Ferhaan Ahmad, MD, PhD

Portrait
Director, Cardiovascular Genetics Center
Associate Professor of Internal Medicine - Cardiovascular Medicine
Associate Professor of Radiology

Contact Information

Iowa City, IA 52242
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Education

MD, McGill University
PhD, Cardiovascular Sciences, Genetics, Baylor College of Medicine

Resident, Internal Medicine, McGill University
Fellow, Cardiology and Critical Care Medicine, McGill University
Fellow, American Heart Association-Bugher Foundation Center for Molecular Biology in the Cardiovascular System, Baylor College of Medicine
Fellow, Nuclear Cardiology, Brigham and Women’s Hospital
Fellow, Genetics, Howard Hughes Medical Institute, Harvard Medical School

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Genetics, Medical Scientist Training Program

Center, Program and Institute Affiliations

Cardiovascular Research Center, Iowa Institute of Human Genetics.

Research Summary

Dr. Ahmad is the Director of the Cardiovascular Genetics Program at the University of Iowa, which brings together basic scientists at the Carver College of Medicine and clinicians at the University of Iowa Hospitals and Clinics (UIHC) who are focusing on heritable cardiovascular disorders. He directs a laboratory conducting basic and translational research into the genetic and genomic mechanisms underlying inherited cardiovascular disorders, including hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, glycogen storage cardiomyopathy, inherited arrhythmias, and pulmonary hypertension. His laboratory uses a wide range of techniques in human and mouse genetics and genomics, and fosters crosstalk between clinical studies, human molecular genetic studies, animal modeling, basic cellular and molecular studies, and computational systems biology analyses. At the UIHC Cardiovascular Genetics Clinic, an interdisciplinary team evaluates, counsels, and treats patients with inherited cardiovascular disorders and their families.

Publications

Wang, Y., Wang, J., Zou, Y., Bao, J., Sun, K., Zhu, L., Tian, T., Shen, H., Zhou, X., Ahmad, F., Hui, R. & Song, L. (2014). Female sex is associated with worse prognosis in patients with hypertrophic cardiomyopathy in China. PloS one, 9(7), e102969. PMID: 25047602.

Su, M., Wang, J., Kang, L., Wang, Y., Zou, Y., Feng, X., Wang, D., Ahmad, F., Zhou, X., Hui, R. & Song, L. (2014). Rare variants in genes encoding MuRF1 and MuRF2 are modifiers of hypertrophic cardiomyopathy. International journal of molecular sciences, 15(6), 9302-13. PMID: 24865491.

Ramratnam, M., Sharma, R. K., D'Auria, S., Lee, S. J., Wang, D., Huang, X. Y. & Ahmad, F. (2014). Transgenic knockdown of cardiac sodium/glucose cotransporter 1 (SGLT1) attenuates PRKAG2 cardiomyopathy, whereas transgenic overexpression of cardiac SGLT1 causes pathologic hypertrophy and dysfunction in mice. Journal of the American Heart Association, 3(4). PMID: 25092788.

Wang, J., Wang, Y., Zou, Y., Sun, K., Wang, Z., Ding, H., Yuan, J., Wei, W., Hou, Q., Wang, H., Liu, X., Zhang, H., Ji, Y., Zhou, X., Sharma, R. K., Wang, D., Ahmad, F., Hui, R. & Song, L. (2014). Malignant effects of multiple rare variants in sarcomere genes on the prognosis of patients with hypertrophic cardiomyopathy. European journal of heart failure, 16(9), 950-7. PMID: 25132132.

George, M. P., Yao, M., Ahmad, F., Sembrat, J., Rajkumar, R., Enrico, N., Stenmark, K., Gladwin, M., Champion, H. C. & Isenberg, J. S. (2013). End-stage sickle cell disease (SCD)-associated pulmonary hypertension (PH) is characterized by abnormal cellular, mechanical and vaso-active profiles. Proceedings of the 5th World Symposium on Pulmonary Hypertension.

Wang, Y., Wang, Z., Yang, Q., Zou, Y., Zhang, H., Yan, C., Feng, X., Chen, Y., Zhang, Y., Wang, J., Zhou, X., Ahmad, F., Hui, R. & Song, L. (2013). Autosomal recessive transmission of MYBPC3 mutation results in malignant phenotype of hypertrophic cardiomyopathy. PloS one, 8(6), e67087. PMID: 23840593.

Rogers, N. M., Yao, M., Sembrat, J., George, M. P., Knupp, H., Ross, M., Sharifi-Sanjani, M., Milosevic, J., St Croix, C., Rajkumar, R., Frid, M. G., Hunter, K. S., Mazzaro, L., Novelli, E. M., Stenmark, K. R., Gladwin, M. T., Ahmad, F., Champion, H. C. & Isenberg, J. S. (2013). Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension. Pulmonary circulation, 3(4), 936-51. PMID: 25006410.

