Hiroto Kawasaki, MD, PhD

Portrait
Associate Professor of Neurosurgery

Contact Information

Office
1620 JCP
200 Hawkins Dr
Iowa City, IA 52242
319-384-8239

Education

MD, School of Medicine, Chiba University
PhD, Medical Science, Tokyo Women's Medical University
Resident, Neurosurgery, Neurological Institute, Toyko Women's Medical University
Postdoctoral Fellow, Neurology, Neurosurgery, Physiology, Montreal Neurological Institute, McGill University
Postdoctoral Fellow, Neurology, University of Iowa Carver College of Medicine

Licensure and Certifications

Iowa Medical License - Iowa Board of Medicine
Board Certification - Japan Neurosurgical Society

Research Summary

Neurophysiology of Emotion Processing in the Human Brain, Neurophysiology of Auditory Cortex, Information processing of the Brain, Surgical Treatment of Epilepsy

Publications

Nourski, K. V., Steinschneider, M., Rhone, A. E., Kawasaki, H., Howard 3rd, M. A. & Banks, M. I. (2018). Auditory Predictive Coding across Awareness States under Anesthesia: An Intracranial Electrophysiology Study. JNeuroscience, 38(39), 8441-8452. PMID: 30126970.

Kovach, C. K., Oya, H. & Kawasaki, H. (2018). The bispectrum and its relationship to phase-amplitude coupling. Neuroimage, 173, 518-39. PMID: 29481965.

Oya, H., Gander, P. E., Petkov, C. I., Aolphs, R., Nourski, K. V., Kawasaki, H., Howard, M. A. & Griffiths, T. D. (2017). Neural phase locking predicts BOLD response in human auditory cortex. Neuroimage, 169, 286-301. PMID: 29274745.

Louty, O. `., Reddy, C., Holland, M., Kovach, C., Kawasaki, H., Oya, H., Greenlee, J., Hitchon, P. & Howard, M. (2017). Precision surgery of rolandic glioma and insights from extended functional mapping. Clin Neurol Neurosurg, 163, 60-6. PMID: 29073500.

Baroni, F., van Kempen, J., Kawasaki, H., Kovach, C. K., Oya, H., Howard, M. A., Adolphs, R. & Tsuchiya, N. (2017). Intracranial markers of conscious face perception in humans. Neuroimage, 162, 322-43. PMID: 28882629.

Abel, T. J., Woodroffe, R. W., Nourski, K. V., Moritani, T., Capizzano, A. A., Kirby, P., Kawasaki, H., Howard 3rd, M. & Werz, M. A. (2017). Role of the temporal pole in temporal lobe epilepsy seizure networks: an intracranial electrode investigation. J Neurosurg, Epub ahead of print. PMID: 29027858.

Nagahama, Y., Kovach, C. K., Ciliberto, M., Joshi, C., Rhone, A. E., Vesole, A., Gander, P. E., Nourski, K. V., Oya, H., Howard 3rd, M. A., Kawasaki, H. & Dlouhy, B. J. (2017). Localization of musicogenic epilepsy to Heschl's gyrus and superior temporal plane: case report. J Neurosurg, Epub ahead of print. PMID: 28946181.

Nagahama, Y., Dlouhy, B. J., Nakagawa, D., Kamm, J., Hasan, D., Howard 3rd, M. A. & Kawasaki, H. (2017). Bone flap elevation for intracranial EEG monitoring: technical note. J Neurosurg, Epub ahead of print. PMID: 28946179.

Haun, A. M., Oizumi, M., Kovach, C. K., Kawasaki, H., Oya, H., Howard, M. A., Adolphs, R. & Tsuchiya, N. (2017). Conscious Perception as Integrated Information Patterns in Human Electrocorticography. eNeuro, 4(5), pii: ENEURO.0085-17.2017. PMID: 29085895.

Nourski, K. V., Banks, M., Steinschneider, M., Rhone, A. E., Kawasaki, H., Mueller, R. N., Todd, M. M. & Howard 3rd, M. A. (2017). Electrocorticographic delineation of human auditory cortical fields based on effects of propofol anesthesia. Neuroimage, 152, 78-93. PMID: 28254512.

