Logo for University of Iowa Health Care This logo represents the University of Iowa Health Care

Addison Woll

Mentor: Curt D. Sigmund, Ph.D.
Lab Room: 2-340 BSB
Lab Phone: 319-335-8926

Elucidation of the PPAR gamma:RBP7 feedforward loop

Hypertension is a major healthcare concern in the US, affecting over 67 million adults, and significantly increases risk of death from myocardial infraction, stroke, and renal failure. Presently 10% of antihypertensive therapeutics target nuclear receptors, including Peroxisome Proliferator-Activated Receptor gamma (PPARg). However, PPARg is an orphan nuclear receptor which has over 1000 target genes across almost every cell type. Activation of PPARg with a class of drugs call TZDs leads to clinically detrimental side-effects. Retinol Binding Protein 7 (RBP7) is a PPARg target gene, and evidence indicates it is required for PPARg’s anti-hypertensive effects in mice. Using CRISPR edited cell lines and transgenic mouse models, I am studying how RBP7 interacts with and activates PPARg in the vascular endothelium.

Woll AW, Quelle FW, Sigmund CD. PPARγ and retinol binding protein 7 form a regulatory hub promoting antioxidant properties of the endothelium. Physiol Genomics. 2017 Nov 1;49(11):653-658. doi: 10.1152/physiolgenomics.00055.2017. Epub 2017 Sep 15. Review. PubMed PMID: 28916634.