Bradley D. Jones, PhD

Portrait
Professor of Microbiology and Immunology

Contact Information

Office
3-330A Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-353-5457

Lab
3-330 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-335-7794

Education

BS, Microbiology, University of Maryland
PhD, Biochemistry, University of Maryland School of Medicine, Baltimore
Postdoctoral Fellow, Molecular Genetics of Pathogenic Microorganisms, Stanford University

Education/Training Program Affiliations

Biomedical Science Program, Department of Microbiology Graduate Program, Interdisciplinary Graduate Program in Genetics, Medical Scientist Training Program

Center, Program and Institute Affiliations

Bacterial Respiratory Pathogens Research Unit, Inflammation Program

Research Summary

The Jones laboratory is interested in carrying out research to understand the virulence mechanisms of bacterial pathogens and to design and develop strategies to intervene in diseases caused by bacteria. We currently have an active project studying the virulence properties of Streptococcus sanguinis and its ability to cause human infection. S. sanguinis is a Gram positive organism that typically colonizes the oropharyngeal environment of a human host but causes an infection of the heart, called bacterial endocarditis, if the organism gains access to the bloodstream. While the organism is an important cause of human endocarditis, there is relatively little understood about the molecular mechanisms of this serious health concern. We have used both bioinformatics information and literature-based evidence about virulence genes in S. sanguinis to construct a large library of mutants that are mutated in these genes of interest. Work in the lab is focused on characterizing these mutants by screening them in various in vitro assays. These assays include adherence to human platelets, the ability to form biofilms, adherence and invasion to human endothelial cells, the production of hydrogen peroxide which has an anti-immunity effect and the ability to cause platelet aggregation. These experimental results will be used to identify mutants that will be tested in a rabbit model of bacterial endocarditis. Collectively, these data will be used to contribute to our understanding of the virulence strategy of S. sanguinis and to devise a strategy to intervene in bacterial endocarditis infections caused by this Gram positive bacterial pathogen.

Work in the lab has been focused for many years on both the pathogenesis of Salmonella spp. and the Select agent Francisella tularensis and Salmonella spp. An active area of research in the lab is to understand the Salmonella factors that allow this important human pathogen to cause foodborne diseases. We are actively studying factors such as Type 1 fimbriae to understand the role that this extracellular factor plays in promoting the ability of Salmonella to colonize the gastrointestinal tract and to establish itself as an important component of the intestinal microbiome. We are primarily examining these interactions in poultry which is an important source of foodborne infection, as well as in the human intestinal tract using tissue culture cells as a model for disease. The long-term goals of the project are to identify an intervention strategy that might allow us to supplant pathogenic Salmonella species as dominant constituents of the poultry intestinal microbiome.

We have also studied in some detail the virulence strategy of Francisella tularensis and have created and identified mutants that are significantly attenuated for disease in animal models. In collaboration with other research groups, we continue to study these attenuated mutants and are actively participating in collaborations to develop a vaccine to Francisella tularensis.

Publications

Fletcher, J. R., Crane, D. D., Wehrly, T. D., Martens, C. A., Bosio, C. M. & Jones, B. D. (2018). The Ability to Acquire Iron Is Inversely Related to Virulence and the Protective Efficacy of Francisella tularensis Live Vaccine Strain. Front Microbiol, 9, 607. PMID: 29670588.

Stevenson, T. C., Cywes-Bentley, C., Moeller, T. D., Weyant, K. B., Putnam, D., Chang, Y. F., Jones, B. D., Pier, G. B. & DeLisa, M. P. (2018). Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies. Proc Natl Acad Sci U S A, 115(14), E3106-E3115. PMID: 29555731.

Kinkead, L. C., Whitmore, L. C., McCracken, J. M., Fletcher, J. R., Ketelsen, B. B., Kaufman, J. W., Jones, B. D., Weiss, D. S., Barker, J. H. & Allen, L. H. (2018). Bacterial lipoproteins and other factors released by Francisella tularensis modulate human neutrophil lifespan: Effects of a TLR1 SNP on apoptosis inhibition. Cell Microbiol, 20(2). PMID: 29063667.

