Brian J. Dlouhy, MD

Portrait
Assistant Professor of Neurosurgery

Contact Information

Primary Office: 1615-B JCP
200 Hawkins Drive
Iowa City, IA 52242
319-356-2542

Education

BS, Chemical Engineering, University of Florida
MD, Medicine, New York University School of Medicine

Postdoctoral Fellow, Surgical Neurology, Howard Hughes Medical Institute-National Institutes of Health
Postdoctoral Fellow, Human Brain Research Lab/Department of Psychiatry, University of Iowa Carver College of Medicine
Resident, Neurosurgery, University of Iowa Carver College of Medicine
Fellow, Minimally Invasive Neurosurgery, Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital
Postdoctoral Fellow, Neurosurgery, University of Iowa Carver College of Medicine
Fellow, Pediatric Neurosurgery, Washington University/St. Louis Children's Hospital

Research Summary

Dr. Dlouhy's basic science and translational research lab focuses on understanding the mechanisms of sudden unexpected death in epilepsy (SUDEP). We use animal models and study children and adults with epilepsy to identify the neural networks in the brain that influence breathing and to better understand how breathing is inhibited during seizures.

In the pediatric human brain research lab, the group studies normal brain function (speech, language, hearing, emotion) and brain physiology of children with epilepsy. This research will allow a better understanding of how the child’s brain is organized, how brain function develops in humans, and give better insight into treating children with epilepsy.

Dr. Dlouhy also has a clinical interest and research interest in understanding the pathophysiology, genetics, and proper treatment strategies for Chiari disorders and disorders of the craniovertebral junction (CVJ).

Publications

Nakagawa, D., Nagahama, Y., Policeni, B. A., Raghavan, M. L., Dillard, S. I., Schumacher, A. L., Sarathy, S., Dlouhy, B. J., Wilson, S., Allan, L., Henry, W. H., Huston III, J., Cloft, H. J., Wintermark, M., Torner, J. C., Brown, R. D. & Hasan, D. M. (In Press). Accuracy of Detecting Enlargement of Aneurysms Using Different MRI Imaging Modalities and Measurement Protocols. J Neurosurg.

Menezes, A. H., Hitchon, P. W. & Dlouhy, B. J. (2017). Symptomatic spinal extradural arachnoid cyst with cord compression in a family: case report. J Neurosurg Spine, 27(3), 341-5. PMID: 28665244.

Dlouhy, B. J., Policeni, B. A. & Menezes, A. H. (2017). Reduction of atlantoaxial dislocation prevented by pathological position of the transverse ligament in fixed, irreducible os odontoideum: operative illustrations and radiographic correlates in 41 patients. J Neurosurg Spine, 27(1), 20-8. PMID: 28387614.

Flouty, O. E., Piscopo, A. J., Holland, M. T., Abode-Iyamah, K., Bruch, L., Menezes, A. H. & Dlouhy, B. J. (2017). Infantile cranial fasciitis: case-based review and operative technique. Childs Nerv Syst, 33(6), 899-908. PMID: 28451777.

Dlouhy, B. J., Ciliberto, M. A., Cifra, C. L., Kirby, P. A., Shrock, D. L., Nashelsky, M. & Richerson, G. B. (2017). Unexpected Death of a Child with Complex Febrile Seizures-Pathophysiology Similar to Sudden Unexpected Death in Epilepsy?. Front Neurol, 8, 21. PMID: 28203222.

Hawasli, A. H., Chacko, R., Szrama, N. {., Bundy, D. T., Pahwa, M., Yarbrough, C. K., Dlouhy, B. J., Limbrick, D. D., Barbour, D. L., Smyth, M. D. & Leuthardt, E. C. (2017). Electrophysiological Sequelae of Hemispherotomy in Ipsilateral Human Cortex. Front Hum Neurosci, eCollection 2017. PMID: 28424599.

