John Wemmie, MD, PhD

Portrait
Vice Chair for Research
Professor of Psychiatry
Professor of Molecular Physiology and Biophysics
Professor of Neurosurgery

Contact Information

Office
1314 Pappajohn Biomedical Discovery Building
Iowa City, IA 52242
319-384-3173

Education

BA, Chemistry, Central College, Pella, IA
MD, The University of Iowa College of Medicine, Iowa City, IA
PhD, Physiology and Biophysics, The University of Iowa, Iowa City, IA
Resident, Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA

Licensure and Certifications

ABPN Certification: Psychiatry - American Board of Psychiatry and Neurology

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Neuroscience, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

We recently found that the Acid Sensing Ion Channel, ASIC contributes to synaptic plasticity, learning and memory. ASIC is one of three mammalian members of the DEG/ENaC cation channel family in mammals that are transiently activated by low extracellular pH. ASIC channels are voltage-insensitive and share a large extracellular domain thought to serve as a receptor for extracellular stimuli. Disrupting ASIC in mice eliminated acid-evoked cation currents in central neurons and led to impaired hippocampal long-term potentiation (LTP), learning and memory. Our current research focuses on identifying the mechanism for ASIC activation in vivo, understanding the role of ASIC in synaptic plasticity, and establishing an uninterrupted link between ASIC channel activity and its behavioral impact.

Publications

Gutman, A. L., Cosme, C. V., Noterman, M. F., Worth, W. R., Wemmie, J. A. & LaLumiere, R. T. (2018). Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior. Addiction biology. PMID: 30397978.

Ghobbeh, A., Taugher, R. J., Alam, S. M., Fan, R., LaLumiere, R. T. & Wemmie, J. A. (2018). A novel role for acid-sensing ion channels in Pavlovian reward conditioning. Genes, brain, and behavior, e12531. PMID: 30375184.

Müller Ewald, V. A., De Corte, B. J., Gupta, S. C., Lillis, K. V., Narayanan, N. S., Wemmie, J. A. & LaLumiere, R. T. (2018). Attenuation of cocaine seeking in rats via enhancement of infralimbic cortical activity using stable step-function opsins. Psychopharmacology. PMID: 30003306.

Yang, T., Britt, J. K., Cintrón-Pérez, C. J., Vázquez-Rosa, E., Tobin, K. V., Stalker, G., Hardie, J., Taugher, R. J., Wemmie, J., Pieper, A. A. & Lee, A. (2018). Ca2+-Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity. Neuroscience, 380, 90-102. PMID: 29660444.

Johnson, C. P., Christensen, G. E., Fiedorowicz, J. G., Mani, M., Shaffer, Jr., J. J., Magnotta, V. A. & Wemmie, J. A. (2018). Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1? mapping. Bipolar disorders. PMID: 29316081.

Shaffer, J. J., Johnson, C. P., Fiedorowicz, J. G., Christensen, G. E., Wemmie, J. A. & Magnotta, V. A. (2017). Functional MRI Activation of Visual Sensory Areas is Reduced in Bipolar Disorder Manic and Depressed Mood States. Brain Imaging Behav. PMID: 28674759.

Taugher, R. J., Lu, Y., Fan, R., Ghobbeh, A., Kreple, C. J., Faraci, F. M. & Wemmie, J. A. (2017). ASIC1A in neurons is critical for fear-related behaviors. Genes Brain Behav.

Du, J., Price, M. P., Taugher, R. J., Grigsby, D., Ash, J. J., Stark, A. C., Hossain Saad, M. Z., Singh, K., Mandal, J., Wemmie, J. A. & Welsh, M. J. (2017). Transient acidosis while retrieving a fear-related memory enhances its lability. Elife.

Gutman, A. L., Nett, K. E., Cosme, C. V., Worth, W. R., Gupta, S. C., Wemmie, J. A. & LaLumiere, R. T. (2017). The extinction of cocaine seeking requires a window of infralimbic pyramidal neuron activity after unreinforced lever presses. J Neurosci, 3821-16.