Post, D., Sl├╝tter, B., Schilling, B., Chande, A. T., Rasmussen, J. A., Jones, B. D., D'Souza, A. K., Reinders, L. M., Harty, J. T., Gibson, B. W. & Apicella, M. A. (2017). Characterization of Inner and Outer Membrane Proteins from Francisella tularensis Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates. MBio, 8(5), e01592-17. PMID: 29018123.

Roberts, L. M., Crane, D. D., Wehrly, T. D., Fletcher, J. R., Jones, B. D. & Bosio, C. M. (2016). Inclusion of Epitopes That Expand High-Avidity CD4+ T Cells Transforms Subprotective Vaccines to Efficacious Immunogens against Virulent Francisella tularensis. J Immunol, 197(7), 2738-47. PMID: 27543611.

Chen, L., Valentine, J. L., Huang, C. J., Endicott, C. E., Moeller, T. D., Rasmussen, J. A., Fletcher, J. R., Boll, J. M., Rosenthal, J. A., Dobruchowska, J., Wang, Z., Heiss, C., Azadi, P., Putnam, D., Trent, M. S., Jones, B. D. & DeLisa, M. P. (2016). Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies. Proc Natl Acad Sci U S A, 113(26), E3609-18. PMID: 27274048.

Wyatt, E. V., Diaz, K., Griffin, A. J., Rasmussen, J. A., Crane, D. D., Jones, B. D. & Bosio, C. M. (2016). Metabolic Reprogramming of Host Cells by Virulent Francisella tularensis for Optimal Replication and Modulation of Inflammation. J Immunol, 196(10), 4227-36. PMID: 27029588.

Faron, M., Fletcher, J. R., Rasmussen, J. A., Apicella, M. A. & Jones, B. D. (2015). Interactions of Francisella tularensis with Alveolar Type II Epithelial Cells and the Murine Respiratory Epithelium. PLoS One, 10(5), e0127458. PMID: 26010977.

Rasmussen, J. A., Fletcher, J. R., Long, M. E., Allen, L. A. & Jones, B. D. (2015). Characterization of Francisella tularensis Schu S4 mutants identified from a transposon library screened for O-antigen and capsule deficiencies. Front Microbiol, 6, 338. PMID: 25999917.

Baxter, M. A., Jones, B. D. (2015). Two-Component Regulators Control hilA Expression by Controlling fimZ and hilE Expression within Salmonella enterica Serovar Typhimurium. Infect Immun, 83(3), 978-85. PMID: 25547794.

Workalemahu, G., Wang, H., Puan, K. J., Nada, M. H., Kuzuyama, T., Jones, B. D., Jin, C. & Morita, C. T. (2014). Metabolic Engineering of Salmonella Vaccine Bacteria To Boost Human V?2Vd2 T Cell Immunity. J Immunol, 193(2), 708-21. PMID: 24943221.

Rasmussen, J. A., Post, D. M., Gibson, B. W., Lindemann, S. R., Apicella, M. A., Meyerholz, D. K. & Jones, B. D. (2014). Francisella tularensis Schu S4 lipopolysaccharide core sugar and O-antigen mutants are attenuated in a mouse model of tularemia. Infect Immun, 82(4), 1523-39. PMID: 24452684.

Jones, B. D., Faron, M., Rasmussen, J. A. & Fletcher, J. R. (2014). Uncovering the components of the Francisella tularensis virulence stealth strategy. Front Cell Infect Microbiol, 4, 32. PMID: 24639953.

Faron, M., Fletcher, J. R., Rasmussen, J. A., Long, M. E., Allen, L. A. & Jones, B. D. (2013). The Francisella tularensis migR, trmE, and cphA genes contribute to FPI gene regulation and intracellular growth by modulation of the stress alarmone ppGpp. Infect Immun, 81(8), 2800-11. PMID: 23716606.