Abode-Iyamah, K. O., Chiang, H. Y., Winslow, N., Park, B., Zanaty, M., Dlouhy, B. J., Flouty, O. E., Rasmussen, Z. D., Herwaldt, L. A. & Greenlee, J. D. (In Press). Risk factors for surgical site infections and assessment of vancomycin powder as a preventive measure in patients undergoing first-time cranioplasty. J Neurosurg, 12, 1-9. PMID: 28498056.

Li, L., Ali, M., Menezes, A. H. & Dlouhy, B. J. (2017). Intracranial extradural arachnoid cyst in a child. Childs Nerv Syst, 33(12), 2201-4. PMID: 28744688.

Nagahama, Y., Kovach, C. K., Ciliberto, M., Joshi, C., Rhone, A. E., Vesole, A., Gander, P. E., Nourski, K. V., Oya, H., Howard 3rd, M. A., Kawasaki, H., Kawasaki, H. & Dlouhy, B. J. (2017). Localization of musicogenic epilepsy to Heschl's gyrus and superior temporal plane: case report. J Neurosurg, Epub ahead of print. PMID: 28946181.

Hudson, J. S., Nagahama, Y., Nakagawa, D., Starke, R. M., Dlouhy, B. J., Torner, J. C., Jabbour, P., Allan, L., Derdeyn, C. P., Greenlee, J. D. & Hasan, D. (2017). Hemorrhage associated with ventriculoperitoneal shunt placement in aneurysmal subarachnoid hemorrhage patients on a regimen of dual antiplatelet therapy: a retrospective analysis. J Neurosurg, Epub ahead of print. PMID: 29125410.

Dlouhy, B. J., Dawson, J. D. & Menezes, A. H. (2017). Intradural pathology and pathophysiology associated with Chiari I malformation in children and adults with and without syringomyelia. J Neurosurg Pediatr, 13, 1-16. PMID: 29027876.

Rao, R. C., Larson, S. A. & Dlouhy, B. J. (2017). Growth Hormone Deficiency, Basal Encephalocele, and Morning Glory Anomaly. Ophthalmology, 124(10), 1531. PMID: 28938928.

Nagahama, Y., Dlouhy, B. J., Nakagawa, D., Kamm, J., Hasan, D., Howard 3rd, M. A. & Kawasaki, H. (2017). Bone flap elevation for intracranial EEG monitoring: technical note. J Neurosurg, Epub ahead of print. PMID: 28946179.

Dahdaleh, N. S., Khanna, R., Menezes, A. H., Smith, Z. A., Viljoen, S. V., Koski, T. R. & Dlouhy, B. J. (2016). The Application of the Revised Condyle-C1 Interval Method to Diagnose Traumatic Atlanto-occipital Dissociation in Adults. Global Spine J, 6(6), 529-34. PMID: 27555993.

Erwood, A. M., Abel, T. J., Grossbach, A. J., Ahmed, R., Dahdaleh, N. S. & Dlouhy, B. J. (2016). Acutely unstable cervical spine injury with normal CT scan findings: MRI detects ligamentous injury. J Clin Neurosci, 24, 165-7. PMID: 26601812.

Abode-Iyamah, K. O., Dlouhy, B. J., Lopez, A. J., Menezes, A. H., Hitchon, P. W. & Dahdaleh, N. S. (2016). Comparison of hinged and contoured rods for occipitocervical arthrodesis in adults: A clinical study. J Craniovert Junction Spine, 7(3), 171-5. PMID: 27630479.

Nagahama, Y., Joshi, C., Dlouhy, B., Wu, A. Y., Abel, T. J., Baumbach, G. & Kawasaki, H. (2016). Functional hemispherotomy in Rasmussen syndrome in the absence of classic MRI findings. Epilepsy Behav Case Rep, 7, 24-27. PMID: 28239546.

Dlouhy, B. J., Miller, B., Jeong, A., Bertrand, M. E., Limbrick Jr, D. D. & Smyth, M. D. (2016). Palliative epilepsy surgery in Dravet syndrome-case series and review of the literature. Childs Nerv Syst, 32(9), 1703-8. PMID: 27465677.

