Mark K. Santillan, MD, PhD, FACOG, FAHA

Portrait
Assistant Professor of Obstetrics and Gynecology - Maternal Fetal Medicine
Co-Director, OB/GYN Residency Research
Clinical Research Director, Maternal Fetal Tissue Bank
Faculty, Molecular and Cellular Biology

Contact Information

Primary Office
31313 PFP
Iowa City, IA 52242
319-356-3180

Lab
464 MRF
Iowa City, IA 52242
319-384-8667

Education

BS, Chemistry with Biochemistry emphasis, Loyola University Chicago, Chicago, IL
BA, Philosophy, Loyola University Chicago, Chicago, IL
MD, Doctor of Medicine, Loyola University Stritch School of Medicine, Maywood, IL
PhD, Translational Biomedicine, University of Iowa Carver College of Medicine, Iowa City, IA
Resident, Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL
Fellow, Maternal Fetal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA

Licensure and Certifications

Maternal Fetal Medicine Subspecialty Board Certification - American Board of Obstetrics and Gynecology
General OB/Gyn Board Certification - American Board of Obstetrics and Gynecology
DEA Controlled Substance
Iowa Controlled Substance
Iowa Board of Medicine
Illinois Medical License

Research Summary

The Santillan lab is particularly interested in the relationship between maternal health during pregnancy and the short and long-term health effects to the mother and child. Specifically, our current work focuses on the early mechanisms involved in the development of preeclampsia, including immunological and vascular function changes during pregnancy. A central focus in the lab is investigating the predictive, preventative, therapeutic and curative potential of the arginine vasopressin pathway in preeclampsia. Leveraging the group’s novel discovery of a very early biomarker for preeclampsia and a novel mouse model for preeclampsia, our lab works to investigate the mechanistic underpinnings of the predictive and therapeutic potential of vasopressin in the management of preeclampsia in a translational manner. As a practicing academic high-risk obstetrician, Dr. Santillan is very qualified in caring for women with high risk pregnancies, in understanding their clinical management, and in conducting clinical/translational research in perinatal biology. He has been successful in conducting studies in both murine and human pregnancies. As the clinical research director and co-founder of the Maternal Fetal Tissue Bank, Dr. Santillan has significant experience in clinical data acquisition, management, and analysis as well as molecular biology techniques needed for translational studies. Furthermore, as the Principal Investigator of the Population project of the University of Iowa American Heart Association Strategically Focused Research Network in Hypertension, Dr. Santillan has developed the PREDICTV network of prenatal providers around the state of Iowa to collect samples and clinical information from a diverse cohort of pregnant women.

Publications

Santillan, M. K., Pelham, C. J., Ketsawatsomkron, P., Santillan, D. A., Davis, D. R., Devor, E. J., Gibson-Corley, K. N., Scroggins, S. M., Grobe, J. L., Yang, B., Hunter, S. K. & Sigmund, C. D. (2015). Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep, 3(1), pii: e12257. PMID: 25602015.

Santillan, M. K., Leslie, K. K., Hamilton, W. S., Boese, B. J., Ahuja, M., Hunter, S. K. & Santillan, D. A. (2014). Collection of a lifetime: a practical approach to developing a longitudinal collection of women's healthcare biological samples. Eur J Obstet Gynecol Reprod Biol, 179, 94-9. PMID: 24965987.

Santillan, M. K., Santillan, D. A., Scroggins, S. M., Min, J. Y., Sandgren, J. A., Pearson, N. A., Leslie, K. K., Hunter, S. K., Zamba, G. K., Gibson-Corley, K. N. & Grobe, J. L. (2014). Vasopressin in Preeclampsia: A Novel Very Early Human Pregnancy Biomarker and Clinically Relevant Mouse Model. Hypertension, 64(4), 852-859. PMID: 25001273.

Devor, E. J., Reyes, H. D., Santillan, D. A., Santillan, M. K., Onukwugha, C., Goodheart, M. J. & Leslie, K. K. (2014). Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OB/GYN Research Questions. Obstet Gynecol Int, 2014, 5 pages. PMID: 24757447.

Kyser, K. L., Lu, X., Santillan, D., Santillan, M., Caughey, A. B., Wilson, M. C. & Cram, P. (2014). Forceps Delivery Volumes in Teaching and Non-Teaching Hospitals: Are Volumes Sufficient for Acquisition and Maintenance of Competence?. (Vols. 1). (89), pp. 71-6. Academic Medicine. PMID: 24280847.

