Leslie A. Bruch, MD

Portrait
Clinical Professor of Pathology
Clinical Professor of Neurosurgery

Contact Information

Primary Office
5244D Roy Carver Pavilion
Iowa City, IA 52242
319-384-8871

Education

BS, University of Iowa
MD, University of Iowa College of Medicine
Internship, St Joseph Mercy Hospital
Resident, Neurology, University of Michigan Hospitals
Resident, Anatomic Pathology, University of Michigan Hospitals
Fellow, Neuropathology, Barnes Jewish Hospital/Washington University School of Medicine

Licensure and Certifications

State of Iowa Medical License - Iowa Board of Medicine
Neuropathology - American Board of Pathology
State of Nebraska Medical License - Nebraska Department of Health and Human Services
Anatomic Pathology - American Board of Pathology

Research Summary

I am interested in diagnostic neuropathology, including neoplastic and non-neoplastic disease. Special interest in brain tumors and the application of immunohistochemistry and molecular techniques in the diagnosis, classification and epidemiology of brain tumors. I am also interested in medical education at all levels of training, with particular interest in graduate medical education and developing new and innovative methods of training the next generation of physicians.

Publications

Essenmacher, A. C., Watal, P., Bathla, G., Bruch, L. A., Moritani, T. & Capizzano, A. A. (2018). Brain metastases from adenocarcinoma of the lung with truly cystic magnetic resonance imaging appearance. Clinical imaging, 52, 203-207. PMID: 30125846.

Jerath, N. U., Reddy, C. G., Moritani, T., Bruch, L. A., Holman, C. & Gutmann, L. (2014). Clinical Reasoning: A 47-year-old woman with left shoulder pain after a fall. Neurology, 83(11), e112-6. PMID: 25200718.

Bruch, L., Mundy, S., Shen, J. & Hauser, N. (2014). Novel Homozygous Cofilin-2 (CFL2) Mutation Causing a Congenital Form of Nemaline Myopathy with Filamentous Inclusions. American Association of Neuropathologists Meeting.

Mundy, S., Bruch, L., Hauser, N. & Shen, J. (2014). Novel homozygous CFL2 mutation causing a congenital form of nemaline myopathy. Annual Clinical Genetics Meeting.

Albert, G., Wassef, S., Dahdaleh, N. S., Lindley, T., Bruch, L. & Hitchon, P. (2013). Intracranial glioblastoma with drop metastases to the spine after stereotactic biopsy. J Neurol Surg A Cent Eur Neurosurg, 74(suppl 1), e221-4. PMID: 23804229.

Bridge, J. A., Liu, X. Q., Sumegi, J., Nelson, M., Reyes, C., Bruch, L. A., Rosenblum, M., Puccioni, M. J., Bowdino, B. S. & McComb, R. D. (2013). Identification of a Novel, Recurrent SLC44A1-PRKCA Fusion in Papillary Glioneuronal Tumor. Brain pathology (Zurich, Switzerland), 23(2), 121-8. PMID: 22725730.

Smucker, J. D., Ramme, A. J., LeBlond, R. F., Bruch, L. A. & Bakhshandehpour, G. (2011). Hypertrophic spinal pachymeningitis with thoracic myelopathy: the initial presentation of ANCA-related systemic vasculitis. Journal of spinal disorders & techniques, 24(8), 525-32. PMID: 21436740.

Liu, W., Kung, D. K., Bruch, L. A., Howard, M. A., Hasan, D. M. & Policeni, B. (2011). Cerebellar dural arteriovenous fistula mimicking a hypervascular tumor on MR imaging. American Society of Neuroradiology Annual Meeting.

Ismail, A., Bruch, L. A., Moritani, T. & Capizzano, A. A. (2011). Lymphomartosis cerebri: A rare imaging presentation of central nervous system lymphoma. American Society of Neuroradiology Annual Meeting.

McComb, R. D., Bruch, L. A., Reyes, C. A., Puccioni, M. J. & Bridge, J. A. (2010). Novel Translocation t)9;17) (q32;q24) in a glioneuronal tumor. United States and Canadian Academy of Pathology Annual Meeting.

Bruch, L. A., Deyoung, B., Kreiter, C., Haugen, T. H., Leaven, T. C. & DEE, F. R. (2009). Competency assessment of residents in surgical pathology using virtual microscopy. Human pathology, 40(8), 1122-8. PMID: 19552936.

