Past Seminar Speakers

Fall 2018

Jon Houtman, PhD, Associate Professor of Microbiology & Immunology, University of Iowa
Effects of Glycerol Monolaurate on Human T Cell Activation

Yi Zhang, MD, PhD,  Professor of Microbiology & Immunology, Temple University
 EZH2 Maintenance of Memory T Cell Precursors: Toward Clinical Translation  

Sonja Best, PhD, Chief, Innate Immunity & Pathogenesis - Unit Rocky Mountain Labs, National Institutes of Health (NIH)
Beyond retroviruses: Restriction of flavivirus replication by primate TRIM5α

APICELLA LECTURE  Steve Beverley, PhD, Chair of Molecular Microbiology, Washington University, St. Louis
Origins and contributions of endogenous protozoal viruses to parasite virulence   

Francis Impens, PhD,  VIB-UGent Center for Medical Biotechnology
Proteomics technologies to study host-bacteria interactions   


Spring 2018

Damian Krysan, Director Of the Division of Infectious Disease in Pediatrics, University of Iowa
Antifungal Drug Discover in the Academic Setting

Imtiaz Khan, George Washington University
CD8 T cell functionality during chronic toxoplasmosis: Role of CD4 help

Alexis Kalergis, Pontifical Catholic University of Chile
Vaccines against respiratory syncytial virus

Paul Friesen, University of Wiscosin, Madison, WI
A novel mechanism by which DNA virus manipulates the host DNA dage response to promote remarkable replication

Richard Kuhn, Purdue Institute
Dengue and Zika viruses have a hard time growing up

Christine Peterson, University of Iowa
What's worse than Leishmania infantum infection? Infection with L. infantum and tick-borne pathogens!

Keun Seok Seo,   Mississippi State University
Molecular Mechanism of Immunosuppression Induced by Superantigens

Ashraful Haque,  Queensland Institute of Medical Research (QIMR), Brisbane, Australia
Using single-cell genomics, mathematical and computational modelling to examine host-parasite interactions in experimental malaria

Andrew Camilli, Tufts University, School of Medicine
Impact of Phages on Cholera and Development of Two Preventatives

Virginia Shapiro,  Mayo Clinic, Rochester, NY
Regulation of T cell Development, Lineage Commitment and Maturation by HDAC3

Elina Zuniga, University of California - San Diego
Immune Adaptations During Chronic Viral Infection

Ileana Cristea, Princeton University
Dynamic proteome organization and host defense during herpesvirus infection

Fall 2017

Noah Butler, University of Iowa  - Department of Microbiology & Immunology
Th1-like Plasmodium-specific memory CD4+ T cells unexpectedly support humoral immunity

Joe Sorg, Texas A & M
Dissecting the mechanism of Clostridium difficile spore germination

Laura Haynes, UConn Health (Co-sponsored with Immunology)
How aging impacts the response to influenza infection        

Barbara Kazmierczak, Yale University
Should I stay or should I go?: "Virulence regulation in Pseudomonas aeruginosa"

Kevin McIver, University of Maryland
Defining Group A Streptococcal Fitness Determinants Within In Vivo Environments    

Ken Stedman, Portland State University
Viruses from Hell

Carolina Lopez, University of Pennsylvania (Co=sponsored with Immunology)
Lung infections; anti-viral immune responses

Imtiaz Khan, George Washington University (Cancelled - rescheduled Spring 18)

Shannon Kenney,University of Wisconsin - Madison
Epstein Barr Virus (EBV)

Tajie Harris, University of Virginia
Brain infections with Toxoplasma parasites

Jeffrey Gordon, MD, Washington University in St. Louis (Irving Crawford Lecture)
Gut microbiome

Kim Orth, U of TX, Southwestern Med. Ctr.
Getting in and getting out: A vibrio invasion

Walther Mothes, Yale School of Medicine
HIV-1 entry and neutralization

Spring 2017

Pete Chandrngsu, Cornell University (faculty candidiate)
Zinc-ing responsibly: Novel insights into zinc homeostasis and intoxication in Bacillus subtilis