Kyser, K., Lu, X., Santillan, D., Santillan, M. K., Hunter, S., Cahill, A. G. & Cram, P. (2012). The Association Between Hospital Obstetrical Volume and Maternal Postpartum Complications. (Vols. 204). pp. 42.e1-17. Am J Obstet Gynecol. PMID: 22727347.

Santillan, M. K., Santillan, D. A., Fleener, D., Stegmann, B., Zamba, G., Hunter, S. & Yankowitz, J. (2012). Single Umbilical Artery: Does Side Matter?. (Vols. 32). (3), pp. 201-208. Fetal Diagn Ther. PMID: 22678110.

Tabor, H. K., Murray, J., Gammill, H. S., Kitzman, J. O., Snyder, M. W., Ventura, M., Lewis, A. P., Qiu, R., Simmons, L. E., Rubens, C. E., Santillan, M. K., Eichler, E. E., Cheng, E. Y., Bamshad, M. J. & Shendure, J. (2012). Non-invasive Fetal Genome Sequencing: Opportunities and Challenges. (Vols. 9999). (1), pp. 3. Am J Med Genet Part A. PMID: 22887792.

Santillan, D. A., Santillan, M. K. & Hunter, S. (2009). Cell Encapsulation Technology as a Useful Non-Dietary Therapy for Maternal Phenylketonuria. (Vols. 201). (3), pp. 289.E1-6. Am J Obstet Gynecol. PMID: 19631922.

Santillan, M. K., Herring, J., Hoppensteadt, D. A., Jeske, W., Herbert, J. M. & Fareed, J. (2001). The effect of a novel glycoprotein IIb/IIIa antagonist, SR 121566A, on platelet aggregation and activation in rhesus monkeys. (Vols. 7). (1), pp. 10-5. Clin Appl Thromb Hemost. PMID: 11190897.

Sandren, J. A., Deng, G., Linggonergoro, D. W., Scroggins, S. M., Perschbacher, K. J., Nair, A. R., Nishimura, T. E., Zhang, S. Y., Agbor, L. N., Wu, J., Keen, H. L., Naber, M. C., Pearson, N. A., Zimmerman, K. A., Weiss, R. M., Bowdler, N. C., Usachev, Y. M., Santillan, D. A., Potthoff, M. J., Pierce, G. L., Gibson-Corley, K. N., Sigmund, C. D., Santillan, M. K. & Grobe, J. L. (In Press). Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. JCI Insight 2018.

Perschbacher, K. J., Deng, G., Fisher, R. A., Gibson-Corley, K. N., Santillan, M. K. & Grobe, J. L. (2018). Regulators of G-Protein Signaling in Cardiovascular Function During Pregnancy. Physiol Genomics, 50(8), 590-604. PMID: 29702036.

Sandgren, J. A., Linggonegoro, D. W., Zhang, S. Y., Sapouckey, S. A., Claflin, K. E., Pearson, N. A., Leidinger, M. R., Pierce, G. L., Santillan, M. K., Gibson-Corley, K. N., Sigmund, C. D. & Grobe, J. L. (2018). Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin. AM J Physiol Regul Integr Comp Physiol, 314(6), R770-R780. PMID: 29364700.

Alexander, L. B., Nishimura, T. E., Brandt, D. S., Thomas, K. M., Evans, N. J., Polgreen, P. M., Polgreen, L. A., Santillan, M. K. & Santillan, D. A. (2018). Evaluating the association of physical activity and weight gain in pregnancy. (Vols. 8). (1), pp. 2 p. Iowa City, IA: Proc Obstet Gynecol.

Scroggins, S. M., Santillan, D. A., Lund, J. M., Sandgren, J. A., Krotz, L. K., Hamilton, W. S., Devor, E. J., Davis, H. A., Pierce, G. L., Gibson-Corley, K. N., Sigmund, C. D., Grobe, J. L. & Santillan, M. K. (2018). Elevated Vasopressin in Pregnant Mice Induces T Helper Subset Alterations Consistent with Human Preeclampsia. Clin Sci (Lond), 132(3), 419-436. PMID: 29371289.

Kempuraj, D., Thangavel, R., Fattal, R., Pattani, S., Yang, E., Zaheer, S., Santillan, D. A., Santillan, M. K. & Zaheer, A. (2016). Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP+). Neurochem Res, 41(5), 1042-9. PMID: 26646004.

Sandgren, J. A., Santillan, M. K. & Grobe, J. L. (2016). Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions. Hypertension, 67(6), 1119-20. PMID: 27113050.