Oya, H., Howard, M. A., Magnotta, V. A., Kruger, A., Griffiths, T. D., Lemieux, L., Carhmichael, D. W., Petkov, C. I., Kawasaki, H., Kovach, C. K., Sutterer, M. J. & Adolphs, R. (2017). Mapping effective connectivity in the human brain with concurrent intracranial electrical stimulation and BOLD-fMRI. J Neurosci Methods, 277, 101-12. PMID: 28012852.

Nagahama, Y., Peters, D., Kumonda, S., Vesole, A., Joshi, C., Dlouhy, B. & Kawasaki, H. (2017). Delayed diagnosis of shunt overdrainage following functional hemispherotomy and ventriculoperitoneal shunt placement in a hemimegalencephaly patient. Epilepsy Behav Case Rep, 7, 34-6. PMID: 28348960.

Nagahama, Y., Joshi, C., Dlouhy, B., Wu, A. Y., Abel, T. J., Baumbach, G. & Kawasaki, H. (2016). Functional hemispherotomy in Rasmussen syndrome in the absence of classic MRI findings. Epilepsy Behav Case Rep, 7, 24-7. PMID: 28239546.

Yang, J., Bassuk, A. G., Merl-Pham, J., Hsu, C. S., Colgan, D. F., Li, X., Au, K. S., Zhank, L., Smemo, S., Justus, S., Nagahama, Y., Grossbach, A. J., Howard 3rd, M. A., Kawasaki, H., Feldstein, N. A., Dobyns, W. B., Northrup, H., Hauck, S. M., Ueffing, M., Mahajan, V. B. & Tsang, S. H. (2016). Catenin delta-1 (CTNND1) phosphorylation controls the mesenchymal to epithelial transition in astrocytic tumors. Hum Mol Genet, 25(19), 4201-10. PMID: 27516388.

Abel, T. J., Woodroffe, R., Moritani, T., Kirby, P., Howard, M. A., Kawasaki, H. & Werz, M. A. (2016). The Role of the Temporal Pole in Temporal Lobe Seizure Networks: An Intracranial Electrode Investigation. Neurosurgery, 63(Suppl 1), 194. PMID: 27399521.

Kingyon, J., Behroozmand, R., Kelley, R., Oya, H., Kawasaki, H., Narayanan, N. S. & Greenlee, J. D. (2016). Corrigendum to "High-gamma band fronto-temporal coherence as a measure of functional connectivity in speech motor control" [Neuroscience 305 (2015) 15-25]. pp. pii: S0306-4522(16)30324-4. Neuroscience. PMID: 27448528.

Abel, T. J., Rhone, A. E., Nourski, K. V., Ando, T. K., Oya, H., Kovach, C. K., Kawasaki, H., Howard 3rd, M. A. & Tranel, D. (2016). Beta modulation reflects name retrieval in the human anterior temporal lobe: an intracranial recording study. J Neurophysiol, 115(6), 3052-61. PMID: 27075536.

Sedley, W., Gander, P. E., Kumar, S., Kovach, C. K., Oya, H., Kawasaki, H., Howard, M. A. & Griffiths, T. D. (2016). Neural Signatures of Perceptual Inference. Elife, pii: e11476. PMID: 26949254.

Behroozmand, R., Oya, H., Nourski, K. V., Kawasaki, H., Larson, C. R., Brugge, J. F., Howard 3rd, M. A. & Greenlee, J. D. (2016). Neural Correlates of Vocal Production and Motor Control in Human Heschl's Gyrus. J Neurosci, 36(7), 2302-15. PMID: 26888939.

Rhone, A. E., Nourski, K. V., Oya, H., Kawasaki, H., Howard 3rd, M. A. & McMurray, B. (2016). Can you hear me yet? An intracranial investigation of speech and non-speech audiovisual interactions in human cortex. Lang Cogn Neurosci, 31(2), 284-302. PMID: 27182530.

Kingyon, J., Behroozmand, R., Kelley, R., Oya, H., Kawasaki, H., Narayanan, N. S. & Greenlee, J. D. (2015). High-gamma band fronto-temporal coherence as a measure of functional connectivity in speech motor control. Neuroscience, 305, 15-25. PMID: 26232713.

