Joseph Zabner, MD

Portrait
Director, Division of Pulmonary, Critical Care and Occupational Medicine
Professor of Internal Medicine - Pulmonary, Critical Care and Occupational Medicine

Contact Information

Primary Office: 6324 PBDB
Iowa City, IA 52242
319-384-5401

Lab: 440 EMRB
Iowa City, IA 52242
319-385-8460

Education

MD, Universidad Central de Venezuela

Internship, Presbyterian Hospital
Resident, Internal Medicine, Parkland Hospital, Dallas, TX
Fellow, Research Fellow, Pulmonary Disease, University of Iowa Hospitals and Clinics

Licensure and Certifications

Texas License - Inactive

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

Dr. Zabner's research interests are in gene transfer to human airway epithelia in particular to develop gene therapy for cystic fibrosis. Dr. Zabner also has an interest in the fluid composition of the airway surface liquid, and how it affects innate immunity. His clinical interests are in cystic fibrosis and non-cystic fibrosis bronchiectasis.

Publications

Adam, R. J., Abou Alaiwa, M. H., Bouzek, D. C., Cook, D. P., Gansemer, N. D., Taft, P. J., Powers, L. S., Stroik, M. R., Hoegger, M. J., McMenimen, J. D., Hoffman, E. A., Zabner, J., Welsh, M. J., Meyerholz, D. K. & Stoltz, D. A. (2017). Postnatal airway growth in cystic fibrosis piglets. Journal of applied physiology (Bethesda, Md. : 1985), 123(3), 526-533. PMID: 28620056.

Vargas Buonfiglio, L. G., Mudunkotuwa, I. A., Abou Alaiwa, M. H., Vanegas Calderón, O. G., Borcherding, J. A., Gerke, A. K., Zabner, J., Grassian, V. H. & Comellas, A. P. (2017). Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid. Environmental health perspectives, 125(7), 077003. PMID: 28696208.

Vargas Buonfiglio, L. G., Cano, M., Pezzulo, A. A., Vanegas Calderon, O. G., Zabner, J., Gerke, A. K. & Comellas, A. P. (2017). Effect of vitamin D<sub>3</sub> on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial. BMJ open respiratory research, 4(1), e000211. PMID: 28883932.

Abston, E., Comellas, A., Reed, R. M., Kim, V., Wise, R. A., Brower, R., Fortis, S., Beichel, R., Bhatt, S., Zabner, J., Newell, J., Hoffman, E. A. & Eberlein, M. (2017). Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25-75/FVC) in COPD. BMJ open respiratory research, 4(1), e000231. PMID: 29071083.

Li, X., Vargas Buonfiglio, L. G., Adam, R. J., Stoltz, D. A., Zabner, J. & Comellas, A. P. (2017). Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs. Critical care medicine, 45(12), e1240-e1246. PMID: 28953499.

Bruse, S., Moreau, M., Bromberg, Y., Jang, J. H., Wang, N., Ha, H., Picchi, M., Lin, Y., Langley, R. J., Qualls, C., Klensney-Tait, J., Zabner, J., Leng, S., Mao, J., Belinsky, S. A., Xing, J. & Nyunoya, T. (2016). Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility. Human genomics, 10, 1. PMID: 26744305.

Bartlett, J. A., Ramachandran, S., Wohlford-Lenane, C. L., Barker, C. K., Pezzulo, A. A., Zabner, J., Welsh, M. J., Meyerholz, D. K., Stoltz, D. A. & McCray, Jr, P. B. (2016). Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus. American journal of respiratory and critical care medicine. PMID: 27027566.

Shah, V. S., Meyerholz, D. K., Tang, X. X., Reznikov, L., Abou Alaiwa, M., Ernst, S. E., Karp, P. H., Wohlford-Lenane, C. L., Heilmann, K. P., Leidinger, M. R., Allen, P. D., Zabner, J., McCray, Jr, P. B., Ostedgaard, L. S., Stoltz, D. A., Randak, C. O. & Welsh, M. J. (2016). Airway acidification initiates host defense abnormalities in cystic fibrosis mice. Science (New York, N.Y.), 351(6272), 503-7. PMID: 26823428.

Li, X., Tang, X. X., Vargas Buonfiglio, L. G., Comellas, A. P., Thornell, I. M., Ramachandran, S., Karp, P. H., Taft, P. J., Sheets, K., Abou Alaiwa, M. H., Welsh, M. J., Meyerholz, D. K., Stoltz, D. A. & Zabner, J. (2016). Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense. American journal of physiology. Lung cellular and molecular physiology, ajplung.00422.2015. PMID: 26801568.

Lee, M., Vecchio-Pagán, B., Sharma, N., Waheed, A., Li, X., Raraigh, K. S., Robbins, S., Han, S. T., Franca, A. L., Pellicore, M. J., Evans, T. A., Arcara, K. M., Nguyen, H., Luan, S., Belchis, D., Hertecant, J., Zabner, J., Sly, W. S. & Cutting, G. R. (2016). Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease. Human molecular genetics. PMID: 26911677.

Vargas Buonfiglio, L. G., Bagegni, M., Borcherding, J. A., Sieren, J. C., Caraballo, J. C., Reger, A., Zabner, J., Li, X. & Comellas, A. P. (2016). Protein Kinase C Zeta Inhibitor Promotes Resolution of Bleomycin-induced Acute Lung Injury. American journal of respiratory cell and molecular biology. PMID: 27486964.

Steines, B., Dickey, D. D., Bergen, J., Excoffon, K. J., Weinstein, J. R., Li, X., Yan, Z., Alaiwa, M. H., Shah, V. S., Bouzek, D. C., Powers, L. S., Gansemer, N. D., Ostedgaard, L. S., Engelhardt, J. F., Stoltz, D. A., Welsh, M. J., Sinn, P. L., Schaffer, D. V. & Zabner, J. (2016). <i>CFTR</i> gene transfer with AAV improves early cystic fibrosis pig phenotypes. JCI insight, 1(14), e88728. PMID: 27699238.

Abou Alaiwa, M. H., Launspach, J. L., Sheets, K. A., Rivera, J. A., Gansemer, N. D., Taft, P. J., Thorne, P. S., Welsh, M. J., Stoltz, D. A. & Zabner, J. (2016). Repurposing tromethamine as inhaled therapy to treat CF airway disease. JCI insight, 1(8). PMID: 27390778.

Jaffer, O. A., Carter, A. B., Sanders, P. N., Dibbern, M. E., Winters, C. J., Murthy, S., Ryan, A. J., Rokita, A. G., Prasad, A. M., Zabner, J., Kline, J. N., Grumbach, I. M. & Anderson, M. E. (2015). Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-ß-mediated collagen production in a murine asthma model. American journal of respiratory cell and molecular biology, 52(1), 106-15. PMID: 24988374.

Chang, E. H., Tang, X. X., Shah, V. S., Launspach, J. L., Ernst, S. E., Hilkin, B., Karp, P. H., Abou Alaiwa, M. H., Graham, S. M., Hornick, D. B., Welsh, M. J., Stoltz, D. A. & Zabner, J. (2015). Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor. International forum of allergy & rhinology, 5(2), 178-81. PMID: 25363320.

Klesney-Tait, J., Eberlein, M., Geist, L., Keech, J., Zabner, J., Gruber, P. J., Iannettoni, M. D. & Parekh, K. (2015). Starting a lung transplant program: a roadmap for long-term excellence. Chest, 147(5), 1435-43. PMID: 25940255.

