Brian J. Dlouhy, MD

Portrait
Assistant Professor of Neurosurgery

Contact Information

Primary Office
1615-B JCP
200 Hawkins Drive
Iowa City, IA 52242
319-356-2542

Education

BS, Chemical Engineering, University of Florida
MD, Medicine, New York University School of Medicine
Postdoctoral Fellow, Surgical Neurology, Howard Hughes Medical Institute-National Institutes of Health
Postdoctoral Fellow, Human Brain Research Lab/Department of Psychiatry, University of Iowa Carver College of Medicine
Resident, Neurosurgery, University of Iowa Carver College of Medicine
Fellow, Minimally Invasive Neurosurgery, Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital
Postdoctoral Fellow, Neurosurgery, University of Iowa Carver College of Medicine
Fellow, Pediatric Neurosurgery, Washington University/St. Louis Children's Hospital

Research Summary

Dr. Dlouhy's basic science and translational research lab focuses on understanding the mechanisms of sudden unexpected death in epilepsy (SUDEP). We use animal models and study children and adults with epilepsy to identify the neural networks in the brain that influence breathing and to better understand how breathing is inhibited during seizures.

In the pediatric human brain research lab, the group studies normal brain function (speech, language, hearing, emotion) and brain physiology of children with epilepsy. This research will allow a better understanding of how the child’s brain is organized, how brain function develops in humans, and give better insight into treating children with epilepsy.

Dr. Dlouhy also has a clinical interest and research interest in understanding the pathophysiology, genetics, and proper treatment strategies for Chiari disorders and disorders of the craniovertebral junction (CVJ).

Publications

Shinozaki, G., Braun, P. R., Hing, B. W., Ratanatharathorn, A., Klisares, M. J., Duncan, G. N., Jellison, S. S., Heinzman, J. T., Nagahama, Y., Close, L., Sabbagh, S., Dlouhy, B. J., Howard, M. A., Kawasaki, H. & Cho, H. R. (2018). Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging. Front Aging Neurosci, 10, 311. PMID: 30405391.

Hudson, J. S., Nagahama, Y., Nakagawa, D., Starke, R. M., Dlouhy, B. J., Torner, J. C., Jabbour, P., Allan, L., Derdeyn, C. P., Greenlee, J. D. & Hasan, D. (2018). Hemorrhage associated with ventriculoperitoneal shunt placement in aneurysmal subarachnoid hemorrhage patients on a regimen of dual antiplatelet therapy: a retrospective analysis. J Neurosurg, 129(4), 916-21. PMID: 29125410.

Nagahama, Y., Schmitt, A. J., Dlouhy, B. J., Vesole, A. S., Gander, P. E., Kovach, C. K., Nakagawa, D., Granner, M. A., Howard 3rd, M. A. & Kawasaki, H. (2018). Utility and safety of depth electrodes within the supratemporal plane for intracranial EEG. J Neurosurg, Epub ahead of print. PMID: 30192197.

Dlouhy, B. J., Menezes, A. H. (2018). Autologous cervical fascia duraplasty in 123 children and adults with Chiari malformation type I: surgical technique and complications. J Neurosurg Pediatr, 22(3), 297-305. PMID: 29932369.

Woodroffe, R. W., Zanaty, M., Kirby, P., Dlouhy, B. J. & Menezes, A. H. (2018). Resection of a Pediatric Intramedullary Spinal Cord Tumor: 2-Dimensional Operative Video. Oper Neurosurg (Hagerstown), Epub ahead of print. PMID: 30085227.

Nagahama, Y., Dlouhy, B. J., Nakagawa, D., Kamm, J., Hasan, D., Howard 3rd, M. A. & Kawasaki, H. (2018). Bone flap elevation for intracranial EEG monitoring: technical note. J Neurosurg, 129(1), 182-7. PMID: 28946179.

Nagahama, Y., Kovach, C. K., Ciliberto, M., Joshi, C., Rhone, A. E., Vesole, A., Gander, P. E., Nourski, K. V., Oya, H., Howard 3rd, M. A., Kawasaki, H., Kawasaki, H. & Dlouhy, B. J. (2018). Localization of musicogenic epilepsy to Heschl's gyrus and superior temporal plane: case report. J Neurosurg, 129(1), 157-64. PMID: 28946181.

Menezes, A. H., Greenlee, J. D. & Dlouhy, B. J. (2018). Syringobulbia in pediatric patients with Chiari malformation type I. J Neurosurg Pediatr, 22(1), 52-60. PMID: 29701558.