Jenison, R. L., Reale, R. A., Armstrong, A. L., Oya, H., Kawasaki, H. & Howard 3rd, M. A. (2015). Sparse Spectro-Temporal Receptive Fields Based on Multi-Unit and High-Gamma Responses in Human Auditory Cortex. (Vols. 10). (9), pp. e0137915. PLoS One. PMID: 26367010.

Nourski, K. V., Steinschneider, M., Rhone, A. E., Oya, H., Kawasaki, H., Howard 3rd, M. A. & McMurray, B. (2015). Sound identification in human auditory cortex: Differential contribution of local field potentials and high gamma power as revealed by direct intracranial recordings. Brain Lang, 148, 37-50. PMID: 25819402.

Abel, T. J., Kawasaki, H. & Barrash, J. (2015). In response: Naming and recognition after laser amygdalohippocampotomy: Is the hippocampus involved?. (Vols. 56). (8), pp. 1317. Epilepsia. PMID: 26235736.

Dlouhy, B. J., Gehlbach, B. K., Kreple, C. J., Kawasaki, H., Oya, H., Buzza, C., Granner, M. A., Welsh, M. J., Howard, M. A., Wemmie, J. A. & Richerson, G. B. (2015). Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation. J Neurosci, 35(28), 10281-9. PMID: 26180203.

Sedley, W., Gander, P. E., Kumar, S., Oya, H., Kovach, C. K., Nourski, K. V., Kawasaki, H., Howard 3rd, M. A. & Griffiths, T. D. (2015). Intracranial Mapping of a Cortical Tinnitus System using Residual Inhibition. Curr Biol, 25(9), 1208-14. PMID: 25913402.

Nourski, K. V., Steinschneider, M., Oya, H., Kawasaki, H. & Howard 3rd, M. A. (2015). Modulation of response patterns in human auditory cortex during a target detection task: An intracranial electrophysiology study. Int J Psychophysiol, 95(2), 191-201. PMID: 24681353.

Abel, T. J., Rhone, A. E., Nourski, K. V., Kawasaki, H., Oya, H., Griffiths, T. D., Howard 3rd, M. A. & Tranel, D. (2015). Direct physiologic evidence of a heteromodal convergence region for proper naming in human left anterior temporal lobe. J Neurosci, 35(4), 1513-20. PMID: 25632128.

Nourski, K. V., Steinschneider, M., McMurray, B., Kovach, C. K., Oya, H., Kawasaki, H. & Howard 3rd, M. A. (2014). Functional organization of human auditory cortex: investigation of response latencies through direct recordings. Neuroimage, 101, 598-609. PMID: 25019680.

Bijanki, K. R., Kovach, C. K., McCormick, L. M., Kawasaki, H., Dlouhy, B. J., Feinstein, J., Jones, R. D. & Howard 3rd, M. A. (2014). Case report: stimulation of the right amygdala induces transient changes in affective bias. Brain Stimul, 7(5), 690-3. PMID: 24972588.

Steinschneider, M., Nourski, K. V., Rhone, A. E., Kawasaki, H., Oya, H. & Howard 3rd, M. A. (2014). Differential activation of human core, non-core and auditory-related cortex during speech categorization tasks as revealed by intracranial recordings. Front Neurosci, 8, 240. PMID: 25157216.

Nourski, K. V., Steinschneider, M., Oya, H., Kawasaki, H., Jones, R. D. & Howard, M. A. (2014). Spectral organization of the human lateral superior temporal gyrus revealed by intracranial recordings. Cereb Cortex, 24(2), 340-52. PMID: 23048019.

Abel, T. J., Rhone, A. E., Nourski, K. V., Granner, M. A., Oya, H., Griffiths, T. D., Tranel, D. T., Kawasaki, H. & Howard, M. A. (2014). Mapping the temporal pole with a specialized electrode array: technique and preliminary results. Physiol Meas, 35(3), 323-37. PMID: 24480831.

Greenlee, J. D., Behroozmand, R., Nourski, K. V., Oya, H., Kawasaki, H. & Howard, M. A. (2014). Using speech and electrocorticography to map human auditory cortex. Conf Proc IEEE Eng Med Biol Soc, 2014, 6798-801. PMID: 25571557.

