Mark Granner, MD

Portrait
Specialty: Epilepsy and EEG
Director: Iowa Comprehensive Epilepsy Program
Medical Director: Epilepsy Monitoring Unit
Medical Director: Neurology Outpatient Clinic
Vice Chair for Clinical Programs
Clinical Professor of Neurology
Clinical Professor of Neurosurgery

Contact Information

Primary Office: S212 GH
200 Hawkins Dr.
Iowa City, IA 52242
319-356-7235

Education

BA, Mathematics, Grinnell College
MD, University of Iowa College of Medicine

Internship, Internal Medicine, Evanston Hospital
Chief Resident, Neurology, University of Virginia
Resident, Neurology, University of Virginia
Fellow, EEG/Epilepsy, University of Virginia

Licensure and Certifications

American Board of Clinical Neurophysiology (Formerly ABQEEG)
American Board of Psychiatry and Neurology
DEA
Iowa (Permanent) - State of Iowa
Iowa Controlled Substance

Research Summary

Applications of video-EEG monitoring, EEG in nonconvulsive status epilepticus, Pharmacotherapy of epilepsy, Surgical treatment of epilepsy

Publications

Dlouhy, B. J., Gehlbach, B. K., Kreple, C. J., Kawasaki, H., Oya, H., Buzza, C., Granner, M. A., Welsh, M. J., Howard, M. A., Wemmie, J. A. & Richerson, G. B. (2015). Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation. Journal of Neuroscience, 35(28), 10281–10289. DOI: 10.1523/JNEUROSCI.0888-15.2015.

Abel, T. J., Rhone, A. E., Nourski, K. V., Granner, M. A., Oya, H., Griffiths, T. D., Tranel, D. T., Kawasaki, H. & Howard, M. A. (2014). Mapping the temporal pole with a specialized electrode array: technique and preliminary results. Physiological Measurement, 35(3), 323-337. DOI: 10.1088/0967-3334/35/3/323.

Jerath, N. U., Lamichhane, D., Jasti, M., Yarlagadda, V., Zilli, E., Nazzal, Y. & Granner, M. (2014). Treating Epilepsy in the Setting of Medical Comorbidities. Current Treatment Options in Neurology, 16(7), 298. PMID: 24861129.

Sowers, L. P., Massey, C. A., Gehlbach, B. K., Granner, M. A. & Richerson, G. B. (2013). Sudden unexpected death in epilepsy: Fatal post-ictal respiratory and arousal mechanisms. Respiratory Physiology & Neurobiology, 189(2), 315–323. DOI: 10.1016/j.resp.2013.05.010.

Dlouhy, B. J., Viljoen, S. V., Kung, D. K., Vogel, T. W., Granner, M. A., Howard, M. A. & Kawasaki, H. (2012). Vagus nerve stimulation after lead revision. Neurosurgical focus, 32(3), E11. PMID: 22380852.

Kee, V. R., Gilchrist, B., Granner, M. A., Sarrazin, N. R. & Carnahan, R. M. (2012). A systematic review of validated methods for identifying seizures, convulsions, or epilepsy using administrative and claims data. Pharmacoepidemiology and drug safety, 21 Suppl 1, 183-93. PMID: 22262605.

Granner, M. A. (2011). Invasive Video-EEG Monitoring in Epilepsy Surgery Candidates: Indications, Technique and Interpretation. In , T. Y. Yamada , E. M. Meng (Eds.) Practical Guide For Clinical Neurophysiologic Testing: EP, LTM, IOM, PSG, and NCS. Lippincott, Williams & Wilkins.

Karafin, M., St Louis, E. K., Zimmerman, M. B., Sparks, J. D. & Granner, M. A. (2010). Bimodal ultradian seizure periodicity in human mesial temporal lobe epilepsy. Seizure : the journal of the British Epilepsy Association, 19(6), 347-51. PMID: 20580271.

St. Louis, E. K., Granner, M. A. (2010). Seizures and Epilepsy in Adolescents and Adults. In R. E. Rakel , E. T. Bope , R. D. Kellerman (Eds.) Conn’s Current Therapy 2010. Elsevier.

Chahin, S., Garwood, M. D., St Louis, E. K., Shivapour, E. T., Kelkar, P. M. & Granner, M. A. (2009). Intramedullary Sjögren syndrome. Neurology, 73(23), 2041-2. PMID: 19996081.

Gurol, M. E., Caillier, R., Granner, M. A. & St.Louis, E. K. (2008). Episodic neurologic deficits with headaches and reversible imaging findings long after cranial irradiation are epileptic phenomena. (Vols. 64). (Suppl 12), pp. S21-22. Ann Neurol.

Wolff, H., St. Louis, E. K., Zimmerman, M. B. & Granner, M. A. (2008). Seizure occurrence in primary generalized epilepsies is predominantly diurnal. pp. S25. Ann Neurol.