Nagahama, Y., Schmitt, A. J., Nakagawa, D., Vesole, A. S., Kamm, J., Kovach, C. K., Hasan, D., Granner, M., Dlouhy, B. J., Howard 3rd, M. A. & Kawasaki, H. (2018). Intracranial EEG for seizure focus localization: evolving techniques, outcomes, complications, and utility of combining surface and depth electrodes. J Neurosurg, Epub ahead of print. PMID: 29799342.

Abode-Iyamah, K. O., Chiang, H. Y., Winslow, N., Park, B., Zanaty, M., Dlouhy, B. J., Flouty, O. E., Rasmussen, Z. D., Herwaldt, L. A. & Greenlee, J. D. (2018). Risk factors for surgical site infections and assessment of vancomycin powder as a preventive measure in patients undergoing first-time cranioplasty. J Neurosurg, 128(4), 1241-9. PMID: 28498056.

Nakagawa, D., Nagahama, Y., Policeni, B. A., Raghavan, M. L., Dillard, S. I., Schumacher, A. L., Sarathy, S., Dlouhy, B. J., Wilson, S., Allan, L., Woo, H. H., Huston 3rd, J., Cloft, H. J., Wintermark, M. C., Torner, J. C., Brown Jr, R. D. & Hasan, D. M. (2018). Accuracy of detecting enlargement of aneurysms using different MRI modalities and measurement protocols. J Neurosurg, 9, 1-7. PMID: 29521585.

Vesole, A. S., Nagahama, Y., Granner, M. A., Howard, M. A., Kawasaki, H. & Dlouhy, B. J. (2018). Drug-resistant epilepsy development following stem cell transplant and cyclosporine neurotoxicity induced seizures: Case report in an adult and analysis of reported cases in the literature. Epilepsy Behav Case Rep, 10, 8-13. PMID: 30062084.

Li, L., Ali, M., Menezes, A. H. & Dlouhy, B. J. (2017). Intracranial extradural arachnoid cyst in a child. Childs Nerv Syst, 33(12), 2201-4. PMID: 28744688.

Rao, R. C., Larson, S. A. & Dlouhy, B. J. (2017). Growth Hormone Deficiency, Basal Encephalocele, and Morning Glory Anomaly. Ophthalmology, 124(10), 1531. PMID: 28938928.

Dlouhy, B. J., Dawson, J. D. & Menezes, A. H. (2017). Intradural pathology and pathophysiology associated with Chiari I malformation in children and adults with and without syringomyelia. J Neurosurg Pediatr, 13, 1-16. PMID: 29027876.

Menezes, A. H., Hitchon, P. W. & Dlouhy, B. J. (2017). Symptomatic spinal extradural arachnoid cyst with cord compression in a family: case report. J Neurosurg Spine, 27(3), 341-5. PMID: 28665244.

Nakagawa, D., Nagahama, Y., Policeni, B. A., Raghavan, M. L., Dillard, S. I., Schumacher, A. L., Sarathy, S., Dlouhy, B. J., Wilson, S., Allan, L., Henry, W. H., Huston III, J., Cloft, H. J., Wintermark, M., Torner, J. C., Brown, R. D. & Hasan, D. M. (In Press). Accuracy of Detecting Enlargement of Aneurysms Using Different MRI Imaging Modalities and Measurement Protocols. J Neurosurg.

Dlouhy, B. J., Policeni, B. A. & Menezes, A. H. (2017). Reduction of atlantoaxial dislocation prevented by pathological position of the transverse ligament in fixed, irreducible os odontoideum: operative illustrations and radiographic correlates in 41 patients. J Neurosurg Spine, 27(1), 20-8. PMID: 28387614.

Flouty, O. E., Piscopo, A. J., Holland, M. T., Abode-Iyamah, K., Bruch, L., Menezes, A. H. & Dlouhy, B. J. (2017). Infantile cranial fasciitis: case-based review and operative technique. Childs Nerv Syst, 33(6), 899-908. PMID: 28451777.

Hawasli, A. H., Chacko, R., Szrama, N. {., Bundy, D. T., Pahwa, M., Yarbrough, C. K., Dlouhy, B. J., Limbrick, D. D., Barbour, D. L., Smyth, M. D. & Leuthardt, E. C. (2017). Electrophysiological Sequelae of Hemispherotomy in Ipsilateral Human Cortex. Front Hum Neurosci, eCollection 2017. PMID: 28424599.

Dlouhy, B. J., Ciliberto, M. A., Cifra, C. L., Kirby, P. A., Shrock, D. L., Nashelsky, M. & Richerson, G. B. (2017). Unexpected Death of a Child with Complex Febrile Seizures-Pathophysiology Similar to Sudden Unexpected Death in Epilepsy?. Front Neurol, 8, 21. PMID: 28203222.