Garell, P. C., Bakken, H., Greenlee, J. D., Volkov, I. O., Reale, R. A., Oya, H., Kawasaki, H., Howard, M. A. & Brugge, J. F. (2013). Functional connection between posterior superior temporal gyrus and ventrolateral prefrontal cortex in human. Cereb Cortex, 23(10), 2309-21. PMID: 22879355.

Nourski, K. V., Etler, C. P., Brugge, J. F., Oya, H., Kawasaki, H., Reale, R. A., Abbas, P. J., Brown, C. J. & Howard, M. A. (2013). Direct recordings from the auditory cortex in a cochlear implant user. J Assoc Res Otolaryngol, 14(3), 435-50. PMID: 23519390.

Greenlee, J. D., Behroozmand, R., Larson, C. R., Jackson, A. W., Chen, F., Hansen, D. R., Oya, H., Kawasaki, H. & Howard, M. A. (2013). Sensory-motor interactions for vocal pitch monitoring in non-primary human auditory cortex. PLoS One, 8(4), e60783. PMID: 23577157.

Nourski, K. V., Brugge, J. F., Reale, R. A., Kovach, C. K., Oya, H., Kawasaki, H., Jenison, R. L. & Howard, M. A. (2013). Coding of repetitive transients by auditory cortex on posterolateral superior temporal gyrus in humans: an intracranial electrophysiology study. J Neurophysiol, 109(5), 1283-95. PMID: 23236002.

Flouty, O. E., Oya, H., Kawasaki, H., Reddy, C. G., Fredericks, D. C., Gibson-Corley, K. N., Jeffery, N. D., Gillies, G. T. & Howard, M. A. (2013). Intracranial somatosensory responses with direct spinal cord stimulation in anesthetized sheep. PLoS One, 8(2), e56266. PMID: 23457542.

Flouty, O., Oya, H., Kawasaki, H., Wilson, S., Reddy, C. G., Jeffrey, N. D., Brennan, T. J., Gibson-Corley, K. N., Utz, M., Gillies, G. T. & Howard, M. A. (2012). A new device concept for directly modulating spinal cord pathways: initial in vivo experimental results. Physiol Meas, 33(12), 2003-15. PMID: 23151433.

Kawasaki, H., Tsuchiya, N., Kovach, C. K., Nourski, K. V., Oya, H., Howard, M. A. & Adolphs, R. (2012). Processing of facial emotion in the human fusiform gyrus. J Cogn Neurosci, 24(6), 1358-70. PMID: 22185494.

Dlouhy, B. J., Viljoen, S. V., Kung, D. K., Vogel, T. W., Granner, M. A., Howard, M. A. & Kawasaki, H. (2012). Vagus nerve stimulation after lead revision. Neurosurg Focus, 32(3), E11. PMID: 22380852.

Steinschneider, M., Nourski, K. V., Kawasaki, H., Oya, H., Brugge, J. & Howard, M. A. (2011). Intracranial study of speech-elicited activity on the human posterolateral superior temporal gyrus. Cereb Cortex, 21(10), 2332-47. PMID: 21368087.

Kumar, S., Sedley, W., Nourski, K. V., Kawasaki, H., Oya, H., Patterson, R. D., Howard, M. A., Friston, K. J. & Griffiths, T. D. (2011). Predictive coding and pitch processing in the auditory cortex. J Cogn Neurosci, 23(10), 3084-94. PMID: 21452943.

Jenison, R. L., Rangel, A., Oya, H., Kawasaki, H. & Howard, M. A. (2011). Value encoding in single neurons in the human amygdala during decision making. J Neurosci, 31(1), 331-8. PMID: 21209219.

Greenlee, J. D., Jackson, A. W., Chen, F., Larson, C. R., Oya, H., Kawasaki, H., Chen, H. & Howard, M. A. (2011). Human auditory cortical activation during self-vocalization. PLoS One, 6(3), e14744. PMID: 21390228.

Kovach, C. K., Tsuchiya, N., Kawasaki, H., Oya, H., Howard, M. A. & Adolphs, R. (2011). Manifestation of ocular-muscle EMG contamination in human intracranial recordings. Neuroimage, 54(1), 213-33. PMID: 20696256.