Ahmed, R., Morris, A. M., Jacob, A., Bruch, L. A., Buatti, J. M. & Hitchon, P. W. (2008). Management and treatment outcomes for spinal chordomas: A case series review. Congress of Neurological Surgeons Annual Meeting.

Velderman, P. N., Bruch, L. A. & Lawry, G. V. (2008). Dermatomyositis: A unique case and a review of the disease. J Musculoskel Med, 25, 315-420, 444.

Park, D. C., Murman, D. L., Perry, K. D. & Bruch, L. A. (2007). An autopsy case of limbic encephalitis with voltage-gated potassium channel antibodies. European journal of neurology: the official journal of the European Federation of Neurological Societies, 14(10), e5-6. PMID: 17880556.

Vanderheyden, D. A., Bruch, L. A. & Deyoung, B. (2007). The EGFR/PI3K/PTEN/AKT pathway in glioblastoma multiforme: Increased PI3K immunohistochemical expression correlates with decreased survival. (Vols. 20). pp. 302A. Mod Pathol.

Ghorpade, A., Bruch, L. A., Persidsky, Y., Chin, B., Brown, W. H., Borgmann, K., Persidsky, R., Wu, L., Holter, S., Cotter, R., Faraci, J., Heilman, D., Meyer, V., Potter, J. F., Swindells, S. & Gendelman, H. E. (2005). Development of a rapid autopsy program for studies of brain immunity. Journal of Neuroimmunology, 163(2-Jan), 135-44. PMID: 15885316.

Crain, B. J., Alston, S. R., Bruch, L. A., Hamilton, R. L., McLendon, R. E., Rhodes, C. H., Tihan, T. & Weidenheim, K. M. (2005). Accreditation council for graduate medical education (ACGME) competencies in neuropathology training. Journal of neuropathology and experimental neurology, 64(4), 273-9. PMID: 15835263.

Bridge, R. S., Bridge, J. A., Neff, J. R., Naumann, S., Althof, P. & Bruch, L. A. (2004). Recurrent chromosomal imbalances and structurally abnormal breakpoints within complex karyotypes of malignant peripheral nerve sheath tumour and malignant triton tumour: a cytogenetic and molecular cytogenetic study. J Clin Pathol, 57(11), 1172-8. PMID: 15509679.

Lacy, N. L., Bruch, L. A., Newland, M. C. & Lough, D. R. (2004). Faculty as educators: A needs assessment for faculty development of teaching skills. Central Group on Educational Affairs (CGEA) Meeting.

Bruch, L. A., Bridge, R. S., Neff, J. R., naumann, S., Althof, P. & Bridge, J. A. (2004). Recurrent chromosomal imbalances and structurally abnormal breakpoints within complex karyotypes of malignant peripheral nerve sheath tumor and malignant triton tumor: A cytogenetic and molecular cytogenetic study. United States and Canadian Academy of Pathology Annual Meeting.

Lacy, N. L., Bruch, L. A., Newland, M. C. & Lough, D. R. (2003). What development do faculty think they need?. Innovations in Medical Education (IME) Exhibit, AAMC Annual Meeting.

Ghorpade, A., Swindells, S., Persidsky, Y., Borgmann, K., Persidsky, R., Holter, S., Cotter, R., Carlson, K., McComb, R., Bruch, L. A. & Gendelman, H. E. (2002). Successful rapid autopsy isolation of human microglia from a patient with HIV-1 encephalitis: Identfiication of immune dysfunction in brain cells during disease. International AIDS Congress.

Sajini, M., Mrak, R. E., Perry, A., Bruch, L. A., Cai, D. X., Parrish, R. S., Spencer, T., Palmer, C. A., Fratkin, J. D., Husain, M. & Gokden, M. (2002). Interobserver variability in meningioma grading. (Vols. 61). pp. 483. J Neuropathol Exp Neurol.

Bridge, R. S., Neff, J. R., Bridge, J. A., Zhou, M., Krallman, P., Naumann, S. & Bruch, L. A. (2001). Cytogenetic and molecular genetic findings in malignant peripheral nerve sheath tumor. UNMC Undergraduate Research Colloquium.

Rivet, D. J., Bruch, L. A., Lee, B. C. & Park, T. S. (2001). A seven-week-old infant with fever, CSF pleocytosis and intraspinal mass. (Vols. 35). (1), pp. 53-5. Pediatric neurosurgery. PMID: 11490196.