Bauer, E. M., Shapiro, R., Zheng, H., Ahmad, F., Ishizawar, D., Comhair, S. A., Erzurum, S. C., Billiar, T. R. & Bauer, P. M. (2012). High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4. Molecular medicine (Cambridge, Mass.), 18, 1509-18. PMID: 23269975.

Rajkumar, R., Sembrat, J. C., McDonough, B., Seidman, C. E. & Ahmad, F. (2012). Functional effects of the TMEM43 Ser358Leu mutation in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. BMC medical genetics, 13, 21. PMID: 22458570.

Sembrat, J., Rajkumar, R., Huang, X. N., White, J. & Ahmad, F. (2012). Pulmonary arterial hypertension induces gene expression changes in the right ventricle in advance of right ventricular failure that are more severe in female rats. Thomas L Petty Aspen Lung Conference.

Rajkumar, R., Shariff, A. I., Choi, J. I., Huang, G. T., Pandit, K. V., Sembrat, J. C., Le, H. S., Ishizawar, D. C., Richards, T. J., Bar Joseph, Z., Benos, P. V., Kaminski, N. & Ahmad, F. (2012). Integration of genome-wide microRNA and mRNA expression profiles in pulmonary arterial hypertension and pulmonary hypertension associated with idiopathic pulmonary fibrosis. Thomas L Petty Aspen Lung Conference.

Sembrat, J., Rajkumar, R., Huang, T. W., White, J. & Ahmad, F. (2012). Pulmonary arterial hypertension induces gene expression changes in the right ventricle in advance of right ventricular failure that are more severe in female rats. Proceedings of the 10th International Pulmonary Hypertension Conference and Scientific Sessions.

Sembrat, J., Rajkumar, R., Huang, T. W., Haight, D., Meoli, D., White, J. & Ahmad, F. (2012). Microarray expression profiles of female rats with severe pulmonary hypertension and right ventricular dysfunction. Proceedings of the 20th Annual American Heart Association Fellows Research Day.

White, R. J., Sembrat, J., Meoli, D. F., Rajkumar, R., Haight, D., Huang, X. N. & Ahmad, F. (2012). Pulmonary arterial hypertension induces gene expression changes in the right ventricle in advance of right ventricular failure that are more severe in female rats. Proceedings of the Keystone Symposium on Pulmonary Vascular Disease and Right Ventricular Dysfunction: Current Concepts and Future Therapies.

Rajkumar, R., Shariff, A. I., Choi, J. I., Huang, G. T., Pandit, K. V., Sembrat, J. C., Le, H. S., Ishizawar, D. C., Richards, T. J., Bar-Joseph, Z., Benos, P. V., Kaminski, N. & Ahmad, F. (2012). Integration of genome-wide microRNA and mRNA expression profiles in pulmonary arterial hypertension and pulmonary hypertension associated with idiopathic pulmonary fibrosis. Proceedings of the 20th Annual American Heart Association Fellows Research Day.

White, R. J., Sembrat, J. C., Meoli, D. F., Rajkumar, R., Haight, D., Huang, X. N. & Ahmad, F. (2012). Pulmonary arterial hypertension induces gene expression changes in the right ventricle in advance of right ventricular failure that are more severe in female rats. (Vols. 126). pp. A11696. Circulation.

Ahmad, F., Sharma, R. K., Wang, D., Ramratnam, M., Smith, S. H., Banerjee, S. K., Huang, X. N., Lage, M. L., Gabris, B. E., Saba, S., Shroff, S. G. & Salama, G. (2012). A gene-targeted murine model of the human cardiac troponin T (TNNT2) R141W mutation develops dilated cardiomyopathy with calcium desensitization. (Vols. 126). pp. A11710. Circulation.

White, R. J., Meoli, D. F., Haight, D. & Ahmad, F. (2012). A female rat model of pulmonary hypertension with neointimal formation, severe vascular pruning, and right ventricular failure. (Vols. 185). pp. A3434. American Thoracic Society International Conference.

Rajkumar, R., Shariff, A. I., Choi, J. I., Huang, G. T., Pandit, K. V., Sembrat, J. C., Le, H. S., Ishizawar, D. C., Richards, T. J., Bar-Joseph, Z., Benos, P. V., Kaminski, N. & Ahmad, F. (2012). Integration of genome-wide microRNA and mRNA expression profiles in pulmonary arterial hypertension and pulmonary hypertension associated with idiopathic pulmonary fibrosis. Proceedings of the 10th International Pulmonary Hypertension Conference and Scientific Sessions.