Nagahama, Y., Joshi, C., Dlouhy, B., Wu, A. Y., Abel, T. J., Baumbach, G. & Kawasaki, H. (2016). Functional hemispherotomy in Rasmussen syndrome in the absence of classic MRI findings. Epilepsy Behav Case Rep, 7, 24-27. PMID: 28239546.

Dlouhy, B. J., Nguyen, D. C., Patel, K. B., Hoben, G. M., Skolnick, G. B., Naidoo, S. D., Woo, A. S. & Smyth, M. D. (2016). Endoscope-assisted management of sagittal synostosis: wide vertex suturectomy and barrel stave osteotomies versus narrow vertex suturectomy. J Neurosurg Pediatr, 25(6), 674-678. PMID: 27611899.

Dlouhy, B. J., Miller, B., Jeong, A., Bertrand, M. E., Limbrick Jr, D. D. & Smyth, M. D. (2016). Palliative epilepsy surgery in Dravet syndrome-case series and review of the literature. Childs Nerv Syst, 32(9), 1703-8. PMID: 27465677.

Dahdaleh, N. S., Khanna, R., Menezes, A. H., Smith, Z. A., Viljoen, S. V., Koski, T. R. & Dlouhy, B. J. (2016). The Application of the Revised Condyle-C1 Interval Method to Diagnose Traumatic Atlanto-occipital Dissociation in Adults. Global Spine J, 6(6), 529-34. PMID: 27555993.

Dlouhy, B. J., Gehlbach, B. K. & Richerson, G. B. (2016). Sudden unexpected death in epilepsy: basic mechanisms and clinical implications for prevention. J Neurol Neurosurg Psychiatry, 87(4), 402-13. PMID: 26979537.

Erwood, A. M., Abel, T. J., Grossbach, A. J., Ahmed, R., Dahdaleh, N. S. & Dlouhy, B. J. (2016). Acutely unstable cervical spine injury with normal CT scan findings: MRI detects ligamentous injury. J Clin Neurosci, 24, 165-7. PMID: 26601812.

Abode-Iyamah, K. O., Dlouhy, B. J., Lopez, A. J., Menezes, A. H., Hitchon, P. W. & Dahdaleh, N. S. (2016). Comparison of hinged and contoured rods for occipitocervical arthrodesis in adults: A clinical study. J Craniovert Junction Spine, 7(3), 171-5. PMID: 27630479.

Abode-Iyamah, K. O., Dlouhy, B. J., Lopez, A., Menezes, A. H., Hitchon, P. W. & Dahdaleh, N. S. (2016). Comparison of hinged and contoured rods for occipitocervical arthrodesis in adults: A clinical study. J Craniovertebr Junction Spine, 7(3), 171-5. PMID: 27630479.

Khan, M., Walters, L. L., Li, Q., Thomas, D. G., Miller, J. M., Zhang, Q., Sciallis, A. P., Liu, Y., Dlouhy, B. J., Fort, P. E., Archer, S. M., Demirci, H., Dou, Y. & Rao, R. C. (2015). Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma. Lab Invest, 95(11), 1278-90. PMID: 26280220.

Kalani, M. Y., Wilson, D. A., Koechlin, N. O., Abuhusain, H. J., Dlouhy, B. J., Gunawardena, M. P., Nozue-Okada, K. & Tea, C. (2015). Pineal cyst resection in the absence of ventriculomegaly or Parinaud's syndrome: clinical outcomes and implications for patient selection. J Neurosurg, 123(2), 352-6. PMID: 25932610.

Dlouhy, B. J., Gehlbach, B. K., Kreple, C. J., Kawasaki, H., Oya, H., Buzza, C., Granner, M. A., Welsh, M. J., Howard, M. A., Wemmie, J. A. & Richerson, G. B. (2015). Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation. J Neurosci, 35(28), 10281-9. PMID: 26180203.

Lopez, A. J., Scheer, J. K., Leibl, K. E., Smith, Z. A., Dlouhy, B. J. & Dahdaleh, N. S. (2015). Anatomy and biomechanics of the craniovertebral junction. Neurosurg Focus, 38(4), E2. PMID: 25828496.

Dlouhy, B. J., Dahdaleh, N. S. & Menezes, A. H. (2015). Evolution of transoral approaches, endoscopic endonasal approaches, and reduction strategies for treatment of craniovertebral junction pathology: a treatment algorithm update. Neurosurg Focus, 38(4), E8. PMID: 25828502.

