Recent Publications - July 2024

July 16-31, 2024

Social Determinants of Health and Surgical Desirability of Outcome Ranking in Older Veterans. Jacobs MA, Gao Y, Schmidt S, Shireman PK, Mader M, Duncan CA, Hausmann LRM, Stitzenberg KB, Kao LS, Vaughan Sarrazin M, Hall DE. JAMA Surg. 2024 Jul 31. doi: 10.1001/jamasurg.2024.2489. Online ahead of print. PMID: 39083255

Impact of frailty in hospitalized patients undergoing catheter ablation for atrial fibrillation. Ali S, Kumar M, Khlidj Y, Hendricks E, Farooq F, Alruwaili W, Keisham B, Duhan S, Gonuguntla K, Sattar Y, Shaik A, Brar V, Asad ZUA, Sorajja D, Dominic P, Helmy T. J Cardiovasc Electrophysiol. 2024 Jul 29. doi: 10.1111/jce.16383. Online ahead of print. PMID: 39075813

Home health utilization in the Veterans Health Administration: Are there rural and urban differences? Davila H, Mayfield B, Mengeling MA, Holcombe A, Miell KR, Jaske E, Iverson W, Walkner T, Stewart G, Solimeo S. J Rural Health. 2024 Jul 29. doi: 10.1111/jrh.12865. Online ahead of print. PMID: 39075777

Leveraging Patient Education to Amplify Colorectal Cancer Screening in the United States: Strategies and Implications. Baskar S, Schoeneich R, Baskar A, Grewal US. J Cancer Educ. 2024 Jul 26. doi: 10.1007/s13187-024-02482-1. Online ahead of print. PMID: 39060864 Review.

Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation. Shao F, Phan AV, Yu W, Guo Y, Thompson J, Coppinger C, Venugopalan SR, Amendt BA, Van Otterloo E, Cao H. PLoS Genet. 2024 Jul 25;20(7):e1011364. doi: 10.1371/journal.pgen.1011364. Online ahead of print. PMID: 39052671

MTGR1 is required to maintain small intestinal stem cell populations. Short SP, Brown RE, Chen Z, Pilat JM, McElligott BA, Meenderink LM, Bickart AC, Blunt KM, Jacobse J, Wang J, Simmons AJ, Xu Y, Yang Y, Parang B, Choksi YA, Goettel JA, Lau KS, Hiebert SW, Williams CS. Cell Death Differ. 2024 Jul 25. doi: 10.1038/s41418-024-01346-x. Online ahead of print. PMID: 39048708

Eosinophil expression of triggering receptor expressed on myeloid cells 1 (TREM-1) restricts type 2 lung inflammation. Bowen JL, Keck K, Baruah S, Nguyen KH, Thurman AL, Pezzulo AA, Klesney-Tait J. J Leukoc Biol. 2024 Jul 25;116(2):409-423. doi: 10.1093/jleuko/qiae061. PMID: 38547428

Long-term survival and safety of elranatamab in patients with relapsed or refractory multiple myeloma: Update from the MagnetisMM-3 study. Tomasson MH, Iida S, Niesvizky R, Mohty M, Bahlis NJ, Martinez-Lopez J, Koehne G, Rodriguez-Otero P, Miles Prince H, Viqueira A, Leip E, Conte U, Sullivan ST, Lesokhin AM. Hemasphere. 2024 Jul 24;8(7):e136. doi: 10.1002/hem3.136. eCollection 2024 Jul. PMID: 39055646 Free PMC article. No abstract available.

Metagenomic next-generation sequencing in patients with fever of unknown origin: A comprehensive systematic literature review and meta-analysis. Marra AR, Lopes GOV, Pardo I, Hsieh MK, Kobayashi T, Marra PS, Marschall J, Pinho JRR, Amgarten DE, de Mello Malta F, Dos Santos NV, Edmond MB. Diagn Microbiol Infect Dis. 2024 Jul 23;110(2):116465. doi: 10.1016/j.diagmicrobio.2024.116465. Online ahead of print. PMID: 39059148 Review.