Johnson, C. P., Follmer, R. L., Oguz, I., Warren, L. A., Christensen, G. E., Fiedorowicz, J. G., Magnotta, V. A. & Wemmie, J. A. (2015). Brain abnormalities in bipolar disorder detected by quantitative T1? mapping. Molecular psychiatry, 20(2), 201-6. PMID: 25560762.

Johnson, C. P., Follmer, R. L., Oguz, I., Warren, L. A., Christensen, G. E., Fiedorowicz, J. G., Magnotta, V. A. & Wemmie, J. A. (2015). Quantitative T1? mapping links the cerebellum and lithium use in bipolar disorder. Molecular psychiatry, 20(2), 149. PMID: 25727373.

Taugher, R. J., Ghobbeh, A., Sowers, L. P., Fan, R. & Wemmie, J. A. (2015). ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing. Front Neurosci, 9, 239. DOI: 10.3389/fnins.2015.00239.

Dlouhy, B. J., Gehlbach, B. K., Kreple, C. J., Kawasaki, H., Oya, H., Buzza, C., Granner, M. A., Welsh, M. J., Howard, M. A., Wemmie, J. A. & Richerson, G. B. (2015). Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation. J Neurosci, 35(28), 10281-9. DOI: 10.1523/jneurosci.0888-15.2015.

Heo, H. Y., Wemmie, J. A., Johnson, C. P., Thedens, D. R. & Magnotta, V. A. (2015). Eccentricity mapping of the human visual cortex to evaluate temporal dynamics of functional T1rho mapping. J Cereb Blood Flow Metab, 35(7), 1213-9. DOI: 10.1038/jcbfm.2015.94.

Fiedorowicz, J. G., Prossin, A. R., Johnson, C. P., Christensen, G. E., Magnotta, V. A. & Wemmie, J. A. (2015). Peripheral inflammation during abnormal mood states in bipolar I disorder. J Affect Disord, 187, 172-8. DOI: 10.1016/j.jad.2015.08.036.

Wassef, S. N., Wemmie, J., Johnson, C. P., Johnson, H., Paulsen, J. S., Long, J. D. & Magnotta, V. A. (2015). T1rho imaging in premanifest Huntington disease reveals changes associated with disease progression. Mov Disord, 30(8), 1107-14. DOI: 10.1002/mds.26203.

Johnson, C. P., Heo, H. Y., Thedens, D. R., Wemmie, J. A. & Magnotta, V. A. (2014). Rapid acquisition strategy for functional T1rho mapping of the brain. Magn Reson Imaging, 32(9), 1067-77. PMID: 25093630.

Kreple, C. J., Lu, Y., Taugher, R. J., Schwager-Gutman, A. L., Du, J., Stump, M., Wang, Y., Ghobbeh, A., Fan, R., Cosme, C. V., Sowers, L. P., Welsh, M. J., Radley, J. J., LaLumiere, R. T. & Wemmie, J. A. (2014). Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Nat Neurosci, 17(8), 1083-91. DOI: 10.1038/nn.3750.

Kreple, C. J., Lu, Y., LaLumiere, R. T. & Wemmie, J. A. (2014). Drug abuse and the simplest neurotransmitter. ACS Chem Neurosci, 5(9), 746-8. DOI: 10.1021/cn500154w.

Heo, H. Y., Wemmie, J., Thedens, D. & Magnotta, V. A. (2014). Evaluation of activity-dependent functional pH and T1rho response in the visual cortex. Neuroimage, 95, 336-43. DOI: 10.1016/j.neuroimage.2014.01.042.

Magnotta, V. A., Johnson, C. P., Follmer, R. & Wemmie, J. A. (2014). Functional t1rho imaging in panic disorder. Biol Psychiatry, 75(11), 884-91. DOI: 10.1016/j.biopsych.2013.09.008.

