Jason H. Barker, MD

Portrait
Associate Professor of Internal Medicine - Infectious Diseases
Associate Professor of Microbiology and Immunology

Contact Information

Primary Office
529 EMRB
Iowa City, IA 52242
319-335-4594

Education

MD, Baylor College of Medicine
Resident, Internal Medicine, University of Texas Southwestern
Fellow, Infectious Diseases, University of Iowa Hospitals and Clinics

Licensure and Certifications

Infectious Diseases - American Board of Medicine

Center, Program and Institute Affiliations

Inflammation Program

Research Summary

Dr. Barker's research focuses on interactions between the immune system and lipopolysaccharide, and important component of man medically important bacteria. In particular, he is interested in understanding how Francisella tularensis alters the structure of its lipopolysaccharide during growth in phagocytes. In addition, he is interested in how lipopolysaccharide interacts with inflammatory caspases 4 and 11.

Publications

Weiss, J., Barker, J. H. (2018). Diverse pro-inflammatory endotoxin recognition systems of mammalian innate immunity. F1000Research, 7, 516. DOI: 10.12688/f1000research.13977.1.

Kinkead, L., Whitmore, L., McCracken, J., Fletcher, J., Ketelsen, B., Kaufman, J., Weiss, D., Barker, J. H., Allen, L. H. (In Press). Bacterial lipoproteins and other factors released by Francisella tularensis modulate human neutrophil lifespan: effects of a TLR1 SNP on apoptosis inhibition. Cellular Microbiology.

Wacker, M. A., Teghanemt, A., Weiss, J. P. & Barker, J. H. (2017). High Affinity Caspase-4 Binding to Lipopolysaccharide Presented as High Molecular Weight Aggregates or in Outer Membrane Vesicles. Innate Immunity, 23(4), 336-344. PMID: 28409545.

Barker, J. H., Kaufman, J. W., Apicella, M. A. & Weiss, J. P. (2016). Evidence Suggesting That Francisella tularensis O-Antigen Capsule Contains a Lipid A-Like Molecule That Is Structurally Distinct from the More Abundant Free Lipid A. (Vols. 11). pp. e0157842. San Francisco, California: PLoS One. PMID: 27326857.

Barker, J. H., Kaufman, J. W., Zhang, D. S. & Weiss, J. P. (2014). Metabolic labeling to characterize the overall composition of Francisella Lipid A and LPS grown in broth and in human phagocytes. Innate immunity, 20(1), 88-103. PMID: 23729477.

Yao, C., Dixit, U. G., Barker, J. H., Teesch, L., Love-Homan, L., Donelson, J. & Wilson, M. E. (2013). Attenuation of Leishmania metacyclic promastigotes by sterol depletion. Infection and Immunity, 81(7), 2507-17. PMID: 23630964.

Barker, J. H., Zhang, D. S., Kaufman, J. W. & Weiss, J. P. (2012). Metabolic Labeling with [14C]acetate to Characterize the Overall Composition of Lipid A and Lipopolysaccharide (LPS) of Francisella Grown in Broth and Human Dendritic Cells. 12th International Endotoxin and Innate Immunity Society Meeting.

Barker, J. H., Zhang, D. S., Kaufman, J. W. & Weiss, J. P. (2012). Metabolic Labeling with [14C]acetate to Characterize the Overall Composition of Lipid A and Lipopolysaccharide (LPS) of Francisella Grown in Broth and Human Dendritic Cells. 7th International Conference on Tularemia.

Schwartz, J. T., Barker, J. H., Long, M. E., Kaufman, J., McCracken, J. & Allen, L. A. (2012). Natural IgM mediates complement-dependent uptake of Francisella tularensis by human neutrophils via complement receptors 1 and 3 in nonimmune serum. Journal of immunology (Baltimore, Md. : 1950), 189(6), 3064-77. PMID: 22888138.

Schwartz, J. T., Barker, J. H., Kaufman, J., Fayram, D. C. & Allen, L. H. (2012). Francisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespan. J. Immunol., 188(7), 3351-63. PMID: 22357630.