Prevalence of Bronchodilator Responsiveness: A Comparison of Old Versus New Criteria. de la Serna S, Skinner B, Schwartz A, Fortis S. Respir Care. 2024 Jul 23:respcare.11603. doi: 10.4187/respcare.11603. Online ahead of print. PMID: 39043424

Ultra-low dose hip CT-based automated measurement of volumetric bone mineral density at proximal femoral subregions. Zhang X, Nadeem SA, DiCamillo PA, Shibli-Rahhal A, Regan EA, Barr RG, Hoffman EA, Comellas AP, Saha PK. Med Phys. 2024 Jul 23. doi: 10.1002/mp.17319. Online ahead of print. PMID: 39042053

Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of Dementia With Lewy Bodies in Men. Hart A, Aldridge G, Zhang Q, Narayanan NS, Simmering JE. Neurology. 2024 Jul 23;103(2):e209570. doi: 10.1212/WNL.0000000000209570. Epub 2024 Jun 19. PMID: 38896813

Genetic ablation of myeloid integrin α9 attenuates early atherosclerosis.

Barbhuyan T, Patel RB, Budnik I, Chauhan AK. J Leukoc Biol. 2024 Jul 22:qiae161. doi: 10.1093/jleuko/qiae161. Online ahead of print. PMID: 39036986

Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial. Morais A, Imai T, Jin X, Locascio JJ, Boisserand L, Herman AL, Chauhan A, Lamb J, Nagarkatti K, Diniz MA, Kumskova M, Dhanesha N, Kamat PK, Badruzzaman Khan M, Dhandapani KM, Patel RB, Sutariya B, Shi Y, van Leyen K, Kimberly WT, Hess DC, Aronowski J, Leira EC, Koehler RC, Chauhan AK, Sansing LH, Lyden PD, Ayata C. Circ Res. 2024 Jul 22. doi: 10.1161/CIRCRESAHA.123.324139. Online ahead of print. PMID: 39034919

Evaluation of hospital-onset bacteraemia and fungaemia in the USA as a potential healthcare quality measure: a cross-sectional study. Leekha S, Robinson GL, Jacob JT, Fridkin S, Shane A, Sick-Samuels A, Milstone AM, Nair R, Perencevich E, Puig-Asensio M, Kobayashi T, Mayer J, Lewis J, Bleasdale S, Wenzler E, Mena Lora AJ, Baghdadi J, Schrank GM, Wilber E, Aldredge AA, Sharp J, Dyer KE, Kendrick L, Ambalam V, Borgetti S, Carmack A, Gushiken A, Patel A, Reddy S, Brown CH, Dantes RB, Harris AD; CDC Prevention Epicenters Program. BMJ Qual Saf. 2024 Jul 22;33(8):487-498. doi: 10.1136/bmjqs-2023-016831. PMID: 38782579 Free PMC article.

Medications for alcohol-use disorder and follow-up after hospitalization for alcohol withdrawal: A multicenter study. Allaudeen N, Akwe J, Arundel C, Boggan JC, Caldwell P, Cornia PB, Cyr J, Ehlers E, Elzweig J, Godwin P, Gordon KS, Guidry M, Gutierrez J, Heppe D, Hoegh M, Jagannath A, Kaboli P, Krug M, Laudate JD, Mitchell C, Pescetto M, Rodwin BA, Ronan M, Rose R, Shah MN, Smeraglio A, Trubitt M, Tuck M, Vargas J, Yarbrough P, Gunderson CG. J Hosp Med. 2024 Jul 19. doi: 10.1002/jhm.13458. Online ahead of print. PMID: 39031461

A Call for a Reinvention of Antibiogram. Goto M. Clin Infect Dis. 2024 Jul 19;79(1):282. doi: 10.1093/cid/ciad749. PMID: 38059549 No abstract available.