Mark Weber, National Institute of Health (NIH) (faculty candidate)
Chlamydia Inc.:  The business of hijacking the host

Lilliana Radoshevich (faculty candidate)
Linking ISG15 to the ER:  Lessons from Listeria infection

Hongbaek Cho,  Harvard University (faculty candidate)
New lesson from classic antibiotics: learning and exploiting the lethal mechanism of beta-lectam antibiotics

Stephanie Shames, Yale University, (faculty candidate)
Identification of novel Legionella pneumophila effector phenotypes using high-throughout analysis of targeted mutant libraries

Matt Evans, Department of Microbiology, Mr. Sinai
Deep insertional mutagenesis of the Zika virus genome

Peter A. Jorth, California Institute of Technology, (faculty candidate)
Regional isolation drives bacterial diversification during chronic cystic fibrosis infections

John McCormick, Department of Microbiology & Immunology, Western University, Ontario, Canada
Streptococcus pyogenes: Human pathogen or 'super' commensal

Jonathan Lai, Department of Biochemistry, Albert Einstein College of Medicine
Protein engineering strategies for the development of viral immunotherapies & vaccines

Sarah Gaffen, Department of Immunology, University of Pittsburgh
Oh to be seventeen again: IL-17 receptor signaling in fungal immunity and autoimmune disease

Sang-Moo Kang, Center for Inflammation Immunity & Infection, Georgia State University  (Co-sponsored with Immunology)
"Vaccines against respiratory viruses and adjuvants"

Ronald Breaker, Department of Molecular, Cellular, and Developmental Biology, Yale University
"Riboswitches: Nature's chemical sensors and switches made of RNA"

Hui Hu, Department of Microbiology, University of Alabama
Tfh cell differentiation and Tfh help to GC responses

Barney Graham, Vaccine Research Center, National Institute of Health (NIH)
RSV Vaccine Development:  A Paradigm for Structure-Based Vaccine Design

Special Microbiology Seminar:  Robert Faris, PhD, Rocky Mountain Laboratories, NIH/NIAID
Prions and mitochondrial dysfunction: consequence or coincidence?

Tuli Mukhopadhyay, Department of Biology, Indiana University
The tale of TF in Alphavirus assembly:  What does it do?

Fall 2016

David Weiss, Department of Microbiology, University of Iowa
Using fluorescemt proteins to illuminate bacterial cell division and pathogenesis   
Chioma Okeoma, Department of Microbiology, University of Iowa
BST-2 at the nexus of viral pathogenesis and cancer 

Marvin Whiteley, Department of Biosciences, University of Texas at Austin
The role of community composition and biogeography in polymicrobial infection

Andrew Goodman, Microbial Sciences Institute, Yale University
Microbiome offense and defense

Hongbo Chi, Immunology Department, St. Jude Children's Research Hospital
mTOR signaling and metabolic control of T cell fate decisions

Aloysius J. Klingelhutz, Department of Microbiology, University of Iowa
Why immortalize fat cells? Uncovering the roles of toxins in adipose dysfunction and type II diabetes 

Andreas Bäumler, Department of Medical Microbiology & Immunology, UC Davis School of Medicine
The pyromaniac inside you: salmonella metabolism in the host gut 

Hai-Hui Xue, Department of Microbiology, University of Iowa
Choice and fidelity for a T lymphocyte

Jason Barker, Department of Internal Medicine, University of Iowa
Lipopolysaccharide structural heterogeneity and the host-pathogen interface

Judith White, Department of Cell Biology, University of Virginia
Mechanism and inhibition of ebolavirus entry

Vladimir Badovinac, Department of Pathology & Interdisciplinary Program in Immunology, University of Iowa
Impact of polymicrobial sepsis on CD8 T cell immunity

Lee-Ann H. Allen, Departments of Internal Medicine and Microbiology, University of Iowa
Neutrophil plasticity in Helicobacter pylori infection

