.06.12.544372

NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data. Bahl E, Chatterjee S, Elsadany M, Vanrobaeys Y, Lin LC, Giese KP, Abel T, Michaelson JJ. Nat Commun. 2024 Jan 26;15(1):779. doi: 10.1038/s41467-023-44503-5. PMID: 38278804; PMCID: PMC10817898. https://pubmed.ncbi.nlm.nih.gov/38278804/ 

Brain Banking:

RGS6 mediates exercise-induced recovery of hippocampal neurogenesis, learning, and memory in an Alzheimer’s mouse model. Spicer MM, Yang J, Fu D, DeVore AN, Lauffer M, Atasoy NS, Atasoy D, Fisher RA. bioRxiv 2023.04.17.537272; doi: https://doi.org/10.1101/2023.04.17.537272

A Pilot Study of ex vivo Human Prefrontal RNA Transcriptomics in Parkinson’s Disease. Lin L, Cole R.A, Greenlee J.D.W, *Narayanan N.S. Cellular and Molecular Neurobiology, 2023. https://pubmed.ncbi.nlm.nih.gov/36952070/

Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies. Fiock K, Betters R, Hefti M. Journal of Histochemistry & Cytochemistry, vol 71, issue 2, 2023 https://doi.org/10.1369/00221554231158428

Tau pathology in the dorsal raphe may be a prodromal indicator of Alzheimer's disease.  Pierson S, Fiock K, Wang R, Balasubramanian N, Khan K, Betters R, Lee G, Hefti M, Marcinkiewcz C bioRxiv 2022. doi: https://doi.org/10.1101/2022.11.22.517403

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain. Fernández-Castañeda A, Lu P, Geraghty AC, Eric Song E , Lee MH, Wood J, Yalçın B, Taylor KR, Dutton S, Acosta-Alvarez L, Ni L, Contreras-Esquivel D, Gehlhausen JR, Klein J, Lucas C, Mao T, Silva J, Peña-Hernández MA, Tabachnikova A, Takahashi T, Tabacof L, Tosto-Mancuso J, Breyman E, Kontorovich A, McCarthy D, Quezado M, Hefti MM, Perl D, Folkerth R, Putrino D, Nath A, Iwasaki A, Monje M. Cell. 2022 Jul 7;185(14):2452-2468.e16. doi: 10.1016/j.cell.2022.06.008. Epub 2022 Jun 13. PMID: 35768006; PMCID: PMC9189143. https://pubmed.ncbi.nlm.nih.gov/35768006/

Neuropathology of COVID-19. Lin LC, Hollis B, Hefti MM. Indian J Pathol Microbiol. 2022. 65:S146-S152. PMID: 35562145

An 18-month-old with white matter calcifications and seizures. Fiock KL, Lin LC, Colwell S, Hefti MM. 2022. Brain Pathology. PMID: 35701888.

Microvascular Injury in the Brains of Patients with Covid-19. Lee MH, Perl DP, Nair G, Li W, Maric D, Murray H, Dodd SJ, Koretsky AP, Watts JA, Cheung V, Masliah E, Horkayne-Szakaly I, Jones R, Stram MN, Moncur J, Hefti MM, Folkerth RD, Nath A. N Engl J Med. 2021. 384(5):481-483. PMID: 33378608 

DMPK mRNA Expression in Human Brain Tissue Throughout the Lifespan. Langbehn KE, Carlson-Stadler Z, van der Plas E, Hefti MM, Dawson JD, Moser DJ, Nopoulos PC. Neurol Genet. 2020. 7:e537. PMID: 33575482 

Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. Fiock KL, Smalley ME, Crary JF, Pasca AM, Hefti MM. eNeuro. 2020. 7:ENEURO.0058-20.2020. PMID: 32393582

Conference Posters:

Human dorsal raphe tau pathology and related depressive-like behaviors in adult C57BL/6J mice. Pierson S, Fiock K, Khan M, Hefti M, Marcinkiewcz C. Society for Neuroscience Annual Meeting, San Diego, CA. 2022

Neuroestimator: using deep learning to quantify neuronal activation from single-cell and spatial transcriptomic data. Chatterjee S, Bahl E, Elsadany M, Vanrobaeys Y, Lin LC, Giese K, Abel T, Michaelson JJ. Society for Neuroscience Annual Meeting, San Diego, CA. 2021.

Optimizing immunofluorescence staining of microglia in thick human brain tissue. Strief D & Dailey M. Fall Undergraduate Research Festivals (FURF). 2022. 

Selective vulnerability in von Economo neurons with frontotemporal lobar degeneration. Jendro M, Hollis B, Lin LC. Fall Undergraduate Research Festivals (FURF). 2022. 

Convergency of Attention-Deficit Hyperactivity Disorrder and Parkinson's Disease. Jaeger P,  Hollis B, Lin LC. Fall Undergraduate Research Festivals (FURF). 2022. 

Probing the Impact of SARS-CoV-2 (COVID-19) in the Human Brain. Hollis B, Lin LC. Fall Undergraduate Research Festivals (FURF). 2021. 

Molecular Characterization of Neovascular AMD in Human Eyes using Spatial Transcriptomics and Single Cell RNA Sequencing. Mullins RF, Voigt AP, Scheetz TE, Mullin NK, Flamme-Wiese, MJ,  Lin, LC,Stone EM, Han I; Tucker BA. Association for Research in Vision and Ophthalmology (ARVO). 2022.

Spatial transcriptomics reveals unique gene expression changes in different regions after sleep deprivation.Vanrobaeyes Y, Walsh EN, Lyons LC, Lin LC, Abel T, Synapse, 2022.

Sex Differences of APOE in the prefrontal cortex of patients with Major Depressive Disorder. Eggmann S, Lin LC. Spring Undergraduate Research Festival (SURF). 2023.

The Pathophysiology of Attention-Deficit Hyperactivity Disorder, Parkinson's Disease, & Lewy Body Dementia. Jaeger P, Lin LC. Spring Undergraduate Research Festival (SURF). 2023.