Joseph Zabner, MD

Portrait
Director, Division of Pulmonary, Critical Care and Occupational Medicine
Professor of Internal Medicine - Pulmonary, Critical Care and Occupational Medicine

Contact Information

Office
6324 PBDB
Iowa City, IA 52242
319-384-5401

Lab
6310 PBDB
Iowa City, IA 52242
319-385-8460

Education

MD, Universidad Central de Venezuela
Internship, Presbyterian Hospital
Resident, Internal Medicine, Parkland Hospital, Dallas, TX
Fellow, Research Fellow, Pulmonary Disease, University of Iowa Hospitals and Clinics

Licensure and Certifications

Iowa License
Texas License - Inactive

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Molecular Medicine, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

Dr. Zabner's research interests are in gene transfer to human airway epithelia in particular to develop gene therapy for cystic fibrosis. Dr. Zabner also has an interest in the fluid composition of the airway surface liquid, and how it affects innate immunity. His clinical interests are in cystic fibrosis and non-cystic fibrosis bronchiectasis.

Publications

Gehlbach, B. K., Patel, S. B., Van Cauter, E., Pohlman, A. S., Hall, J. B. & Zabner, J. (2018). The Effects of Timed Light Exposure in Critically Ill Patients: A Randomized Controlled Pilot Clinical Trial. American journal of respiratory and critical care medicine, 198(2), 275-278. PMID: 29529381.

O'Malley, Y., Rotti, P. G., Thornell, I. M., Vanegas Calderón, O. G., Febres-Aldana, C., Durham, K., Yao, J., Li, X., Zhu, Z., Norris, A. W., Zabner, J., Engelhardt, J. F. & Uc, A. (2018). Development of a polarized pancreatic ductular cell epithelium for physiological studies. Journal of applied physiology (Bethesda, Md. : 1985), 125(1), 97-106. PMID: 29517421.

Taher, H., Bauer, C., Abston, E., Kaczka, D. W., Bhatt, S. P., Zabner, J., Brower, R. G., Beichel, R. R. & Eberlein, M. (2018). Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs. Journal of applied physiology (Bethesda, Md. : 1985), 124(5), 1186-1193. PMID: 29357485.

Vargas Buonfiglio, L. G., Borcherding, J. A., Frommelt, M., Parker, G. J., Duchman, B., Vanegas Calderón, O. G., Fernandez-Ruiz, R., Noriega, J. E., Stone, E. A., Gerke, A. K., Zabner, J. & Comellas, A. P. (2018). Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance. Respiratory research, 19(1), 42. PMID: 29524964.

Thornell, I. M., Li, X., Tang, X. X., Brommel, C. M., Karp, P. H., Welsh, M. J. & Zabner, J. (2018). Nominal carbonic anhydrase activity minimizes airway-surface liquid pH changes during breathing. Physiological reports, 6(2). PMID: 29380953.

Li, X., Vargas Buonfiglio, L. G., Adam, R. J., Stoltz, D. A., Zabner, J. & Comellas, A. P. (2017). Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs. Critical care medicine, 45(12), e1240-e1246. PMID: 28953499.

Abston, E., Comellas, A., Reed, R. M., Kim, V., Wise, R. A., Brower, R., Fortis, S., Beichel, R., Bhatt, S., Zabner, J., Newell, J., Hoffman, E. A. & Eberlein, M. (2017). Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25-75/FVC) in COPD. BMJ open respiratory research, 4(1), e000231. PMID: 29071083.

Adam, R. J., Abou Alaiwa, M. H., Bouzek, D. C., Cook, D. P., Gansemer, N. D., Taft, P. J., Powers, L. S., Stroik, M. R., Hoegger, M. J., McMenimen, J. D., Hoffman, E. A., Zabner, J., Welsh, M. J., Meyerholz, D. K. & Stoltz, D. A. (2017). Postnatal airway growth in cystic fibrosis piglets. Journal of applied physiology (Bethesda, Md. : 1985), 123(3), 526-533. PMID: 28620056.

Vargas Buonfiglio, L. G., Mudunkotuwa, I. A., Abou Alaiwa, M. H., Vanegas Calderón, O. G., Borcherding, J. A., Gerke, A. K., Zabner, J., Grassian, V. H. & Comellas, A. P. (2017). Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid. Environmental health perspectives, 125(7), 077003. PMID: 28696208.

Vargas Buonfiglio, L. G., Cano, M., Pezzulo, A. A., Vanegas Calderon, O. G., Zabner, J., Gerke, A. K. & Comellas, A. P. (2017). Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial. BMJ open respiratory research, 4(1), e000211. PMID: 28883932.

Steines, B., Dickey, D. D., Bergen, J., Excoffon, K. J., Weinstein, J. R., Li, X., Yan, Z., Alaiwa, M. H., Shah, V. S., Bouzek, D. C., Powers, L. S., Gansemer, N. D., Ostedgaard, L. S., Engelhardt, J. F., Stoltz, D. A., Welsh, M. J., Sinn, P. L., Schaffer, D. V. & Zabner, J. (2016). CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes. JCI insight, 1(14), e88728. PMID: 27699238.

Vargas Buonfiglio, L. G., Bagegni, M., Borcherding, J. A., Sieren, J. C., Caraballo, J. C., Reger, A., Zabner, J., Li, X. & Comellas, A. P. (2016). Protein Kinase C Zeta Inhibitor Promotes Resolution of Bleomycin-induced Acute Lung Injury. American journal of respiratory cell and molecular biology. PMID: 27486964.

Abou Alaiwa, M. H., Launspach, J. L., Sheets, K. A., Rivera, J. A., Gansemer, N. D., Taft, P. J., Thorne, P. S., Welsh, M. J., Stoltz, D. A. & Zabner, J. (2016). Repurposing tromethamine as inhaled therapy to treat CF airway disease. JCI insight, 1(8). PMID: 27390778.

Bartlett, J. A., Ramachandran, S., Wohlford-Lenane, C. L., Barker, C. K., Pezzulo, A. A., Zabner, J., Welsh, M. J., Meyerholz, D. K., Stoltz, D. A. & McCray, Jr, P. B. (2016). Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus. American journal of respiratory and critical care medicine. PMID: 27027566.

Lee, M., Vecchio-Pagán, B., Sharma, N., Waheed, A., Li, X., Raraigh, K. S., Robbins, S., Han, S. T., Franca, A. L., Pellicore, M. J., Evans, T. A., Arcara, K. M., Nguyen, H., Luan, S., Belchis, D., Hertecant, J., Zabner, J., Sly, W. S. & Cutting, G. R. (2016). Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease. Human molecular genetics. PMID: 26911677.

Shah, V. S., Meyerholz, D. K., Tang, X. X., Reznikov, L., Abou Alaiwa, M., Ernst, S. E., Karp, P. H., Wohlford-Lenane, C. L., Heilmann, K. P., Leidinger, M. R., Allen, P. D., Zabner, J., McCray, Jr, P. B., Ostedgaard, L. S., Stoltz, D. A., Randak, C. O. & Welsh, M. J. (2016). Airway acidification initiates host defense abnormalities in cystic fibrosis mice. Science (New York, N.Y.), 351(6272), 503-7. PMID: 26823428.

Li, X., Tang, X. X., Vargas Buonfiglio, L. G., Comellas, A. P., Thornell, I. M., Ramachandran, S., Karp, P. H., Taft, P. J., Sheets, K., Abou Alaiwa, M. H., Welsh, M. J., Meyerholz, D. K., Stoltz, D. A. & Zabner, J. (2016). Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense. American journal of physiology. Lung cellular and molecular physiology, ajplung.00422.2015. PMID: 26801568.