Joanna B. Goldberg, Department of Pediatrics, Emory University School of Medicine
Pseudomonas aeruginosa EF-Tu Trimethylation and Pathogenesis

Katherine L. Knight, Departments of Microbiology and Immunology, Loyola University Chicago
Anti-inflammatory effect of commensal-derived exopolysaccharide

Tim Hoover, Department of Microbiology, University of Georgia, Athens
Control of flagellum biogenesis in Helicobacter pylori

Spring 2016

Andres Vazquez-Torres, Department of Immunology & Microbiology, University of Colorado School of Medicine
Antioxidant defenses of thioredoxin independent of canonical thiol-disulfide oxidoreductase enzymatic activity 

Hillel Haim, Department of Microbiology, University of Iowa
Identifying the order that underlies randomness in HIV-1 evolution at the patient and population level

Susan Hafenstein, Professor of Medicine & Microbiology and Immunology, Penn State College of Medicine
Transformative advance in cryo-EM used to explore virus-host interactions 
Aimee Shen, Dept. of Microbiology & Molecular Genetics, University of Vermont
Clostridium difficile spore formation and germination

Samantha King, Pediatrics, Ohio State University
Streptococcus oralis utilizes a novel mechanism of sequential adherence to host glycans

Rita Tamayo, Department of Microbiology and Immunology, University of North Carolina
Regulation of flagellum and cytotoxin biosynthesis in Clostridium difficile

Heather Allen, Research Microbiologist at USDA-ARS
Collateral effects of antibiotics on the swine gut microbiota

Christopher Snyder, Thomas Jefferson University
Co-sponsored with Immmunology (T cell responses against persistent viral infections) 

Ian Hewson, Department of Microbiology, Cornell University
The sea star microbiome orchestra:  Old players on a new stage

Susan K. Pierce, PhD, Chief, Laboratory of Immunogenetics, NIH/NIAID 
The immune response to malaria:  What malaria knows about the immune system that Immunologists don't

Thomas Gallagher, Department of Microbiology & Immunology, Loyola University Chicago
MERS Coronavirus - Cell Entry 

Fall 2015

John V. Williams, Division of Pediatric Infectious Diseases, Children's Hospital of Pittsburgh
Why Pulmonary CD8 T Cells Won't Fight, Fight, Fight for Iowa

Blaise R. Boles, Department of Microbiology, University of Iowa
Fold modulating function: Functional amyloids produced by Staphylococcus aureus

Dorian McGavern, National Institute of Neurological Disorders and Stroke, NIH
Real-time insights into the regulation of sterile vs. antimicrobial CNS immunity

Christopher Waters, Department of Microbiology & Molecular Genetics, Michigan State University
Cyclic di-GMP: A global regulatory maestro that orchestrates the adaptation of bacteria to changing environments

Melissa B. Lodoen, Molecular Biology and Biochemistry, University of California Irvine
Host-Parasite Interactions, Immunity, and Pathogenesis

Moriah L. Szpara, Biochemistry and Molecular Biology, Penn State University
Variability, adaptation, and evolution in alpha-herpesviruses

Matthew Wargo, Department of Microbiology & Molecular Genetics, University of Vermont
Pseudomonas detection of host-derived amines using a particular sub-family of AraC-like regulators

Alexander R. Horswill, Department of Microbiology, University of Iowa
The social life of Staphylococci

Catharine Bosio, National Institute of Allergy and Infectious Diseases, NIH
Building a Better Mousetrap: Using Classic Immunology to Develop Effective Tularemia Vaccines

Katherine P. Lemon, The Forsyth Institute
Nose Picking for Progress: Mining the Nasal Microbiome for New Insights into Pathobionts

Elsa Bou Ghanem, Department of Molecular Biology and Microbiology, Tufts University School of Medicine
The role of neutrophils and extracellular adenosine in shaping host resistance to Streptococcus pneumoniae lung infection