Du, J., Reznikov, L. R., Price, M. P., Zha, X. M., Lu, Y., Moninger, T. O., Wemmie, J. A. & Welsh, M. J. (2014). Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proc Natl Acad Sci U S A, 111(24), 8961-6. DOI: 10.1073/pnas.1407018111.

Stewart, A., Maity, B., Wunsch, A. M., Meng, F., Wu, Q., Wemmie, J. A. & Fisher, R. A. (2014). Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. Faseb j, 28(4), 1735-44. DOI: 10.1096/fj.13-235648.

Taugher, R. J., Lu, Y., Wang, Y., Kreple, C. J., Ghobbeh, A., Fan, R., Sowers, L. P. & Wemmie, J. A. (2014). The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis. J Neurosci, 34(31), 10247-55. DOI: 10.1523/jneurosci.1680-14.2014.

Wemmie, J. A., Taugher, R. J. & Kreple, C. J. (2013). Acid-sensing ion channels in pain and disease. Nat Rev Neurosci, 14(7), 461-71. DOI: 10.1038/nrn3529.

Feinstein, J. S., Buzza, C., Hurlemann, R., Follmer, R. L., Dahdaleh, N. S., Coryell, W. H., Welsh, M. J., Tranel, D. & Wemmie, J. A. (2013). Fear and panic in humans with bilateral amygdala damage. Nat Neurosci, 16(3), 270-2. PMID: 23377128.

Paemka, L., Mahajan, V. B., Skeie, J. M., Sowers, L. P., Ehaideb, S. N., Gonzalez-Alegre, P., Sasaoka, T., Tao, H., Miyagi, A., Ueno, N., Takao, K., Miyakawa, T., Wu, S., Darbro, B. W., Ferguson, P. J., Pieper, A. A., Britt, J. K., Wemmie, J. A., Rudd, D. S., Wassink, T., El-Shanti, H., Mefford, H. C., Carvill, G. L., Manak, J. R. & Bassuk, A. G. (2013). PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. PLoS One, 8(12), e80737. DOI: 10.1371/journal.pone.0080737.

Holland, P. R., Akerman, S., Andreou, A. P., Karsan, N., Wemmie, J. A. & Goadsby, P. J. (2012). Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura. Ann Neurol, 72(4), 559-63. PMID: 23109150.

Magnotta, V. A., Heo, H. Y., Dlouhy, B. J., Dahdaleh, N. S., Follmer, R. L., Thedens, D. R., Welsh, M. J. & Wemmie, J. A. (2012). Detecting activity-evoked pH changes in human brain. Proc Natl Acad Sci U S A, 109(21), 8270-3. PMID: 22566645.

Vralsted, V. C., Price, M. P., Du, J., Schnizler, M., Wunsch, A. M., Ziemann, A. E., Welsh, M. J. & Wemmie, J. A. (2011). Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning. Genes Brain Behav, 10(4), 444-50. PMID: 21324060.

Roghair, R. D., Wemmie, J. A., Volk, K. A., Scholz, T. D., Lamb, F. S. & Segar, J. L. (2011). Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice. Clin Sci (Lond), 121(10), 427-36. PMID: 21615331.

Tao, H., Manak, J. R., Sowers, L., Mei, X., Kiyonari, H., Abe, T., Dahdaleh, N. S., Yang, T., Wu, S., Chen, S., Fox, M. H., Gurnett, C., Montine, T., Bird, T., Shaffer, L. G., Rosenfeld, J. A., McConnell, J., Madan-Khetarpal, S., Berry-Kravis, E., Griesbach, H., Saneto, R. P., Scott, M. P., Antic, D., Reed, J., Boland, R., Ehaideb, S. N., El-Shanti, H., Mahajan, V. B., Ferguson, P. J., Axelrod, J. D., Lehesjoki, A. E., Fritzsch, B., Slusarski, D. C., Wemmie, J., Ueno, N. & Bassuk, A. G. (2011). Mutations in prickle orthologs cause seizures in flies, mice, and humans. Am J Hum Genet, 88(2), 138-49. PMID: 21276947.