Long, M. E., Lindemann, S. R., Rasmussen, J. A., Jones, B. D. & Allen, L. A. (2013). Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC Genes Results in Attenuation for Growth in Human Macrophages and In Vivo Virulence in Mice and Reveals a Unique Phenotype for pdpC. Infect Immun, 81(3), 850-61. PMID: 23275090.

Ulland, T. K., Janowski, A. M., Buchan, B. W., Faron, M., Cassel, S. L., Jones, B. D. & Sutterwala, F. S. (2013). Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. Infect Immun, 81(1), 201-8. PMID: 23115038.

Lindemann, S. R., Peng, K., Long, M. E., Hunt, J. R., Apicella, M. A., Monack, D. M., Allen, L. A. & Jones, B. D. (2011). Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages. Infect Immun, 79(2), 581-94. PMID: 21078861.

McCaffrey, R. L., Schwartz, J. T., Lindemann, S. R., Moreland, J. G., Buchan, B. W., Jones, B. D. & Allen, L. A. (2010). Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis. J Leukoc Biol, 88(4), 791-805. PMID: 20610796.

Ulland, T. K., Buchan, B. W., Ketterer, M. R., Fernandes-Alnemri, T., Meyerholz, D. K., Apicella, M. A., Alnemri, E. S., Jones, B. D., Nauseef, W. M. & Sutterwala, F. S. (2010). Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence. J Immunol, 185(5), 2670-4. PMID: 20679532.

Apicella, M. A., Post, D. M., Fowler, A. C., Jones, B. D., Rasmussen, J. A., Hunt, J. R., Imagawa, S., Choudhury, B., Inzana, T. J., Maier, T. M., Frank, D. W., Zahrt, T. C., Chaloner, K., Jennings, M. P., McLendon, M. K. & Gibson, B. W. (2010). Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of Francisella tularensis. PLoS One, 5(7), e11060. PMID: 20625403.

Buchan, B. W., McCaffrey, R. L., Lindemann, S. R., Allen, L. A. & Jones, B. D. (2009). Identification of migR, a regulatory element of the Francisella tularensis live vaccine strain iglABCD virulence operon required for normal replication and trafficking in macrophages. Infect Immun, 77(6), 2517-29. PMID: 19349423.

Schulert, G. S., McCaffrey, R. L., Buchan, B. W., Lindemann, S. R., Hollenback, C., Jones, B. D. & Allen, L. A. (2009). Francisella tularensis genes required for inhibition of the neutrophil respiratory burst and intramacrophage growth identified by random transposon mutagenesis of strain LVS. Infect Immun, 77(4), 1324-36. PMID: 19204089.

Buchan, B. W., McLendon, M. K. & Jones, B. D. (2008). Identification of differentially regulated Francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system. Appl Environ Microbiol, 74(9), 2637-45. PMID: 18344342.

Lindemann, S. R., McLendon, M. K., Apicella, M. A. & Jones, B. D. (2007). An in vitro model system used to study adherence and invasion of Francisella tularensis live vaccine strain in nonphagocytic cells. Infect Immun, 75(6), 3178-82. PMID: 17339345.

Ledeboer, N. A., Frye, J. G., McClelland, M. & Jones, B. D. (2006). Salmonella enterica serovar Typhimurium requires the Lpf, Pef, and Tafi fimbriae for biofilm formation on HEp-2 tissue culture cells and chicken intestinal epithelium. Infect Immun, 74(6), 3156-69. PMID: 16714543.

Jones, B. D. (2006). Foodborne microbe mechanisms of colonization, attachment, and invasion.

Esteves, C. L., Jones, B. D. & Clegg, S. (2005). Biofilm formation by Salmonella enterica serovar Typhimurium and Escherichia coli on epithelial cells following mixed inoculations. Infect Immun, 73(8), 5198-203. PMID: 16041039.

Ledeboer, N. A., Jones, B. D. (2005). Exopolysaccharide sugars contribute to biofilm formation by Salmonella enterica serovar Typhimurium on HEp-2 cells and chicken intestinal epithelium. J Bacteriol, 187(9), 3214-26. PMID: 15838049.

