Logo for University of Iowa Health Care This logo represents the University of Iowa Health Care

Kristin Claflin, PhD

Address: 3310C PBDB
Phone: (319) 335-7660
Email: kristin-claflin@uiowa.edu

Mentor: Matthew J. Potthoff, PhD

PhD Institution: University of Iowa, 2016

Research Description

Neural control of energy expenditure by FGF21


  • Pharmaceutical and Pharmacological Sciences Research Retreat, Poster Presentation Award, University of Iowa, 2022
  • NIH/NRSA Postdoctoral Fellowship (F32 DK117510 ), 2018-2020
  • Cardiovascular Interdisciplinary Research Fellowship (T32 HL007121), 2017-2018
  • American Heart Association, Midwest Affiliate Predoctoral Fellowship (14PRE20380401), 2014-2016


  1. Jensen-Cody, SO, Flippo, KH, Claflin, KE, Yavuz, Y, Sapouckey, SA, Walters, GC, Usachev, YM, Atasoy, D, Gillum, MP, and Potthoff, MJ.: FGF21 signals to glutamatergic neurons in the ventromedial hypothalamus to suppress carbohydrate intake. Cell Metabolism, 32(2):273-286.e6, 2020. PMID: 32640184
  2. Markan, KR, Boland, LK, King-McAlpin, AQ, Claflin, KE, Leaman, MP, Kemerling, MK, Stonewall, MM, Amendt, BA, Ankrum, JA, and Potthoff, MJ.:  Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo. Molecular Metabolism, 36:100965, 2020. PMID: 32240964; PMCID: PMC7115112
  3. Sapouckey, SA, Morselli, LL, Deng, G, Patil, C, Balapattabi, K, Oliveira V, Claflin, KE, Gomez, J, Pearson, NA, Potthoff, MJ, Gibson-Corley, KN, Sigmund, CD and Grobe, JL.: Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Am J Physiol Regul Integr Comp Physiol, 318(5):R855-R869, 2020. PMID: 32186897; PMCID: PMC7272763
  4. Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidiner MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, and Grobe JL.:  Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin. Am J Physiol Regul Integr Comp Physiol, 314(6):R770-R780, 2018. PMCID: PMC6032302
  5. Morselli LL, Claflin KE, Cui H, and Grobe JL.:  Control of energy expenditure by AgRP neurons of the arcuate nucleus: neurocircuitry and signaling pathways. Curr Hypertens Rep. 20(3):25, 2018.  PMCID: PMC5882211
  6. Claflin, KE, Sandgren, JA, Lambert, AM, Weidemann, BJ, Littlejohn, NK, Burnett, CML, Pearson, NA, Morgan, DA, Rahmouni, K. and Grobe, JL.: Angiotensin AT1A receptors on leptin receptor-expressing cells control metabolism. J Clin Invest. 127(4):1414-1424, 2017. PMCID: PMC5373887
  7. Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL.: Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 16(6):1548-60, 2016.  PMCID: PMC4981564
  8. von Holstein-Rathlou S, BonDurant LD, Peltekian L, Naber MC, Yin TC, Claflin KE, Urizar AI, Madsen AN, Ratner C, Holst B, Karstoft K, Vandenbeuch A, Anderson CB, Cassell MD, Thompson AP, Solomon TP, Rahmouni K, Kinnamon SC, Pieper AA, Gillum MP, Potthoff MJ.:  FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. Cell Metab 23(2):335-43, 2016.  PMCID: PMC4756759
  9. Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL.: Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System. Sci Rep. 5:11123, 2015.  PMCID: PMC4464075
  10. Claflin KE, Grobe JL.:  Control of energy balance by the brain renin-angiotensin system. Curr Hypertens Rep. 17(5):38, 2015.  PMID: 25833461
  11. Chen, Y.H., Claflin, K., Geoghegan, J.C. and Davidson, B.L.: Sialic acid deposition impairs the utility of AAV9, but not peptide-modified AAVs for brain gene therapy in a mouse model of lysosomal storage disease. Mol Ther. 20(7):1393-1399, 2012. PMCID:3392983