Reddy, C. G., Dahdaleh, N. S., Albert, G., Chen, F., Hansen, D. R., Nourski, K. V., Kawasaki, H., Oya, H. & Howard, M. A. (2010). A method for placing Heschl gyrus depth electrodes. J Neurosurg, 112(6), 1301-7. PMID: 19663547.

Griffiths, T. D., Kumar, S., Sedley, W., Nourski, K. V., Kawasaki, H., Oya, H., Patterson, R. D., Brugge, J. & Howard, M. A. (2010). Direct recordings of pitch responses from human auditory cortex. Curr Biol, 20(12), 1128-32. PMID: 20605456.

Albert, G. W., Dahdaleh, N. S., Reddy, C. G., Hansen, D. R., Vogel, T. W., Kawasaki, H. & Howard, M. A. (2010). Postoperative radiographic findings in patients undergoing intracranial electrode monitoring for medically refractory epilepsy. J Neurosurg, 112(2), 449-54. PMID: 19698047.

Nourski, K. V., Reale, R. A., Oya, H., Kawasaki, H., Kovach, C. K., Chen, H., Howard, M. A. & Brugge, J. (2009). Temporal envelope of time-compressed speech represented in the human auditory cortex. J Neurosci, 29(49), 15564-74. PMID: 20007480.

Brugge, J., Nourski, K. V., Oya, H., Reale, R. A., Kawasaki, H., Steinschneider, M. & Howard, M. A. (2009). Coding of repetitive transients by auditory cortex on Heschl's gyrus. J Neurophysiol, 102(4), 2358-74. PMID: 19675285.

Reddy, C. G., Reddy, G. G., Kawasaki, H., Oya, H., Miller, L. E. & Howard, M. A. (2009). Decoding movement-related cortical potentials from electrocorticography. Neurosurg Focus, 27(1), E11. PMID: 19569886.

Oya, H., Kawasaki, H., Dahdaleh, N. S., Wemmie, J. A. & Howard, M. A. (2009). Stereotactic atlas-based depth electrode localization in the human amygdala. Stereotact Funct Neurosurg, 87(4), 219-28. PMID: 19556831.

Brugge, J., Volkov, I. O., Oya, H., Kawasaki, H., Reale, R. A., Fenoy, A., Steinschneider, M. & Howard, M. A. (2008). Functional localization of auditory cortical fields of human: click-train stimulation. Hear Res, 238(1-2), 12-24. PMID: 18207680.

Tsuchiya, N., Kawasaki, H., Oya, H., Howard, M. A. & Adolphs, R. (2008). Decoding face information in time, frequency and space from direct intracranial recordings of the human brain. PLoS One, 3(12), e3892. PMID: 19065268.

Greenlee, J. D., Oya, H., Kawasaki, H., Volkov, I. O., Severson, M. A., Howard, M. A. & Brugge, J. F. (2007). Functional connections within the human inferior frontal gyrus. J Comp Neurol, 503(4), 550-9. PMID: 17534935.

Oya, H., Poon, P. W., Brugge, J. F., Reale, R. A., Kawasaki, H., Volkov, I. O. & Howard, M. A. (2007). Functional connections between auditory cortical fields in human revealed by granger causality analysis of intracranial evoked potentials to sounds: comparison of two methods. Biosystems, 89(1-3), 198-207. PMID: 17184906.

D'Antuono, M., Kawasaki, H., Palmieri, C., Curia, G., Biagini, G. & Avoli, M. (2007). Antiepileptic drugs and muscarinic receptor-dependent excitation in the rat subiculum. Neuropharmacology, 52(5), 1291-302. PMID: 17337018.

Reale, R. A., Calvert, G. A., Thesen, T., Jenison, R. L., Kawasaki, H., Oya, H., Howard, M. A. & Brugge, J. F. (2007). Auditory-visual processing represented in the human superior temporal gyrus. Neuroscience, 145(1), 162-84. PMID: 17241747.