Baxter, M. A., Jones, B. D. (2005). The fimYZ genes regulate Salmonella enterica serovar Typhimurium invasion in addition to type 1 fimbrial expression and bacterial motility. Infect Immun, 73(3), 1377-85. PMID: 15731035.

Jones, B. D. (2005). Salmonella invasion gene regulation: a story of environmental awareness. J Microbiol, 43 Spec No, 110-7. PMID: 15765064.

Frana, T. S., Carlson, S. A., Rauser, D. C., Jones, B. D., Fergen, B. J. & Griffith, R. W. (2004). Effects of microcin 24-producing Escherichia coli on shedding and multiple-antimicrobial resistance of Salmonella enterica serotype typhimurium in pigs. Am J Vet Res, 65(12), 1616-20. PMID: 15631023.

Boddicker, J., Jones, B. D. (2004). Lon protease activity causes down-regulation of Salmonella pathogenicity island 1 invasion gene expression after infection of epithelial cells. Infect Immun, 72(4), 2002-13. PMID: 15039320.

Catron, D. M., Lange, Y., Borensztajn, J., Sylvester, M. D., Jones, B. D. & Haldar, K. (2004). Salmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferation. Infect Immun, 72(2), 1036-42. PMID: 14742551.

Baxter, M. A., Fahlen, T. F., Wilson, R. L. & Jones, B. D. (2003). HilE interacts with HilD and negatively regulates hilA transcription and expression of the Salmonella enterica serovar Typhimurium invasive phenotype. Infect Immun, 71(3), 1295-305. PMID: 12595445.

Boddicker, J., Knosp, B. M. & Jones, B. D. (2003). Transcription of the Salmonella invasion gene activator, hilA, requires HilD activation in the absence of negative regulators. J Bacteriol, 185(2), 525-33. PMID: 12511499.

Carlson, S. A., Casey, T. A., Wu, M. T., Hammes, B. D. & Jones, B. D. (2002). A high-throughput genetic system for assessing the inhibition of proteins: identification of antibiotic resistance and virulence targets and their cognate inhibitors in Salmonella. Anal Biochem, 310(1), 72-83. PMID: 12413476.

Meyerholz, D., Stabel, T. J., Ackermann, M. R., Carlson, S. A., Jones, B. D. & Pohlenz, J. (2002). Early epithelial invasion by Salmonella enterica serovar Typhimurium DT104 in the swine ileum. Vet Pathol, 39(6), 712-20. PMID: 12450202.

Boddicker, J., Ledeboer, N. A., Jagnow, J., Jones, B. D. & Clegg, S. (2002). Differential binding to and biofilm formation on, HEp-2 cells by Salmonella enterica serovar Typhimurium is dependent upon allelic variation in the fimH gene of the fim gene cluster. Mol Microbiol, 45(5), 1255-65. PMID: 12207694.

Catron, D. M., Sylvester, M. D., Lange, Y., Kadekoppala, M., Jones, B. D., Monack, D. M., Falkow, S. & Haldar, K. (2002). The Salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55. Cell Microbiol, 4(6), 315-28. PMID: 12067317.

Carlson, S. A., Omary, M. B. & Jones, B. D. (2002). Identification of cytokeratins as accessory mediators of Salmonella entry into eukaryotic cells. Life Sci, 70(12), 1415-26. PMID: 11883717.

Boddicker, J. D., Jones, B. D. (2002). Salmonella invasion gene regulation: Being sensitive to the environment. Seoul National University, 1-30.

Fahlen, T. F., Wilson, R. L., Boddicker, J. & Jones, B. D. (2001). Hha is a negative modulator of transcription of hilA, the Salmonella enterica serovar Typhimurium invasion gene transcriptional activator. J Bacteriol, 183(22), 6620-9. PMID: 11673432.