Du, K., Karp, P. H., Ackerley, C., Zabner, J., Keshavjee, S., Cutz, E. & Yeger, H. (2015). Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: new pathologic observations. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 14(2), 182-93. PMID: 25453871.

Weirather, J. L., Afshar, P. T., Clark, T. A., Tseng, E., Powers, L. S., Underwood, J. G., Zabner, J., Korlach, J., Wong, W. H. & Au, K. F. (2015). Characterization of fusion genes and the significantly expressed fusion isoforms in breast cancer by hybrid sequencing. Nucleic acids research, 43(18), e116. PMID: 26040699.

Chang, E. H., Zabner, J. (2015). Precision Genomic Medicine in Cystic Fibrosis. Clinical and translational science, 8(5), 606-10. PMID: 26073768.

Caraballo, J. C., Borcherding, J., Rector, M., Hornick, E., Stoltz, D., Zabner, J. & Comellas, A. P. (2014). Role of PON in anoxia-reoxygenation injury: a Drosophila melanogaster transgenic model. PloS one, 9(1), e84434. PMID: 24400090.

Borcherding, J., Baltrusaitis, J., Chen, H., Stebounova, L., Wu, C. M., Rubasinghege, G., Mudunkotuwa, I. A., Caraballo, J. C., Zabner, J., Grassian, V. H. & Comellas, A. P. (2014). Iron oxide nanoparticles induce <i>Pseudomonas aeruginosa</i> growth, induce biofilm formation, and inhibit antimicrobial peptide function. Environmental science. Nano, 1(2), 123-132. PMID: 25221673.

Hoegger, M. J., Fischer, A. J., McMenimen, J. D., Ostedgaard, L. S., Tucker, A. J., Awadalla, M. A., Moninger, T. O., Michalski, A. S., Hoffman, E. A., Zabner, J., Stoltz, D. A. & Welsh, M. J. (2014). Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Science (New York, N.Y.), 345(6198), 818-22. PMID: 25124441.

Abou Alaiwa, M. H., Beer, A. M., Pezzulo, A. A., Launspach, J. L., Horan, R. A., Stoltz, D. A., Starner, T. D., Welsh, M. J. & Zabner, J. (2014). Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 13(4), 373-7. PMID: 24418186.

Abou Alaiwa, M. H., Reznikov, L. R., Gansemer, N. D., Sheets, K. A., Horswill, A. R., Stoltz, D. A., Zabner, J. & Welsh, M. J. (2014). pH modulates the activity and synergism of the airway surface liquid antimicrobials ß-defensin-3 and LL-37. Proceedings of the National Academy of Sciences of the United States of America, 111(52), 18703-8. PMID: 25512526.

Klesney-Tait, J., Keck, K., Li, X., Gilfillan, S., Otero, K., Baruah, S., Meyerholz, D. K., Varga, S. M., Knudson, C. J., Moninger, T. O., Moreland, J., Zabner, J. & Colonna, M. (2013). Transepithelial migration of neutrophils into the lung requires TREM-1. The Journal of clinical investigation, 123(1), 138-49. PMID: 23241959.

Klesney-Tait, J., Keck, K., Li, X., Gilfillan, S., Otero, K., Baruah, S., Meyerholz, D. K., Varga, S. M., Knudson, C. J., Moninger, T. O., Moreland, J., Zabner, J. & Colonna, M. (2013). Transepithelial migration of neutrophils into the lung requires TREM-1. The Journal of clinical investigation, 123(1), 138-49. PMID: 23241959.

Li, X., Rossen, N., Sinn, P. L., Hornick, A. L., Steines, B. R., Karp, P. H., Ernst, S. E., Adam, R. J., Moninger, T. O., Levasseur, D. N. & Zabner, J. (2013). Integrin a6ß4 identifies human distal lung epithelial progenitor cells with potential as a cell-based therapy for cystic fibrosis lung disease. PloS one, 8(12), e83624. PMID: 24349537.

Borcherding, J. A., Chen, H., Caraballo, J. C., Baltrusaitis, J., Pezzulo, A. A., Zabner, J., Grassian, V. H. & Comellas, A. P. (2013). Coal fly ash impairs airway antimicrobial peptides and increases bacterial growth. PloS one, 8(2), e57673. PMID: 23469047.

Bartlett, J. A., Albertolle, M. E., Wohlford-Lenane, C., Pezzulo, A. A., Zabner, J., Niles, R. K., Fisher, S. J., McCray, Jr, P. B. & Williams, K. E. (2013). Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs. American journal of physiology. Lung cellular and molecular physiology, 305(3), L256-66. PMID: 23709621.

Potash, A. E., Wallen, T. J., Karp, P. H., Ernst, S., Moninger, T. O., Gansemer, N. D., Stoltz, D. A., Zabner, J. & Chang, E. H. (2013). Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model. Molecular therapy : the journal of the American Society of Gene Therapy, 21(5), 947-53. PMID: 23511247.

Pezzulo, A. A., Kelly, P. H., Nassar, B. S., Rutland, C. J., Gansemer, N. D., Dohrn, C. L., Costello, A. J., Stoltz, D. A. & Zabner, J. (2013). Abundant DNase I-sensitive bacterial DNA in healthy porcine lungs and its implications for the lung microbiome. Applied and environmental microbiology, 79(19), 5936-41. PMID: 23872563.

Sanders, P. N., Koval, O. M., Jaffer, O. A., Prasad, A. M., Businga, T. R., Scott, J. A., Hayden, P. J., Luczak, E. D., Dickey, D. D., Allamargot, C., Olivier, A. K., Meyerholz, D. K., Robison, A. J., Winder, D. G., Blackwell, T. S., Dworski, R., Sammut, D., Wagner, B. A., Buettner, G. R., Pope, R. M., Miller, Jr, F. J., Dibbern, M. E., Haitchi, H. M., Mohler, P. J., Howarth, P. H., Zabner, J., Kline, J. N., Grumbach, I. M. & Anderson, M. E. (2013). CaMKII is essential for the proasthmatic effects of oxidation. Science translational medicine, 5(195), 195ra97. PMID: 23884469.

Stoltz, D. A., Rokhlina, T., Ernst, S. E., Pezzulo, A. A., Ostedgaard, L. S., Karp, P. H., Samuel, M. S., Reznikov, L. R., Rector, M. V., Gansemer, N. D., Bouzek, D. C., Alaiwa, M. H., Hoegger, M. J., Ludwig, P. S., Taft, P. J., Wallen, T. J., Wohlford-Lenane, C., McMenimen, J. D., Chen, J. H., Bogan, K. L., Adam, R. J., Hornick, E. E., Nelson, 4th, G. A., Hoffman, E. A., Chang, E. H., Zabner, J., McCray, Jr, P. B., Prather, R. S., Meyerholz, D. K. & Welsh, M. J. (2013). Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. The Journal of clinical investigation, 123(6), 2685-93. PMID: 23676501.

Lacruz, R. S., Smith, C. E., Moffatt, P., Chang, E. H., Bromage, T. G., Bringas, Jr, P., Nanci, A., Baniwal, S. K., Zabner, J., Welsh, M. J., Kurtz, I. & Paine, M. L. (2012). Requirements for ion and solute transport, and pH regulation during enamel maturation. Journal of cellular physiology, 227(4), 1776-85. PMID: 21732355.