Body Size Remains the Major Source of Sex Disparity Despite Updated Liver Transplant Allocation Policies. Tanaka T, Ross-Driscoll K, Pancholia S, Axelrod D. Transplantation. 2024 Jul 18. doi: 10.1097/TP.0000000000005142. Online ahead of print. PMID: 39020468

Sequential Endoluminal Gemcitabine and Cabazitaxel with Intravenous Pembrolizumab as a Bladder-Preserving Strategy for Docetaxel-Unresponsive Non-Muscle Invasive Urothelial Carcinoma Following Transurethral Resection of Bladder Tumor. McElree IM, Packiam VT, Steinberg RL, Hougen HY, Mott SL, Abou Chakra M, Zakharia Y, O'Donnell MA. Cancers (Basel). 2024 Jul 17;16(14):2561. doi: 10.3390/cancers16142561. PMID: 39061200 Free PMC article.

Association of personalized and tumor-informed ctDNA with patient survival outcomes in pancreatic adenocarcinoma. Botta GP, Abdelrahim M, Drengler RL, Aushev VN, Esmail A, Laliotis G, Brewer CM, George GV, Abbate SM, Chandana SR, Tejani MA, Malla M, Bansal D, Rivero-Hinojosa S, Spickard E, McCormick N, Cecchini M, Lacy J, Fei N, Kasi PM, Kasi A, Dayyani F, Hanna DL, Sharma S, Malhotra M, Aleshin A, Liu MC, Jurdi A. Oncologist. 2024 Jul 17:oyae155. doi: 10.1093/oncolo/oyae155. Online ahead of print. PMID: 39022993

Respiratory Therapist-Driven Mechanical Ventilation Protocol Is Associated With Increased Lung Protective Ventilation.

Berg AC, Evans E, Okoro UE, Pham V, Foley TM, Hlas C, Kuhn JD, Nassar B, Fuller BM, Mohr NM. Respir Care. 2024 Jul 16:respcare.11599. doi: 10.4187/respcare.11599. Online ahead of print. PMID: 39013570

July 1-15, 2024

Systemic loxoscelism leading to autoimmune haemolytic anaemia in a healthy young adult. Mai D, Muthukumarasamy N, Ford B, Sekar P. BMJ Case Rep. 2024 Jul 12;17(7):e260045. doi: 10.1136/bcr-2024-260045. PMID: 39002955

Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC). Schenk S, Sagendorf TJ, Many GM, Lira AK, de Sousa LGO, Bae D, Cicha M, Kramer KS, Muehlbauer M, Hevener AL, Rector RS, Thyfault JP, Williams JP, Goodyear LJ, Esser KA, Newgard CB, Bodine SC; MoTrPAC Study Group. Function (Oxf). 2024 Jul 11;5(4):zqae014. doi: 10.1093/function/zqae014. PMID: 38984994 Free PMC article.

Autologous stem cell transplant in fit patients with late relapsed diffuse large B-cell lymphoma that responded to salvage chemotherapy. Tun AM, Wang Y, Maliske S, Micallef I, Inwards DJ, Habermann TM, Porrata L, Paludo J, Bisneto JV, Rosenthal A, Kharfan-Dabaja MA, Ansell SM, Nowakowski GS, Farooq U, Johnston PB. Transplant Cell Ther. 2024 Jul 10:S2666-6367(24)00532-3. doi: 10.1016/j.jtct.2024.07.008. Online ahead of print. PMID: 38996973

Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells. Sousa AA, Hemez C, Lei L, Traore S, Kulhankova K, Newby GA, Doman JL, Oye K, Pandey S, Karp PH, McCray PB Jr, Liu DR. Nat Biomed Eng. 2024 Jul 10. doi: 10.1038/s41551-024-01233-3. Online ahead of print. PMID: 38987629