Ramratnam, M., Huang, X. N., Sharma, R., Lee, S. J., D'Auria, S., Wang, D. & Ahmad, F. (2012). Transgenic overexpression of cardiac sodium/glucose cotransporter 1 (SGLT1) in mice mimics PRKAG2 cardiomyopathy, whereas transgenic knockdown of cardiac SGLT1 attenuates PRKAG2 cardiomyopathy. (Vols. 126). pp. A14247. Circulation.

Ramratnam, M., Banerjee, S. K., Witham, W., Sharma, R., Huang, X. N., Rajkumar, R., Ramani, R., McGaffin, K. R. & Ahmad, F. (2012). SGLT1, a novel cardiac glucose transporter, is cardioprotective in ischemia-reperfusion. Proceedings of the 20th Annual American Heart Association Fellows Research Day.

Ahmad, F., Champion, H. C. & Kaminski, N. (2012). Toward systems biology of pulmonary hypertension. Circulation, 125(12), 1477-9. PMID: 22371329.

Ramratnam, M., Huang, X. N., Sharma, R., Lee, S. J., D'Auria, S., Wang, D. & Ahmad, F. (2012). Transgenic overexpression of cardiac sodium/glucose cotransporter 1 (Sglt1) in mice mimics PRKAG2 cardiomyopathy, whereas transgenic knockdown of cardiac SGLT1 attenuates PRKAG2 cardiomyopathy. Proceedings of the 20th Annual American Heart Association Fellows Research Day.

Tong, C., Ramratnam, M., Huang, T. W., Sembrat, J. & Ahmad, F. (2012). AMP-activated protein kinase downstream target, sodium-dependent glucose transporter SGLT1, is associated with impaired Cardioprotection during ischemia and reperfusion. Proceedings of the 20th Annual American Heart Association Fellows Research Day.

Kass, D. J., Rattigan, E., Kahloon, R., Loh, K., Yu, L., Savir, A., Markowski, M., Saqi, A., Rajkumar, R., Ahmad, F. & Champion, H. C. (2012). Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats. PloS one, 7(4), e35388. PMID: 22509410.

Lee, S. J., Huang, X. N. & Ahmad, F. (2012). Cardiac-specific knockdown of the sodium dependent glucose cotransporter 1 (SGLT1) attenuates the cardiomyopathy caused by a mutation in PRKAG2. Proceedings of the 20th Annual American Heart Association Fellows Research Day.

Ramratnam, M., Banerjee, S. K., Witham, W., Sharma, R., Ramani, R., McGaffin, K. R. & Ahmad, F. (2012). Cardiac sodium/glucose cotransporter 1 (SGLT1), a novel cardiac glucose transporter, is cardioprotective in ischemia-reperfusion. (Vols. 111). pp. 111. Circ Res.

Kim, A. J., Ramirez, R., Liu, X., Chen, G., Ahmad, F., London, B., Tobita, K. & Lo, C. W. (2011). Identification of novel cardiomyopathy mutants with quantitation of ventricular dimensions in neonatal mice using micro-computed tomography. Proceedings of the 2011 Weinstein Cardiovascular Development Conference.

Rajkumar, R., Shariff, A. I., Choi, J. I., Huang, G. T., Pandit, K. V., Sembrat, J. C., Ishizawar, D. C., Richards, T. J., Benos, P. V., Kaminski, N. & Ahmad, F. (2011). Integration of genome-wide microRNA and mRNA expression profiles in pulmonary arterial hypertension and pulmonary hypertension associated with idiopathic pulmonary fibrosis. (Vols. 124). pp. A15511. Circulation.

Rajkumar, R., Sembrat, J. & Ahmad, F. (2011). Functional role of mutant TMEM 43 in development of arrhythmogenic right ventricular cardiomyopathy. Proceedings of the 19th Annual American Heart Association Fellows Research Day.

Shayan, H., Rocha, R., Wei, L., Gleason, T., Zaldonis, D., Pellegrini, R., Toyoda, Y., Shapiro, R., Ahmad, F. & Bermudez, C. (2011). Midterm outcomes of off-pump and on-pump coronary artery revascularization in renal transplant recipients. Journal of cardiac surgery, 26(6), 591-5. PMID: 21995559.

Shayan, H., Rocha, R., Wei, L., Gleason, T., Zaldonis, D., Pellegrini, R., Toyoda, Y., Shapiro, R., Ahmad, F. & Bermudez, C. (2011). Midterm outcomes of off-pump and on-pump coronary artery revascularization in renal transplant recipients. Journal of cardiac surgery, 26(6), 591-5. PMID: 21995559.

Rajkumar, R., Sembrat, J. & Ahmad, F. (2011). Functional role of mutant TMEM 43 in development of arrhythmogenic right ventricular cardiomyopathy. Presented at the University of Pittsburgh Department of Medicine Research Day.