Barker, J. H., Kaufman, J. W., Buchan, B. W., Jones, B. D. & Apicella, M. A. (2011). Francisella tularensis Capsule Modulates Complement Deposition. University of Iowa Internal Medicine Research Day.

Barker, J. H., Zhang, D., Kaufman, J. W. & Weiss, J. P. (2011). Radiolabeling of Francisella Reveals the Heterogeneity of Francisella LPS Molecules. Midwest Microbial Pathogenesis Conference.

Barker, J. H., Baman, N. K., Kaufman, J. W. & Allen, L. A. (2010). Francisella tularensis Modulates Membrane Trafficking in Human Monocyte-Derived Dendritic Cells. University of Iowa Health Sciences Research Week.

Barker, J. H., Kaufman, J. W., Buchan, B. W., Jones, B. D. & Apicella, M. A. (2010). Francisella tularensis Capsule Modulates Complement Deposition. University of Iowa Internal Medicine Research Day.

Barker, J. H., Kaufman, J. W., Buchan, B. W., Jones, B. D., Apicella, M. A. & Allen, L. A. (2010). An Avirulent fevR mutant of F. tularensis LVS activates complement more readily than wild-type bacteria. Midwest Microbial Pathogenesis Conference.

Barker, J. H., Baman, N. K. & Allen, L. A. (2009). Francisella tularensis LVS Escapes from the Phagosome of Human Monocyte-Derived Dendritic Cells. Keystone Symposium-Dendritic Cells.

Barker, J. H., McCaffrey, R. L., Baman, N. K., Allen, L. A., Weiss, J. P. & Nauseef, W. M. (2009). The role of complement opsonization in interactions between F. tularensis subsp. novicida and human neutrophils. Microbes and infection / Institut Pasteur, 11(8-9), 762-9. PMID: 19409509.

Barker, J. H., Baman, N. K. & Allen, L. A. (2008). Francisella tularensis LVS Escapes from the Phagosome of Human Monocyte-Derived Dendritic Cells. Society for Leukocyte Biology.

Barker, J. H., Nauseef, W. M. (2008). The Role of Complement Opsonization in the Phagocytosis of Francisella tularensis by Human Neutrophils. Tularemia Workshop.

Barker, J. H. (2007). The Role of Complement Opsonization in the Phagocytosis of Francisella tularensis by Human Neutrophils. 40th Annual Meeting of the Society for Leukocyte Biology, Boston, MA.

Barker, J. H. (2007). The Role of Complement Opsonization in the Phagocytosis of Francisella tularensis by Human Neutrophils. Midwest Microbial Pathogenesis Conference.

Barker, J. H., Weiss, J., Apicella, M. A. & Nauseef, W. M. (2006). Basis for the failure of Francisella tularensis lipopolysaccharide to prime human polymorphonuclear leukocytes. Infection and immunity, 74(6), 3277-84. PMID: 16714555.

Barker, J. H., Weiss, J., Apicella, M. A. & Nauseef, W. M. (2004). Francisella tularensis Live Vaccine Strain (LVS) Lipopolysaccharide Does Not Modulate Priming of Human Neutrophils. Society for Leukocyte Biology.

Barker, J. H., Weiss, J., Apicella, M. A. & Nauseef, W. M. (2004). Francisella tularensis Live Vaccine Strain Lipopolysaccharide does not Bind to Lipopolysaccharide-binding Protein. International Endotoxin Society.

Barker, J. H., Luby, J. P., Dalley, A. S., Bartek, W. M., Burns, D. K. & Erdman, D. D. (2003). Fatal type 3 adenoviral pneumonia in immunocompetent adult identical twins. Clin. Infect. Dis., 37(10), e142-6. PMID: 14583886.

Barker, J. H., Musher, D. M., Silberman, R., Phan, H. M. & Watson, D. A. (1999). Genetic relatedness among nontypeable pneumococci implicated in sporadic cases of conjunctivitis. Journal of clinical microbiology, 37(12), 4039-41. PMID: 10565927.