Pezzulo, A. A., Hornick, E. E., Rector, M. V., Estin, M., Reisetter, A. C., Taft, P. J., Butcher, S. C., Carter, A. B., Manak, J. R., Stoltz, D. A. & Zabner, J. (2012). Expression of human paraoxonase 1 decreases superoxide levels and alters bacterial colonization in the gut of Drosophila melanogaster. PloS one, 7(8), e43777. PMID: 22952763.

Reed, M. D., McCombie, B. E., Sivillo, A. E., Thorne, P. S., Welsh, M. J., March, T. H., McDonald, J. D., Seilkop, S. K., Zabner, J. & Durairaj, L. (2012). Safety assessment of nebulized xylitol in beagle dogs. Inhalation toxicology, 24(6), 365-72. PMID: 22564094.

Chang, E. H., Pezzulo, A. A., Meyerholz, D. K., Potash, A. E., Wallen, T. J., Reznikov, L. R., Sieren, J. C., Karp, P. H., Ernst, S., Moninger, T. O., Gansemer, N. D., McCray, Jr, P. B., Stoltz, D. A., Welsh, M. J. & Zabner, J. (2012). Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. The Laryngoscope, 122(9), 1898-905. PMID: 22711071.

Dickey, D. D., Excoffon, K. J., Young, K. R., Parekh, K. R. & Zabner, J. (2012). Hoechst increases adeno-associated virus-mediated transgene expression in airway epithelia by inducing the cytomegalovirus promoter. The journal of gene medicine, 14(6), 366-73. PMID: 22610695.

Pezzulo, A. A., Tang, X. X., Hoegger, M. J., Alaiwa, M. H., Ramachandran, S., Moninger, T. O., Karp, P. H., Wohlford-Lenane, C. L., Haagsman, H. P., van Eijk, M., Bánfi, B., Horswill, A. R., Stoltz, D. A., McCray, Jr, P. B., Welsh, M. J. & Zabner, J. (2012). Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature, 487(7405), 109-13. PMID: 22763554.

Li, X., Comellas, A. P., Karp, P. H., Ernst, S. E., Moninger, T. O., Gansemer, N. D., Taft, P. J., Pezzulo, A. A., Rector, M. V., Rossen, N., Stoltz, D. A., McCray, Jr, P. B., Welsh, M. J. & Zabner, J. (2012). CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia. American journal of physiology. Lung cellular and molecular physiology, 303(2), L152-60. PMID: 22637155.

Chang, E. H., Lacruz, R. S., Bromage, T. G., Bringas, Jr, P., Welsh, M. J., Zabner, J. & Paine, M. L. (2011). Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells, tissues, organs, 194(2-4), 249-54. PMID: 21525720.

Pezzulo, A. A., Starner, T. D., Scheetz, T. E., Traver, G. L., Tilley, A. E., Harvey, B. G., Crystal, R. G., McCray, Jr, P. B. & Zabner, J. (2011). The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. American journal of physiology. Lung cellular and molecular physiology, 300(1), L25-31. PMID: 20971803.

Pezzulo, A. A., Gutiérrez, J., Duschner, K. S., McConnell, K. S., Taft, P. J., Ernst, S. E., Yahr, T. L., Rahmouni, K., Klesney-Tait, J., Stoltz, D. A. & Zabner, J. (2011). Glucose depletion in the airway surface liquid is essential for sterility of the airways. PloS one, 6(1), e16166. PMID: 21311590.

Ostedgaard, L. S., Meyerholz, D. K., Chen, J. H., Pezzulo, A. A., Karp, P. H., Rokhlina, T., Ernst, S. E., Hanfland, R. A., Reznikov, L. R., Ludwig, P. S., Rogan, M. P., Davis, G. J., Dohrn, C. L., Wohlford-Lenane, C., Taft, P. J., Rector, M. V., Hornick, E., Nassar, B. S., Samuel, M., Zhang, Y., Richter, S. S., Uc, A., Shilyansky, J., Prather, R. S., McCray, Jr, P. B., Zabner, J., Welsh, M. J. & Stoltz, D. A. (2011). The ?F508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Science translational medicine, 3(74), 74ra24. PMID: 21411740.

Chang, E. H., Pezzulo, A. A. & Zabner, J. (2011). Do cell junction protein mutations cause an airway phenotype in mice or humans?. American journal of respiratory cell and molecular biology, 45(2), 202-20. PMID: 21297078.

Pezzulo, A. A., Asif, M. H., Willander, M. & Zabner, J. (2011). In Situ Quantification of Glucose Concentration in Airway Surface Liquid With Functionalized ZnO Nanorod-Coated Microelectrodes. Journal of analytical & bioanalytical techniques, S7(2). PMID: 23227447.

Lorentzen, D., Durairaj, L., Pezzulo, A. A., Nakano, Y., Launspach, J., Stoltz, D. A., Zamba, G., McCray, Jr, P. B., Zabner, J., Welsh, M. J., Nauseef, W. M. & Bánfi, B. (2011). Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions. Free radical biology & medicine, 50(9), 1144-50. PMID: 21334431.

Itani, O. A., Chen, J. H., Karp, P. H., Ernst, S., Keshavjee, S., Parekh, K., Klesney-Tait, J., Zabner, J. & Welsh, M. J. (2011). Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance. Proceedings of the National Academy of Sciences of the United States of America, 108(25), 10260-5. PMID: 21646513.

Dickey, D. D., Excoffon, K. J., Koerber, J. T., Bergen, J., Steines, B., Klesney-Tait, J., Schaffer, D. V. & Zabner, J. (2011). Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus. Journal of virology, 85(17), 9023-30. PMID: 21697483.

Chang, E. H., Lee, J. H. & Zabner, J. (2010). Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells. American journal of rhinology & allergy, 24(2), 126-8. PMID: 20338110.

Estin, M. L., Stoltz, D. A. & Zabner, J. (2010). Paraoxonase 1, quorum sensing, and P. aeruginosa infection: a novel model. Advances in experimental medicine and biology, 660, 183-93. PMID: 20221881.

Granio, O., Ashbourne Excoffon, K. J., Henning, P., Melin, P., Norez, C., Gonzalez, G., Karp, P. H., Magnusson, M. K., Habib, N., Lindholm, L., Becq, F., Boulanger, P., Zabner, J. & Hong, S. S. (2010). Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia. Human gene therapy, 21(3), 251-69. PMID: 19788389.

Stoltz, D. A., Meyerholz, D. K., Pezzulo, A. A., Ramachandran, S., Rogan, M. P., Davis, G. J., Hanfland, R. A., Wohlford-Lenane, C., Dohrn, C. L., Bartlett, J. A., Nelson, 4th, G. A., Chang, E. H., Taft, P. J., Ludwig, P. S., Estin, M., Hornick, E. E., Launspach, J. L., Samuel, M., Rokhlina, T., Karp, P. H., Ostedgaard, L. S., Uc, A., Starner, T. D., Horswill, A. R., Brogden, K. A., Prather, R. S., Richter, S. S., Shilyansky, J., McCray, Jr, P. B., Zabner, J. & Welsh, M. J. (2010). Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Science translational medicine, 2(29), 29ra31. PMID: 20427821.

Excoffon, K. J., Gansemer, N. D., Mobily, M. E., Karp, P. H., Parekh, K. R. & Zabner, J. (2010). Isoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epithelia. PloS one, 5(3), e9909. PMID: 20361046.