Erkonen, G. E., Hermann, G. M., Miller, R. L., Thedens, D. L., Nopoulos, P. C., Wemmie, J. A. & Roghair, R. D. (2011). Neonatal leptin administration alters regional brain volumes and blocks neonatal growth restriction-induced behavioral and cardiovascular dysfunction in male mice. Pediatr Res, 69(5 Pt 1), 406-12. PMID: 21258265.

Wemmie, J. (2011). Neurobiology of Panic and pH chemosensation in the brain.

Wemmie, J. A. (2011). Neurobiology of panic and pH chemosensation in the brain. Dialogues Clin Neurosci, 13(4), 475-83. PMID: 22275852.

van der Plas, E. A., Boes, A. D., Wemmie, J. A., Tranel, D. & Nopoulos, P. (2010). Amygdala volume correlates positively with fearfulness in normal healthy girls. Soc Cogn Affect Neurosci, 5(4), 424-31. PMID: 20150341.

Walder, R. Y., Rasmussen, L. A., Rainier, J. D., Light, A. R., Wemmie, J. A. & Sluka, K. A. (2010). ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury. The journal of pain : official journal of the American Pain Society, 11(3), 210-8. PMID: 20015700.

Render, J. A., Howe, K. R., Wunsch, A. M., Guionaud, S., Cox, P. J. & Wemmie, J. A. (2010). Histologic examination of the eye of acid-sensing ion channel 1a knockout mice. International journal of physiology, pathophysiology and pharmacology, 2(1), 69-72. PMID: 21383900.

Wemmie, J. A. (2009). A New Target for Pain and CNS Diseases. Current Opinion in Drug Discovery and Development, 12(5), 693-704.

Angelaki, D. E., Klier, E. M. & Snyder, L. H. (2009). A vestibular sensation: probabilistic approaches to spatial perception. Neuron, 64(4), 448-61. DOI: 10.1016/j.neuron.2009.11.010.

Coryell, M. W., Wunsch, A. M., Haenfler, J. M., Allen, J. E., Schnizler, M., Ziemann, A. E., Cook, M. N., Dunning, J. P., Price, M. P., Rainier, J. D., Liu, Z., Light, A. R., Langbehn, D. R. & Wemmie, J. A. (2009). Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(17), 5381-8. PMID: 19403806.

Sluka, K. A., Winter, O. C. & Wemmie, J. A. (2009). Acid-sensing ion channels: A new target for pain and CNS diseases. Current opinion in drug discovery & development, 12(5), 693-704. PMID: 19736627.

Zha, X. M., Wang, R., Collier, D. M., Snyder, P. M., Wemmie, J. A. & Welsh, M. J. (2009). Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits. Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3573-8. PMID: 19218436.

Recober, A., Kuburas, A., Zhang, Z., Wemmie, J. A., Anderson, M. G. & Russo, A. F. (2009). Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(27), 8798-804. PMID: 19587287.

Oya, H., Kawasaki, H., Dahdaleh, N. S., Wemmie, J. A. & Howard, M. A. (2009). Stereotactic atlas-based depth electrode localization in the human amygdala. Stereotactic and functional neurosurgery, 87(4), 219-28. PMID: 19556831.

Ziemann, A. E., Allen, J. E., Dahdaleh, N. S., Drebot, I. I., Coryell, M. W., Wunsch, A. M., Lynch, C. M., Faraci, F. M., Howard, M. A., Welsh, M. J. & Wemmie, J. A. (2009). The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell, 139(5), 1012-21. PMID: 19945383.

Schnizler, M. K., Schnizler, K., Zha, X. M., Hall, D. D., Wemmie, J. A., Hell, J. W. & Welsh, M. J. (2009). The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction. The Journal of biological chemistry, 284(5), 2697-705. PMID: 19028690.

Wemmie, J., Zha, X. & Welsh, M. J. (2008). Acid Sensing Ion Channels and pH in Synapse Physiology.