Bruse, S., Moreau, M., Bromberg, Y., Jang, J. H., Wang, N., Ha, H., Picchi, M., Lin, Y., Langley, R. J., Qualls, C., Klensney-Tait, J., Zabner, J., Leng, S., Mao, J., Belinsky, S. A., Xing, J. & Nyunoya, T. (2016). Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility. Human genomics, 10, 1. PMID: 26744305.

Weirather, J. L., Afshar, P. T., Clark, T. A., Tseng, E., Powers, L. S., Underwood, J. G., Zabner, J., Korlach, J., Wong, W. H. & Au, K. F. (2015). Characterization of fusion genes and the significantly expressed fusion isoforms in breast cancer by hybrid sequencing. Nucleic acids research, 43(18), e116. PMID: 26040699.

Chang, E. H., Zabner, J. (2015). Precision Genomic Medicine in Cystic Fibrosis. Clinical and translational science, 8(5), 606-10. PMID: 26073768.

Klesney-Tait, J., Eberlein, M., Geist, L., Keech, J., Zabner, J., Gruber, P. J., Iannettoni, M. D. & Parekh, K. (2015). Starting a lung transplant program: a roadmap for long-term excellence. Chest, 147(5), 1435-43. PMID: 25940255.

Du, K., Karp, P. H., Ackerley, C., Zabner, J., Keshavjee, S., Cutz, E. & Yeger, H. (2015). Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: new pathologic observations. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 14(2), 182-93. PMID: 25453871.

Chang, E. H., Tang, X. X., Shah, V. S., Launspach, J. L., Ernst, S. E., Hilkin, B., Karp, P. H., Abou Alaiwa, M. H., Graham, S. M., Hornick, D. B., Welsh, M. J., Stoltz, D. A. & Zabner, J. (2015). Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor. International forum of allergy & rhinology, 5(2), 178-81. PMID: 25363320.

Jaffer, O. A., Carter, A. B., Sanders, P. N., Dibbern, M. E., Winters, C. J., Murthy, S., Ryan, A. J., Rokita, A. G., Prasad, A. M., Zabner, J., Kline, J. N., Grumbach, I. M. & Anderson, M. E. (2015). Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-ß-mediated collagen production in a murine asthma model. American journal of respiratory cell and molecular biology, 52(1), 106-15. PMID: 24988374.

Abou Alaiwa, M. H., Reznikov, L. R., Gansemer, N. D., Sheets, K. A., Horswill, A. R., Stoltz, D. A., Zabner, J. & Welsh, M. J. (2014). pH modulates the activity and synergism of the airway surface liquid antimicrobials ß-defensin-3 and LL-37. Proceedings of the National Academy of Sciences of the United States of America, 111(52), 18703-8. PMID: 25512526.

Hoegger, M. J., Fischer, A. J., McMenimen, J. D., Ostedgaard, L. S., Tucker, A. J., Awadalla, M. A., Moninger, T. O., Michalski, A. S., Hoffman, E. A., Zabner, J., Stoltz, D. A. & Welsh, M. J. (2014). Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Science (New York, N.Y.), 345(6198), 818-22. PMID: 25124441.

Abou Alaiwa, M. H., Beer, A. M., Pezzulo, A. A., Launspach, J. L., Horan, R. A., Stoltz, D. A., Starner, T. D., Welsh, M. J. & Zabner, J. (2014). Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 13(4), 373-7. PMID: 24418186.

Borcherding, J., Baltrusaitis, J., Chen, H., Stebounova, L., Wu, C. M., Rubasinghege, G., Mudunkotuwa, I. A., Caraballo, J. C., Zabner, J., Grassian, V. H. & Comellas, A. P. (2014). Iron oxide nanoparticles induce Pseudomonas aeruginosa growth, induce biofilm formation, and inhibit antimicrobial peptide function. Environmental science. Nano, 1(2), 123-132. PMID: 25221673.

Caraballo, J. C., Borcherding, J., Rector, M., Hornick, E., Stoltz, D., Zabner, J. & Comellas, A. P. (2014). Role of PON in anoxia-reoxygenation injury: a Drosophila melanogaster transgenic model. PloS one, 9(1), e84434. PMID: 24400090.

Pezzulo, A. A., Kelly, P. H., Nassar, B. S., Rutland, C. J., Gansemer, N. D., Dohrn, C. L., Costello, A. J., Stoltz, D. A. & Zabner, J. (2013). Abundant DNase I-sensitive bacterial DNA in healthy porcine lungs and its implications for the lung microbiome. Applied and environmental microbiology, 79(19), 5936-41. PMID: 23872563.

Bartlett, J. A., Albertolle, M. E., Wohlford-Lenane, C., Pezzulo, A. A., Zabner, J., Niles, R. K., Fisher, S. J., McCray, Jr, P. B. & Williams, K. E. (2013). Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs. American journal of physiology. Lung cellular and molecular physiology, 305(3), L256-66. PMID: 23709621.

Sanders, P. N., Koval, O. M., Jaffer, O. A., Prasad, A. M., Businga, T. R., Scott, J. A., Hayden, P. J., Luczak, E. D., Dickey, D. D., Allamargot, C., Olivier, A. K., Meyerholz, D. K., Robison, A. J., Winder, D. G., Blackwell, T. S., Dworski, R., Sammut, D., Wagner, B. A., Buettner, G. R., Pope, R. M., Miller, Jr, F. J., Dibbern, M. E., Haitchi, H. M., Mohler, P. J., Howarth, P. H., Zabner, J., Kline, J. N., Grumbach, I. M. & Anderson, M. E. (2013). CaMKII is essential for the proasthmatic effects of oxidation. Science translational medicine, 5(195), 195ra97. PMID: 23884469.

Stoltz, D. A., Rokhlina, T., Ernst, S. E., Pezzulo, A. A., Ostedgaard, L. S., Karp, P. H., Samuel, M. S., Reznikov, L. R., Rector, M. V., Gansemer, N. D., Bouzek, D. C., Alaiwa, M. H., Hoegger, M. J., Ludwig, P. S., Taft, P. J., Wallen, T. J., Wohlford-Lenane, C., McMenimen, J. D., Chen, J. H., Bogan, K. L., Adam, R. J., Hornick, E. E., Nelson, 4th, G. A., Hoffman, E. A., Chang, E. H., Zabner, J., McCray, Jr, P. B., Prather, R. S., Meyerholz, D. K. & Welsh, M. J. (2013). Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. The Journal of clinical investigation, 123(6), 2685-93. PMID: 23676501.

Potash, A. E., Wallen, T. J., Karp, P. H., Ernst, S., Moninger, T. O., Gansemer, N. D., Stoltz, D. A., Zabner, J. & Chang, E. H. (2013). Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model. Molecular therapy : the journal of the American Society of Gene Therapy, 21(5), 947-53. PMID: 23511247.

Borcherding, J. A., Chen, H., Caraballo, J. C., Baltrusaitis, J., Pezzulo, A. A., Zabner, J., Grassian, V. H. & Comellas, A. P. (2013). Coal fly ash impairs airway antimicrobial peptides and increases bacterial growth. PloS one, 8(2), e57673. PMID: 23469047.

Li, X., Rossen, N., Sinn, P. L., Hornick, A. L., Steines, B. R., Karp, P. H., Ernst, S. E., Adam, R. J., Moninger, T. O., Levasseur, D. N. & Zabner, J. (2013). Integrin a6ß4 identifies human distal lung epithelial progenitor cells with potential as a cell-based therapy for cystic fibrosis lung disease. PloS one, 8(12), e83624. PMID: 24349537.