Cardiac biomarkers for diagnosing Takotsubo syndrome. Schweiger V, Di Vece D, Cammann VL, Koleva I, Würdinger M, Gilhofer T, Rajman K, Szawan KA, Niederseer D, Citro R, Vecchione C, Bossone E, Gili S, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Jansen T, D'Ascenzo F, Bruno F, De Filippo O, Stefanini G, Campo G, Wanha W, Raposeiras Roubin S, Dichtl W, von Lewinski D, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Massoomi M, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Kato K, Ishibashi I, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Budnik M, Opolski G, Thiele H, Bauersachs J, Horowitz JD, Di Mario C, Kong W, Dalakoti M, Imori Y, Münzel T, Bax JJ, Lüscher TF, Crea F, Ruschitzka F, Ghadri JR, Templin C. Eur Heart J. 2024 Jul 9;45(25):2254-2258. doi: 10.1093/eurheartj/ehae231. PMID: 38717630 No abstract available.

Agreement between patient-reported and clinically documented symptoms of acute myeloid leukemia: Study protocol. Chae S, Bae J, Youn N, Lopez KD, Sutamtewagul G, Rakel B. J Adv Nurs. 2024 Jul 5. doi: 10.1111/jan.16320. Online ahead of print. PMID: 38969361

Geographic distance to Commission on Cancer-accredited and nonaccredited hospitals in the United States. Schroeder MC, Semprini J, Kahl AR, Lizarraga IM, Birken SA, Wahlen MM, Johnson EC, Gorzelitz J, Seaman AT, Charlton ME. J Rural Health. 2024 Jul 4. doi: 10.1111/jrh.12862. Online ahead of print. PMID: 38963176

A Survey of Infection Prevention and Animal Assisted Activity Policies in Healthcare Facilities - United States, 2023. Ben-Aderet MA, Louis S, Grein JD, Beekmann SE, Polgreen PM, Uslan DZ. Am J Infect Control. 2024 Jul 2:S0196-6553(24)00583-2. doi: 10.1016/j.ajic.2024.06.024. Online ahead of print. PMID: 38964660

Fazirsiran for Adults with Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA). Clark VC, Strange C, Strnad P, Sanchez AJ, Kwo P, Pereira VM, van Hoek B, Barjaktarevic I, Corsico AG, Pons M, Goldklang M, Gray M, Kuhn B, Vargas HE, Vierling JM, Vuppalanchi R, Brantly M, Kappe N, Chang T, Schluep T, Zhou R, Hamilton J, San Martin J, Loomba R. Gastroenterology. 2024 Jul 2:S0016-5085(24)05181-3. doi: 10.1053/j.gastro.2024.06.028. Online ahead of print. PMID: 38964420

Short-Term Statin Treatment Reduces, and Long-Term Statin Treatment Abolishes, Chronic Vascular Injury by Radiation Therapy. Ait-Aissa K, Guo X, Klemmensen M, Juhr D, Leng LN, Koval OM, Grumbach IM. J Am Heart Assoc. 2024 Jul 2;13(13):e033558. doi: 10.1161/JAHA.123.033558. Epub 2024 Jun 21. PMID: 38904226

Endoscopic ultrasound-guided antegrade treatment versus balloon enteroscopy endoscopic retrograde cholangiopancreatography for choledocholithiasis in patients with Roux-en-Y gastric bypass: a systematic review and meta-analysis. Ahmed Z, Iqbal A, Aziz M, Iqbal F, Gangwani MK, Sohail A, Chaudhary A, Smith WL, Hayat U, Singh S, Mohan BP, Javaid T. Ann Gastroenterol. 2024 Jul-Aug;37(4):493-498. doi: 10.20524/aog.2024.0888. Epub 2024 Jun 14. PMID: 38974078 Free PMC article.

The Obsolescence of Azithromycin for Syphilis Treatment and the Value of Contrasting Different Types of Evidence. Callado GY, Salinas JL, Marra AR. Open Forum Infect Dis. 2024 Jun 24;11(7):ofae325. doi: 10.1093/ofid/ofae325. eCollection 2024 Jul. PMID: 38957686 Free PMC article. No abstract available.