Drew Kitchen, Department of Anthropology, University of Iowa
Evolutionary genetics reveal the shared history of humans and our parasites and pathogens

Mishtu Dey, Department of Chemistry, University of Iowa
Structural enzymology of mononuclear non-heme iron enzymes

Elsa Bou Ghanem, Molecular Microbiology Program, Tufts University
The role of neutrophils and extracellular adenosine in shaping host resistance to Streptococcus pneumoniae lung infection

Qi Yang, Department of Pathology & Laboratory Medicine, University of Pennsylvania
Development and function of innate lymphoid cells

Aaron G. Schmidt, Department of Pediatrics, Boston Children's Hospital
Immuno-viral archaeology: Uncovering history of antigen exposure and mechanisms of antibody affinity maturation

Spring 2015

George Dimopoulos, Department of Molecular Microbiology and Immunology, Johns Hopkins University
The mosquito microbiota in disease transmission

Margaret Kielian, Department of Cell Biology, Albert Einstein College of Medicine
Enveloped virus entry: Mechanisms and regulation of membrane fusion

Tom Bobik, Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University
Bacterial microcompartments, widespread prokaryotic organelles for metabolic optimization

Victor J. DiRita, Department of Microbiology & Immunology, University of Michigan
Campylobacter colonization mechanisms in a natural host model

Shaden Kamhawi, National Institute of Allergy and Infectious Diseases, NIH
The influence of vector-derived factors on Leishmania transmission and disease progression

Kevin B. Urdahl, Department of Immunology, University of Washington
Understanding and overcoming the barriers to T cell mediated immunity against tuberculosis

Ilya V. Frolov, Department of Microbiology, University of Alabama Birmingham
Let's make our knowledge of virus-host interactions useful. Engineering of alphaviruses with programmed phenotypes

Pradeep Singh, Department of Microbiology, University of Washington
Regional lung evolution produces bacterial diversity during cystic fibrosis infections

Martin L. Moore, Department of Pediatrics, Emory University School of Medicine
Interaction of the respiratory syncytial virus fusion protein with epidermal growth factor receptor

Thomas J. Braciale, Department of Pathology, University of Virginia
Dendritic cells and the control of antiviral effector and memory T cell responses during respiratory virus infection

Steve Melville, Department of Biological Sciences, Virginia Tech
Looking at Type IV pili at the cellular and atomic level

Lauren O. Bakaletz, The Research Institute at Nationwide Children's Hospital
Extracellular DNA-associated DNABII proteins as a target for disruption of biofilms formed by nontypeableHaemophilus influenzae

Fall 2014

Robin G. Lorenz, Department of Pathology, University of Alabama Birmingham
The role of p-glycoprotein in intestinal inflammation

Guido Silvestri, Pathology & Laboratory Medicine, Emory University
Target cell restriction in AIDS pathogenesis and eradication

Hector Aguilar-Carreno, Veterinary Microbiology and Pathology, Washington State University
Multiple Glycoprotein Functions of a Deadly CONTAGION: Nipah Virus

Steven M. Varga, Department of Microbiology, University of Iowa
The Good, the Bad and the Ugly Consequences of CD8 T Cell Memory to RSV

E. Peter Greenberg, Department of Microbiology, University of Washington
Microbial social engineering: Control of cooperation in Pseudomonas aeruginosa

Gregory A. Smith, Department of Microbiology-Immunology, Northwestern University
Alphaherpesviruses in the spotlight: a neuroinvasive nanomachine in action

Matthew C. Wolfgang, Department of Microbiology and Immunology, University of North Carolina
Reciprocal regulation of cyclic AMP signaling drives acute and chronic virulence phenotypes in Pseudomonas aeruginosa

Zuoan Yi, Department of Microbiology, University of Iowa
The regulation of T cells in specialized tissue microenvironments

M. Suresh, Department of Pathobiological Sciences, University of Wisconsin
Signaling and Transcriptional Basis of T-Cell Memory