Klesney-Tait, J., Keck, K., Li, X., Gilfillan, S., Otero, K., Baruah, S., Meyerholz, D. K., Varga, S. M., Knudson, C. J., Moninger, T. O., Moreland, J., Zabner, J. & Colonna, M. (2013). Transepithelial migration of neutrophils into the lung requires TREM-1. The Journal of clinical investigation, 123(1), 138-49. PMID: 23241959.

Klesney-Tait, J., Keck, K., Li, X., Gilfillan, S., Otero, K., Baruah, S., Meyerholz, D. K., Varga, S. M., Knudson, C. J., Moninger, T. O., Moreland, J., Zabner, J. & Colonna, M. (2013). Transepithelial migration of neutrophils into the lung requires TREM-1. The Journal of clinical investigation, 123(1), 138-49. PMID: 23241959.

Chang, E. H., Pezzulo, A. A., Meyerholz, D. K., Potash, A. E., Wallen, T. J., Reznikov, L. R., Sieren, J. C., Karp, P. H., Ernst, S., Moninger, T. O., Gansemer, N. D., McCray, Jr, P. B., Stoltz, D. A., Welsh, M. J. & Zabner, J. (2012). Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis. The Laryngoscope, 122(9), 1898-905. PMID: 22711071.

Pezzulo, A. A., Tang, X. X., Hoegger, M. J., Alaiwa, M. H., Ramachandran, S., Moninger, T. O., Karp, P. H., Wohlford-Lenane, C. L., Haagsman, H. P., van Eijk, M., Bánfi, B., Horswill, A. R., Stoltz, D. A., McCray, Jr, P. B., Welsh, M. J. & Zabner, J. (2012). Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature, 487(7405), 109-13. PMID: 22763554.

Li, X., Comellas, A. P., Karp, P. H., Ernst, S. E., Moninger, T. O., Gansemer, N. D., Taft, P. J., Pezzulo, A. A., Rector, M. V., Rossen, N., Stoltz, D. A., McCray, Jr, P. B., Welsh, M. J. & Zabner, J. (2012). CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia. American journal of physiology. Lung cellular and molecular physiology, 303(2), L152-60. PMID: 22637155.

Dickey, D. D., Excoffon, K. J., Young, K. R., Parekh, K. R. & Zabner, J. (2012). Hoechst increases adeno-associated virus-mediated transgene expression in airway epithelia by inducing the cytomegalovirus promoter. The journal of gene medicine, 14(6), 366-73. PMID: 22610695.

Reed, M. D., McCombie, B. E., Sivillo, A. E., Thorne, P. S., Welsh, M. J., March, T. H., McDonald, J. D., Seilkop, S. K., Zabner, J. & Durairaj, L. (2012). Safety assessment of nebulized xylitol in beagle dogs. Inhalation toxicology, 24(6), 365-72. PMID: 22564094.

Lacruz, R. S., Smith, C. E., Moffatt, P., Chang, E. H., Bromage, T. G., Bringas, Jr, P., Nanci, A., Baniwal, S. K., Zabner, J., Welsh, M. J., Kurtz, I. & Paine, M. L. (2012). Requirements for ion and solute transport, and pH regulation during enamel maturation. Journal of cellular physiology, 227(4), 1776-85. PMID: 21732355.

Pezzulo, A. A., Hornick, E. E., Rector, M. V., Estin, M., Reisetter, A. C., Taft, P. J., Butcher, S. C., Carter, A. B., Manak, J. R., Stoltz, D. A. & Zabner, J. (2012). Expression of human paraoxonase 1 decreases superoxide levels and alters bacterial colonization in the gut of Drosophila melanogaster. PloS one, 7(8), e43777. PMID: 22952763.

Dickey, D. D., Excoffon, K. J., Koerber, J. T., Bergen, J., Steines, B., Klesney-Tait, J., Schaffer, D. V. & Zabner, J. (2011). Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus. Journal of virology, 85(17), 9023-30. PMID: 21697483.

Pezzulo, A. A., Asif, M. H., Willander, M. & Zabner, J. (2011). In Situ Quantification of Glucose Concentration in Airway Surface Liquid With Functionalized ZnO Nanorod-Coated Microelectrodes. Journal of analytical & bioanalytical techniques, S7(2). PMID: 23227447.

Chang, E. H., Pezzulo, A. A. & Zabner, J. (2011). Do cell junction protein mutations cause an airway phenotype in mice or humans?. American journal of respiratory cell and molecular biology, 45(2), 202-20. PMID: 21297078.

Itani, O. A., Chen, J. H., Karp, P. H., Ernst, S., Keshavjee, S., Parekh, K., Klesney-Tait, J., Zabner, J. & Welsh, M. J. (2011). Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance. Proceedings of the National Academy of Sciences of the United States of America, 108(25), 10260-5. PMID: 21646513.

Lorentzen, D., Durairaj, L., Pezzulo, A. A., Nakano, Y., Launspach, J., Stoltz, D. A., Zamba, G., McCray, Jr, P. B., Zabner, J., Welsh, M. J., Nauseef, W. M. & Bánfi, B. (2011). Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions. Free radical biology & medicine, 50(9), 1144-50. PMID: 21334431.

Ostedgaard, L. S., Meyerholz, D. K., Chen, J. H., Pezzulo, A. A., Karp, P. H., Rokhlina, T., Ernst, S. E., Hanfland, R. A., Reznikov, L. R., Ludwig, P. S., Rogan, M. P., Davis, G. J., Dohrn, C. L., Wohlford-Lenane, C., Taft, P. J., Rector, M. V., Hornick, E., Nassar, B. S., Samuel, M., Zhang, Y., Richter, S. S., Uc, A., Shilyansky, J., Prather, R. S., McCray, Jr, P. B., Zabner, J., Welsh, M. J. & Stoltz, D. A. (2011). The ?F508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Science translational medicine, 3(74), 74ra24. PMID: 21411740.

Pezzulo, A. A., Gutiérrez, J., Duschner, K. S., McConnell, K. S., Taft, P. J., Ernst, S. E., Yahr, T. L., Rahmouni, K., Klesney-Tait, J., Stoltz, D. A. & Zabner, J. (2011). Glucose depletion in the airway surface liquid is essential for sterility of the airways. PloS one, 6(1), e16166. PMID: 21311590.

Chang, E. H., Lacruz, R. S., Bromage, T. G., Bringas, Jr, P., Welsh, M. J., Zabner, J. & Paine, M. L. (2011). Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells, tissues, organs, 194(2-4), 249-54. PMID: 21525720.

Pezzulo, A. A., Starner, T. D., Scheetz, T. E., Traver, G. L., Tilley, A. E., Harvey, B. G., Crystal, R. G., McCray, Jr, P. B. & Zabner, J. (2011). The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. American journal of physiology. Lung cellular and molecular physiology, 300(1), L25-31. PMID: 20971803.

Chen, J. H., Stoltz, D. A., Karp, P. H., Ernst, S. E., Pezzulo, A. A., Moninger, T. O., Rector, M. V., Reznikov, L. R., Launspach, J. L., Chaloner, K., Zabner, J. & Welsh, M. J. (2010). Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia. Cell, 143(6), 911-23. PMID: 21145458.

Rogan, M. P., Reznikov, L. R., Pezzulo, A. A., Gansemer, N. D., Samuel, M., Prather, R. S., Zabner, J., Fredericks, D. C., McCray, Jr, P. B., Welsh, M. J. & Stoltz, D. A. (2010). Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proceedings of the National Academy of Sciences of the United States of America, 107(47), 20571-5. PMID: 21059918.