Bruch, L. A., Jefferson, R. J., Pike, M. G., Gould, S. J. & Squier, W. (2001). Mycoplasma pneumoniae infection, meningoencephalitis, and hemophagocytosis. Pediatric neurology, 25(1), 67-70. PMID: 11483400.

Bruch, L. A., Hill, D. A., Cai, D. X., Levy, B. K., Dehner, L. P. & Perry, A. (2001). A role for fluorescence in situ hybridization detection of chromosome 22q dosage in distinguishing atypical teratoid/rhabdoid tumors from medulloblastoma/central primitive neuroectodermal tumors. Human pathology, 32(2), 156-62. PMID: 11230702.

Kluin, K., Gilman, S., Foster, N., Sima, A., D'Amato, C., Bruch, L. A., Bluemlein, L., Little, R. & Johanns, J. (2001). Neuropathological correlates of dysarthria in progressive supranuclear palsy. Archives of neurology, 58(2), 265-9. PMID: 11176965.

Fuller, C. E., Pfeifer, J., Humphrey, P., Bruch, L. A., Dehner, L. P. & Perry, A. (2001). Chromosome 22q dosage in composite extrarenal rhabdoid tumors: clonal evolution or a phenotypic mimic?. (Vols. 32). pp. 1102-1108. Human Pathol.

Fuller, C. E., Pfeifer, J., Humphrey, P., Bruch, L. A., Dehner, L. P. & Perry, A. (2001). INI1 gene abnormalities in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic. (Vols. 14). pp. 213A. Mod Pathol.

Bruch, L. A., Schmidt, R. E. (2000). Pathology of the autojnomic nervous system. In O. Appenzeller (Eds.) Handbook of Clinical Neurology: Autonomic Nervous System - Part II Dysfunctions. pp. 1-52. Elsevier, Amsterdam.

Bruch, L. A., Hill, D. A., Dehner, L. P. & Perry, A. (1999). A role of FISH detection of chromosome 22q dosage in distinguishing atypical teratoid/rhabdoid tumors from central nervous system PNET/medulloblastomas. (Vols. 1). pp. 301. Neuro-Oncology.

Schmidt, R. E., Dorsey, D. A., Beaudet, L. N., Plurad, S. B., Parvin, C. A. & Bruch, L. A. (1998). Vacuolar neuritic dystrophy in aged mouse superior cervical sympathetic ganglia is strain-specific. Brain Research, 806(2), 141-51. PMID: 9739127.

Bruch, L. A., Flint, A. & Hirschl, R. B. (1997). Pulmonary pathology of patients treated with partial liquid ventilation. Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc, 10(5), 463-8. PMID: 9160311.

Kluin, K. J., Gilman, S., Foster, N. L., Sima, A. F., D'Amato, C., Bruch, L. A., Bluemlein, L., Little, R. J. & Johanns, J. (1997). Degeneration of substantia nigra pars compacta contributes to the dysarthria of PSP. (Vols. 48). pp. A97. Neurol.

Bruch, L. A., Blaivas, M. & Parisi, J. E. (1997). Primary cerebral angiitis with selective permeability and serum protein extravasation. (Vols. 56). pp. 577. J Neuropathol Exp Neurol.

Foster, N. L., Sima, A. F., D'Amato, C., Bruch, L. A., Kluin, K., Bluemlein, L. A., Little, R. J., Johanns, J. & Gilman, S. (1996). Cerebral cortical pathology in progressive supranuclear palsy is correlated with severity of dementia. (Vols. 46). pp. A363. Neurol.

Bruch, L. A., Flint, A. & Hirschl, R. B. (1996). Pulmonary pathology of patients treatedwith perfluorocarbon partial liquid ventilation. (Vols. 9). pp. 154A. Mod Pathol.

Bruch, L. A., Schwartz, D. A., Galvin, J. R., Helmers, R. A., Dayton, C. S. & HUNNINGHAKE, G. W. (1992). Anatomic determinants of airflow obstruction in sarcoidosis. (Vols. 145). pp. A192. Am Rev Resp Dis.

Loven, D. P., Schedl, H. P., Oberley, L. W., Wilson, H. D., Bruch, L. A. & Niehaus, C. L. (1982). Superoxide dismutase activity in the intestine of the streptozotocin-diabetic rat. Endocrinology, 111(3), 737-42. PMID: 7049672.