Adachi, K., Naitza, C. S., Huang, X. N., Ahmad, F. & Nakai, H. (2011). Development of an effective AAV vector-based gene therapy to treat the PRKAG2-Tg mice, an animal model of autosomal dominant progressive cardiomyopathy. (Vols. 19). pp. S253. Mol Ther.

Sembrat, J., Rajkumar, R. & Ahmad, F. (2011). Downregulation of PPPP2CA in pulmonary artery smooth muscle cells is potentially linked to the development of pulmonary arterial hypertension. Proceedings of the 19th Annual American Heart Association Fellows Research Day.

Sembrat, J., Rajkumar, R. & Ahmad, F. (2010). Downregulation of PPPP2CA in pulmonary artery smooth muscle cells is potentially linked to the development of pulmonary arterial hypertension. Presented at the University of Pittsburgh Department of Medicine Research Day.

Shariff, A. I., Pandit, K. V., Huang, T. W., Rajkumar, R., Richards, T. J., Benos, P. V., Kaminski, N. & Ahmad, F. (2010). Genome-wide comparison of miRNA and mRNA expression profiles in pulmonary arterial hypertension (PAH). Presented at the University of Pittsburgh Department of Medicine Research Day.

Rajkumar, R., Sembrat, J. & Ahmad, F. (2010). Dissection of the role of PPPP2CA in the pathogenesis of pulmonary arterial hypertension. Presented at the University of Pittsburgh Science.

Shariff, A. I., Pandit, K. V., Huang, T. W., Rajkumar, R., Richards, T. J., Benos, P. V., Kaminski, N. & Ahmad, F. (2010). Genome-wide comparison of miRNA and mRNA expression profiles in pulmonary arterial hypertension (PAH). Presented at the University of Pittsburgh Science.

Banerjee, S. K., Wang, D. W., Alzamora, R., Huang, X. N., Pastor-Soler, N. M., Hallows, K. R., McGaffin, K. R. & Ahmad, F. (2010). SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. Journal of molecular and cellular cardiology, 49(4), 683-92. PMID: 20600102.

Rajkumar, R., Sembrat, J. & Ahmad, F. (2010). Dissection of the role of PPP2CA in the pathogenesis of pulmonary arterial hypertension. Proceedings of the 9th International Pulmonary Hypertension Conference and Scientific Sessions.

Austin, E. D., Hamid, R. & Ahmad, F. (2010). Somatic mutations in pulmonary arterial hypertension: primary or secondary events?. American journal of respiratory and critical care medicine, 182(9), 1094-6. PMID: 21041561.

Rajkumar, R., Konishi, K., Richards, T. J., Ishizawar, D. C., Wiechert, A. C., Kaminski, N. & Ahmad, F. (2010). Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension. American journal of physiology. Heart and circulatory physiology, 298(4), H1235-48. PMID: 20081107.

Banerjee, S. K., McGaffin, K. R., Huang, X. N. & Ahmad, F. (2010). Activation of cardiac hypertrophic signaling pathways in a transgenic mouse with the human PRKAG2 Thr400Asn mutation. Biochimica et biophysica acta, 1802(2), 284-91. PMID: 20005292.

Banerjee, S. K., Wang, D., Pastor-Soler, N. M., McGaffin, K. R. & Ahmad, F. (2009). A novel cardiac glucose transporter, SGLT1, mediates increased glucose uptake in PRKAG2 cardiomyopathy. (Vols. 120). pp. S619. Circulation.

Schmitt, J. P., Ahmad, F., Lorenz, K., Hein, L., Schulz, S., Asahi, M., Maclennan, D. H., Seidman, C. E., Seidman, J. G. & Lohse, M. J. (2009). Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition. Circulation, 119(3), 436-44. PMID: 19139388.

Ahmad, F. (2009). Novel Genetic Insights into the Mechanisms of Cardiomyopathies and Heart Failure. (Vols. 114). pp. 79. Cardiology.

Banerjee, S. K., McGaffin, K. R. & Ahmad, F. (2009). SGLT1 is a novel cardiac glucose transporter that contributes critically to the pathophysiology of heart disease. Proceedings of the 17th Annual American Heart Association Fellows Research Day.

Rajkumar, R., Ahmad, F. (2009). Novel mutations contribute to arrhythmogenic right ventricular dysplasia: a screen of six genes. Proceedings of the 17th Annual American Heart Association Fellows Research Day.

Banerjee, S. K., McGaffin, K. R., Pastor-Soler, N. M. & Ahmad, F. (2009). SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states. Cardiovascular research, 84(1), 111-8. PMID: 19509029.

Banerjee, S. K., Ahmad, F. (2009). SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. Proceedings of the Keystone Symposium on Common Mechanisms in Arrhythmias and Heart Failure.