Meyerholz, D. K., Stoltz, D. A., Namati, E., Ramachandran, S., Pezzulo, A. A., Smith, A. R., Rector, M. V., Suter, M. J., Kao, S., McLennan, G., Tearney, G. J., Zabner, J., McCray, Jr, P. B. & Welsh, M. J. (2010). Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. American journal of respiratory and critical care medicine, 182(10), 1251-61. PMID: 20622026.

Stoltz, D. A., Meyerholz, D. K., Pezzulo, A. A., Ramachandran, S., Rogan, M. P., Davis, G. J., Hanfland, R. A., Wohlford-Lenane, C., Dohrn, C. L., Bartlett, J. A., Nelson, 4th, G. A., Chang, E. H., Taft, P. J., Ludwig, P. S., Estin, M., Hornick, E. E., Launspach, J. L., Samuel, M., Rokhlina, T., Karp, P. H., Ostedgaard, L. S., Uc, A., Starner, T. D., Horswill, A. R., Brogden, K. A., Prather, R. S., Richter, S. S., Shilyansky, J., McCray, Jr, P. B., Zabner, J. & Welsh, M. J. (2010). Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Science translational medicine, 2(29), 29ra31. PMID: 20427821.

Excoffon, K. J., Gansemer, N. D., Mobily, M. E., Karp, P. H., Parekh, K. R. & Zabner, J. (2010). Isoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epithelia. PloS one, 5(3), e9909. PMID: 20361046.

Granio, O., Ashbourne Excoffon, K. J., Henning, P., Melin, P., Norez, C., Gonzalez, G., Karp, P. H., Magnusson, M. K., Habib, N., Lindholm, L., Becq, F., Boulanger, P., Zabner, J. & Hong, S. S. (2010). Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia. Human gene therapy, 21(3), 251-69. PMID: 19788389.

Chang, E. H., Lee, J. H. & Zabner, J. (2010). Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells. American journal of rhinology & allergy, 24(2), 126-8. PMID: 20338110.

Estin, M. L., Stoltz, D. A. & Zabner, J. (2010). Paraoxonase 1, quorum sensing, and P. aeruginosa infection: a novel model. Advances in experimental medicine and biology, 660, 183-93. PMID: 20221881.

Stoltz, D. A., Ozer, E. A., Recker, T. J., Estin, M., Yang, X., Shih, D. M., Lusis, A. J. & Zabner, J. (2009). A common mutation in paraoxonase-2 results in impaired lactonase activity. The Journal of biological chemistry, 284(51), 35564-71. PMID: 19840942.

Vermeer, P. D., Denker, J., Estin, M., Moninger, T. O., Keshavjee, S., Karp, P., Kline, J. N. & Zabner, J. (2009). MMP9 modulates tight junction integrity and cell viability in human airway epithelia. American journal of physiology. Lung cellular and molecular physiology, 296(5), L751-62. PMID: 19270179.

Excoffon, K. J., Koerber, J. T., Dickey, D. D., Murtha, M., Keshavjee, S., Kaspar, B. K., Zabner, J. & Schaffer, D. V. (2009). Directed evolution of adeno-associated virus to an infectious respiratory virus. Proceedings of the National Academy of Sciences of the United States of America, 106(10), 3865-70. PMID: 19237554.

Durairaj, L., Mohamad, Z., Launspach, J. L., Ashare, A., Choi, J. Y., Rajagopal, S., Doern, G. V. & Zabner, J. (2009). Patterns and density of early tracheal colonization in intensive care unit patients. Journal of critical care, 24(1), 114-21. PMID: 19272547.

Rogers, C. S., Stoltz, D. A., Meyerholz, D. K., Ostedgaard, L. S., Rokhlina, T., Taft, P. J., Rogan, M. P., Pezzulo, A. A., Karp, P. H., Itani, O. A., Kabel, A. C., Wohlford-Lenane, C. L., Davis, G. J., Hanfland, R. A., Smith, T. L., Samuel, M., Wax, D., Murphy, C. N., Rieke, A., Whitworth, K., Uc, A., Starner, T. D., Brogden, K. A., Shilyansky, J., McCray, Jr, P. B., Zabner, J., Prather, R. S. & Welsh, M. J. (2008). Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (New York, N.Y.), 321(5897), 1837-41. PMID: 18818360.

Stoltz, D. A., Ozer, E. A., Taft, P. J., Barry, M., Liu, L., Kiss, P. J., Moninger, T. O., Parsek, M. R. & Zabner, J. (2008). Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1. The Journal of clinical investigation, 118(9), 3123-31. PMID: 18704198.

Rogers, C. S., Abraham, W. M., Brogden, K. A., Engelhardt, J. F., Fisher, J. T., McCray, Jr, P. B., McLennan, G., Meyerholz, D. K., Namati, E., Ostedgaard, L. S., Prather, R. S., Sabater, J. R., Stoltz, D. A., Zabner, J. & Welsh, M. J. (2008). The porcine lung as a potential model for cystic fibrosis. American journal of physiology. Lung cellular and molecular physiology, 295(2), L240-63. PMID: 18487356.

Excoffon, K. J., Guglielmi, K. M., Wetzel, J. D., Gansemer, N. D., Campbell, J. A., Dermody, T. S. & Zabner, J. (2008). Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells. The Journal of infectious diseases, 197(8), 1189-97. PMID: 18419529.

Granio, O., Norez, C., Ashbourne Excoffon, K. J., Karp, P. H., Lusky, M., Becq, F., Boulanger, P., Zabner, J. & Hong, S. S. (2007). Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells. American journal of respiratory cell and molecular biology, 37(6), 631-9. PMID: 17641299.

Vermeer, P. D., McHugh, J., Rokhlina, T., Vermeer, D. W., Zabner, J. & Welsh, M. J. (2007). Vaccinia virus entry, exit, and interaction with differentiated human airway epithelia. Journal of virology, 81(18), 9891-9. PMID: 17581984.

Excoffon, K. J., Gansemer, N., Traver, G. & Zabner, J. (2007). Functional effects of coxsackievirus and adenovirus receptor glycosylation on homophilic adhesion and adenoviral infection. Journal of virology, 81(11), 5573-8. PMID: 17376928.

Stoltz, D. A., Ozer, E. A., Ng, C. J., Yu, J. M., Reddy, S. T., Lusis, A. J., Bourquard, N., Parsek, M. R., Zabner, J. & Shih, D. M. (2007). Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. American journal of physiology. Lung cellular and molecular physiology, 292(4), L852-60. PMID: 17122353.

Gelbman, B. D., Heguy, A., O'Connor, T. P., Zabner, J. & Crystal, R. G. (2007). Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis. Respiratory research, 8, 10. PMID: 17288615.

Moskwa, P., Lorentzen, D., Excoffon, K. J., Zabner, J., McCray, Jr, P. B., Nauseef, W. M., Dupuy, C. & Bánfi, B. (2007). A novel host defense system of airways is defective in cystic fibrosis. American journal of respiratory and critical care medicine, 175(2), 174-83. PMID: 17082494.

Durairaj, L., Launspach, J., Watt, J. L., Mohamad, Z., Kline, J. & Zabner, J. (2007). Safety assessment of inhaled xylitol in subjects with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 6(1), 31-4. PMID: 16781897.

Vermeer, P. D., Panko, L., Karp, P., Lee, J. H. & Zabner, J. (2006). Differentiation of human airway epithelia is dependent on erbB2. American journal of physiology. Lung cellular and molecular physiology, 291(2), L175-80. PMID: 16489114.