Leira, E. C., Granner, M. A., Torner, J. C., Callison, R. C. & Adams, H. P. (2008). Education Research: The challenge of incorporating formal research methodology training in a neurology residency. Neurology, 70(20), e79-84. PMID: 18474837.

St. Louis, E. K., Granner, M. A. (2007). Seizures and Epilepsy in Adolescents and Adults. In R. E. Rakel (Eds.) Conn’s Current Therapy 2007. Elsevier.

Genilo, P., St. Louis, E. K., Granner, M. A. & Zimmerman, B. (2005). The influence of sleep on mesial temporal lobe epilepsy. (Vols. 22). (5), pp. 369. J Clinical Neurophysiology.

St Louis, E. K., Genilo, P., Granner, M. A. & Zimmerman, B. (2004). Sleep-onset mesial temporal seizures arise from light NREM sleep. (Vols. 45). (Suppl 7), pp. 86-7. Epilepsia.

Carlson, C. E., St. Louis, E. K. & Granner, M. A. (2004). Yield of video-EEG monitoring in patients over the age of 50. (Vols. 45). (Suppl 7), pp. 241. Epilepsia.

Genilo, P., St Louis, E. K., Granner, M. A. & Zimmerman, B. (2004). Partial seizure duration during sleep and wakefulness in mesial temporal epilepsy. (Vols. 45). (Suppl 7), pp. 260. Epilepsia.

Martin, C. O., Denburg, N. L., Tranel, D., Granner, M. A. & Bechara, A. (2004). The effects of vagus nerve stimulation on decision-making. Cortex; a journal devoted to the study of the nervous system and behavior, 40(4-5), 605-12. PMID: 15505970.

Garwood, M. D., St. Louis, E. K., Kelkar, P. M. & Granner, M. A. (2004). Neuropathology in intramedullary Sjogren’s Syndrome. (Vols. 56). (Suppl 8), pp. S32. Annals of Neurology.

St. Louis, E. K., Granner, M. A. (2003). Sleep and epilepsy: a review. www.advanceforsleep.com.

Al-Kaylani, M., Granner, M. A., Howard, M. & St. Louis, E. (2002). Epilepsy surgical outcome at the University of Iowa. (Vols. 43). (7), pp. 335. Epilepsia.

Kawasaki, H., Buchanan, T., Oya, H., Howard, M., Kaufman, O., Damasio, H., Granner, M. A. & Adolphs, R. (2001). Human prefrontal cortex and amygdala show correlated single-unit responses to emotional pictures. Eighth Annual Meeting of the Cognitive Neuroscience Society.

Kaufman, O., Howard, M., Kawasaki, H., Damasio, H., Granner, M. A. & Adolphs, R. (2001). Lateralized processing of pleasant and unpleasant emotions from single-unit recordings in human prefrontal cortex and amygdala. Eighth Annual Meeting of the Cognitive Neuroscience Society.

Martin, C. O., Bechara, A., Denberg, N. L., Granner, M. A. & Tranel, D. (2001). The effect of vagus nerve stimulation on decision-making. 31st Annual Meeting of the Society for Neuroscience.

Kawasaki, H., Kaufman, O., Damasio, H., Damasio, A. R., Granner, M., Bakken, H., Hori, T., Howard, M. A. & Adolphs, R. (2001). Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortex. Nature neuroscience, 4(1), 15-6. PMID: 11135639.

Kawasaki, M., Howard, M., Kaufman, O., Bakken, H., Damasio, H., Granner, M. A., Hori, T. & Adolphs, R. (2000). Single-unit responses to emotional pictures recorded in human orbitofrontal cortex. (Vols. 26). Soc. Neurosci. Abstr.

Howard, M. A., Volkov, I. O., Mirsky, R., Garell, P. C., Noh, M. D., Granner, M., Damasio, H., Steinschneider, M., Reale, R. A., Hind, J. E. & Brugge, J. F. (2000). Auditory cortex on the human posterior superior temporal gyrus. The Journal of comparative neurology, 416(1), 79-92. PMID: 10578103.

Kawasaki, H., Adolphs, R., Kaufman, O., Bakken, H., Damasio, H., Granner, M. A. & Howard, M. (2000). Single-unit responses to emotional faces and scenes recorded in human orbitofrontal cortex. Seventh Annual Meeting of the Cognitive Neuroscience Society.

Adolphs, R., Bechara, A., Kaufman, O., Kawasaki, H., Bakken, H., Damasio, H., Granner, M. A. & Howard, M. (2000). Single-unit responses in human orbitofrontal cortex: decision-making on a gambling task. Seventh Annual Meeting of the Cognitive Neuroscience Society.

Kaufman, O., Howard, M., Kawasaki, H., Bakken, H., Damasio, H., Granner, M. A. & Adolphs, R. (2000). Single-unit responses in human orbitofrontal cortex: emotional experience from movies. Seventh Annual Meeting of the Cognitive Neuroscience Society.