D'Auria, S., Ahmad, F. (2009). Regulation and function of a novel cardiac glucose transporter, SGLT1. Presented at the University of Pittsburgh Scholars Day.

King, J. C., Moskowitz, I. P., Burgon, P. G., Ahmad, F., Stone, J. R., Seidman, J. G. & Lees, J. A. (2008). E2F3 plays an essential role in cardiac development and function. Cell cycle (Georgetown, Tex.), 7(23), 3775-80. PMID: 19029823.

Wolf, C. M., Wang, L., Alcalai, R., Pizard, A., Burgon, P. G., Ahmad, F., Sherwood, M., Branco, D. M., Wakimoto, H., Fishman, G. I., See, V., Stewart, C. L., Conner, D. A., Berul, C. I., Seidman, C. E. & Seidman, J. G. (2008). Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. Journal of molecular and cellular cardiology, 44(2), 293-303. PMID: 18182166.

Rajkumar, R., Konishi, K., Richards, T., Wiechert, A. C., Kaminski, N. & Ahmad, F. (2008). Molecular mechanisms of pulmonary arterial hypertension: insights from genome-wide RNA expression analysis. Proceedings of the 16th Annual American Heart Association Fellows Research Day.

Wolf, C. M., Arad, M., Ahmad, F., Sanbe, A., Bernstein, S. A., Toka, O., Konno, T., Morley, G., Robbins, J., Seidman, J. G., Seidman, C. E. & Berul, C. I. (2008). Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations. Circulation, 117(2), 144-54. PMID: 18158359.

Rajkumar, R., Konishi, K., Richards, T., Wiechert, A. C., Kaminski, N. & Ahmad, F. (2008). A genome-wide RNA expression analysis of pulmonary arterial hypertension provides novel insights into genetic mechanisms of disease. Presented at the University of Pittsburgh Science.

Ahmad, F., Banerjee, S. K., Lage, M. L., Huang, X. N., Smith, S. H., Saba, S., Rager, J., Conner, D. A., Janczewski, A. M., Tobita, K., Tinney, J. P., Moskowitz, I. P., Perez-Atayde, A. R., Keller, B. B., Mathier, M. A., Shroff, S. G., Seidman, C. E. & Seidman, J. G. (2008). The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy. PloS one, 3(7), e2642. PMID: 18612386.

Soman, P., Rajagopalan, M. S., Ahmad, F., Ruszkiewicz, M. & Follansbee, W. P. (2008). Attenuation correction improves specificity of myocardial perfusion imaging: analysis without verification bias. (Vols. 15). pp. S15. J Nucl Cardiol.

Soman, P., Rajagopalan, M. S., Ahmad, F., Ruszkiewicz, M. & Follansbee, W. P. (2008). Attenuation correction improves specificity of myocardial perfusion imaging: analysis without verification bias. Presented at the University of Pittsburgh Department of Medicine Research Day.

Banerjee, S. K., Ahmad, F. (2008). Molecular mechanisms of cardiac remodeling in PRKAG2 mutations: roles of transcription factors, oxidative stress, extracellular matrix, and mitochondrial biogenesis. Proceedings of the Keystone Symposium on Physiological and Pathological Regulation of Cardiac Hypertrophy.

Banerjee, S. K., Ahmad, F. (2008). Molecular mechanisms of cardiac remodeling in PRKAG2 mutations: roles of transcription factors, oxidative stress, extracellular matrix, and mitochondrial biogenesis. Proceedings of the 16th Annual American Heart Association Fellows Research Day.

Ahmad, F., Lage, M. L., Janczewski, A. M., Tobita, K., Smith, S., Saba, S., Conner, D. A., Tinney, J. P., Rager, J., Moskowitz, I. P., Perez-Atayde, A. R., Keller, B. B., Mathier, M. A., Shroff, S., Seidman, C. E. & Seidman, J. G. (2007). Human cardiomyopathies secondary to troponin T mutations result from abnormal function of proteins rather than haploinsufficiency. Proceedings of the Keystone Symposium on Molecular Pathways in Cardiac Development and Disease.

Banerjee, S. K., Ramani, R., Saba, S., Rager, J., Mathier, M. A. & Ahmad, F. (2007). The mechanism of glycogen storage cardiomyopathy in a transgenic mouse model of a human mutation in PRKAG2 (Thr400Asn). Proceedings of the 15th Annual American Heart Association Fellows Research Day.

Banerjee, S. K., Ramani, R., Saba, S., Rager, J., Tian, R., Mathier, M. A. & Ahmad, F. (2007). A PRKAG2 mutation causes biphasic changes in myocardial AMPK activity and does not protect against ischemia. Biochemical and biophysical research communications, 360(2), 381-7. PMID: 17597581.