Excoffon, K. J., Avenarius, M. R., Hansen, M. R., Kimberling, W. J., Najmabadi, H., Smith, R. J. & Zabner, J. (2006). The Coxsackievirus and Adenovirus Receptor: a new adhesion protein in cochlear development. Hearing research, 215(1-2), 1-9. PMID: 16678988.

Durairaj, L., Neelakantan, S., Launspach, J., Watt, J. L., Allaman, M. M., Kearney, W. R., Veng-Pedersen, P. & Zabner, J. (2006). Bronchoscopic assessment of airway retention time of aerosolized xylitol. Respiratory research, 7, 27. PMID: 16483382.

Keriel, A., René, C., Galer, C., Zabner, J. & Kremer, E. J. (2006). Canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors. Journal of virology, 80(3), 1487-96. PMID: 16415025.

Vermeer, P. D., Panko, L., Welsh, M. J. & Zabner, J. (2006). erbB1 functions as a sensor of airway epithelial integrity by regulation of protein phosphatase 2A activity. The Journal of biological chemistry, 281(3), 1725-30. PMID: 16293617.

Seiler, M. P., Miller, A. D., Zabner, J. & Halbert, C. L. (2006). Adeno-associated virus types 5 and 6 use distinct receptors for cell entry. Human gene therapy, 17(1), 10-9. PMID: 16409121.

Farmen, S. L., Karp, P. H., Ng, P., Palmer, D. J., Koehler, D. R., Hu, J., Beaudet, A. L., Zabner, J. & Welsh, M. J. (2005). Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR. American journal of physiology. Lung cellular and molecular physiology, 289(6), L1123-30. PMID: 16085675.

Ozer, E. A., Pezzulo, A., Shih, D. M., Chun, C., Furlong, C., Lusis, A. J., Greenberg, E. P. & Zabner, J. (2005). Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS microbiology letters, 253(1), 29-37. PMID: 16260097.

Zabner, J., Scheetz, T. E., Almabrazi, H. G., Casavant, T. L., Huang, J., Keshavjee, S. & McCray, Jr, P. B. (2005). CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia. American journal of physiology. Lung cellular and molecular physiology, 289(4), L545-53. PMID: 15937068.

Cong, W., Wang, G., Kumar, D., Liu, Y., Jiang, M., Wang, L., Hoffman, E., McLennan, G., McCray, P., Zabner, J. & Cong, A. (2005). Practical reconstruction method for bioluminescence tomography. Optics express, 13(18), 6756-71. PMID: 19498692.

Dajani, R., Zhang, Y., Taft, P. J., Travis, S. M., Starner, T. D., Olsen, A., Zabner, J., Welsh, M. J. & Engelhardt, J. F. (2005). Lysozyme secretion by submucosal glands protects the airway from bacterial infection. American journal of respiratory cell and molecular biology, 32(6), 548-52. PMID: 15746432.

Excoffon, K. J., Traver, G. L. & Zabner, J. (2005). The role of the extracellular domain in the biology of the coxsackievirus and adenovirus receptor. American journal of respiratory cell and molecular biology, 32(6), 498-503. PMID: 15778494.

Mutlu, G. M., Adir, Y., Jameel, M., Akhmedov, A. T., Welch, L., Dumasius, V., Meng, F. J., Zabner, J., Koenig, C., Lewis, E. R., Balagani, R., Traver, G., Sznajder, J. I. & Factor, P. (2005). Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport. Circulation research, 96(9), 999-1005. PMID: 15802612.

Suter, M., Reinhardt, J., Montague, P., Taft, P., Lee, J., Zabner, J. & McLennan, G. (2005). Bronchoscopic imaging of pulmonary mucosal vasculature responses to inflammatory mediators. Journal of biomedical optics, 10(3), 034013. PMID: 16229657.

Ostedgaard, L. S., Rokhlina, T., Karp, P. H., Lashmit, P., Afione, S., Schmidt, M., Zabner, J., Stinski, M. F., Chiorini, J. A. & Welsh, M. J. (2005). A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia. Proceedings of the National Academy of Sciences of the United States of America, 102(8), 2952-7. PMID: 15703296.

Zhang, L. N., Karp, P., Gerard, C. J., Pastor, E., Laux, D., Munson, K., Yan, Z., Liu, X., Godwin, S., Thomas, C. P., Zabner, J., Shi, H., Caldwell, C. W., Peluso, R., Carter, B. & Engelhardt, J. F. (2004). Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway. Molecular therapy : the journal of the American Society of Gene Therapy, 10(6), 990-1002. PMID: 15564131.

Brown, C. L., Graham, S. M., Cable, B. B., Ozer, E. A., Taft, P. J. & Zabner, J. (2004). Xylitol enhances bacterial killing in the rabbit maxillary sinus. The Laryngoscope, 114(11), 2021-4. PMID: 15510034.

Durairaj, L., Launspach, J., Watt, J. L., Businga, T. R., Kline, J. N., Thorne, P. S. & Zabner, J. (2004). Safety assessment of inhaled xylitol in mice and healthy volunteers. Respiratory research, 5, 13. PMID: 15377394.

Excoffon, K. J., Hruska-Hageman, A., Klotz, M., Traver, G. L. & Zabner, J. (2004). A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. Journal of cell science, 117(Pt 19), 4401-9. PMID: 15304526.

Davis, B., Nguyen, J., Stoltz, D., Depping, D., Excoffon, K. J. & Zabner, J. (2004). Adenovirus-mediated erythropoietin production by airway epithelia is enhanced by apical localization of the coxsackie-adenovirus receptor in vivo. Molecular therapy : the journal of the American Society of Gene Therapy, 10(3), 500-6. PMID: 15336650.

Ackermann, M. R., Gallup, J. M., Zabner, J., Evans, R. B., Brockus, C. W., Meyerholz, D. K., Grubor, B. & Brogden, K. A. (2004). Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia. Microbial pathogenesis, 37(1), 21-7. PMID: 15194156.

You, Y., Huang, T., Richer, E. J., Schmidt, J. E., Zabner, J., Borok, Z. & Brody, S. L. (2004). Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology, 286(4), L650-7. PMID: 12818891.

Walters, R. W., Agbandje-McKenna, M., Bowman, V. D., Moninger, T. O., Olson, N. H., Seiler, M., Chiorini, J. A., Baker, T. S. & Zabner, J. (2004). Structure of adeno-associated virus serotype 5. Journal of virology, 78(7), 3361-71. PMID: 15016858.

Scheetz, T. E., Zabner, J., Welsh, M. J., Coco, J., Eyestone Mde, F., Bonaldo, M., Kucaba, T., Casavant, T. L., Soares, M. B. & McCray, Jr, P. B. (2004). Large-scale gene discovery in human airway epithelia reveals novel transcripts. Physiological genomics, 17(1), 69-77. PMID: 14701920.

Chun, C. K., Ozer, E. A., Welsh, M. J., Zabner, J. & Greenberg, E. P. (2004). Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia. Proceedings of the National Academy of Sciences of the United States of America, 101(10), 3587-90. PMID: 14970327.

Zhou, J., You, Y., Zabner, J., Ryan, A. J. & Mallampalli, R. K. (2004). The CCT promoter directs high-level transgene expression in distal lung epithelial cell lines. American journal of respiratory cell and molecular biology, 30(1), 61-8. PMID: 12829450.

Huang, T., You, Y., Spoor, M. S., Richer, E. J., Kudva, V. V., Paige, R. C., Seiler, M. P., Liebler, J. M., Zabner, J., Plopper, C. G. & Brody, S. L. (2003). Foxj1 is required for apical localization of ezrin in airway epithelial cells. Journal of cell science, 116(Pt 24), 4935-45. PMID: 14625387.

