Joel C. Geerling, MD, PhD

Portrait
Assistant Professor of Neurology

Contact Information

Clinic: 2nd floor Roy Carver Pavilion
200 Hawkins
Iowa City, IA 52242-1009
319-356-2571

Lab: 1320 PBDB
169 Newton Rd.
Iowa City, IA 52242-1009
319-353-5425

Education

MD, Medicine, Washington University School of Medicine
PhD, Neuroscience, Washington University School of Medicine

Postdoctoral Fellow, Neuroscience, Washington University School of Medicine
Internship, Internal Medicine, Columbia University Medical Center / New York-Presbyterian Hospital
Resident, Neurology, Harvard Medical School / Beth Israel Deaconess Medical Center
Fellow, Cognitive and behavioral neurology, Beth Israel Deaconess Medical Center / Harvard Medical School
Postdoctoral Fellow, Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School

Licensure and Certifications

American Board of Neurology and Psychiatry certification - American Board of Neurology and Psychiatry

Center, Program and Institute Affiliations

Aging Mind and Brain Initiative

Research Summary

In the lab, we use genetic techniques to isolate and manipulate neurons that mediate basic physiologic functions including sleep, appetite, bladder control, and thermoregulation. My focus lies in identifying and deciphering previously unknown connections between neurons in the brainstem and other subcortical brain regions by applying basic developmental-genetic information and selecting Cre-transgenic mouse models that allow us to target specific subpopulation(s) of neurons that control wakefulness and other basic functions. Beyond the basic scientific importance of this work, we hope to improve the understanding and treatment of patients with disorders of arousal and autonomic function, particularly in disorders of consciousness and patients with age-related neurodegenerative diseases such as Parkinson's, Lewy body disease, Alzheimer's dementia, MSA, and FTD.

Publications

Verstegen AMJ,, Vanderhorst, V., Gray, P. A., Zeidel, M. L. & Geerling, J. C. (2017). Barrington's nucleus: Neuroanatomic landscape of the mouse "pontine micturition center". The Journal of comparative neurology, 525(10), 2287-2309. PMID: 28340519.

Resch, J. M., Fenselau, H., Madara, J. C., Wu, C., Campbell, J. N., Lyubetskaya, A., Dawes, B. A., Tsai, L. T., Li, M. M., Livneh, Y., Ke, Q., Kang, P. M., Fejes-Tóth, G., Náray-Fejes-Tóth, A., Geerling, J. C. & Lowell, B. B. (2017). Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Neuron, 96(1), 190-206.e7. PMID: 28957668.

Geerling, J. C., Yokota, S., Rukhadze, I., Roe, D. & Chamberlin, N. L. (2017). Kölliker-Fuse GABAergic and glutamatergic neurons project to distinct targets. The Journal of comparative neurology. PMID: 28032634.

Hale, A., Geerling, J., Schmolze, D., Pfannl, R. & Karchmer, A. W. (2016). A 63-Year-Old Man With Rapidly Progressive Dementia. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 63(1), 138-9. PMID: 27288527.

Abbott, S. B., Machado, N. L., Geerling, J. C. & Saper, C. B. (2016). Reciprocal Control of Drinking Behavior by Median Preoptic Neurons in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(31), 8228-37. PMID: 27488641.

Fischer, D. B., Boes, A. D., Demertzi, A., Evrard, H. C., Laureys, S., Edlow, B. L., Liu, H., Saper, C. B., Pascual-Leone, A., Fox, M. D. & Geerling, J. C. (2016). A human brain network derived from coma-causing brainstem lesions. Neurology. PMID: 27815400.

Geerling, J. C., Kim, M., Mahoney, C. E., Abbott, S. B., Agostinelli, L. J., Garfield, A. S., Krashes, M. J., Lowell, B. B. & Scammell, T. E. (2016). Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. American journal of physiology. Regulatory, integrative and comparative physiology, 310(1), R41-54. PMID: 26491097.

McCarron, D. A., Kazaks, A. G., Geerling, J. C., Stern, J. S. & Graudal, N. A. (2014). Response to "Salt: the dying echoes of the food industry". (Vols. 27). (2), pp. 282-4. American journal of hypertension. PMID: 24356573.

Geerling, J. C. (2013). Waking under pressure. (Vols. 14). (11), pp. 1045-6. Sleep medicine. PMID: 24047535.

McCarron, D. A., Kazaks, A. G., Geerling, J. C., Stern, J. S. & Graudal, N. A. (2013). Normal range of human dietary sodium intake: a perspective based on 24-hour urinary sodium excretion worldwide. American journal of hypertension, 26(10), 1218-23. PMID: 23978452.

Shin, J. W., Geerling, J. C., Stein, M. K., Miller, R. L. & Loewy, A. D. (2011). FoxP2 brainstem neurons project to sodium appetite regulatory sites. Journal of chemical neuroanatomy, 42(1), 1-23. PMID: 21605659.

Geerling, J. C., Stein, M. K., Miller, R. L., Shin, J. W., Gray, P. A. & Loewy, A. D. (2011). FoxP2 expression defines dorsolateral pontine neurons activated by sodium deprivation. Brain research, 1375, 19-27. PMID: 21108936.