Granner, M. A. (1999). Epilepsy in Adolescents and Adults. In R. E. Rakel (Eds.) Conn’s Current Therapy (51st ed.). W.B. Saunders Company.

Wellman, B. J., Loftus, C. M., Kresowik, T. F., Todd, M. & Granner, M. A. (1998). The differences in electroencephalographic changes in patients undergoing carotid endarterectomies while under local versus general anesthesia. Neurosurgery, 43(4), 769-73; discussion 773-5. PMID: 9766302.

Garell, P. C., Granner, M. A., Noh, M. D., Howard, M. A., Volkov, I. O. & Gillies, G. T. (1998). An introductory overview of research instrumentation for recording of electrical activity of neurons in the human brain. Review of Scientific Instruments, 69, 4027-4037.

Howard, M. A., Volkov, I. O., Mirsky, R., Noh, M. D., Granner, M. A., Abbas, P., Damasio, H., Steinschneider, M., Reale, R. A., Hind, J. E. & Brugge, J. F. (1997). An auditory field on the posterior superior temporal gyrus of human cerebral cortex. Society for Neuroscience Abstracts.

Howard, M. A., Volkov, I. O., Noh, M. D., Granner, M. A., Mirsky, R. & Garell, P. C. (1997). Chronic microelectrode investigations of normal human brain physiology using a hybrid depth electrode. Stereotactic and functional neurosurgery, 68(1-4 Pt 1), 236-42. PMID: 9711723.

Dyken, M. E., Granner, M. A., Yamada, T. & Yeh, M. (1996). The role of digital, split-screen, video-polysomnography in the assessment of nocturnal seizures. American Clinical Neurophysiology Society Annual Meeting.

Howard, M. A., Volkov, I. O., Granner, M. A., Damasio, H. M., Ollendieck, M. C. & Bakken, H. E. (1996). A hybrid clinical-research depth electrode for acute and chronic in vivo microelectrode recording of human brain neurons. Technical note. Journal of neurosurgery, 84(1), 129-32. PMID: 8613821.

Howard, M. A., Volkov, I. O., Abbas, P. J., Damasio, H., Ollendieck, M. C. & Granner, M. A. (1996). A chronic microelectrode investigation of the tonotopic organization of human auditory cortex. Brain research, 724(2), 260-4. PMID: 8828578.

Granner, M. A. (1995). Post-traumatic Epilepsy. In M. Rizzo , D. Tranel (Eds.) Head Injury and Postconcussive Syndrome. pp. 227-241. Churchill Livingstone.

Yamada, T., Dyken, M. E., Granner, M. A. & Yeh, M. (1995). Split-screen video and polysomnographic/EEG analysis. In: EMG and Neurophysiology. J. Kimura , H. Shibanski (Eds.) pp. 904-907. Elsevier Science BV.

Howard, M. A., Dobbs, M. B., Simonson, T. M., LaVelle, W. E. & Granner, M. A. (1995). A noninvasive, reattachable skull fiducial marker system. Technical note. Journal of neurosurgery, 83(2), 372-6. PMID: 7616289.

Gates, J. R., Granner, M. A. (1995). Nonepileptic Events. In M. Rizzo , D. Tranel (Eds.) Head Injury and Postconcussive Syndrome. pp. 243-253. Churchill Livingstone.

Granner, M. A., Howard, M. A. & Volkov, I. (1995). A hybrid clinical-research depth electrode for chronic in vivo electrophysiologic recording in patients with medically refractory epilepsy. AES Annual Meeting.

Granner, M. A. (1994). The Surgical Management of Epilepsy. Butterworth-Heinemann.

Granner, M. A., Lee, S. I. (1994). Nonconvulsive status epilepticus: EEG analysis in a large series. Epilepsia, 35(1), 42-7. PMID: 8112256.

Davis, B. J., Aul, E. A., Granner, M. A. & Rodnitzky, R. L. (1994). Ranitidine-induced cranial dystonia. Clinical neuropharmacology, 17(5), 489-91. PMID: 9316702.

Waterhouse, E., Granner, M. A. (1993). Comprehensive analysis of EEG, radiographic and performance data in the intracarotid amytal test (ICAT). AES Annual Meeting.

Granner, M. A., Lee, S. I. (1992). Nonconvulsive status epilepticus: in-depth study in a large series of cases. AAN Annual Meeting.

Granner, M. A., Wooten, G. F. (1991). Neuroleptic malignant syndrome or parkinsonism hyperpyrexia syndrome. Seminars in neurology, 11(3), 228-35. PMID: 1947485.

Beale, E., Andreone, T., Koch, S., Granner, M. & Granner, D. (1984). Insulin and glucagon regulate cytosolic phosphoenolpyruvate carboxykinase (GTP) mRNA in rat liver. Diabetes, 33(4), 328-32. PMID: 6323236.