Banerjee, S. K., Ramani, R., Saba, S., Rager, J., Mathier, M. A. & Ahmad, F. (2007). The mechanism of glycogen storage cardiomyopathy in a transgenic mouse model of a human mutation in PRKAG2 (Thr400Asn). Presented by invitation at the plenary session of the University of Pittsburgh Department of Medicine Research Day.

Banerjee, S. K., Ahmad, F. (2007). Molecular mechanisms of cardiac remodeling in PRKAG2 mutations: roles of transcription factors, oxidative stress, extracellular matrix, and mitochondrial biogenesis. Presented at the University of Pittsburgh Science.

Ahmad, F., Lage, M. L., Janczewski, A. M., Tobita, K., Smith, S., Saba, S., Conner, D. A., Tinney, J. P., Rager, J., Moskowitz, I. P., Perez-Atayde, A. R., Keller, B. B., Mathier, M. A., Shroff, S., Seidman, C. E. & Seidman, J. G. (2006). Cardiomyopathies secondary to troponin T mutations result from abnormal function of proteins rather than haploinsufficiency. (Vols. 114). (II) Circulation.

Schmitt, J. P., Debold, E. P., Ahmad, F., Armstrong, A., Frederico, A., Conner, D. A., Mende, U., Lohse, M. J., Warshaw, D., Seidman, C. E. & Seidman, J. G. (2006). Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14525-30. PMID: 16983074.

Ahmad, F., Seidman, J. G. & Seidman, C. E. (2005). The genetic basis for cardiac remodeling. Annual review of genomics and human genetics, 6, 185-216. PMID: 16124859.

Debold, E. P., Schmitt, J. P., Ahmad, F., Conner, D. A., Mende, U., Seidman, C. E., Seidman, J. G., Armstrong, A., Frederico, A., Patlak, J. & Warshaw, D. (2005). Molecular characterization of a murine model of dilated cardiomyopathy. (Vols. 97). pp. E41-E42. Circ Res.

Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P. H., Rybkin, I. I., Shelton, J. M., Manieri, M., Cinti, S., Schoen, F. J., Bassel-Duby, R., Rosenzweig, A., Ingwall, J. S. & Spiegelman, B. M. (2005). Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell metabolism, 1(4), 259-71. PMID: 16054070.

Ahmad, F., Arad, M., Musi, N., He, H., Wolf, C., Branco, D., Perez-Atayde, A. R., Stapleton, D., Bali, D., Xing, Y., Tian, R., Goodyear, L. J., Berul, C. I., Ingwall, J. S., Seidman, C. E. & Seidman, J. G. (2005). Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. Circulation, 112(20), 3140-8. PMID: 16275868.

Musi, N., Hirshman, M. F., Arad, M., Xing, Y., Fujii, N., Pomerleau, J., Ahmad, F., Berul, C. I., Seidman, J. G., Tian, R. & Goodyear, L. J. (2005). Functional role of AMP-activated protein kinase in the heart during exercise. FEBS letters, 579(10), 2045-50. PMID: 15811316.

Schmitt, J. P., Ahmad, F., Kranias, E. G., Hein, L., Seidman, J. G. & Seidman, C. E. (2004). Lethal dilated cardiomyopathy caused by a missense mutation in phospholamban is rescued by ablation of the wild-type gene. (Vols. 110). pp. III-598-III599. Circulation.

Wolf, C. M., Arad, M., Ahmad, F., Branco, D., Bourgoun, M., Sanbe, A., Seidman, J. G., Seidman, C. E. & Berul, C. I. (2004). Disappearance of pre-excitation in glycogen storage cardiomyopathy with arresting of PRKAG2 transgene expression. (Vols. 110). pp. III-231. Circulation.

Ahmad, F. (2004). Genetic clues to disease pathways in hypertrophic and dilated cardiomyopathies. Syllabus of the American College of Cardiology Toronto International Heart Failure Summit.

Ahmad, F. (2003). Genetic clues to disease pathways in hypertrophic and dilated cardiomyopathies. Syllabus of the American College of Cardiology New York Cardiovascular Symposium.

Schmitt, J. P., Kamisago, M., Asahi, M., Li, G. H., Ahmad, F., Mende, U., Kranias, E. G., MacLennan, D. H., Seidman, J. G. & Seidman, C. E. (2003). Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science (New York, N.Y.), 299(5611), 1410-3. PMID: 12610310.

Ahmad, F., Arad, M., He, H., Musi, N., Branco, D., Xing, Y., Fujii, N., Tian, R., Goodyear, L. J., Berul, C. I., Ingwall, J. S., Seidman, C. E. & Seidman, J. G. (2003). PRKAG2 cardiomyopathy mice demonstrate preserved resting cardiac energy levels and are able to increase cardiac contractility with exercise. (Vols. 108). pp. IV-118-IV-119. Circulation.