Muntner, P., Becker, R. C., Calhoun, D., Chen, D., Cowley Jr, A. W., Flynn, J. T., Grobe, J. L., Kidambi, S., Kotchen, T. A., Lackland, D. T., Leslie, K. K., Li, Y., Liang, M., Lloyd, A., Mattson, D. L., Mendizabal, B., Mitsnefes, M., Nair, A., Pierce, G. L., Pollock, J. S., Safford, M. M., Santillan, M. K., Sigmund, C. D., Thomas, S. J. & Urbina, E. M. (2016). Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. Hypertension, 67(4), 674-80.

Sandgren, J. A., Scroggins, S. M., Santillan, D. A., Devor, E. J., Gibson-Corley, K. N., Pierce, G. L., Sigmund, C. D., Santillan, M. K. & Grobe, J. L. (2015). Vasopressin: The Missing Link for Preeclampsia?. Am J Physiol Regul Integr Comp Physiol, 309(9), R1062-4. PMID: 25810383.

Kempuraj, D., Thangavel, R., Yang, E., Pattani, S., Zaheer, S., Santillan, D. A., Santillan, M. K. & Zaheer, A. (2015). Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins a-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators. PloS One, 10(8), e0135776. PMID: 26074093.

Stegmann, B. J., Santillan, M., Leader, B., Smith, E. & Santillan, D. (2015). Changes in antimullerian hormone levels in early pregnancy are associated with preterm birth. Fertil Steril, 104(2), 347-55.e3. PMID: 26074093.

Li, C., Raikwar, N. S., Santillan, M. K., Santillan, D. A. & Thomas, C. P. (2015). Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1. Placenta, 36(4), 446-453. PMID: 25638730.

Adams, A., Hubb, A. J., Santillan, M. K., Nishimura, T. E., Ruback, R., Gravatt, L., Higdon, E., Schroeder, K., Conklin, J., Bender, R. M., Hunter, S. K. & Santillan, D. A. (2015). Adherence to the updated guidelines for the prevention of perinatal Group B streptococcal disease. Proc Obstet Gynecol, 4(3), [2 p].

Solheim, K. N., Santillan, D. A., Scroggins, S., Devor, E. J. & Santillan, M. K. (2015). Global fetal DNA methylation and birth outcomes in obese women. Proc Obstet Gynecol, 4(3), [2 p].

Li, C., Railkwar, N. S., Santillan, M. S., Santillan, D. A. & Thomas, C. P. (2015). Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1. Placenta, pii: S0143-4004(15)00034-X. PMID: 25638730.

Santillan, M., Santillan, D., Scroggins, S., Sandgren, J., Pearson, N., Gibson-Corley, K. & Grobe, J. (2015). Chronic vasopressin infusion throughout pregnancy phenocopies the physiologic, vascular, obstetric and immunologic phenotypes of human preeclampsia in mice. Pregnancy Hypertens, 5(1). PMID: 25787384.

Santillan, M., Santillan, D., Scroggins, S., Min, J., Leslie, K., Hunter, S., Zamba, G., Gibson-Corley, K. & Grobe, J. (2015). Vasopressin secretion in human pregnancy predicts the development of preeclampsia as early as the sixth week of gestation. Pregnancy Hypertens, 5(1), 25-26. PMID: 25787398.

Hansen, J., Santillan, M. K., Stegmann, B. J., Foster, T. & Hardy-Fairbanks, A. J. (2014). Maternal demographic and clinical variables do not predict intrauterine contraception placement: Evidence for postplacental intrauterine contraception placement. Proc Obstet Gynecol, 4(2), [7 p].

Santillan, M. K. (2013). Wandering womb, water and worms: the history, myths, and messy immunologic etiology of preeclampsia/eclampsia. Proc Obstet Gynecol, 3(3).

Kowalski, J. T., Santillan, D. A., Netz, R., Sinkey, C. A., Fleener, D., Hunter, S. K. & Santillan, M. K. (2013). Flow mediated vasodilation predicts the development of gestational diabetes mellitus. Proc Obstet Gynecol, 3(3), [2 p].

Taylor, J., Conklin, J., Hunter, S. K., Empey, R., Tyler, E., Christensen, A., Talcott, A., Ballas, Z., Santillan, D. (2013). Defining normal IgG changes throughout pregnancy. Proc Obstet Gynecol, 3(2), 2.

Snyder, M. W., Simmons, L. E., Kitzman, J. O., Santillan, D. A., Santillan, M. K., Gammill, H. S. & Shendure, J. (2013). Noninvasive fetal genome sequencing: a primer. Prenat Diagn, 33(6), 547-54. PMID: 23553552.