Dlouhy, B. J., Gehlbach, B. K. & Richerson, G. B. (2016). Sudden unexpected death in epilepsy: basic mechanisms and clinical implications for prevention. J Neurol Neurosurg Psychiatry, 87(4), 402-13. PMID: 26979537.

Dlouhy, B. J., Nguyen, D. C., Patel, K. B., Hoben, G. M., Skolnick, G. B., Naidoo, S. D., Woo, A. S. & Smyth, M. D. (2016). Endoscope-assisted management of sagittal synostosis: wide vertex suturectomy and barrel stave osteotomies versus narrow vertex suturectomy. J Neurosurg Pediatr, 25(6), 674-678. PMID: 27611899.

Abode-Iyamah, K. O., Dlouhy, B. J., Lopez, A., Menezes, A. H., Hitchon, P. W. & Dahdaleh, N. S. (2016). Comparison of hinged and contoured rods for occipitocervical arthrodesis in adults: A clinical study. J Craniovertebr Junction Spine, 7(3), 171-5. PMID: 27630479.

Lopez, A. J., Scheer, J. K., Leibl, K. E., Smith, Z. A., Dlouhy, B. J. & Dahdaleh, N. S. (2015). Anatomy and biomechanics of the craniovertebral junction. Neurosurg Focus, 38(4), E2. PMID: 25828496.

Dlouhy, B. J., Gehlbach, B. K., Kreple, C. J., Kawasaki, H., Oya, H., Buzza, C., Granner, M. A., Welsh, M. J., Howard, M. A., Wemmie, J. A. & Richerson, G. B. (2015). Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation. J Neurosci, 35(28), 10281-9. PMID: 26180203.

Khan, M., Walters, L. L., Li, Q., Thomas, D. G., Miller, J. M., Zhang, Q., Sciallis, A. P., Liu, Y., Dlouhy, B. J., Fort, P. E., Archer, S. M., Demirci, H., Dou, Y. & Rao, R. C. (2015). Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma. Lab Invest, 95(11), 1278-90. PMID: 26280220.

Dlouhy, B. J., Chae, M. P. & Teo, C. (2015). The supraorbital eyebrow approach in children: clinical outcomes, cosmetic results, and complications. J Neurosurg Pediatr, 15(1), 12-9. PMID: 25396702.

Dlouhy, B. J., Dahdaleh, N. S. & Menezes, A. H. (2015). Evolution of transoral approaches, endoscopic endonasal approaches, and reduction strategies for treatment of craniovertebral junction pathology: a treatment algorithm update. Neurosurg Focus, 38(4), E8. PMID: 25828502.

Kalani, M. Y., Wilson, D. A., Koechlin, N. O., Abuhusain, H. J., Dlouhy, B. J., Gunawardena, M. P., Nozue-Okada, K. & Tea, C. (2015). Pineal cyst resection in the absence of ventriculomegaly or Parinaud's syndrome: clinical outcomes and implications for patient selection. J Neurosurg, 123(2), 352-6. PMID: 25932610.

Khanna, R., Dlouhy, B. J., Smith, Z. A., Lam, S. K., Koski, T. R. & Dahdaleh, N. S. (2015). The impact of steroids, methotrexate, and biologics on clinical and radiographic outcomes in patients with rheumatoid arthritis undergoing fusions at the craniovertebral junction. J Craniovertebr Junction Spine, 6(2), 60-4. PMID: 25972710.

Dlouhy, B. J., Awe, O., Rao, R. C., Kirby, P. A. & Hitchon, P. W. (2014). Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient: Case report. J Neurosurg Spine, 21(4), 618-22. PMID: 25002238.

Dlouhy, B. J., Teo, C. (2014). Supraorbital Eyebrow Approach for Craniopharyngiomas. In Kenning , Evans (Eds.) Craniopharyngiomas. Philadelphia PA: Elsevier.

Dlouhy, B. J., Teo, C. (2014). Surgical Management of Hemifacial Spasm. In R. Spetzler , P. Nakaji (Eds.) Neurovascular Surgery. (2nd ed) New York, NY: Thieme.