Ann M. Stock, Center for Advanced Biotechnology and Medicine, Rutgers University
Insights into Two-Component System Architecture from Phosphorylation Profiling: Enough is Enough

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology
Mucosal T cells: Same Players Different Strategies

Joseph Dillard, Medical Microbiology & Immunology, University of Wisconsin
Breaking down the wall: Peptidoglycan degradation and the pathogenesis of Neisseria gonorrhoeae

Wendy Maury, Department of Microbiology, University of Iowa
The Role of TIM Proteins in Ebola Virus Infection

Gabriel Nunez, Department of Pathology, University of Michigan
Linking Pathogen Virulence, the Microbiota and Immunity

Spring 2014

Pamela Hall, Department of Pharmaceutical Sciences, University of New Mexico
Pharmacological disruption of agr quorum sensing in Staphylococcus aureus protects against skin and soft tissue infection

David Weiss, Emory Vaccine Center, Emory University
CRISPR/Cas-mediated endogenous gene regulation is required for bacterial innate immune evasion

Kim Lewis, Department of Biology, Northeastern University
Persisters and the quest for a biofilm-sterilizing antibiotic

Christine Petersen, Department of Epidemiology, University of Iowa
Lessons from a Tropical Disease in the Midwest

Jenny Gumperz, Medical Microbiology & Immunology, University of Wisconsin-Madison
Linking NKT cells to Inflammation

Shan-Lu Liu, Molecular Microbiology & Immunology, University of Missouri
New Cellular Factors Modulating Viral Infections

S. Celeste Morley, Department of Pediatrics, Washington University School of Medicine in St Louis
Immunodeficiency as a movement disorder: impaired immunity in mice deficient for L-plastin

Robert Schleif, Department of Biology, Johns Hopkins University
The Bottom Line on the Regulatory Protein AraC (240 Person-years of work)

Dennis W. Metzger, Center for Immunology & Microbial Disease, Albany Medical College
Influenza and Secondary Bacterial Pneumonia Mechanisms

George A. O'Toole, Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth
To Build a Biofilm

Daniel Zurawski, Walter Reed Army Institute of Research
Defining an appropriate strain and developing animal models to study Acinetobacter baumannii pathogenesis and novel antimicrobials

Ekaterina Heldwein, Department of Molecular Biology & Microbiology, Tufts University
Herpesviruses on the way out: what structures and biophysics can tell us

Fall 2013

John Kirby, Department of Microbiology, University of Iowa
Chemosensory regulation of microbial communities

William Goldman, Department of Microbiology & Immunology, University of North Carolina
The Progression of Pneumonic Plague

Craig Ellermeier, Department of Microbiology, University of Iowa
A Bacterial Receptor for Lysozyme Controls σ Factor Activation and Lysozyme Resistance

Wilmara Salgado-Pabón, Department of Microbiology, University of Iowa
Molecular Pathogenesis of Staphylococcal Infective Endocarditis

Steven McElroy, Department of Pediatrics, University of Iowa
Untangling the Role of Bacteria in Development of Neonatal Necrotizing Enterocolitis 

Keji Zhao, Laboratory of Epigenome Biology, National Heart Lung & Blood Institute
Epigenetic regulation of T cell differentiation

Erhard Bremer, Laboratory for Molecular Microbiology, University of Marburg, Germany
The big fight of a small bacterium with osmotic challenges - cellular stress responses to a ubiquitous cue

Peter Crompton, Laboratory of Immunogenetics, National Institute of Allergy & Infectious Diseases
Unraveling the Mechanisms of Naturally-Acquired Immunity to Malaria

Felipe Diaz-Griffero, Department of Microbiology & Immunology, Albert Einstein College of Medicine
Innate immunity against HIV-1

David Farrar, Department of Immunology, University of Texas Southwestern Medical Center
Interfering with allergic diseases

Douglas B. Weibel, Department of Biochemistry, University of Wisconsin
Studying bacterial cell division and chromosome segregation using small molecules

Carol Duffy, Department of Biological Sciences, University of Alabama
Don't kill the messenger! Does the HSV-1 VP22 protein promote translation by preventing mRNA cleavage by a viral nuclease?