Grabie, N., Delfs, M. W., Westrich, J. R., Love, V. A., Stavrakis, G., Ahmad, F., Seidman, C. E., Seidman, J. G. & Lichtman, A. H. (2003). IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis. The Journal of clinical investigation, 111(5), 671-80. PMID: 12618521.

Schmitt, J. P., Semsarian, C., Arad, M., Gannon, J., Ahmad, F., Duffy, C., Lee, R. T., Seidman, C. E. & Seidman, J. G. (2003). Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomyopathy. Circulation, 108(9), 1133-8. PMID: 12925456.

Ahmad, F. (2003). The molecular genetics of arrhythmogenic right ventricular dysplasia-cardiomyopathy. Clinical and investigative medicine. Médecine clinique et experimentale, 26(4), 167-78. PMID: 12934820.

Arad, M., Moskowitz, I. P., Patel, V. V., Ahmad, F., Perez-Atayde, A. R., Sawyer, D. B., Walter, M., Li, G. H., Burgon, P. G., Maguire, C. T., Stapleton, D., Schmitt, J. P., Guo, X. X., Pizard, A., Kupershmidt, S., Roden, D. M., Berul, C. I., Seidman, C. E. & Seidman, J. G. (2003). Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation, 107(22), 2850-6. PMID: 12782567.

Arad, M., Patel, V. V., Perez-Atayde, A. R., Ahmad, F., Li, G. H., Burgon, P. G., Moskowitz, I. P., Maguire, C. T., Sawyer Stapleton, D., Schmitt, J. P., Berul, C. I., Seidman, J. G. & Seidman, C. E. (2002). Transgenic mice overexpressing mutant PRKAG2 recapitulate the human cardiomyopathy, characterized by ventricular hypertrophy and preexcitation. Proceedings of the 67th Cold Spring Harbor Symposium on the Cardiovascular System.

Schmitt, J. P., Kamisago, M., Asahi, M., Li, G. H., Ahmad, F., MacLennan, D. H., Seidman, C. E. & Seidman, J. G. (2002). Phospholamban missense mutation Arg9Cys causes autosomal dominant dilated cardiomyopathy in man and mouse. (Vols. 106). (II), pp. II-7. Circulation.

Arad, M., Moskowitz, I. P., Patel, V. V., Ahmad, F., Perez-Atayde, A. R., Sawyer, D. B., Li, G. H., Burgon, P. G., Maguire, C. T., Stapleton, D., Schmitt, J. P., Guo, X. X., Berul, C. I., Seidman, J. G. & Seidman, C. E. (2002). Transgenic mice overexpressing mutant PRKAG2 recapitulate the human cardiomyopathy, characterized by ventricular hypertrophy and preexcitation. (Vols. 106). (II), pp. II-140. Circulation.

Ahmad, F. (2001). The genetic basis of arrhythmogenic right ventricular dysplasia/ cardiomyopathy.

Gollob, M. H., Green, M. S., Tang, A. S., Gollob, T., Karibe, A., Ali Hassan, A. S., Ahmad, F., Lozado, R., Shah, G., Fananapazir, L., Bachinski, L. L., Roberts, R. & Hassan, A. S. (2001). Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. The New England journal of medicine, 344(24), 1823-31. PMID: 11407343.

Natarajan, A., Yamagishi, H., Ahmad, F., Li, D., Roberts, R., Matsuoka, R., Hill, S. & Srivastava, D. (2001). Human eHAND, but not dHAND, is down-regulated in cardiomyopathies. Journal of molecular and cellular cardiology, 33(9), 1607-14. PMID: 11549340.

Ahmad, F., Li, D., Gollob, M. H., Furey, M., Sharratt, G. P., Gardner, M. J., Bachinski, L. L. & Roberts, R. (2000). The molecular genetics of two Canadian families with arrhythmogenic right ventricular dysplasia (ARVD). Canadian Society for Clinical Investigation.

Li, D., Ahmad, F., Gardner, M. J., Weilbaecher, D., Hill, R., Karibe, A., Gonzalez, O., Tapscott, T., Sharratt, G. P., Bachinski, L. L. & Roberts, R. (2000). The locus of a novel gene responsible for arrhythmogenic right-ventricular dysplasia characterized by early onset and high penetrance maps to chromosome 10p12-p14. American journal of human genetics, 66(1), 148-56. PMID: 10631146.

Ahmad, F., Li, D., Gollob, M. H., Furey, M., Sharratt, G. P., Gardner, M. J., Bachinski, L. L. & Roberts, R. (2000). The molecular genetics of two Canadian families with arrhythmogenic right ventricular dysplasia (ARVD). (Vols. 16). (F), pp. 180F. Can J Cardiol.