Adapting to the Changing Landscape of Open Access Medical Publishing at JAMA Network Open. Perencevich EN. JAMA Netw Open. 2024 Jul 1;7(7):e2424099. doi: 10.1001/jamanetworkopen.2024.24099. PMID: 38949815 No abstract available.

Tetanus occurrence in a man with diabetes and neuropathy. Hasegawa S, Simpson R, Oladele-Ajose A, Sekar P. Lancet Infect Dis. 2024 Jul;24(7):e472. doi: 10.1016/S1473-3099(24)00173-7. PMID: 38906584 No abstract available.

The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer. Benej M, Hoyd R, Kreamer M, Wheeler CE, Grencewicz DJ, Choueiry F, Chan CHF, Zakharia Y, Ma Q, Dodd RD, Ulrich CM, Hardikar S, Churchman ML, Tarhini AA, Robinson LA, Singer EA, Ikeguchi AP, McCarter MD, Tinoco G, Husain M, Jin N, Tan AC, Osman AEG, Eljilany I, Riedlinger G, Schneider BP, Benejova K, Kery M, Papandreou I, Zhu J, Denko N, Spakowicz D; exORIEN Consortium. Cancer Res Commun. 2024 Jul 1;4(7):1690-1701. doi: 10.1158/2767-9764.CRC-23-0367. PMID: 38904265 Free PMC article.

Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer. Ambrosini M, Rousseau B, Manca P, Artz O, Marabelle A, André T, Maddalena G, Mazzoli G, Intini R, Cohen R, Cercek A, Segal NH, Saltz L, Varghese AM, Yaeger R, Nusrat M, Goldberg Z, Ku GY, El Dika I, Margalit O, Grinshpun A, Murtaza Kasi P, Schilsky R, Lutfi A, Shacham-Shmueli E, Khan Afghan M, Weiss L, Westphalen CB, Conca V, Decker B, Randon G, Elez E, Fakih M, Schrock AB, Cremolini C, Jayachandran P, Overman MJ, Lonardi S, Pietrantonio F. Ann Oncol. 2024 Jul;35(7):643-655. doi: 10.1016/j.annonc.2024.03.009. Epub 2024 May 22. PMID: 38777726

Prevalence of kidney health genetic variants in adults with sickle cell nephropathy. Ruiz MA, Zhang X, Mansilla MA, Zahr RS, Thomas CP, Smith RJ, Gordeuk VR, Saraf SL. Br J Haematol. 2024 Jul;205(1):316-319. doi: 10.1111/bjh.19525. Epub 2024 May 12. PMID: 38735682

Prevalence of pain in a sample of long-term survivors of head and neck cancer. Howren MB, Christensen AJ, Pagedar NA. Am J Otolaryngol. 2024 Jul-Aug;45(4):104300. doi: 10.1016/j.amjoto.2024.104300. Epub 2024 Apr 16. PMID: 38640810

Mitochondrial bioenergetics: coupling of transport to tubular mitochondrial metabolism. Cheng YW, Cheng CJ. Curr Opin Nephrol Hypertens. 2024 Jul 1;33(4):405-413. doi: 10.1097/MNH.0000000000000986. Epub 2024 Apr 4. PMID: 38573234 Free PMC article. Review.

Association of diabetes mellitus with dementia- and non-dementia-related mortality amongst women: a secondary competing risks analysis of the California Teachers Study. Morgan C, Annegers B, Taylor MK, Shuger Fox S, Titcomb TJ. Eur J Neurol. 2024 Jul;31(7):e16294. doi: 10.1111/ene.16294. Epub 2024 Apr 2. PMID: 38563189