Zabner, J., Winter, M., Excoffon, K. J., Stoltz, D., Ries, D., Shasby, S. & Shasby, M. (2003). Histamine alters E-cadherin cell adhesion to increase human airway epithelial permeability. Journal of applied physiology (Bethesda, Md. : 1985), 95(1), 394-401. PMID: 12794099.

Zabner, J., Karp, P., Seiler, M., Phillips, S. L., Mitchell, C. J., Saavedra, M., Welsh, M. & Klingelhutz, A. J. (2003). Development of cystic fibrosis and noncystic fibrosis airway cell lines. American journal of physiology. Lung cellular and molecular physiology, 284(5), L844-54. PMID: 12676769.

Vermeer, P. D., Einwalter, L. A., Moninger, T. O., Rokhlina, T., Kern, J. A., Zabner, J. & Welsh, M. J. (2003). Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. Nature, 422(6929), 322-6. PMID: 12646923.

Zabner, J., Winter, M. C., Shasby, S., Ries, D. & Shasby, D. M. (2003). Histamine decreases E-cadherin-based adhesion to increase permeability of human airway epithelium. Chest, 123(3 Suppl), 385S. PMID: 12628997.

Vermeer, P. D., Harson, R., Einwalter, L. A., Moninger, T. & Zabner, J. (2003). Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia. American journal of respiratory cell and molecular biology, 28(3), 286-95. PMID: 12594054.

Novoa, E., D'Suze, G., Winter, M., Crespo, A., Tortoledo, M. A., Marcano, H., Friedman, E., Sevcik, C., Zabner, J. & de Sánchez León, R. (2003). The indirect effect of Tityus discrepans on rabbit pulmonary vasculature. Respiratory physiology & neurobiology, 134(1), 33-41. PMID: 12573879.

Ashbourne Excoffon, K. J., Moninger, T. & Zabner, J. (2003). The coxsackie B virus and adenovirus receptor resides in a distinct membrane microdomain. Journal of virology, 77(4), 2559-67. PMID: 12551994.

Rooney, C. P., Suter, M., McLennan, G., Donnelley, M., Reinhardt, J., Delsing, A., Hoffman, E. A. & Zabner, J. (2002). Laser fluorescence bronchoscopy for detection of fluorescent reporter genes in airway epithelia. Gene therapy, 9(23), 1639-44. PMID: 12424617.

Aldallal, N., McNaughton, E. E., Manzel, L. J., Richards, A. M., Zabner, J., Ferkol, T. W. & Look, D. C. (2002). Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis. American journal of respiratory and critical care medicine, 166(9), 1248-56. PMID: 12403695.

Rooney, C. P., Denning, G. M., Davis, B. P., Flaherty, D. M., Chiorini, J. A. & Zabner, J. (2002). Bronchoalveolar fluid is not a major hindrance to virus-mediated gene therapy in cystic fibrosis. Journal of virology, 76(20), 10437-43. PMID: 12239320.

Walters, R. W., Freimuth, P., Moninger, T. O., Ganske, I., Zabner, J. & Welsh, M. J. (2002). Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape. Cell, 110(6), 789-99. PMID: 12297051.

Seiler, M. P., Luner, P., Moninger, T. O., Karp, P. H., Keshavjee, S. & Zabner, J. (2002). Thixotropic solutions enhance viral-mediated gene transfer to airway epithelia. American journal of respiratory cell and molecular biology, 27(2), 133-40. PMID: 12151304.

Walters, R. W., Pilewski, J. M., Chiorini, J. A. & Zabner, J. (2002). Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5. The Journal of biological chemistry, 277(26), 23709-13. PMID: 11925433.

Glasspool-Malone, J., Steenland, P. R., McDonald, R. J., Sanchez, R. A., Watts, T. L., Zabner, J. & Malone, R. W. (2002). DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. The journal of gene medicine, 4(3), 323-2. PMID: 12112649.

Graham, S. M., Scott, S. N., Launspach, J. & Zabner, J. (2002). The effects of fluticasone propionate on nasal epithelial potential difference. American journal of rhinology, 16(3), 145-9. PMID: 12141771.

Ostedgaard, L. S., Zabner, J., Vermeer, D. W., Rokhlina, T., Karp, P. H., Stecenko, A. A., Randak, C. & Welsh, M. J. (2002). CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo. Proceedings of the National Academy of Sciences of the United States of America, 99(5), 3093-8. PMID: 11854474.

Karp, P. H., Moninger, T. O., Weber, S. P., Nesselhauf, T. S., Launspach, J. L., Zabner, J. & Welsh, M. J. (2002). An in vitro model of differentiated human airway epithelia. Methods for establishing primary cultures. Methods in molecular biology (Clifton, N.J.), 188, 115-37. PMID: 11987537.

Wang, G., Sinn, P. L., Zabner, J. & McCray, Jr, P. B. (2002). Gene transfer to airway epithelia using feline immunodeficiency virus-based lentivirus vectors. Methods in enzymology, 346, 500-14. PMID: 11883087.

Yi, S. M., Harson, R. E., Zabner, J. & Welsh, M. J. (2001). Lectin binding and endocytosis at the apical surface of human airway epithelia. Gene therapy, 8(24), 1826-32. PMID: 11821935.

Kaludov, N., Brown, K. E., Walters, R. W., Zabner, J. & Chiorini, J. A. (2001). Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity. Journal of virology, 75(15), 6884-93. PMID: 11435568.

Walters, R. W., van't Hof, W., Yi, S. M., Schroth, M. K., Zabner, J., Crystal, R. G. & Welsh, M. J. (2001). Apical localization of the coxsackie-adenovirus receptor by glycosyl-phosphatidylinositol modification is sufficient for adenovirus-mediated gene transfer through the apical surface of human airway epithelia. Journal of virology, 75(16), 7703-11. PMID: 11462042.

Yi, S. M., Lee, J. H., Graham, S., Zabner, J. & Welsh, M. J. (2001). Adenovirus calcium phosphate coprecipitates enhance squamous cell carcinoma gene transfer. The Laryngoscope, 111(7), 1290-6. PMID: 11568557.

Walters, R. W., Yi, S. M., Keshavjee, S., Brown, K. E., Welsh, M. J., Chiorini, J. A. & Zabner, J. (2001). Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer. The Journal of biological chemistry, 276(23), 20610-6. PMID: 11262413.

Drouin, S. M., Kildsgaard, J., Haviland, J., Zabner, J., Jia, H. P., McCray, Jr, P. B., Tack, B. F. & Wetsel, R. A. (2001). Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. Journal of immunology (Baltimore, Md. : 1950), 166(3), 2025-32. PMID: 11160252.

Jepsen, M., Graham, S., Karp, P. H. & Zabner, J. (2000). Effect of topical nasal pharmaceuticals on sodium and chloride transport by human airway epithelia. American journal of rhinology, 14(6), 405-9. PMID: 11197117.

Zabner, J., Seiler, M. P., Launspach, J. L., Karp, P. H., Kearney, W. R., Look, D. C., Smith, J. J. & Welsh, M. J. (2000). The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing. Proceedings of the National Academy of Sciences of the United States of America, 97(21), 11614-9. PMID: 11027360.

Toyoda, K., Andresen, J. J., Zabner, J., Faraci, F. M. & Heistad, D. D. (2000). Calcium phosphate precipitates augment adenovirus-mediated gene transfer to blood vessels in vitro and in vivo. Gene therapy, 7(15), 1284-91. PMID: 10918499.

Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L. & Schwartz, D. A. (2000). TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature genetics, 25(2), 187-91. PMID: 10835634.

Zabner, J., Seiler, M., Walters, R., Kotin, R. M., Fulgeras, W., Davidson, B. L. & Chiorini, J. A. (2000). Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. Journal of virology, 74(8), 3852-8. PMID: 10729159.

Davidson, B. L., Stein, C. S., Heth, J. A., Martins, I., Kotin, R. M., Derksen, T. A., Zabner, J., Ghodsi, A. & Chiorini, J. A. (2000). Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. Proceedings of the National Academy of Sciences of the United States of America, 97(7), 3428-32. PMID: 10688913.

Drapkin, P. T., O'Riordan, C. R., Yi, S. M., Chiorini, J. A., Cardella, J., Zabner, J. & Welsh, M. J. (2000). Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia. The Journal of clinical investigation, 105(5), 589-96. PMID: 10712430.

Wang, G., Zabner, J., Deering, C., Launspach, J., Shao, J., Bodner, M., Jolly, D. J., Davidson, B. L. & McCray, Jr, P. B. (2000). Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo. American journal of respiratory cell and molecular biology, 22(2), 129-38. PMID: 10657931.

Prince, L. S., Launspach, J. L., Geller, D. S., Lifton, R. P., Pratt, J. H., Zabner, J. & Welsh, M. J. (1999). Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism. The Journal of pediatrics, 135(6), 786-9. PMID: 10586189.

Wang, G., Slepushkin, V., Zabner, J., Keshavjee, S., Johnston, J. C., Sauter, S. L., Jolly, D. J., Dubensky, Jr, T. W., Davidson, B. L. & McCray, Jr, P. B. (1999). Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect. The Journal of clinical investigation, 104(11), R55-62. PMID: 10587528.

Romanczuk, H., Galer, C. E., Zabner, J., Barsomian, G., Wadsworth, S. C. & O'Riordan, C. R. (1999). Dressing up adenoviruses to modify their tropism.. Interview by Florence Paillard. (Vols. 10). (16), pp. 2575-6. Human gene therapy. PMID: 10566885.

Romanczuk, H., Galer, C. E., Zabner, J., Barsomian, G., Wadsworth, S. C. & O'Riordan, C. R. (1999). Modification of an adenoviral vector with biologically selected peptides: a novel strategy for gene delivery to cells of choice. Human gene therapy, 10(16), 2615-26. PMID: 10566889.

Zabner, J., Chillon, M., Grunst, T., Moninger, T. O., Davidson, B. L., Gregory, R. & Armentano, D. (1999). A chimeric type 2 adenovirus vector with a type 17 fiber enhances gene transfer to human airway epithelia. Journal of virology, 73(10), 8689-95. PMID: 10482622.

Armentano, D., Smith, M. P., Sookdeo, C. C., Zabner, J., Perricone, M. A., St George, J. A., Wadsworth, S. C. & Gregory, R. J. (1999). E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors. Journal of virology, 73(8), 7031-4. PMID: 10400804.

Lee, J. H., Baker, T. J., Mahal, L. K., Zabner, J., Bertozzi, C. R., Wiemer, D. F. & Welsh, M. J. (1999). Engineering novel cell surface receptors for virus-mediated gene transfer. The Journal of biological chemistry, 274(31), 21878-84. PMID: 10419507.

McCray, Jr, P. B., Zabner, J., Jia, H. P., Welsh, M. J. & Thorne, P. S. (1999). Efficient killing of inhaled bacteria in DeltaF508 mice: role of airway surface liquid composition. The American journal of physiology, 277(1 Pt 1), L183-90. PMID: 10409246.

Welsh, M. J., Zabner, J. (1999). Cationic lipid mediated gene transfer of CFTR: safety of a single administration to the nasal epithelia. Human gene therapy, 10(9), 1559-72. PMID: 10395381.

Travis, S. M., Conway, B. A., Zabner, J., Smith, J. J., Anderson, N. N., Singh, P. K., Greenberg, E. P. & Welsh, M. J. (1999). Activity of abundant antimicrobials of the human airway. American journal of respiratory cell and molecular biology, 20(5), 872-9. PMID: 10226057.

Walters, R. W., Grunst, T., Bergelson, J. M., Finberg, R. W., Welsh, M. J. & Zabner, J. (1999). Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia. The Journal of biological chemistry, 274(15), 10219-26. PMID: 10187807.

Graham, S. M., Launspach, J. L., Welsh, M. J. & Zabner, J. (1999). Sequential magnetic resonance imaging analysis of the maxillary sinuses: implications for a model of gene therapy in cystic fibrosis. The Journal of laryngology and otology, 113(4), 329-35. PMID: 10474667.

Lee, J. H., Zabner, J. & Welsh, M. J. (1999). Delivery of an adenovirus vector in a calcium phosphate coprecipitate enhances the therapeutic index of gene transfer to airway epithelia. Human gene therapy, 10(4), 603-13. PMID: 10094203.

Chillon, M., Bosch, A., Zabner, J., Law, L., Armentano, D., Welsh, M. J. & Davidson, B. L. (1999). Group D adenoviruses infect primary central nervous system cells more efficiently than those from group C. Journal of virology, 73(3), 2537-40. PMID: 9971839.

Wang, G., Slepushkin, V. A., Bodner, M., Zabner, J., van Es, H. H., Thomas, P., Jolly, D. J., Davidson, B. L. & McCray, Jr, P. B. (1999). Keratinocyte growth factor induced epithelial proliferation facilitates retroviral-mediated gene transfer to distal lung epithelia in vivo. The journal of gene medicine, 1(1), 22-30. PMID: 10738582.

Factor, P., Saldias, F., Ridge, K., Dumasius, V., Zabner, J., Jaffe, H. A., Blanco, G., Barnard, M., Mercer, R., Perrin, R. & Sznajder, J. I. (1998). Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene. The Journal of clinical investigation, 102(7), 1421-30. PMID: 9769335.

Zabner, J., Smith, J. J., Karp, P. H., Widdicombe, J. H. & Welsh, M. J. (1998). Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro. Molecular cell, 2(3), 397-403. PMID: 9774978.

Fasbender, A., Lee, J. H., Walters, R. W., Moninger, T. O., Zabner, J. & Welsh, M. J. (1998). Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo. The Journal of clinical investigation, 102(1), 184-93. PMID: 9649572.

Fasbender, A., Zabner, J., Zeiher, B. G. & Welsh, M. J. (1997). A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia. Gene therapy, 4(11), 1173-80. PMID: 9425440.

Mullan, B. F., Galvin, J. R., Zabner, J. & Hoffman, E. A. (1997). Evaluation of in vivo total and regional air content and distribution in primate lungs with high-resolution CT. Academic radiology, 4(10), 674-9. PMID: 9344289.

Zabner, J., Cheng, S. H., Meeker, D., Launspach, J., Balfour, R., Perricone, M. A., Morris, J. E., Marshall, J., Fasbender, A., Smith, A. E. & Welsh, M. J. (1997). Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo. The Journal of clinical investigation, 100(6), 1529-37. PMID: 9294121.

Zabner, J., Freimuth, P., Puga, A., Fabrega, A. & Welsh, M. J. (1997). Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection. The Journal of clinical investigation, 100(5), 1144-9. PMID: 9276731.

Zabner, J. (1997). Cationic lipids used in gene transfer. Advanced drug delivery reviews, 27(1), 17-28. PMID: 10837548.