Massey, C. A., Sowers, L. P., Dlouhy, B. J. & Richerson, G. B. (2014). Mechanisms of sudden unexpected death in epilepsy: the pathway to prevention. Nat Rev Neurol, 10(5), 271-82. PMID: 24752120.

Hitchon, P. W., Dlouhy, B. J. (2014). Response. (Vols. 21). (4), pp. 617. J Neurosurg Spine. PMID: 25392886.

Khanna, R., Smith, Z. A., Dlouhy, B. J. & Dahdaleh, N. S. (2014). Complete absence of the posterior arch of C1: Case report. J Craniovertebr Junction Spine, 5(4), 176-8. PMID: 25558151.

Bijanki, K. R., Kovach, C. K., McCormick, L. M., Kawasaki, H., Dlouhy, B. J., Feinstein, J., Jones, R. D. & Howard 3rd, M. A. (2014). Case report: stimulation of the right amygdala induces transient changes in affective bias. Brain Stimul, 7(5), 690-3. PMID: 24972588.

Dahdaleh, N. S., Dlouhy, B. J. & Menezes, A. H. (2013). One-step fixation of atlantoaxial rotatory subluxation: technical note and report of three cases. World Neurosurg, 80(6), e391-5. PMID: 23159650.

Belirgen, M., Dlouhy, B. J., Grossbach, A. J., Torner, J. C. & Hitchon, P. W. (2013). Surgical options in the treatment of subaxial cervical fractures: a retrospective cohort study. Clin Neurol Neurosurg, 115(8), 1420-8. PMID: 23481897.

Grossbach, A. J., Dahdaleh, N. S., Abel, T. J., Woods, G. D., Dlouhy, B. J. & Hitchon, P. W. (2013). Flexion-distraction injuries of the thoracolumbar spine: open fusion versus percutaneous pedicle screw fixation. Neurosurg Focus, 35(2), E2. PMID: 23905953.

Dlouhy, B. J., Dahdaleh, N. S. & Howard 3rd, M. A. (2013). Radiographic and intraoperative imaging of a hemisection of the spinal cord resulting in a pure Brown-Séquard syndrome: case report and review of the literature. J Neurosurg Sci, 57(1), 81-6. PMID: 23584224.

Fogel, A. I., Dlouhy, B. J., Wang, C., Ryu, S. W., Neutzner, A., Hasson, S. A., Sideris, D. P., Abeliovich, H. & Youle, R. J. (2013). Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol Cell Biol, 33(18), 3675-88. PMID: 23878393.

Dahdaleh, N. S., Dlouhy, B. J., Greenlee, J. D., Smoker, W. R. & Hitchon, P. W. (2013). An algorithm for the management of posttraumatic cervical spondyloptosis. J Clin Neurosci, 20(7), 951-7. PMID: 23702373.

Dlouhy, B. J., Greenlee, J. D. (2012). Progressive confusion, memory loss, and gait ataxia in an adult. JAMA, 307(20), 2195-6. PMID: 22618927.

Dlouhy, B. J., Capuano, A. W., Madhavan, K., Torner, J. C. & Greenlee, J. D. (2012). Preoperative third ventricular bowing as a predictor of endoscopic third ventriculostomy success. J Neurosurg Pediatr, 9(2), 182-90. PMID: 22295925.

Dahdaleh, N. S., Dlouhy, B. J., Kirby, P. A. & Greenlee, J. D. (2012). Unusual "double density" colloid cysts. J Clin Neurosci, 19(4), 612-4. PMID: 22249014.

Kung, D. K., Abel, T. J., Madhavan, K. H., Dalyai, R. T., Dlouhy, B. J., Liu, W., Jabbour, P. M. & Hasan, D. M. (2012). Treatment of endovascular coil and stent migration using the merci retriever: report of three cases. Case Rep Med, 2012, 242101. PMID: 22666264.