Carlson, S. A., Meyerholz, D., Stabel, T. J. & Jones, B. D. (2001). Secretion of a putative cytotoxin in multiple antibiotic resistant Salmonella enterica serotype Typhimurium phagetype DT104. Microb Pathog, 31(4), 201-4. PMID: 11562173.

Wilson, R. L., Tvinnereim, A. R., Jones, B. D. & Harty, J. T. (2001). Identification of Listeria monocytogenes in vivo-induced genes by fluorescence-activated cell sorting. Infect Immun, 69(8), 5016-24. PMID: 11447181.

Gallois, A., Klein, J. R., Allen, L. H., Jones, B. D. & Nauseef, W. M. (2001). Salmonella pathogenicity island 2-encoded type III secretion system mediates exclusion of NADPH oxidase assembly from the phagosomal membrane. J Immunol, 166(9), 5741-8. PMID: 11313417.

Klein, J. R., Jones, B. D. (2001). Salmonella pathogenicity island 2-encoded proteins SseC and SseD are essential for virulence and are substrates of the type III secretion system. Infect Immun, 69(2), 737-43. PMID: 11159962.

Wilson, R. L., Libby, S. J., Freet, A. M., Boddicker, J., Fahlen, T. F. & Jones, B. D. (2001). Fis, a DNA nucleoid-associated protein, is involved in Salmonella typhimurium SPI-1 invasion gene expression. Mol Microbiol, 39(1), 79-88. PMID: 11123690.

Wilson, R. L., Elthon, J., Clegg, S. & Jones, B. D. (2000). Salmonella enterica serovars Gallinarum and Pullorum expressing Salmonella enterica serovar typhimurium type 1 fimbriae exhibit increased invasiveness for mammalian cells. Infect Immun, 68(8), 4782-5. PMID: 10899888.

Klein, J. R., Fahlen, T. F. & Jones, B. D. (2000). Transcriptional organization and function of invasion genes within Salmonella enterica serovar Typhimurium pathogenicity island 1, including the prgH, prgI, prgJ, prgK, orgA, orgB, and orgC genes. Infect Immun, 68(6), 3368-76. PMID: 10816487.

Fahlen, T. F., Mathur, N. & Jones, B. D. (2000). Identification and characterization of mutants with increased expression of hilA, the invasion gene transcriptional activator of Salmonella typhimurium. FEMS Immunol Med Microbiol, 28(1), 25-35. PMID: 10767604.

Carlson, S. A., Browning, M., Ferris, K. E. & Jones, B. D. (2000). Identification of diminished tissue culture invasiveness among multiple antibiotic resistant Salmonella typhimurium DT104. Microb Pathog, 28(1), 37-44. PMID: 10623562.

Carlson, S. A., Bolton, L. F., Briggs, C. E., Hurd, H. S., Sharma, V. K., Fedorka-Cray, P. J. & Jones, B. D. (1999). Detection of multiresistant Salmonella typhimurium DT104 using multiplex and fluorogenic PCR. Mol Cell Probes, 13(3), 213-22. PMID: 10369747.

Boddicker, J., Klein, J., Latzke, A. & Jones, B. D. (1999). Cloning and Characterization of Salmonella Pathogenicity Island 1. pp. 95. Abstracts, Annual Meeting, ASM, Chicago, IL.

Klein, J., Latzke, A. & Jones, B. D. (1999). Cloning and Characterization of Salmonella Pathogenicity Island 2. pp. 94. Abstracts, Annual Meeting, ASM, Chicago, IL.

Carlson, S., Wilson, R., Omary, B. & Jones, B. D. (1999). Cytokeratin-18 as a potential mediator of Salmonella invasion. A Cell Biology Approach to Microbial Pathogenesis. pp. 9-10. Abstracts, ASM, Portland, OR.

Fahlen, T., Mathur, N. & Jones, B. D. (1999). Identification and Analysis of a Tn5 Insertion which Results in Hyperinvasive S. typhimurium. pp. 65. Abstracts, Annual Meeting, ASM, Chicago, IL.