Chen, J. H., Stoltz, D. A., Karp, P. H., Ernst, S. E., Pezzulo, A. A., Moninger, T. O., Rector, M. V., Reznikov, L. R., Launspach, J. L., Chaloner, K., Zabner, J. & Welsh, M. J. (2010). Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia. Cell, 143(6), 911-23. PMID: 21145458.

Rogan, M. P., Reznikov, L. R., Pezzulo, A. A., Gansemer, N. D., Samuel, M., Prather, R. S., Zabner, J., Fredericks, D. C., McCray, Jr, P. B., Welsh, M. J. & Stoltz, D. A. (2010). Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proceedings of the National Academy of Sciences of the United States of America, 107(47), 20571-5. PMID: 21059918.

Meyerholz, D. K., Stoltz, D. A., Namati, E., Ramachandran, S., Pezzulo, A. A., Smith, A. R., Rector, M. V., Suter, M. J., Kao, S., McLennan, G., Tearney, G. J., Zabner, J., McCray, Jr, P. B. & Welsh, M. J. (2010). Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. American journal of respiratory and critical care medicine, 182(10), 1251-61. PMID: 20622026.

Durairaj, L., Mohamad, Z., Launspach, J. L., Ashare, A., Choi, J. Y., Rajagopal, S., Doern, G. V. & Zabner, J. (2009). Patterns and density of early tracheal colonization in intensive care unit patients. Journal of critical care, 24(1), 114-21. PMID: 19272547.

Stoltz, D. A., Ozer, E. A., Recker, T. J., Estin, M., Yang, X., Shih, D. M., Lusis, A. J. & Zabner, J. (2009). A common mutation in paraoxonase-2 results in impaired lactonase activity. The Journal of biological chemistry, 284(51), 35564-71. PMID: 19840942.

Excoffon, K. J., Koerber, J. T., Dickey, D. D., Murtha, M., Keshavjee, S., Kaspar, B. K., Zabner, J. & Schaffer, D. V. (2009). Directed evolution of adeno-associated virus to an infectious respiratory virus. Proceedings of the National Academy of Sciences of the United States of America, 106(10), 3865-70. PMID: 19237554.

Vermeer, P. D., Denker, J., Estin, M., Moninger, T. O., Keshavjee, S., Karp, P., Kline, J. N. & Zabner, J. (2009). MMP9 modulates tight junction integrity and cell viability in human airway epithelia. American journal of physiology. Lung cellular and molecular physiology, 296(5), L751-62. PMID: 19270179.

Rogers, C. S., Abraham, W. M., Brogden, K. A., Engelhardt, J. F., Fisher, J. T., McCray, Jr, P. B., McLennan, G., Meyerholz, D. K., Namati, E., Ostedgaard, L. S., Prather, R. S., Sabater, J. R., Stoltz, D. A., Zabner, J. & Welsh, M. J. (2008). The porcine lung as a potential model for cystic fibrosis. American journal of physiology. Lung cellular and molecular physiology, 295(2), L240-63. PMID: 18487356.

Excoffon, K. J., Guglielmi, K. M., Wetzel, J. D., Gansemer, N. D., Campbell, J. A., Dermody, T. S. & Zabner, J. (2008). Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells. The Journal of infectious diseases, 197(8), 1189-97. PMID: 18419529.

Stoltz, D. A., Ozer, E. A., Taft, P. J., Barry, M., Liu, L., Kiss, P. J., Moninger, T. O., Parsek, M. R. & Zabner, J. (2008). Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1. The Journal of clinical investigation, 118(9), 3123-31. PMID: 18704198.

Rogers, C. S., Stoltz, D. A., Meyerholz, D. K., Ostedgaard, L. S., Rokhlina, T., Taft, P. J., Rogan, M. P., Pezzulo, A. A., Karp, P. H., Itani, O. A., Kabel, A. C., Wohlford-Lenane, C. L., Davis, G. J., Hanfland, R. A., Smith, T. L., Samuel, M., Wax, D., Murphy, C. N., Rieke, A., Whitworth, K., Uc, A., Starner, T. D., Brogden, K. A., Shilyansky, J., McCray, Jr, P. B., Zabner, J., Prather, R. S. & Welsh, M. J. (2008). Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (New York, N.Y.), 321(5897), 1837-41. PMID: 18818360.

Gelbman, B. D., Heguy, A., O'Connor, T. P., Zabner, J. & Crystal, R. G. (2007). Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis. Respiratory research, 8, 10. PMID: 17288615.

Moskwa, P., Lorentzen, D., Excoffon, K. J., Zabner, J., McCray, Jr, P. B., Nauseef, W. M., Dupuy, C. & Bánfi, B. (2007). A novel host defense system of airways is defective in cystic fibrosis. American journal of respiratory and critical care medicine, 175(2), 174-83. PMID: 17082494.

Durairaj, L., Launspach, J., Watt, J. L., Mohamad, Z., Kline, J. & Zabner, J. (2007). Safety assessment of inhaled xylitol in subjects with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 6(1), 31-4. PMID: 16781897.

Excoffon, K. J., Gansemer, N., Traver, G. & Zabner, J. (2007). Functional effects of coxsackievirus and adenovirus receptor glycosylation on homophilic adhesion and adenoviral infection. Journal of virology, 81(11), 5573-8. PMID: 17376928.

Granio, O., Norez, C., Ashbourne Excoffon, K. J., Karp, P. H., Lusky, M., Becq, F., Boulanger, P., Zabner, J. & Hong, S. S. (2007). Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells. American journal of respiratory cell and molecular biology, 37(6), 631-9. PMID: 17641299.

Stoltz, D. A., Ozer, E. A., Ng, C. J., Yu, J. M., Reddy, S. T., Lusis, A. J., Bourquard, N., Parsek, M. R., Zabner, J. & Shih, D. M. (2007). Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. American journal of physiology. Lung cellular and molecular physiology, 292(4), L852-60. PMID: 17122353.

Vermeer, P. D., McHugh, J., Rokhlina, T., Vermeer, D. W., Zabner, J. & Welsh, M. J. (2007). Vaccinia virus entry, exit, and interaction with differentiated human airway epithelia. Journal of virology, 81(18), 9891-9. PMID: 17581984.

Seiler, M. P., Miller, A. D., Zabner, J. & Halbert, C. L. (2006). Adeno-associated virus types 5 and 6 use distinct receptors for cell entry. Human gene therapy, 17(1), 10-9. PMID: 16409121.

Keriel, A., René, C., Galer, C., Zabner, J. & Kremer, E. J. (2006). Canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors. Journal of virology, 80(3), 1487-96. PMID: 16415025.

Vermeer, P. D., Panko, L., Welsh, M. J. & Zabner, J. (2006). erbB1 functions as a sensor of airway epithelial integrity by regulation of protein phosphatase 2A activity. The Journal of biological chemistry, 281(3), 1725-30. PMID: 16293617.

Durairaj, L., Neelakantan, S., Launspach, J., Watt, J. L., Allaman, M. M., Kearney, W. R., Veng-Pedersen, P. & Zabner, J. (2006). Bronchoscopic assessment of airway retention time of aerosolized xylitol. Respiratory research, 7, 27. PMID: 16483382.