Khanna, R., Dlouhy, B. J., Smith, Z. A., Lam, S. K., Koski, T. R. & Dahdaleh, N. S. (2015). The impact of steroids, methotrexate, and biologics on clinical and radiographic outcomes in patients with rheumatoid arthritis undergoing fusions at the craniovertebral junction. J Craniovertebr Junction Spine, 6(2), 60-4. PMID: 25972710.

Dlouhy, B. J., Chae, M. P. & Teo, C. (2015). The supraorbital eyebrow approach in children: clinical outcomes, cosmetic results, and complications. J Neurosurg Pediatr, 15(1), 12-9. PMID: 25396702.

Dlouhy, B. J., Awe, O., Rao, R. C., Kirby, P. A. & Hitchon, P. W. (2014). Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient: Case report. J Neurosurg Spine, 21(4), 618-22. PMID: 25002238.

Khanna, R., Smith, Z. A., Dlouhy, B. J. & Dahdaleh, N. S. (2014). Complete absence of the posterior arch of C1: Case report. J Craniovertebr Junction Spine, 5(4), 176-8. PMID: 25558151.

Hitchon, P. W., Dlouhy, B. J. (2014). Response. (Vols. 21). (4), pp. 617. J Neurosurg Spine. PMID: 25392886.

Bijanki, K. R., Kovach, C. K., McCormick, L. M., Kawasaki, H., Dlouhy, B. J., Feinstein, J., Jones, R. D. & Howard 3rd, M. A. (2014). Case report: stimulation of the right amygdala induces transient changes in affective bias. Brain Stimul, 7(5), 690-3. PMID: 24972588.

Massey, C. A., Sowers, L. P., Dlouhy, B. J. & Richerson, G. B. (2014). Mechanisms of sudden unexpected death in epilepsy: the pathway to prevention. Nat Rev Neurol, 10(5), 271-82. PMID: 24752120.

Dlouhy, B. J., Teo, C. (2014). Supraorbital Eyebrow Approach for Craniopharyngiomas. In Kenning , Evans (Eds.) Craniopharyngiomas. Philadelphia PA: Elsevier.

Dlouhy, B. J., Teo, C. (2014). Surgical Management of Hemifacial Spasm. In R. Spetzler , P. Nakaji (Eds.) Neurovascular Surgery. (2nd ed) New York, NY: Thieme.

Dahdaleh, N. S., Dlouhy, B. J. & Menezes, A. H. (2013). One-step fixation of atlantoaxial rotatory subluxation: technical note and report of three cases. World Neurosurg, 80(6), e391-5. PMID: 23159650.

Fogel, A. I., Dlouhy, B. J., Wang, C., Ryu, S. W., Neutzner, A., Hasson, S. A., Sideris, D. P., Abeliovich, H. & Youle, R. J. (2013). Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol Cell Biol, 33(18), 3675-88. PMID: 23878393.

Grossbach, A. J., Dahdaleh, N. S., Abel, T. J., Woods, G. D., Dlouhy, B. J. & Hitchon, P. W. (2013). Flexion-distraction injuries of the thoracolumbar spine: open fusion versus percutaneous pedicle screw fixation. Neurosurg Focus, 35(2), E2. PMID: 23905953.

Belirgen, M., Dlouhy, B. J., Grossbach, A. J., Torner, J. C. & Hitchon, P. W. (2013). Surgical options in the treatment of subaxial cervical fractures: a retrospective cohort study. Clin Neurol Neurosurg, 115(8), 1420-8. PMID: 23481897.

Dahdaleh, N. S., Dlouhy, B. J., Greenlee, J. D., Smoker, W. R. & Hitchon, P. W. (2013). An algorithm for the management of posttraumatic cervical spondyloptosis. J Clin Neurosci, 20(7), 951-7. PMID: 23702373.

Dlouhy, B. J., Dahdaleh, N. S. & Howard 3rd, M. A. (2013). Radiographic and intraoperative imaging of a hemisection of the spinal cord resulting in a pure Brown-Séquard syndrome: case report and review of the literature. J Neurosurg Sci, 57(1), 81-6. PMID: 23584224.

Dlouhy, B. J., Reddy, A., Dahdaleh, N. S. & Greenlee, J. D. (2012). Antibiotic impregnated catheter coverage of deep brain stimulation leads facilitates lead preservation after hardware infection. J Clin Neurosci, 19(10), 1369-75. PMID: 22854128.

Dahdaleh, N. S., Dlouhy, B. J., Viljoen, S. V., Capuano, A. W., Kung, D. K., Torner, J. C., Hasan, D. M. & Howard 3rd, M. A. (2012). Clinical and radiographic predictors of neurological outcome following posterior fossa decompression for spontaneous cerebellar hemorrhage. J Clin Neurosci, 19(9), 1236-41. PMID: 22721890.