Baxter, A., Jones, B. D. (1999). Identification of interactions between Salmonella invasion proteins of SPI-1 that are required for secretion of effector proteins. The Sixth Midwest Pathogenesis Meeting, Milwaukee, WI.

Fahlen, T., Mathur, N. & Jones, B. D. (1999). Identification of Tn5 Transposon Insertions which Alter the Expression of the Invasion Gene Regulator hilA. The Sixth Midwest Pathogenesis Meeting, Milwaukee, WI.

Wilson, R., Elthon, J., Clegg, S. & Jones, B. D. (1999). Salmonella gallinarum and Salmonella pullorum encoding Salmonella typhimurium type 1 fimbriae exhibit increased invasiveness for mammalian cells. pp. 24. Abstracts, Cold Spring Harbor Microbial Pathogenesis and Host Response Meeting, Cold Spring Harbor, NY.

Carlson, S. A., Jones, B. D. (1998). Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteins. Infect Immun, 66(11), 5295-300. PMID: 9784535.

Jensen, V. B., Harty, J. T. & Jones, B. D. (1998). Interactions of the invasive pathogens Salmonella typhimurium, Listeria monocytogenes, and Shigella flexneri with M cells and murine Peyer's patches. Infect Immun, 66(8), 3758-66. PMID: 9673259.

Fahlen, T., Jones, B. D. (1998). A chromosomal Tn5 insertion causes increased expression of hilA and magnesium regulates hilA expression independent of phoP/Q. pp. I-23. Abstracts, Midwest Pathogenesis Meeting, St Louis, MO.

Klein, J., Jones, B. D. (1998). Analysis of a Salmonella operon required for host cell invasion. pp. I-40. Abstracts, Midwest Pathogenesis Meeting, St Louis, MO.

Baxter, A., Jones, B. D. (1998). Characterization of the Role of the OrgA Protein in Salmonella Invasion of Mammalian Cells. pp. I-7. Abstracts, Midwest Pathogenesis Meeting, St Louis, MO.

Jones, B. D., Nichols, W. A., Gibson, B. W., Sunshine, M. G. & Apicella, M. A. (1997). Study of the role of the htrB gene in Salmonella typhimurium virulence. Infect Immun, 65(11), 4778-83. PMID: 9353064.

Sunshine, M. G., Gibson, B. W., Engstrom, J. J., Nichols, W. A., Jones, B. D. & Apicella, M. A. (1997). Mutation of the htrB gene in a virulent Salmonella typhimurium strain by intergeneric transduction: strain construction and phenotypic characterization. J Bacteriol, 179(17), 5521-33. PMID: 9287009.

Penheiter, K. L., Mathur, N., Giles, D., Fahlen, T. & Jones, B. D. (1997). Non-invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches. Mol Microbiol, 24(4), 697-709. PMID: 9194698.

Jones, B. D. (1997). Host responses to pathogenic Salmonella infection. Genes Dev, 11(6), 679-87. PMID: 9087423.

Werner, J., Jones, B. D. (1997). Construction of a Variable-copy Cloning Vector. pp. 298. Abstracts, Annual Meeting, ASM, Miami Beach, FL.

Fahlen, T., Jones, B. D. (1997). Effect of a phoP-mutation on invasion in S. typhimurium. pp. 80. Abstracts, Annual Meeting, ASM, Miami Beach, FL.

Fahlen, T., Mathur, N. & Jones, B. D. (1997). Regulation of Invasion of Salmonella typhimurium phoP and Identification of a Negative Regulator of hilA. pp. 33. Abstracts, Cold Spring Harbor Microbial Pathogenesis and Host Response Meeting, Cold Spring Harbor, NY.

Fahlen, T., Penheiter, K., Mathur, N. & Jones, B. D. (1996). Salmonella Oxygen-regulated Invasion Genes are Essential for Entry and Destruction of M cells and in the Establishment of Infection by an Oral Route. pp. 200. Abstracts, Annual Meeting, ASM, New Orleans, LA.

