Patrick M. Schlievert, PhD

Portrait
Professor of Microbiology and Immunology
Professor of Internal Medicine
Chair and Department Executive Officer

Contact Information

Office
3-403B Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-335-7807

Lab
3-401 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-335-7817

Education

BA, General Science - Geology, University of Iowa
PhD, Microbiology, University of Iowa
Postdoctoral Fellow, University of Minnesota

Education/Training Program Affiliations

Biomedical Science Program, Department of Microbiology Graduate Program, Interdisciplinary Graduate Program in Immunology, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases, NIH Vaccine Treatment and Evaluation Unit

Research Summary

Research in my laboratory studies superantigen and cytolysin exotoxins produced by Staphylococcus aureus and group A streptococci, as immune system modulators, evaluating their roles in serious human illnesses, including pneumonia and infective endocarditis, atopic dermatitis, and diabetes mellitus. Included in the larger family of superantigens are toxic-shock syndrome toxin-1 (TSST-1), the major cause of TSS; staphylococcal enterotoxins, causes of food poisoning and TSS; and streptococcal pyrogenic exotoxins, causes of scarlet fever and a TSS-like illness. Additionally, my laboratory identifies novel strategies to prevent and manage serious human infectious diseases. Specific areas of ongoing research include: 1) elucidation of the mechanisms of cytolysin and superantigen subversion of the immune system at mucosal surfaces; 2) structure-function studies of novel superantigens; 3) development of novel therapeutic agents to prevent infections and treat serious human diseases; 4) characterization of staphylococcal, streptococcal, and enterococcal factors required for development of TSS, pneumonia, infective endocarditis, atopic dermatitis, diabetes mellitus, and selected other illnesses; 5) characterization of the pathogenesis of novel human illnesses associated with gram-positive bacteria.