Vermeer, P. D., Panko, L., Karp, P., Lee, J. H. & Zabner, J. (2006). Differentiation of human airway epithelia is dependent on erbB2. American journal of physiology. Lung cellular and molecular physiology, 291(2), L175-80. PMID: 16489114.

Excoffon, K. J., Avenarius, M. R., Hansen, M. R., Kimberling, W. J., Najmabadi, H., Smith, R. J. & Zabner, J. (2006). The Coxsackievirus and Adenovirus Receptor: a new adhesion protein in cochlear development. Hearing research, 215(1-2), 1-9. PMID: 16678988.

Mutlu, G. M., Adir, Y., Jameel, M., Akhmedov, A. T., Welch, L., Dumasius, V., Meng, F. J., Zabner, J., Koenig, C., Lewis, E. R., Balagani, R., Traver, G., Sznajder, J. I. & Factor, P. (2005). Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport. Circulation research, 96(9), 999-1005. PMID: 15802612.

Suter, M., Reinhardt, J., Montague, P., Taft, P., Lee, J., Zabner, J. & McLennan, G. (2005). Bronchoscopic imaging of pulmonary mucosal vasculature responses to inflammatory mediators. Journal of biomedical optics, 10(3), 034013. PMID: 16229657.

Ostedgaard, L. S., Rokhlina, T., Karp, P. H., Lashmit, P., Afione, S., Schmidt, M., Zabner, J., Stinski, M. F., Chiorini, J. A. & Welsh, M. J. (2005). A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia. Proceedings of the National Academy of Sciences of the United States of America, 102(8), 2952-7. PMID: 15703296.

Excoffon, K. J., Traver, G. L. & Zabner, J. (2005). The role of the extracellular domain in the biology of the coxsackievirus and adenovirus receptor. American journal of respiratory cell and molecular biology, 32(6), 498-503. PMID: 15778494.

Zabner, J., Scheetz, T. E., Almabrazi, H. G., Casavant, T. L., Huang, J., Keshavjee, S. & McCray, Jr, P. B. (2005). CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia. American journal of physiology. Lung cellular and molecular physiology, 289(4), L545-53. PMID: 15937068.

Dajani, R., Zhang, Y., Taft, P. J., Travis, S. M., Starner, T. D., Olsen, A., Zabner, J., Welsh, M. J. & Engelhardt, J. F. (2005). Lysozyme secretion by submucosal glands protects the airway from bacterial infection. American journal of respiratory cell and molecular biology, 32(6), 548-52. PMID: 15746432.

Farmen, S. L., Karp, P. H., Ng, P., Palmer, D. J., Koehler, D. R., Hu, J., Beaudet, A. L., Zabner, J. & Welsh, M. J. (2005). Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR. American journal of physiology. Lung cellular and molecular physiology, 289(6), L1123-30. PMID: 16085675.

Ozer, E. A., Pezzulo, A., Shih, D. M., Chun, C., Furlong, C., Lusis, A. J., Greenberg, E. P. & Zabner, J. (2005). Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS microbiology letters, 253(1), 29-37. PMID: 16260097.

Cong, W., Wang, G., Kumar, D., Liu, Y., Jiang, M., Wang, L., Hoffman, E., McLennan, G., McCray, P., Zabner, J. & Cong, A. (2005). Practical reconstruction method for bioluminescence tomography. Optics express, 13(18), 6756-71. PMID: 19498692.

Zhang, L. N., Karp, P., Gerard, C. J., Pastor, E., Laux, D., Munson, K., Yan, Z., Liu, X., Godwin, S., Thomas, C. P., Zabner, J., Shi, H., Caldwell, C. W., Peluso, R., Carter, B. & Engelhardt, J. F. (2004). Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway. Molecular therapy : the journal of the American Society of Gene Therapy, 10(6), 990-1002. PMID: 15564131.

Durairaj, L., Launspach, J., Watt, J. L., Businga, T. R., Kline, J. N., Thorne, P. S. & Zabner, J. (2004). Safety assessment of inhaled xylitol in mice and healthy volunteers. Respiratory research, 5, 13. PMID: 15377394.

Brown, C. L., Graham, S. M., Cable, B. B., Ozer, E. A., Taft, P. J. & Zabner, J. (2004). Xylitol enhances bacterial killing in the rabbit maxillary sinus. The Laryngoscope, 114(11), 2021-4. PMID: 15510034.

Scheetz, T. E., Zabner, J., Welsh, M. J., Coco, J., Eyestone Mde, F., Bonaldo, M., Kucaba, T., Casavant, T. L., Soares, M. B. & McCray, Jr, P. B. (2004). Large-scale gene discovery in human airway epithelia reveals novel transcripts. Physiological genomics, 17(1), 69-77. PMID: 14701920.

Zhou, J., You, Y., Zabner, J., Ryan, A. J. & Mallampalli, R. K. (2004). The CCT promoter directs high-level transgene expression in distal lung epithelial cell lines. American journal of respiratory cell and molecular biology, 30(1), 61-8. PMID: 12829450.

Excoffon, K. J., Hruska-Hageman, A., Klotz, M., Traver, G. L. & Zabner, J. (2004). A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. Journal of cell science, 117(Pt 19), 4401-9. PMID: 15304526.

Chun, C. K., Ozer, E. A., Welsh, M. J., Zabner, J. & Greenberg, E. P. (2004). Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia. Proceedings of the National Academy of Sciences of the United States of America, 101(10), 3587-90. PMID: 14970327.

Ackermann, M. R., Gallup, J. M., Zabner, J., Evans, R. B., Brockus, C. W., Meyerholz, D. K., Grubor, B. & Brogden, K. A. (2004). Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia. Microbial pathogenesis, 37(1), 21-7. PMID: 15194156.

Walters, R. W., Agbandje-McKenna, M., Bowman, V. D., Moninger, T. O., Olson, N. H., Seiler, M., Chiorini, J. A., Baker, T. S. & Zabner, J. (2004). Structure of adeno-associated virus serotype 5. Journal of virology, 78(7), 3361-71. PMID: 15016858.

Davis, B., Nguyen, J., Stoltz, D., Depping, D., Excoffon, K. J. & Zabner, J. (2004). Adenovirus-mediated erythropoietin production by airway epithelia is enhanced by apical localization of the coxsackie-adenovirus receptor in vivo. Molecular therapy : the journal of the American Society of Gene Therapy, 10(3), 500-6. PMID: 15336650.

You, Y., Huang, T., Richer, E. J., Schmidt, J. E., Zabner, J., Borok, Z. & Brody, S. L. (2004). Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology, 286(4), L650-7. PMID: 12818891.

Vermeer, P. D., Harson, R., Einwalter, L. A., Moninger, T. & Zabner, J. (2003). Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia. American journal of respiratory cell and molecular biology, 28(3), 286-95. PMID: 12594054.

Novoa, E., D'Suze, G., Winter, M., Crespo, A., Tortoledo, M. A., Marcano, H., Friedman, E., Sevcik, C., Zabner, J. & de Sánchez León, R. (2003). The indirect effect of Tityus discrepans on rabbit pulmonary vasculature. Respiratory physiology & neurobiology, 134(1), 33-41. PMID: 12573879.

Ashbourne Excoffon, K. J., Moninger, T. & Zabner, J. (2003). The coxsackie B virus and adenovirus receptor resides in a distinct membrane microdomain. Journal of virology, 77(4), 2559-67. PMID: 12551994.