Jones, B. D., Falkow, S. (1996). Salmonellosis: host immune responses and bacterial virulence determinants. Annu Rev Immunol, 14, 533-61. PMID: 8717524.

Jones, B. D., Pascopella, L. & Falkow, S. (1995). Entry of microbes into the host: using M cells to break the mucosal barrier. Curr Opin Immunol, 7(4), 474-8. PMID: 7495510.

Jones, B. D. (1995). Characterization of Oxygen-Regulated Genes Required for S. typhimurium Host Cell Entry. pp. 219. Abstracts, Annual Meeting, ASM, Washington, DC.

Jones, B. D., Falkow, S. (1994). Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization. Infect Immun, 62(9), 3745-52. PMID: 8063389.

Jones, B. D., Ghori, N. & Falkow, S. (1994). Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches. J Exp Med, 180(1), 15-23. PMID: 8006579.

Jones, B. D. (1994). Salmonella-host cell interactions which lead to bacterial invasion.

Jones, B. D., Ghori, N. & Falkow, S. (1994). Salmonella-host cell interactions which lead to membrane ruffling and bacterial entry. pp. 40. Abstracts, J of Cellular Biochemistry, Keystone Symposia on Molecular and Cellular Biology, Santa Fe, NM.

Jones, B. D., Paterson, H. F., Hall, A. & Falkow, S. (1993). Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanism. Proc Natl Acad Sci U S A, 90(21), 10390-4. PMID: 8234304.

Francis, C. L., Ryan, T. A., Jones, B. D., Smith, S. J. & Falkow, S. (1993). Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria. Nature, 364(6438), 639-42. PMID: 8350922.

Jones, B. D., Falkow, S. (1993). Identification and characterization of an oxygen-regulated S. typhimurium invasion gene. pp. 246. Abstracts, Annual Meeting, ASM, Atlanta, GA.

Jones, B. D., Falkow, S. (1993). Phenotypic and genetic aspects of Salmonella invasion. In C. Kado , J. Crosa (Eds.) Molecular mechanisms of bacterial virulence. Kluwer Academic Publishers.

Jones, B. D., Paterson, H., Hall, A. & Falkow, S. (1993). S. typhimurium induces membrane ruffling by a rac-independent mechanism. The First Bristol-Myers Squibb Symposium on Infectious Disease Research. The Cell and Molecular Biology of Bacterial-Host Cell Interactions. Monterey, CA.

Jones, B. D., Lee, C. A. & Falkow, S. (1992). Invasion by Salmonella typhimurium is affected by the direction of flagellar rotation. Infect Immun, 60(6), 2475-80. PMID: 1587617.

Lee, C. A., Jones, B. D. & Falkow, S. (1992). Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants. Proc Natl Acad Sci U S A, 89(5), 1847-51. PMID: 1311853.

Jones, B. D., Falkow, S. (1992). Characterization of Salmonella typhimurium mutants defective in invasion. pp. 14. Abstracts, Fallen Leaf Lake Conference, South Lake Tahoe, CA.

Hu, L. T., Nicholson, E. B., Jones, B. D., Lynch, M. J. & Mobley, H. L. (1990). Morganella morganii urease: purification, characterization, and isolation of gene sequences. J Bacteriol, 172(6), 3073-80. PMID: 2345135.

Mobley, H. L., Green, D. M., Trifillis, A. L., Johnson, D. E., Chippendale, G. R., Lockatell, C. V., Jones, B. D. & Warren, J. W. (1990). Pyelonephritogenic Escherichia coli and killing of cultured human renal proximal tubular epithelial cells: role of hemolysin in some strains. Infect Immun, 58(5), 1281-9. PMID: 2182540.

Jones, B. D., Lockatell, C. V., Johnson, D. E., Warren, J. W. & Mobley, H. L. (1990). Construction of a urease-negative mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection. Infect Immun, 58(4), 1120-3. PMID: 2180821.

Jones, B. D., Lockatell, V., Johnson, D., Warren, J. & Mobley, H. (1990). Construction of a urease-negative mutant of Proteus mirabilis: analysis of virulence in a mouse model of ascending urinary tract infection. pp. 44. Abstracts, Annual Meeting, ASM, Anaheim, CA.

