Emily A. McMackin

Postdoctoral Research ScholarEmily Williams
Address: 200 EMRB
Phone: (319) 335-8666
Email: emily-williams@uiowa.edu
 

Year Entered into Program: 2016

Training

Ph.D. University of Notre Dame, 2016
B.S. Spring Hill College, 2010

Research

Pseudomonas aeruginosa is an opportunistic pathogen of humans and a leading cause of nosocomial pneumonia,urinary tract and post-operative infections. One of the most important virulence determinants of P. aeruginosa is a type III secretion system (T3SS). The T3SS is required for full virulence in animal infection models and functions by translocating effector proteins with anti-phagocytic and cytotoxic properties into host cells. My project involves defining regulatory mechanisms that control T3SS gene expression.  

Publications

Williams EA*, Mba Medie F*, Bosserman RE, Johnson BK, Reyna C, Ferrell MJ, Champion MM, Abramovitch RB, Champion PA. (2017) “A nonsense mutation in Mycobacterium marinum that is suppressible by a novel mechanism.” Infect. Immun. 85:e00653-16. *Authors contributed equally

Mba Medie F, Champion MM, Williams EA, Champion PA. (2014) “Homeostasis of N-α terminal acetylation of EsxA correlates with virulence in Mycobacterium marinum.” Infect. Immun. 82(11): 4572-86. Article of significant interest selected by the Editors.

Champion MM, Williams EA, Pinapati RS, Champion PA. (2014) “Correlation of phenotypic profiles using targeted proteomics identifies mycobacterial Esx-1 substrates.” J. Proteome Res. 13(11): 5151-64.

Champion MM, Williams EA, Kennedy GM, Champion PA. (2012) “Direct detection of bacterial protein secretion using whole colony proteomics.” Mol. Cell. Proteomics 12(9): 596-604.