Ahmad, F., Gonzalez, O., Ramagli, L., Xu, J., Siciliano, M. J., Bachinski, L. L. & Roberts, R. (2000). Identification and characterization of a novel gene (C4orf5) located on human chromosome 4q with specific expression in cardiac and skeletal muscle. Genomics, 70(3), 347-53. PMID: 11161785.

Ahmad, F., Li, D., Karibe, A., Gonzalez, O., Tapscott, T., Hill, R., Weilbaecher, D., Blackie, P., Furey, M., Gardner, M., Bachinski, L. L. & Roberts, R. (1999). Localization of a gene responsible for arrhythmogenic right ventricular dysplasia to chromosome 3p23. (Vols. 33). (A), pp. 2A. J Am Coll Cardiol.

Li, D., Ahmad, F., Gardner, M. J., Hill, R., Gonzalez, O., Tapscott, T. L., Sharratt, G. P., Bachinski, L. L. & Roberts, R. (1999). A novel locus responsible for arrhythmogenic right ventricular dysplasia maps to chromosome. (Vols. 100). pp. I-216. Circulation.

Natarajan, A., Hill, S., Li, D., Ahmad, F., Roberts, R. & Srivastava, D. (1998). The expression of human dHAND and eHAND in normal adult and diseased hearts. pp. 61. Proceedings of the Keystone Symposium on the Molecular Biology of the Cardiovascular System.

Natarajan, A., Hill, S., Li, D., Ahmad, F., Roberts, R. & Srivastava, D. (1998). Human eHAND, but not dHAND, is down-regulated in cardiomyopathies. (Vols. 98). pp. I-603. Circulation.

Ahmad, F., Li, D., Karibe, A., Gonzalez, O., Tapscott, T., Hill, R., Weilbaecher, D., Blackie, P., Furey, M., Gardner, M., Bachinski, L. L. & Roberts, R. (1998). Localization of a gene responsible for arrhythmogenic right ventricular dysplasia to chromosome 3p23. Circulation, 98(25), 2791-5. PMID: 9860777.

Ahmad, F., Bachinski, L., Gonzalez, O., Ramagli, L. & Roberts, R. (1998). Identification of a novel gene using the differential display polymerase chain reaction on mRNA from the four chambers of the heart. (Vols. 63). pp. A175. Am J Hum Genet.

Ahmad, F., Solymoss, S., Poon, M. C., Berube, C. & Sullivan, A. K. (1996). Characterization of an acquired IgG inhibitor of coagulation factor XIII in a patient with systemic lupus erythematosus. British journal of haematology, 93(3), 700-3. PMID: 8652397.

Fantus, I. G., Ahmad, F. & Deragon, G. (1994). Vanadate augments insulin-stimulated insulin receptor kinase activity and prolongs insulin action in rat adipocytes. Evidence for transduction of amplitude of signaling into duration of response. Diabetes, 43(3), 375-83. PMID: 7508873.

Tuite, P., Ahmad, F., Grant, I., Stewart, J. D., Carpenter, S. & Ethier, R. (1993). Cerebral vein thrombosis due to hereditary antithrombin III deficiency. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 20(2), 158-61. PMID: 8334580.

Tuite, P., Grant, I., Ahmad, F., Stewart, J. & Carpenter, S. (1992). Superior sagittal sinus thrombosis in a post-myelogram patient with anti thrombin III deficiency. (Vols. 19). pp. 299-300. Can J Neurol Sci.

Ahmad, F. (1992). Anencephalic infants as organ donors: beware the slippery slope. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 146(2), 236-41, 244. PMID: 1735049.

Fantus, I. G., Ahmad, F. & Deragon, G. (1990). Vanadate augments insulin binding and prolongs insulin action in rat adipocytes. Endocrinology, 127(6), 2716-25. PMID: 2249624.

Ahmad, F., Fantus, I. G. (1989). The mechanism of the insulin-mimetic effects of vandate. Proceedings of the Canadian Diabetes Association Frontiers in Diabetes Research Symposium.

Ahmad, F., Fantus, I. G. & Deragon, G. (1988). Vanadate inhibits the normal decay in insulin action in rat adipocytes: possible mechanism of action in insulin deficient diabetes mellitus. (11), pp. C26. Clin Invest Med.

Fantus, I. G., Deragon, G. & Ahmad, F. (1988). Vanadate inhibits the normal decay in insulin action in rat adipocytes: possible mechanism in insulin deficient diabetes mellitus. (Vols. 37). (1), pp. 188A. Diabetes.

Ahmad, F., Deragon, G. & Fantus, I. G. (1987). Vanadate increases insulin binding and prolongs insulin action in adipocytes. Proceedings of the 1987 Annual Meeting of the Quebec Diabetes Association.