Vermeer, P. D., Einwalter, L. A., Moninger, T. O., Rokhlina, T., Kern, J. A., Zabner, J. & Welsh, M. J. (2003). Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. Nature, 422(6929), 322-6. PMID: 12646923.

Zabner, J., Winter, M. C., Shasby, S., Ries, D. & Shasby, D. M. (2003). Histamine decreases E-cadherin-based adhesion to increase permeability of human airway epithelium. Chest, 123(3 Suppl), 385S. PMID: 12628997.

Huang, T., You, Y., Spoor, M. S., Richer, E. J., Kudva, V. V., Paige, R. C., Seiler, M. P., Liebler, J. M., Zabner, J., Plopper, C. G. & Brody, S. L. (2003). Foxj1 is required for apical localization of ezrin in airway epithelial cells. Journal of cell science, 116(Pt 24), 4935-45. PMID: 14625387.

Zabner, J., Winter, M., Excoffon, K. J., Stoltz, D., Ries, D., Shasby, S. & Shasby, M. (2003). Histamine alters E-cadherin cell adhesion to increase human airway epithelial permeability. Journal of applied physiology (Bethesda, Md. : 1985), 95(1), 394-401. PMID: 12794099.

Zabner, J., Karp, P., Seiler, M., Phillips, S. L., Mitchell, C. J., Saavedra, M., Welsh, M. & Klingelhutz, A. J. (2003). Development of cystic fibrosis and noncystic fibrosis airway cell lines. American journal of physiology. Lung cellular and molecular physiology, 284(5), L844-54. PMID: 12676769.

Graham, S. M., Scott, S. N., Launspach, J. & Zabner, J. (2002). The effects of fluticasone propionate on nasal epithelial potential difference. American journal of rhinology, 16(3), 145-9. PMID: 12141771.

Wang, G., Sinn, P. L., Zabner, J. & McCray, Jr, P. B. (2002). Gene transfer to airway epithelia using feline immunodeficiency virus-based lentivirus vectors. Methods in enzymology, 346, 500-14. PMID: 11883087.

Ostedgaard, L. S., Zabner, J., Vermeer, D. W., Rokhlina, T., Karp, P. H., Stecenko, A. A., Randak, C. & Welsh, M. J. (2002). CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo. Proceedings of the National Academy of Sciences of the United States of America, 99(5), 3093-8. PMID: 11854474.

Glasspool-Malone, J., Steenland, P. R., McDonald, R. J., Sanchez, R. A., Watts, T. L., Zabner, J. & Malone, R. W. (2002). DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. The journal of gene medicine, 4(3), 323-2. PMID: 12112649.

Karp, P. H., Moninger, T. O., Weber, S. P., Nesselhauf, T. S., Launspach, J. L., Zabner, J. & Welsh, M. J. (2002). An in vitro model of differentiated human airway epithelia. Methods for establishing primary cultures. Methods in molecular biology (Clifton, N.J.), 188, 115-37. PMID: 11987537.

Rooney, C. P., Suter, M., McLennan, G., Donnelley, M., Reinhardt, J., Delsing, A., Hoffman, E. A. & Zabner, J. (2002). Laser fluorescence bronchoscopy for detection of fluorescent reporter genes in airway epithelia. Gene therapy, 9(23), 1639-44. PMID: 12424617.

Walters, R. W., Pilewski, J. M., Chiorini, J. A. & Zabner, J. (2002). Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5. The Journal of biological chemistry, 277(26), 23709-13. PMID: 11925433.

Aldallal, N., McNaughton, E. E., Manzel, L. J., Richards, A. M., Zabner, J., Ferkol, T. W. & Look, D. C. (2002). Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis. American journal of respiratory and critical care medicine, 166(9), 1248-56. PMID: 12403695.

Rooney, C. P., Denning, G. M., Davis, B. P., Flaherty, D. M., Chiorini, J. A. & Zabner, J. (2002). Bronchoalveolar fluid is not a major hindrance to virus-mediated gene therapy in cystic fibrosis. Journal of virology, 76(20), 10437-43. PMID: 12239320.

Seiler, M. P., Luner, P., Moninger, T. O., Karp, P. H., Keshavjee, S. & Zabner, J. (2002). Thixotropic solutions enhance viral-mediated gene transfer to airway epithelia. American journal of respiratory cell and molecular biology, 27(2), 133-40. PMID: 12151304.

Walters, R. W., Freimuth, P., Moninger, T. O., Ganske, I., Zabner, J. & Welsh, M. J. (2002). Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape. Cell, 110(6), 789-99. PMID: 12297051.

Drouin, S. M., Kildsgaard, J., Haviland, J., Zabner, J., Jia, H. P., McCray, Jr, P. B., Tack, B. F. & Wetsel, R. A. (2001). Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. Journal of immunology (Baltimore, Md. : 1950), 166(3), 2025-32. PMID: 11160252.

Walters, R. W., Yi, S. M., Keshavjee, S., Brown, K. E., Welsh, M. J., Chiorini, J. A. & Zabner, J. (2001). Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. The Journal of biological chemistry, 276(23), 20610-6. PMID: 11262413.

Walters, R. W., van't Hof, W., Yi, S. M., Schroth, M. K., Zabner, J., Crystal, R. G. & Welsh, M. J. (2001). Apical localization of the coxsackie-adenovirus receptor by glycosyl-phosphatidylinositol modification is sufficient for adenovirus-mediated gene transfer through the apical surface of human airway epithelia. Journal of virology, 75(16), 7703-11. PMID: 11462042.

Yi, S. M., Lee, J. H., Graham, S., Zabner, J. & Welsh, M. J. (2001). Adenovirus calcium phosphate coprecipitates enhance squamous cell carcinoma gene transfer. The Laryngoscope, 111(7), 1290-6. PMID: 11568557.

Kaludov, N., Brown, K. E., Walters, R. W., Zabner, J. & Chiorini, J. A. (2001). Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity. Journal of virology, 75(15), 6884-93. PMID: 11435568.

Yi, S. M., Harson, R. E., Zabner, J. & Welsh, M. J. (2001). Lectin binding and endocytosis at the apical surface of human airway epithelia. Gene therapy, 8(24), 1826-32. PMID: 11821935.

Drapkin, P. T., O'Riordan, C. R., Yi, S. M., Chiorini, J. A., Cardella, J., Zabner, J. & Welsh, M. J. (2000). Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia. The Journal of clinical investigation, 105(5), 589-96. PMID: 10712430.

Wang, G., Zabner, J., Deering, C., Launspach, J., Shao, J., Bodner, M., Jolly, D. J., Davidson, B. L. & McCray, Jr, P. B. (2000). Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo. American journal of respiratory cell and molecular biology, 22(2), 129-38. PMID: 10657931.

Davidson, B. L., Stein, C. S., Heth, J. A., Martins, I., Kotin, R. M., Derksen, T. A., Zabner, J., Ghodsi, A. & Chiorini, J. A. (2000). Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. Proceedings of the National Academy of Sciences of the United States of America, 97(7), 3428-32. PMID: 10688913.

Toyoda, K., Andresen, J. J., Zabner, J., Faraci, F. M. & Heistad, D. D. (2000). Calcium phosphate precipitates augment adenovirus-mediated gene transfer to blood vessels in vitro and in vivo. Gene therapy, 7(15), 1284-91. PMID: 10918499.