Magnotta, V. A., Heo, H. Y., Dlouhy, B. J., Dahdaleh, N. S., Follmer, R. L., Thedens, D. R., Welsh, M. J. & Wemmie, J. A. (2012). Detecting activity-evoked pH changes in human brain. Proc Natl Acad Sci U S A, 109(21), 8270-3. PMID: 22566645.

Dlouhy, B. J., Viljoen, S. V., Kung, D. K., Vogel, T. W., Granner, M. A., Howard 3rd, M. A. & Kawasaki, H. (2012). Vagus nerve stimulation after lead revision. Neurosurg Focus, 32(3), E11. PMID: 22380852.

Dlouhy, B. J., Madhavan, K., Clinger, J. D., Reddy, A., Dawson, J. D., O'Brien, E. K., Chang, E., Graham, S. M. & Greenlee, J. D. (2012). Elevated body mass index and risk of postoperative CSF leak following transsphenoidal surgery. J Neurosurg, 116(6), 1311-7. PMID: 22443502.

Vogel, T. W., Dlouhy, B. J. & Menezes, A. H. (2012). Craniovertebral junction abnormality in a case of Joubert syndrome. Childs Nerv Syst, 28(7), 1109-12. PMID: 22231569.

Dlouhy, B. J., Reddy, A., Dahdaleh, N. S. & Greenlee, J. D. (2012). Antibiotic impregnated catheter coverage of deep brain stimulation leads facilitates lead preservation after hardware infection. J Clin Neurosci, 19(10), 1369-75. PMID: 22854128.

Dahdaleh, N. S., Dlouhy, B. J., Viljoen, S. V., Capuano, A. W., Kung, D. K., Torner, J. C., Hasan, D. M. & Howard 3rd, M. A. (2012). Clinical and radiographic predictors of neurological outcome following posterior fossa decompression for spontaneous cerebellar hemorrhage. J Clin Neurosci, 19(9), 1236-41. PMID: 22721890.

Dahdaleh, N. S., Dlouhy, B. J. & Menezes, A. H. (2012). Application of neuromuscular blockade and intraoperative 3D imaging in the reduction of basilar invagination. J Neurosurg Pediatr, 9(2), 119-24. PMID: 22295914.

Dlouhy, B. J., Dahdaleh, N. S. & Greenlee, J. D. (2011). Emerging technology in intracranial neuroendoscopy: application of the NICO Myriad. Neurosurg Focus, 30(4), E6. PMID: 21456933.

Dahdaleh, N. S., Dlouhy, B. J. & Hitchon, P. W. (2011). Percutaneous pedicle screw fixation for the treatment of thoracolumbar fractures. Part I: Indications. Contemporary Neurosurgery.

Vogel, T. W., Dlouhy, B. J. & Howard 3rd, M. A. (2011). Don't take the plunge: avoiding adverse events with cranial perforators. J Neurosurg, 115(3), 570-5. PMID: 21456895.

Dahdaleh, N. S., Dlouhy, B. J. & Hitchon, P. W. (2011). Percutaneous pedicle screw fixation for the treatment of thoracolumbar fractures. Part II: Surgical technique. Contemporary Neurosurgery.

Dlouhy, B. J., Menezes, A. H. (2011). Osteopetrosis with Chiari I malformation: presentation and surgical management. J Neurosurg Pediatr, 7(4), 369-74. PMID: 21456907.

Madhavan, K., Dlouhy, B. J., Vogel, T. W., Policeni, B. A., Smoker, W. R. & Hasan, D. M. (2010). Anomalous origins of the calcarine and parieto-occipital arteries. J Clin Neurosci, 17(10), 1334-6. PMID: 20637632.

Vogel, T. W., Dlouhy, B. J. & Howard 3rd, M. A. (2010). Use of confirmatory imaging studies to illustrate adequate treatment of cerebrospinal fluid leak in spontaneous intracranial hypotension. J Neurosurg, 113(5), 955-60. PMID: 20524824.

Dlouhy, B. J., Smucker, J. (2009). Cervical Myelopathy. In F. H. Shen , C. Shaffrey (Eds.) Arthritis. (1st ed) London, England: Saunders.