Vogel, T. W., Dlouhy, B. J. & Menezes, A. H. (2012). Craniovertebral junction abnormality in a case of Joubert syndrome. Childs Nerv Syst, 28(7), 1109-12. PMID: 22231569.

Dlouhy, B. J., Madhavan, K., Clinger, J. D., Reddy, A., Dawson, J. D., O'Brien, E. K., Chang, E., Graham, S. M. & Greenlee, J. D. (2012). Elevated body mass index and risk of postoperative CSF leak following transsphenoidal surgery. J Neurosurg, 116(6), 1311-7. PMID: 22443502.

Dlouhy, B. J., Greenlee, J. D. (2012). Progressive confusion, memory loss, and gait ataxia in an adult. JAMA, 307(20), 2195-6. PMID: 22618927.

Magnotta, V. A., Heo, H. Y., Dlouhy, B. J., Dahdaleh, N. S., Follmer, R. L., Thedens, D. R., Welsh, M. J. & Wemmie, J. A. (2012). Detecting activity-evoked pH changes in human brain. Proc Natl Acad Sci U S A, 109(21), 8270-3. PMID: 22566645.

Dahdaleh, N. S., Dlouhy, B. J., Kirby, P. A. & Greenlee, J. D. (2012). Unusual "double density" colloid cysts. J Clin Neurosci, 19(4), 612-4. PMID: 22249014.

Dlouhy, B. J., Viljoen, S. V., Kung, D. K., Vogel, T. W., Granner, M. A., Howard 3rd, M. A. & Kawasaki, H. (2012). Vagus nerve stimulation after lead revision. Neurosurg Focus, 32(3), E11. PMID: 22380852.

Dahdaleh, N. S., Dlouhy, B. J. & Menezes, A. H. (2012). Application of neuromuscular blockade and intraoperative 3D imaging in the reduction of basilar invagination. J Neurosurg Pediatr, 9(2), 119-24. PMID: 22295914.

Dlouhy, B. J., Capuano, A. W., Madhavan, K., Torner, J. C. & Greenlee, J. D. (2012). Preoperative third ventricular bowing as a predictor of endoscopic third ventriculostomy success. J Neurosurg Pediatr, 9(2), 182-90. PMID: 22295925.

Kung, D. K., Abel, T. J., Madhavan, K. H., Dalyai, R. T., Dlouhy, B. J., Liu, W., Jabbour, P. M. & Hasan, D. M. (2012). Treatment of endovascular coil and stent migration using the merci retriever: report of three cases. Case Rep Med, 2012, 242101. PMID: 22666264.

Vogel, T. W., Dlouhy, B. J. & Howard 3rd, M. A. (2011). Don't take the plunge: avoiding adverse events with cranial perforators. J Neurosurg, 115(3), 570-5. PMID: 21456895.

Dlouhy, B. J., Dahdaleh, N. S. & Greenlee, J. D. (2011). Emerging technology in intracranial neuroendoscopy: application of the NICO Myriad. Neurosurg Focus, 30(4), E6. PMID: 21456933.

Dlouhy, B. J., Menezes, A. H. (2011). Osteopetrosis with Chiari I malformation: presentation and surgical management. J Neurosurg Pediatr, 7(4), 369-74. PMID: 21456907.

Dahdaleh, N. S., Dlouhy, B. J. & Hitchon, P. W. (2011). Percutaneous pedicle screw fixation for the treatment of thoracolumbar fractures. Part I: Indications. Contemporary Neurosurgery.

Dahdaleh, N. S., Dlouhy, B. J. & Hitchon, P. W. (2011). Percutaneous pedicle screw fixation for the treatment of thoracolumbar fractures. Part II: Surgical technique. Contemporary Neurosurgery.

Vogel, T. W., Dlouhy, B. J. & Howard 3rd, M. A. (2010). Use of confirmatory imaging studies to illustrate adequate treatment of cerebrospinal fluid leak in spontaneous intracranial hypotension. J Neurosurg, 113(5), 955-60. PMID: 20524824.

Madhavan, K., Dlouhy, B. J., Vogel, T. W., Policeni, B. A., Smoker, W. R. & Hasan, D. M. (2010). Anomalous origins of the calcarine and parieto-occipital arteries. J Clin Neurosci, 17(10), 1334-6. PMID: 20637632.

Dlouhy, B. J., Smucker, J. (2009). Cervical Myelopathy. In F. H. Shen , C. Shaffrey (Eds.) Arthritis. (1st ed) London, England: Saunders.