Blaise Boles, Department of Molecular, Cellular, and Developmental Biology, University of Michigan
Bacterial Functional Amyloids

Jyoti Misra Sen, Immune Cells and Inflammation Section, National Institute on Aging
T cell factor-1 regulated T cell development and function

Kartik Chandran, Department of Microbiology & Immunology, Albert Einstein College of Medicine
The lysosomal transporter Niemann-Pick C1 is a critical intracellular receptor for Ebola virus

Donna Farber, Department of Surgery, Columbia University Medical Center
Tissue compartmentalization of T cell responses in mice and man

Spring 2013

Keith Jarosinski, Department of Microbiology, University of Iowa
Herpesvirus-induced oncogenesis and transmission

Shelley M. Payne, University of Texas at Austin
Shigella pathogenesis: Life in the intracellular environment

Michael Schmidt, Medical University of South Carolina
Bacteria, Burden and Bundles: How Copper Surfaces Enhance Patient Safety

John Butler, Department of Microbiology, University of Iowa
B cell and repertoire development in swine: a challenge of current paradigms

Daniel C. DiMaio, Yale University
Traptamers: artificial transmembrane proteins that inhibit HIV

John-Demian Sauer, University of Wisconsin-Madison
The role of inflammasome activation in the induction of cell mediated immunity

Morgan Huse, Sloan-Kettering Institute
Lipid-based patterning of the cytoskeleton at the immunological synapse

Arturo Casadevall, Albert Einstein College of Medicine at Yeshiva University
Thoughts on the origin of microbial virulence

Kumaran S. Ramamurthi, National Cancer Institute
Morphogenesis of large structures during development

Stokes Peebles, Vanderbilt University
IL-13 modulation of Th17 cytokine responses

Michael S. Diamond, Washington University in St. Louis
New insights into innate and adaptive immune responses against flaviviruses and alphaviruses

Fall 2012

Timothy L. Yahr, Department of Microbiology, University of Iowa
The Pseuomonas aeruginosa type III secretion system: to be on or not to be on, that is the question

Mark R. Denison, Vanderbilt University
Coronavirus RNA proofreading: a novel determinant of evolution, replication, and pathogenesis

Craig D. Ellermeier, Department of Microbiology, University of Iowa
Activation of ECF sigma factors in response to cell envelope stress in Bacillus subtilis and Clostridium difficile

Valley Stewart, University of California, Davis
Transmitter phosphatase control of two-component signal transduction

Jeffrey Rathmell, Duke University
Lymphocyte metabolism in immunity and leukemia

Stacey L. Schultz-Cherry, St Jude Children's Research Hospital
Pathogenesis of RNA viruses: Fat mice and a viral enterotoxin

William Shafer, Emory University
Mechanisms of antibiotic resistance expressed by Neisseria gonorrhoeae: Implications for pathogenesis

Dennis E. Ohman, Virginia Commonwealth University
All Stressed Out: Adaptation of a Stress Response System in Pseudomonas for Pathogenesis in Cystic Fibrosis

Victor J. Torres, New York University Langone Medical Center
Staphylococcus aureus bi-component toxins: pore-forming toxins involved in the disarmament of the host surveillance system

Thomas G. Bernhardt, Harvard Medical School
The ABCs of bacterial cell division

Carolyn Hovde Bohach, University of Idaho
Cattle: The silent reservoir of E. coli O157:H7

Allan Zajac, University of Alabama Birmingham
Tuning CD8 T cell responses

Tammy L. Kielian, University of Nebraska Medical Center
S. aureus biofilms: identifying mechanisms of immune evasion and strategies for therapeutic intervention

Patrick M. Schlievert, PhD, Department of Microbiology, University of Iowa
Glycerol Monolaurate-Coenzyme Q Based Formations as Topical Microbicides