Zabner, J., Seiler, M., Walters, R., Kotin, R. M., Fulgeras, W., Davidson, B. L. & Chiorini, J. A. (2000). Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. Journal of virology, 74(8), 3852-8. PMID: 10729159.

Jepsen, M., Graham, S., Karp, P. H. & Zabner, J. (2000). Effect of topical nasal pharmaceuticals on sodium and chloride transport by human airway epithelia. American journal of rhinology, 14(6), 405-9. PMID: 11197117.

Zabner, J., Seiler, M. P., Launspach, J. L., Karp, P. H., Kearney, W. R., Look, D. C., Smith, J. J. & Welsh, M. J. (2000). The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing. Proceedings of the National Academy of Sciences of the United States of America, 97(21), 11614-9. PMID: 11027360.

Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L. & Schwartz, D. A. (2000). TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature genetics, 25(2), 187-91. PMID: 10835634.

Travis, S. M., Conway, B. A., Zabner, J., Smith, J. J., Anderson, N. N., Singh, P. K., Greenberg, E. P. & Welsh, M. J. (1999). Activity of abundant antimicrobials of the human airway. American journal of respiratory cell and molecular biology, 20(5), 872-9. PMID: 10226057.

Welsh, M. J., Zabner, J. (1999). Cationic lipid mediated gene transfer of CFTR: safety of a single administration to the nasal epithelia. Human gene therapy, 10(9), 1559-72. PMID: 10395381.

Walters, R. W., Grunst, T., Bergelson, J. M., Finberg, R. W., Welsh, M. J. & Zabner, J. (1999). Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia. The Journal of biological chemistry, 274(15), 10219-26. PMID: 10187807.

Lee, J. H., Zabner, J. & Welsh, M. J. (1999). Delivery of an adenovirus vector in a calcium phosphate coprecipitate enhances the therapeutic index of gene transfer to airway epithelia. Human gene therapy, 10(4), 603-13. PMID: 10094203.

Graham, S. M., Launspach, J. L., Welsh, M. J. & Zabner, J. (1999). Sequential magnetic resonance imaging analysis of the maxillary sinuses: implications for a model of gene therapy in cystic fibrosis. The Journal of laryngology and otology, 113(4), 329-35. PMID: 10474667.

Wang, G., Slepushkin, V. A., Bodner, M., Zabner, J., van Es, H. H., Thomas, P., Jolly, D. J., Davidson, B. L. & McCray, Jr, P. B. (1999). Keratinocyte growth factor induced epithelial proliferation facilitates retroviral-mediated gene transfer to distal lung epithelia in vivo. The journal of gene medicine, 1(1), 22-30. PMID: 10738582.

Chillon, M., Bosch, A., Zabner, J., Law, L., Armentano, D., Welsh, M. J. & Davidson, B. L. (1999). Group D adenoviruses infect primary central nervous system cells more efficiently than those from group C. Journal of virology, 73(3), 2537-40. PMID: 9971839.

Armentano, D., Smith, M. P., Sookdeo, C. C., Zabner, J., Perricone, M. A., St George, J. A., Wadsworth, S. C. & Gregory, R. J. (1999). E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors. Journal of virology, 73(8), 7031-4. PMID: 10400804.

Romanczuk, H., Galer, C. E., Zabner, J., Barsomian, G., Wadsworth, S. C. & O'Riordan, C. R. (1999). Dressing up adenoviruses to modify their tropism.. Interview by Florence Paillard. (Vols. 10). (16), pp. 2575-6. Human gene therapy. PMID: 10566885.

Prince, L. S., Launspach, J. L., Geller, D. S., Lifton, R. P., Pratt, J. H., Zabner, J. & Welsh, M. J. (1999). Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism. The Journal of pediatrics, 135(6), 786-9. PMID: 10586189.

McCray, Jr, P. B., Zabner, J., Jia, H. P., Welsh, M. J. & Thorne, P. S. (1999). Efficient killing of inhaled bacteria in DeltaF508 mice: role of airway surface liquid composition. The American journal of physiology, 277(1 Pt 1), L183-90. PMID: 10409246.

Wang, G., Slepushkin, V., Zabner, J., Keshavjee, S., Johnston, J. C., Sauter, S. L., Jolly, D. J., Dubensky, Jr, T. W., Davidson, B. L. & McCray, Jr, P. B. (1999). Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect. The Journal of clinical investigation, 104(11), R55-62. PMID: 10587528.

Romanczuk, H., Galer, C. E., Zabner, J., Barsomian, G., Wadsworth, S. C. & O'Riordan, C. R. (1999). Modification of an adenoviral vector with biologically selected peptides: a novel strategy for gene delivery to cells of choice. Human gene therapy, 10(16), 2615-26. PMID: 10566889.

Lee, J. H., Baker, T. J., Mahal, L. K., Zabner, J., Bertozzi, C. R., Wiemer, D. F. & Welsh, M. J. (1999). Engineering novel cell surface receptors for virus-mediated gene transfer. The Journal of biological chemistry, 274(31), 21878-84. PMID: 10419507.

Zabner, J., Chillon, M., Grunst, T., Moninger, T. O., Davidson, B. L., Gregory, R. & Armentano, D. (1999). A chimeric type 2 adenovirus vector with a type 17 fiber enhances gene transfer to human airway epithelia. Journal of virology, 73(10), 8689-95. PMID: 10482622.

Fasbender, A., Lee, J. H., Walters, R. W., Moninger, T. O., Zabner, J. & Welsh, M. J. (1998). Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo. The Journal of clinical investigation, 102(1), 184-93. PMID: 9649572.

Factor, P., Saldias, F., Ridge, K., Dumasius, V., Zabner, J., Jaffe, H. A., Blanco, G., Barnard, M., Mercer, R., Perrin, R. & Sznajder, J. I. (1998). Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene. The Journal of clinical investigation, 102(7), 1421-30. PMID: 9769335.

Zabner, J., Smith, J. J., Karp, P. H., Widdicombe, J. H. & Welsh, M. J. (1998). Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro. Molecular cell, 2(3), 397-403. PMID: 9774978.

Fasbender, A., Zabner, J., Chillón, M., Moninger, T. O., Puga, A. P., Davidson, B. L. & Welsh, M. J. (1997). Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo. The Journal of biological chemistry, 272(10), 6479-89. PMID: 9045673.

Armentano, D., Zabner, J., Sacks, C., Sookdeo, C. C., Smith, M. P., St George, J. A., Wadsworth, S. C., Smith, A. E. & Gregory, R. J. (1997). Effect of the E4 region on the persistence of transgene expression from adenovirus vectors. Journal of virology, 71(3), 2408-16. PMID: 9032378.

McCray, Jr, P. B., Wang, G., Kline, J. N., Zabner, J., Chada, S., Jolly, D. J., Chang, S. M. & Davidson, B. L. (1997). Alveolar macrophages inhibit retrovirus-mediated gene transfer to airway epithelia. Human gene therapy, 8(9), 1087-93. PMID: 9189766.

Fasbender, A., Zabner, J., Zeiher, B. G. & Welsh, M. J. (1997). A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia. Gene therapy, 4(11), 1173-80. PMID: 9425440.

Zabner, J. (1997). Cationic lipids used in gene transfer. Advanced drug delivery reviews, 27(1), 17-28. PMID: 10837548.