Gigout, S., Louvel, J., Kawasaki, H., D'Antuono, M., Armand, V., Kurcewicz, I., Oliver, A., Laschet, J., Turak, B., Devaux, B., Pumain, R. & Avoli, M. (2006). Effects of gap junction blockers on human neocortical synchronization. Neurobiol Dis, 22(3), 496-508. PMID: 16478664.

Kawasaki, H., Adolphs, R., Oya, H., Kovach, C., Damasio, H., Kaufman, O. & Howard, M. A. (2005). Analysis of single-unit responses to emotional scenes in human ventromedial prefrontal cortex. J Cogn Neurosci, 17(10), 1509-18. PMID: 16269093.

Oya, H., Adolphs, R., Kawasaki, H., Bechara, A., Damasio, A. & Howard, M. A. (2005). Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex. Proc Natl Acad Sci U S A, 102(23), 8351-6. PMID: 15928095.

Greenlee, J. D., Oya, H., Kawasaki, H., Volkov, I. O., Kaufman, O. P., Kovach, C. K., Howard, M. A. & Brugge, J. F. (2004). A functional connection between inferior frontal gyrus and orofacial motor cortex in human. J Neurophysiol, 92(2), 1153-64. PMID: 15056683.

Bakken, H. E., Kawasaki, H., Oya, H., Greenlee, J. D. & Howard, M. A. (2003). A device for cooling localized regions of human cerebral cortex. Technical note. J Neurosurg, 99(3), 604-8. PMID: 12959453.

Oya, H., Kawasaki, H., Howard, M. A. & Adolphs, R. (2002). Electrophysiological responses in the human amygdala discriminate emotion categories of complex visual stimuli. J Neurosci, 22(21), 9502-12. PMID: 12417674.

D'Antuono, M., Kawasaki, H., Palmieri, C. & Avoli, M. (2001). Network and intrinsic contributions to carbachol-induced oscillations in the rat subiculum. J Neurophysiol, 86(3), 1164-78. PMID: 11535667.

Kawasaki, H., Kaufman, O., Damasio, H., Damasio, A. R., Granner, M., Bakken, H., Hori, T., Howard, M. A. & Adolphs, R. (2001). Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortex. Nat Neurosci, 4(1), 15-6. PMID: 11135639.

Palmieri, C., Kawasaki, H. & Avoli, M. (2000). Topiramate depresses carbachol-induced plateau potentials in subicular bursting cells. Neuroreport, 11(1), 75-8. PMID: 10683833.

Kawasaki, H., Palmieri, C. & Avoli, M. (1999). Muscarinic receptor activation induces depolarizing potentials in bursting neurons of the rat subiculum. J Neurophysiol, 82(5), 2590-601. PMID: 10561429.

D'Antuono, M., Kawasaki, H., Tancredi, V. & Avoli, M. (1998). Contribution of GABAA-mediated conductances to anoxia-induced depolarization. Neuroreport, 9(18), 4189-92. PMID: 9926871.

Kawasaki, H., Tancredi, V., D'Arcangelo, G. & Avoli, M. (1998). Multiple actions of the novel anticonvulsant drug topiramate in the rat subiculum in vitro. Brain Res, 807(1-2), 125-34. PMID: 9757016.

Avoli, M., Methot, M. & Kawasaki, H. (1998). GABA-dependent generation of ectopic action potentials in the rat hippocampus. Eur J Neurosci, 10(8), 2714-22. PMID: 9767401.

Mattia, D., Kawasaki, H. & Avoli, M. (1997). Repetitive firing and oscillatory activity of pyramidal-like bursting neurons in the rat subiculum. Exp Brain Res, 114(3), 507-17. PMID: 9187287.

Mattia, D., Kawasaki, H. & Avoli, M. (1997). In vitro electrophysiology of rat subicular bursting neurons. Hippocampus, 7(1), 48-57. PMID: 9138668.

Kawasaki, H., Avoli, M. (1996). Excitatory effects induced by carbachol on bursting neurons of the rat subiculum. Neurosci Lett, 219(1), 1-4. PMID: 8961289.

Shimizu, T., Kawasaki, H., Kasuya, H. & Kuriata, K. (1995). Diagnosis of vascular compression in facial spasm by stereoscopic short-range magnetic resonance angiography. J Neurosurg, 83(3), 561-2. PMID: 7666238.