McCray, Jr, P. B., Wang, G., Kline, J. N., Zabner, J., Chada, S., Jolly, D. J., Chang, S. M. & Davidson, B. L. (1997). Alveolar macrophages inhibit retrovirus-mediated gene transfer to airway epithelia. Human gene therapy, 8(9), 1087-93. PMID: 9189766.

Fasbender, A., Zabner, J., Chillón, M., Moninger, T. O., Puga, A. P., Davidson, B. L. & Welsh, M. J. (1997). Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo. The Journal of biological chemistry, 272(10), 6479-89. PMID: 9045673.

Armentano, D., Zabner, J., Sacks, C., Sookdeo, C. C., Smith, M. P., St George, J. A., Wadsworth, S. C., Smith, A. E. & Gregory, R. J. (1997). Effect of the E4 region on the persistence of transgene expression from adenovirus vectors. Journal of virology, 71(3), 2408-16. PMID: 9032378.

Fabrega, A. J., Fasbender, A. J., Struble, S. & Zabner, J. (1996). Cationic lipid-mediated transfer of the hIL-10 gene prolongs survival of allogeneic hepatocytes in Nagase analbuminemic rats. Transplantation, 62(12), 1866-71. PMID: 8990378.

Zabner, J., Zeiher, B. G., Friedman, E. & Welsh, M. J. (1996). Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time. Journal of virology, 70(10), 6994-7003. PMID: 8794344.

Goebel, E. A., Davidson, B. L., Zabner, J., Graham, S. M. & Kern, J. A. (1996). Adenovirus-mediated gene therapy for head and neck squamous cell carcinomas. The Annals of otology, rhinology, and laryngology, 105(7), 562-7. PMID: 8678435.

Zabner, J., Wadsworth, S. C., Smith, A. E. & Welsh, M. J. (1996). Adenovirus-mediated generation of cAMP-stimulated Cl- transport in cystic fibrosis airway epithelia in vitro: effect of promoter and administration method. Gene therapy, 3(5), 458-65. PMID: 9156806.

Zabner, J., Ramsey, B. W., Meeker, D. P., Aitken, M. L., Balfour, R. P., Gibson, R. L., Launspach, J., Moscicki, R. A., Richards, S. M. & Standaert, T. A. (1996). Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. The Journal of clinical investigation, 97(6), 1504-11. PMID: 8617884.

Zeiher, B. G., Eichwald, E., Zabner, J., Smith, J. J., Puga, A. P., McCray, Jr, P. B., Capecchi, M. R., Welsh, M. J. & Thomas, K. R. (1995). A mouse model for the delta F508 allele of cystic fibrosis. The Journal of clinical investigation, 96(4), 2051-64. PMID: 7560099.

Zabner, J., Fasbender, A. J., Moninger, T., Poellinger, K. A. & Welsh, M. J. (1995). Cellular and molecular barriers to gene transfer by a cationic lipid. The Journal of biological chemistry, 270(32), 18997-9007. PMID: 7642560.

Fasbender, A. J., Zabner, J. & Welsh, M. J. (1995). Optimization of cationic lipid-mediated gene transfer to airway epithelia. The American journal of physiology, 269(1 Pt 1), L45-51. PMID: 7631813.

McCray, Jr, P. B., Armstrong, K., Zabner, J., Miller, D. W., Koretzky, G. A., Couture, L., Robillard, J. E., Smith, A. E. & Welsh, M. J. (1995). Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo. The Journal of clinical investigation, 95(6), 2620-32. PMID: 7539457.

Cheng, S. H., Fang, S. L., Zabner, J., Marshall, J., Piraino, S., Schiavi, S. C., Jefferson, D. M., Welsh, M. J. & Smith, A. E. (1995). Functional activation of the cystic fibrosis trafficking mutant delta F508-CFTR by overexpression. The American journal of physiology, 268(4 Pt 1), L615-24. PMID: 7733303.

Stewart, B., Zabner, J., Shuber, A. P., Welsh, M. J. & McCray, Jr, P. B. (1995). Normal sweat chloride values do not exclude the diagnosis of cystic fibrosis. American journal of respiratory and critical care medicine, 151(3 Pt 1), 899-903. PMID: 7533604.

Welsh, M. J., Zabner, J., Graham, S. M., Smith, A. E., Moscicki, R. & Wadsworth, S. (1995). Adenovirus-mediated gene transfer for cystic fibrosis: Part A. Safety of dose and repeat administration in the nasal epithelium. Part B. Clinical efficacy in the maxillary sinus. Human gene therapy, 6(2), 205-18. PMID: 7537540.

Zabner, J., Couture, L. A., Smith, A. E. & Welsh, M. J. (1994). Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: efficiency of adenovirus-mediated gene transfer in vitro. Human gene therapy, 5(5), 585-93. PMID: 7519884.

Zabner, J. (1994). Dosing efficiency and particle-size characteristics of pressurized metered-dose inhaler aerosols in narrow catheters. Chest, 105(5), 1621-2. PMID: 8181384.

Welsh, M. J., Smith, A. E., Zabner, J., Rich, D. P., Graham, S. M., Gregory, R. J., Pratt, B. M. & Moscicki, R. A. (1994). Cystic fibrosis gene therapy using an adenovirus vector: in vivo safety and efficacy in nasal epithelium. Human gene therapy, 5(2), 209-19. PMID: 7514450.

Zabner, J., Petersen, D. M., Puga, A. P., Graham, S. M., Couture, L. A., Keyes, L. D., Lukason, M. J., St George, J. A., Gregory, R. J. & Smith, A. E. (1994). Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nature genetics, 6(1), 75-83. PMID: 7511023.

Zabner, J., Couture, L. A., Gregory, R. J., Graham, S. M., Smith, A. E. & Welsh, M. J. (1993). Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell, 75(2), 207-16. PMID: 7691415.

Angeli, S., Bonnet, A., Zabner, J., Martinez-Ruiz, R. & de Sánchez León, R. (1992). Effect of lipoxygenase and cyclo-oxygenase inhibition on oleic acid-induced lung oedema. Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 42(2), 75-85. PMID: 1300158.

Zabner, J., Angeli, L. S., Martinez, R. R. & de Sánchez León, R. (1990). The effects of graded administration of positive end expiratory pressure on the fluid filtration rate in isolated rabbit lungs, using normal lungs, hydrostatic oedema lungs and oleic acid induced oedema. Intensive care medicine, 16(2), 89-94. PMID: 2185291.

Martinez-Ruiz, R., Zabner, J., Angeli, S. & de Sanchez Leon, R. (1989). Effect of high frequency oscillatory ventilation on fluid filtration rate in isolated perfused rabbit lungs. Intensive care medicine, 15(3), 155-9. PMID: 2738219.

Martínez Ruiz, R., Zabner, J., Angeli, S. & de Sánchez León, R. (1988). Effect of ventilatory frequency on fluid filtration rate in isolated perfused rabbit lungs. Acta cientifica venezolana, 39(2), 151-4. PMID: 3075104.

de Sánchez León, R., Brajkovich, I., Zabner, J., Martinez-Ruiz, R. & Angeli, S. (1986). Effect of hypercapnia on fluid filtration rate during forward and reverse perfusion of isolated rabbit lungs. Critical care medicine, 14(4), 285-7. PMID: 3082594.

Zabner, J., Sanchez de Leon R, Brajkovich I, Zabner J, Martinez-Ruiz R, Angeli S (1986). Effect of Hypercapnia on Fluid Filtration Rate During Forward and Reverse Perfusion of Isolated Rabbit. Lungs. Crit. Care Med.,, 14(4), 285-287.