Address: 2-340 BSB
Phone: (319) 335-8926
Email: addison-woll@uiowa.edu
Mentor: Curt D. Sigmund, PhD
Undergraduate Institution: Southeast Missouri State University
Graduate Program: Molecular Medicine
Year Entered Into Program: 2015
Research Description
Elucidation of the RBP7 dependent PPARg antioxidant hub in the endothelium
Peroxisome Proliferator-Activated Receptor gamma (PPARg) has been shown to regulate hypertension in animal models through regulation of nitric oxide bioavailability in the vasculature. Specifically in the endothelium we have found that a PPARg target gene, Retinol Binding Protein 7 (RBP7), is required for these effects. My project is to characterize the mechanism of RBP7 and PPARg interaction, as well as define the necessity of RBP7 expression in the endothelium in vivo in a genetic compliment study.
Awards
- Graduate College Post-Comprehensive Research Award, 2016-2017