Wemmie, J., Zha, X. & Welsh, M. J. (2008). Acid Sensing Ion Channels and pH in Synapse Physiology.

Coryell, M. W., Wunsch, A. M., Haenfler, J. M., Allen, J. E., McBride, J. L., Davidson, B. L. & Wemmie, J. A. (2008). Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(51), 13738-41. PMID: 19091964.

Ziemann, A. E., Schnizler, M. K., Albert, G. W., Severson, M. A., Howard, M. A., Welsh, M. J. & Wemmie, J. A. (2008). Seizure termination by acidosis depends on ASIC1a. Nature neuroscience, 11(7), 816-22. PMID: 18536711.

Friese, M. A., Craner, M. J., Etzensperger, R., Vergo, S., Wemmie, J. A., Welsh, M. J., Vincent, A. & Fugger, L. (2007). Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nature medicine, 13(12), 1483-9. PMID: 17994101.

Coryell, M. W., Ziemann, A. E., Westmoreland, P. J., Haenfler, J. M., Kurjakovic, Z., Zha, X. M., Price, M., Schnizler, M. K. & Wemmie, J. A. (2007). Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit. Biological psychiatry, 62(10), 1140-8. PMID: 17662962.

Zha, X. M., Wemmie, J. A., Green, S. H. & Welsh, M. J. (2006). Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines. Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16556-61. PMID: 17060608.

Wemmie, J. A., Price, M. P. & Welsh, M. J. (2006). Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends in neurosciences, 29(10), 578-86. PMID: 16891000.

Wemmie, J. A., Price, M. P. & Welsh, M. J. (2006). Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends in neurosciences, 29(10), 578-86.

Page, A. J., Brierley, S. M., Martin, C. M., Price, M. P., Symonds, E., Butler, R., Wemmie, J. A. & Blackshaw, L. A. (2005). Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut, 54(10), 1408-15. PMID: 15987792.

Liu, G., Martins, I., Wemmie, J. A., Chiorini, J. A. & Davidson, B. L. (2005). Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(41), 9321-7. PMID: 16221840.

Askwith, C. C., Wemmie, J. A., Price, M. P., Rokhlina, T. & Welsh, M. J. (2004). Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons. The Journal of biological chemistry, 279(18), 18296-305. PMID: 14960591.

Lim, R., Zaheer, A., Khosravi, H., Freeman, J. H., Halverson, H. E., Wemmie, J. A. & Yang, B. (2004). Impaired motor performance and learning in glia maturation factor-knockout mice. Brain research, 1024(1-2), 225-32. PMID: 15451385.

Xiong, Z. G., Zhu, X. M., Chu, X. P., Minami, M., Hey, J., Wei, W. L., MacDonald, J. F., Wemmie, J. A., Price, M. P., Welsh, M. J. & Simon, R. P. (2004). Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell, 118(6), 687-98. PMID: 15369669.

Wemmie, J. A., Coryell, M. W., Askwith, C. C., Lamani, E., Leonard, A. S., Sigmund, C. D. & Welsh, M. J. (2004). Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proceedings of the National Academy of Sciences of the United States of America, 101(10), 3621-6. PMID: 14988500.

Price, M. P., Thompson, R. J., Eshcol, J. O., Wemmie, J. A. & Benson, C. J. (2004). Stomatin modulates gating of acid-sensing ion channels. The Journal of biological chemistry, 279(51), 53886-91. PMID: 15471860.

Chu, X. P., Wemmie, J. A., Wang, W. Z., Zhu, X. M., Saugstad, J. A., Price, M. P., Simon, R. P. & Xiong, Z. G. (2004). Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(40), 8678-89. PMID: 15470133.

Page, A. J., Brierley, S. M., Martin, C. M., Martinez-Salgado, C., Wemmie, J. A., Brennan, T. J., Symonds, E., Omari, T., Lewin, G. R., Welsh, M. J. & Blackshaw, L. A. (2004). The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology, 127(6), 1739-47. PMID: 15578512.