Hu, L. T., Jones, B. D., Nicholson, E. B. & Mobley, H. L. (1990). Purified ureases from Helicobacter (Campylobacter) pylori, Morganella morganii, and jack bean and sequenced urease genes of Proteus mirabilis suggest a common genetic origin. pp. 64. Abstracts, Annual Meeting, ASM, Anaheim, CA.

Jones, B. D., Mobley, H. L. (1989). Proteus mirabilis urease: nucleotide sequence determination and comparison with jack bean urease. J Bacteriol, 171(12), 6414-22. PMID: 2687233.

Hu, L., Jones, B. D., Fox, M., Nicholson, E. & Mobley, H. (1989). Morganella morganii urease: purification and cloning of gene sequences. pp. 41. Abstracts, Annual Meeting, ASM, New Orleans, LA.

Jones, B. D., Mobley, H. L. (1989). Nucleotide sequence of the urease operon of Proteus mirabilis. pp. 41. Abstracts, Annual Meeting, ASM, New Orleans, LA.

Mobley, H. L., Rosenthal, L. E., Trofa, A. F. & Jones, B. D. (1989). Optimization of detection of Campylobacter pylori by urease and DNA hybridization. In F. Megraud , H. Lamouliatte (Eds.) Gastroduodenal pathology and Campylobacter pylori. pp. 127-31. Excerpta Medica.

Jones, B. D., Mobley, H. L. (1988). Proteus mirabilis urease: genetic organization, regulation, and expression of structural genes. J Bacteriol, 170(8), 3342-9. PMID: 2841283.

Mobley, H. L., Cortesia, M. J., Rosenthal, L. E. & Jones, B. D. (1988). Characterization of urease from Campylobacter pylori. J Clin Microbiol, 26(5), 831-6. PMID: 3384908.

Trofa, A. F., Jones, B. D., Rosenthal, L. E., Green, D., Chippendale, G. & Mobley, H. L. (1988). A DNA probe for the detection of Campylobacter pylori. pp. 81. Abstracts, Annual Meeting, ASM, Miami Beach, FL.

Jones, B. D., Lynch, M. J. & Mobley, H. L. (1988). Genetic organization of the Proteus mirabilis urease operon. pp. 64. Abstracts, Annual Meeting, ASM, Miami Beach, FL.

Mobley, H., Rosenthal, L., Trofa, A. & Jones, B. D. (1988). Optimization of detection of Campylobacter pylori by urease and DNA hybridization. Workshop of Gastroduodenal Pathology and Campylobacter pylori, Bordeaux, France.

Mobley, H. L., Jones, B. D. & Penner, J. L. (1987). Urease activity of Proteus penneri. J Clin Microbiol, 25(12), 2302-5. PMID: 3429622.

Jones, B. D., Mobley, H. L. (1987). Genetic and biochemical diversity of ureases of Proteus, Providencia, and Morganella species isolated from urinary tract infection. Infect Immun, 55(9), 2198-203. PMID: 3623698.

Jones, B. D., Mobley, H. L. (1987). Genetic and biochemical diversity among ureases of Proteus, Providencia, and Morganella species isolated from urinary tract infection. Maryland-Washington, DC Meeting, ASM, Baltimore, MD.

Jones, B. D., Mobley, H. L. (1987). Genetic and biochemical diversity among ureases of Proteus, Providencia, and Morganella species isolated from urinary tract infection. pp. 73. Abstracts, Annual Meeting, ASM, Atlanta, GA.

Mobley, H. L., Jones, B. D. & Jerse, A. E. (1986). Cloning of urease gene sequences from Providencia stuartii. Infect Immun, 54(1), 161-9. PMID: 3759233.

Jones, B. D., Mobley, H. L. (1986). Cloning and characterization of urease from Providencia stuartii. pp. 61. Abstracts, Annual Meeting, ASM, Washington, DC.