Mullan, B. F., Galvin, J. R., Zabner, J. & Hoffman, E. A. (1997). Evaluation of in vivo total and regional air content and distribution in primate lungs with high-resolution CT. Academic radiology, 4(10), 674-9. PMID: 9344289.

Zabner, J., Cheng, S. H., Meeker, D., Launspach, J., Balfour, R., Perricone, M. A., Morris, J. E., Marshall, J., Fasbender, A., Smith, A. E. & Welsh, M. J. (1997). Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo. The Journal of clinical investigation, 100(6), 1529-37. PMID: 9294121.

Zabner, J., Freimuth, P., Puga, A., Fabrega, A. & Welsh, M. J. (1997). Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection. The Journal of clinical investigation, 100(5), 1144-9. PMID: 9276731.

Zabner, J., Ramsey, B. W., Meeker, D. P., Aitken, M. L., Balfour, R. P., Gibson, R. L., Launspach, J., Moscicki, R. A., Richards, S. M. & Standaert, T. A. (1996). Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. The Journal of clinical investigation, 97(6), 1504-11. PMID: 8617884.

Zabner, J., Wadsworth, S. C., Smith, A. E. & Welsh, M. J. (1996). Adenovirus-mediated generation of cAMP-stimulated Cl- transport in cystic fibrosis airway epithelia in vitro: effect of promoter and administration method. Gene therapy, 3(5), 458-65. PMID: 9156806.

Goebel, E. A., Davidson, B. L., Zabner, J., Graham, S. M. & Kern, J. A. (1996). Adenovirus-mediated gene therapy for head and neck squamous cell carcinomas. The Annals of otology, rhinology, and laryngology, 105(7), 562-7. PMID: 8678435.

Fabrega, A. J., Fasbender, A. J., Struble, S. & Zabner, J. (1996). Cationic lipid-mediated transfer of the hIL-10 gene prolongs survival of allogeneic hepatocytes in Nagase analbuminemic rats. Transplantation, 62(12), 1866-71. PMID: 8990378.

Zabner, J., Zeiher, B. G., Friedman, E. & Welsh, M. J. (1996). Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time. Journal of virology, 70(10), 6994-7003. PMID: 8794344.

Cheng, S. H., Fang, S. L., Zabner, J., Marshall, J., Piraino, S., Schiavi, S. C., Jefferson, D. M., Welsh, M. J. & Smith, A. E. (1995). Functional activation of the cystic fibrosis trafficking mutant delta F508-CFTR by overexpression. The American journal of physiology, 268(4 Pt 1), L615-24. PMID: 7733303.

Stewart, B., Zabner, J., Shuber, A. P., Welsh, M. J. & McCray, Jr, P. B. (1995). Normal sweat chloride values do not exclude the diagnosis of cystic fibrosis. American journal of respiratory and critical care medicine, 151(3 Pt 1), 899-903. PMID: 7533604.

Welsh, M. J., Zabner, J., Graham, S. M., Smith, A. E., Moscicki, R. & Wadsworth, S. (1995). Adenovirus-mediated gene transfer for cystic fibrosis: Part A. Safety of dose and repeat administration in the nasal epithelium. Part B. Clinical efficacy in the maxillary sinus. Human gene therapy, 6(2), 205-18. PMID: 7537540.

McCray, Jr, P. B., Armstrong, K., Zabner, J., Miller, D. W., Koretzky, G. A., Couture, L., Robillard, J. E., Smith, A. E. & Welsh, M. J. (1995). Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo. The Journal of clinical investigation, 95(6), 2620-32. PMID: 7539457.

Fasbender, A. J., Zabner, J. & Welsh, M. J. (1995). Optimization of cationic lipid-mediated gene transfer to airway epithelia. The American journal of physiology, 269(1 Pt 1), L45-51. PMID: 7631813.

Zeiher, B. G., Eichwald, E., Zabner, J., Smith, J. J., Puga, A. P., McCray, Jr, P. B., Capecchi, M. R., Welsh, M. J. & Thomas, K. R. (1995). A mouse model for the delta F508 allele of cystic fibrosis. The Journal of clinical investigation, 96(4), 2051-64. PMID: 7560099.

Zabner, J., Fasbender, A. J., Moninger, T., Poellinger, K. A. & Welsh, M. J. (1995). Cellular and molecular barriers to gene transfer by a cationic lipid. The Journal of biological chemistry, 270(32), 18997-9007. PMID: 7642560.

Zabner, J., Petersen, D. M., Puga, A. P., Graham, S. M., Couture, L. A., Keyes, L. D., Lukason, M. J., St George, J. A., Gregory, R. J. & Smith, A. E. (1994). Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nature genetics, 6(1), 75-83. PMID: 7511023.

Zabner, J. (1994). Dosing efficiency and particle-size characteristics of pressurized metered-dose inhaler aerosols in narrow catheters. Chest, 105(5), 1621-2. PMID: 8181384.

Welsh, M. J., Smith, A. E., Zabner, J., Rich, D. P., Graham, S. M., Gregory, R. J., Pratt, B. M. & Moscicki, R. A. (1994). Cystic fibrosis gene therapy using an adenovirus vector: in vivo safety and efficacy in nasal epithelium. Human gene therapy, 5(2), 209-19. PMID: 7514450.

Zabner, J., Couture, L. A., Smith, A. E. & Welsh, M. J. (1994). Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: efficiency of adenovirus-mediated gene transfer in vitro. Human gene therapy, 5(5), 585-93. PMID: 7519884.

Zabner, J., Couture, L. A., Gregory, R. J., Graham, S. M., Smith, A. E. & Welsh, M. J. (1993). Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell, 75(2), 207-16. PMID: 7691415.

Angeli, S., Bonnet, A., Zabner, J., Martinez-Ruiz, R. & de Sánchez León, R. (1992). Effect of lipoxygenase and cyclo-oxygenase inhibition on oleic acid-induced lung oedema. Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 42(2), 75-85. PMID: 1300158.

Zabner, J., Angeli, L. S., Martinez, R. R. & de Sánchez León, R. (1990). The effects of graded administration of positive end expiratory pressure on the fluid filtration rate in isolated rabbit lungs, using normal lungs, hydrostatic oedema lungs and oleic acid induced oedema. Intensive care medicine, 16(2), 89-94. PMID: 2185291.

Martinez-Ruiz, R., Zabner, J., Angeli, S. & de Sanchez Leon, R. (1989). Effect of high frequency oscillatory ventilation on fluid filtration rate in isolated perfused rabbit lungs. Intensive care medicine, 15(3), 155-9. PMID: 2738219.

Martínez Ruiz, R., Zabner, J., Angeli, S. & de Sánchez León, R. (1988). Effect of ventilatory frequency on fluid filtration rate in isolated perfused rabbit lungs. Acta cientifica venezolana, 39(2), 151-4. PMID: 3075104.

Zabner, J., Sanchez de Leon R, Brajkovich I, Zabner J, Martinez-Ruiz R, Angeli S (1986). Effect of Hypercapnia on Fluid Filtration Rate During Forward and Reverse Perfusion of Isolated Rabbit. Lungs. Crit. Care Med.,, 14(4), 285-287.

de Sánchez León, R., Brajkovich, I., Zabner, J., Martinez-Ruiz, R. & Angeli, S. (1986). Effect of hypercapnia on fluid filtration rate during forward and reverse perfusion of isolated rabbit lungs. Critical care medicine, 14(4), 285-7. PMID: 3082594.