Wemmie, J. A., Askwith, C. C., Lamani, E., Cassell, M. D., Freeman, J. H. & Welsh, M. J. (2003). Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(13), 5496-502. PMID: 12843249.

Xie, J., Price, M. P., Wemmie, J. A., Askwith, C. C. & Welsh, M. J. (2003). ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons. Journal of neurophysiology, 89(5), 2459-65. PMID: 12612000.

Leonard, A. S., Yermolaieva, O., Hruska-Hageman, A., Askwith, C. C., Price, M. P., Wemmie, J. A. & Welsh, M. J. (2003). cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proceedings of the National Academy of Sciences of the United States of America, 100(4), 2029-34. PMID: 12578970.

Sluka, K. A., Price, M. P., Breese, N. M., Stucky, C. L., Wemmie, J. A. & Welsh, M. J. (2003). Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain, 106(3), 229-39. PMID: 14659506.

Benson, C. J., Xie, J., Wemmie, J. A., Price, M. P., Henss, J. M., Welsh, M. J. & Snyder, P. M. (2002). Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proceedings of the National Academy of Sciences of the United States of America, 99(4), 2338-43. PMID: 11854527.

Hruska-Hageman, A. M., Wemmie, J. A., Price, M. P. & Welsh, M. J. (2002). Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). The Biochemical journal, 361(Pt 3), 443-50. PMID: 11802773.

Wemmie, J. A., Chen, J., Askwith, C. C., Hruska-Hageman, A. M., Price, M. P., Nolan, B. C., Yoder, P. G., Lamani, E., Hoshi, T., Freeman, J. H. & Welsh, M. J. (2002). The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron, 34(3), 463-77. PMID: 11988176.

Wemmie, J. A., Moye-Rowley, W. S. (1997). Mutational analysis of the Saccharomyces cerevisiae ATP-binding cassette transporter protein Ycf1p. Molecular microbiology, 25(4), 683-94. PMID: 9379898.

Wemmie, J. A., Steggerda, S. M. & Moye-Rowley, W. S. (1997). The Saccharomyces cerevisiae AP-1 protein discriminates between oxidative stress elicited by the oxidants H2O2 and diamide. The Journal of biological chemistry, 272(12), 7908-14. PMID: 9065458.

Szczypka, M. S., Wemmie, J. A., Moye-Rowley, W. S. & Thiele, D. J. (1994). A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. The Journal of biological chemistry, 269(36), 22853-7. PMID: 7521334.

Wemmie, J. A., Szczypka, M. S., Thiele, D. J. & Moye-Rowley, W. S. (1994). Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1. The Journal of biological chemistry, 269(51), 32592-7. PMID: 7798263.

Wemmie, J. A., Wu, A. L., Harshman, K. D., Parker, C. S. & Moye-Rowley, W. S. (1994). Transcriptional activation mediated by the yeast AP-1 protein is required for normal cadmium tolerance. The Journal of biological chemistry, 269(20), 14690-7. PMID: 8182076.

Wu, A., Wemmie, J. A., Edgington, N. P., Goebl, M., Guevara, J. L. & Moye-Rowley, W. S. (1993). Yeast bZip proteins mediate pleiotropic drug and metal resistance. The Journal of biological chemistry, 268(25), 18850-8. PMID: 8360174.

Treadway, J. L., Morrison, B. D., Wemmie, J. A., Frias, I., O'Hare, T., Pilch, P. F. & Pessin, J. E. (1990). The endogenous functional turkey erythrocyte and rat liver insulin receptor is an alpha 2 beta 2 heterotetrameric complex. The Biochemical journal, 271(1), 99-105. PMID: 2222423.

Feltz, S. M., Swanson, M. L., Wemmie, J. A. & Pessin, J. E. (1988). Functional properties of an isolated alpha beta heterodimeric human placenta insulin-like growth factor 1 receptor complex. Biochemistry, 27(9), 3234-42. PMID: 2968813.