Dr. Yuriy M. Usachev, an Associate Professor of Pharmacology and Anesthesia, has received a new R01 grant from the NIH/NINDS (NS087068) titled "Mitochondria fission and fusion (MFF)-dependent mechanisms in neuronal toxicity". Dr. Stefan Strack, a Professor of Pharmacology and Pathology, is a Co-Investigator on this grant. This project will examine the roles of the mitochondrial transporters MCU and MCUb, and the accessory molecules MICU1-MICU3 in mitochondrial Ca2+ transport, Ca2+ signaling and toxicity in neurons, and investigate how alteration of the mitochondrial architecture affects MCU/MCUb-mediated Ca2+ transport and Ca2+ homeostasis in neurons exposed to excitotoxic conditions or ischemia. These studies may lead to the development of new therapeutic strategies for neuroprotection in stroke and neurodegenerative disorders.
Dr. Usachev receives new R01 from NIH/NINDS
Date:
Friday, March 21, 2014