Geerling, J. C., Shin, J. W., Chimenti, P. C. & Loewy, A. D. (2010). Paraventricular hypothalamic nucleus: axonal projections to the brainstem. The Journal of comparative neurology, 518(9), 1460-99. PMID: 20187136.

Shin, J. W., Geerling, J. C. & Loewy, A. D. (2009). Vagal innervation of the aldosterone-sensitive HSD2 neurons in the NTS. Brain research, 1249, 135-47. PMID: 19010311.

McCarron, D. A., Geerling, J. C., Kazaks, A. G. & Stern, J. S. (2009). Can dietary sodium intake be modified by public policy?. Clinical journal of the American Society of Nephrology : CJASN, 4(11), 1878-82. PMID: 19833911.

Geerling, J. C., Loewy, A. D. (2009). Aldosterone in the brain. American journal of physiology. Renal physiology, 297(3), F559-76. PMID: 19261742.

Shin, J. W., Geerling, J. C. & Loewy, A. D. (2008). Inputs to the ventrolateral bed nucleus of the stria terminalis. The Journal of comparative neurology, 511(5), 628-57. PMID: 18853414.

Geerling, J. C., Chimenti, P. C. & Loewy, A. D. (2008). Phox2b expression in the aldosterone-sensitive HSD2 neurons of the NTS. Brain research, 1226, 82-8. PMID: 18620340.

Geerling, J. C., Loewy, A. D. (2008). Central regulation of sodium appetite. Experimental physiology, 93(2), 177-209. PMID: 17981930.

Geerling, J. C. (2008). Aldosterone-sensitive neurons and salt appetite. United States – Missouri: Washington University in St. Louis.

Geerling, J. C., Loewy, A. D. (2007). Sodium depletion activates the aldosterone-sensitive neurons in the NTS independently of thirst. American journal of physiology. Regulatory, integrative and comparative physiology, 292(3), R1338-48. PMID: 17068161.

Geerling, J. C., Loewy, A. D. (2007). Sodium deprivation and salt intake activate separate neuronal subpopulations in the nucleus of the solitary tract and the parabrachial complex. The Journal of comparative neurology, 504(4), 379-403. PMID: 17663450.

Shekhtman, E., Geerling, J. C. & Loewy, A. D. (2007). Aldosterone-sensitive neurons of the nucleus of the solitary tract: multisynaptic pathway to the nucleus accumbens. The Journal of comparative neurology, 501(2), 274-89. PMID: 17226797.

Geerling, J. C., Loewy, A. D. (2007). 11beta-hydroxysteroid dehydrogenase 2 vs. transgene: discrepant loci of expression in the adult brain. (Vols. 293). (1), pp. F440-1; author reply F442-3. American journal of physiology. Renal physiology. PMID: 17616576.

Geerling, J. C., Loewy, A. D. (2006). Aldosterone-sensitive neurons in the nucleus of the solitary tract: efferent projections. The Journal of comparative neurology, 497(2), 223-50. PMID: 16705681.

Geerling, J. C., Loewy, A. D. (2006). Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment. Brain research, 1115(1), 54-64. PMID: 16935272.

Geerling, J. C., Kawata, M. & Loewy, A. D. (2006). Aldosterone-sensitive neurons in the rat central nervous system. The Journal of comparative neurology, 494(3), 515-27. PMID: 16320254.

Geerling, J. C., Engeland, W. C., Kawata, M. & Loewy, A. D. (2006). Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(2), 411-7. PMID: 16407537.

Geerling, J. C., Mettenleiter, T. C. & Loewy, A. D. (2006). Viral Tracers for the Analysis of Neural Circuits. In L. Zaborsky , F. G. Wouterlood & J. L. Lanciego (Eds.) Neuroanatomical Tract-Tracing 3. pp. 263-303. New York, NY: Springer.

Geerling, J. C., Loewy, A. D. (2006). Aldosterone-sensitive neurons in the nucleus of the solitary tract: bidirectional connections with the central nucleus of the amygdala. The Journal of comparative neurology, 497(4), 646-57. PMID: 16739197.

Sequeira, S. M., Geerling, J. C. & Loewy, A. D. (2006). Local inputs to aldosterone-sensitive neurons of the nucleus tractus solitarius. Neuroscience, 141(4), 1995-2005. PMID: 16828976.

Geerling, J. C., Loewy, A. D. (2006). Aldosterone-sensitive neurons in the nucleus of the solitary: efferent projections. The Journal of comparative neurology, 498(3), 223-50. PMID: 16933386.

Geerling, J. C., Sequeira, S. M. & Loewy, A. D. (2005). Increased number of aldosterone-sensitive NTS neurons in Dahl salt-sensitive rats. Brain research, 1065(1-2), 142-6. PMID: 16316636.

Geerling, J. C., Mettenleiter, T. C. & Loewy, A. D. (2003). Orexin neurons project to diverse sympathetic outflow systems. Neuroscience, 122(2), 541-50. PMID: 14614918.