Renal complications in patients with predominantly antibody deficiency in the United States Immune Deficiency Network (USIDNET). Materne E, Zhou B, DiGiacomo D, Farmer JR, Fuleihan R, Sullivan KE, Cunningham-Rundles C, Ballas ZK, Suez D, Barmettler S; USIDNET Consortium. J Allergy Clin Immunol. 2024 Jul;154(1):237-242.e1. doi: 10.1016/j.jaci.2024.03.014. Epub 2024 Mar 29. PMID: 38555979

The Increase in Household Transmission of Pertussis Associated With Diagnostic Delays. Arakkal AT, Cavanaugh JE, Polgreen PM, Miller AC. Pediatr Infect Dis J. 2024 Jul 1;43(7):614-619. doi: 10.1097/INF.0000000000004302. Epub 2024 Mar 25. PMID: 38534962

Vessel and Airway Characteristics in One-Year Computed Tomography-defined Rapid Emphysema Progression: SPIROMICS. Gerard SE, Dougherty TM, Nagpal P, Jin D, Han MK, Newell JD Jr, Saha PK, Comellas AP, Cooper CB, Couper D, Fortis S, Guo J, Hansel NN, Kanner RE, Kazeroni EA, Martinez FJ, Motahari A, Paine R 3rd, Rennard S, Schroeder JD, Woodruff PG, Barr RG, Smith BM, Hoffman EA; SPIROMICS Research Group. Ann Am Thorac Soc. 2024 Jul;21(7):1022-1033. doi: 10.1513/AnnalsATS.202304-383OC. PMID: 38530051

Homozygous missense variants in YKT6 result in loss of function and are associated with developmental delay, with or without severe infantile liver disease and risk for hepatocellular carcinoma. Ma M, Ganapathi M, Zheng Y, Tan KL, Kanca O, Bove KE, Quintanilla N, Sag SO, Temel SG, LeDuc CA, McPartland AJ, Pereira EM, Shen Y, Hagen J, Thomas CP, Nguyen Galván NT, Pan X, Lu S, Rosenfeld JA, Calame DG, Wangler MF, Lupski JR, Pehlivan D, Hertel PM, Chung WK, Bellen HJ. Genet Med. 2024 Jul;26(7):101125. doi: 10.1016/j.gim.2024.101125. Epub 2024 Mar 21. PMID: 38522068

Calpain inhibition protects against atrial fibrillation by mitigating diabetes-associated atrial fibrosis and calcium handling dysfunction in type 2 diabetes mice. Wang Q, Yuan J, Shen H, Zhu Q, Chen B, Wang J, Zhu W, Yorek MA, Hall DD, Wang Z, Song LS. Heart Rhythm. 2024 Jul;21(7):1143-1151. doi: 10.1016/j.hrthm.2024.02.036. Epub 2024 Feb 21. PMID: 38395244

Paget Disease as a Rare Mimicker of Giant Cell Arteritis. Walsh M, Strouse J, Bettendorf B. J Rheumatol. 2024 Jul 1;51(7):732. doi: 10.3899/jrheum.2023-1160. PMID: 38359942 No abstract available.

Comparative Analysis of Risk Prediction Scores for Treatment-Emergent Atrial Fibrillation Among Patients With Chronic Lymphocytic Leukemia Treated With Ibrutinib. Babbili A, Lakra R, Thotamgari SR, Gaddam SJ, Grewal US, Dominic P. Am J Ther. 2024 Jul-Aug 01;31(4):e453-e455. doi: 10.1097/MJT.0000000000001666. Epub 2024 Feb 2. PMID: 38305826 No abstract available.

Autologous stem cell transplant in fit patients with refractory or early relapsed diffuse large B-cell lymphoma that responded to salvage chemotherapy. Tun AM, Wang Y, Maliske S, Micallef I, Inwards DJ, Habermann TM, Porrata L, Paludo J, Bisneto JV, Rosenthal A, Kharfan-Dabaja MA, Ansell SM, Nowakowski GS, Farooq U, Johnston PB. Haematologica. 2024 Jul 1;109(7):2186-2195. doi: 10.3324/haematol.2023.284704. PMID: 38235513 Free PMC article.