Snyder, M. W., Simmons, L. E., Kitzman, J. O., Santillan, D. A., Santillan, M. K., Gammill, H. S. & Shendure, J. (2013). Noninvasive fetal genome sequencing: a primer. Prenatal diagnosis, 33(6), 547-54. PMID: 23553552.

Devor, E., Santillan, D. A. & Santillan, M. K. (2013). Preeclampsia and MicroRNAs. Proceedings in Obstetrics and Gynecology, 3(1), 2.

Santillan, D. A., Hamilton, W., Christenson, A., Talcott, K., Gravatt, L., Santillan, M. K. & Hunter, S. (2013). The effects of preeclampsia on signaling to hematopoietic progenitor cells. Proceedings in Obstetrics and Gynecology, 3(1), 3.

Stegmann, B., Santillan, M. K., Santillan, D. A., Smith, E., Van Voorhis, B. & Schultz, K. (2012). Anti-Mullerian Hormone concentration levels in maternal plasma during the first, second and third trimester of pregnancy. S. Schwartz-Rogers (Eds.) (Vols. 2). (3), pp. Article 2 [2p.]. Iowa City, IA: Proc Obstet Gynecol.

Empey, R., Santillan, D. A., Santillan, M. K., Tyler, E., Hunter, S., Smith, E. & Stegmann, B. (2012). The influence of fetal sex on patterns of change in anti-Mullerian hormone during pregnancy. S. Schwartz-Rogers (Eds.) (Vols. 2). (3), pp. Article 4 [2 p.]. Iowa City, IA: Proc Obstet Gynecol.

Santillan, M. K., Raghuraman, N., Naruko-Stewart, K., Cooper, K., Santillan, D. A., Zamba, G. & Greiner, A. (2012). Diuresis: Physiologic Cues to Decrease Postpartum Magnesium Administration. In Preparation.

Santillan, D. A., Rai, K., Santillan, M. K., Krishnamachari, Y., Salem, A. K. & Hunter, S. (2011). Efficacy of Polymeric Encapsulated C5a peptidase-based Group B Streptococci Vaccines in a Murine Model. (Vols. 205). (3), pp. 249.e1-8. Am J Obstet Gynecol. PMID: 21802065.

Stegmann, B., Santillan, D. A., Santillan, M. K., Van Voorhis, B. J. & Smith, E. M. (2011). Hormone Changes in Pregnancy and Prediction of Adverse Pregnancy Outcomes. (Vols. 18). (3, Supplement), pp. 1A-68A. Reproductive Sciences.

Rai, K., Santillan, D. A., Santillan, M. K., Hamilton, W., Krishnamachari, Y., Salem, A. K. & Hunter, S. (2011). Prevention of Group B Streptococcus (GBS) colonization by multiple GBS serotypes using a novel GBS vaccine. (Vols. 204). (1, Supplement), pp. S22-S23. American Journal of Obstetrics & Gynecology.

Santillan, D. A., Santillan, M. K., Rai, K. & Hunter, S. (2011). Treatment of maternal PKU: Safety and Efficacy of a Novel Engineered Metabolic System. (Vols. 204). (1, Supplement), pp. S322-S323. American Journal of Obstetrics & Gynecology.

Santillan, M. K., Santillan, D. A. (2010). 2010 Updates of the CDC Guidelines for GBS in pregnancy. (Vols. XXXI). (4) The Perinatal Letter.

Santillan, M. K., Yankowitz, J. (2010). Fetal effects of drugs commonly used in critical care. In M. A. Belfort , G. R. Saade , M. R. Foley , J. P. Phelan , G. A. Dildy (Eds.) Critical Care Obstetrics. (5th Edition) Wiley-Blackwell.

Santillan, M. K., Yankowitz, J. (2010). Fetal effects of drugs commonly used in critical care. In M. A. Belfort , G. R. Saade , M. R. Foley , J. P. Phelan , G. A. Dildy (Eds.) Critical Care Obstetrics, 5th Edition. (978-1-4021-5273-0) Wiley-Blackwell.

Santillan, M. K., Pelham, C., Ketsawatsomkron, P., Santillan, D. A., Yang, B., Hunter, S. & Sigmund, C. D. (2010). Indoleamine 2,3 Dioxygenase (IDO) Deficiency Results in Vascular Dysfunction and Proteinuria in Pregnancy. (Vols. 56). (e91), pp. 174. Hypertension.

Santillan, M. K., Pelham, C., Ketsawatsomkron, P., Santillan, D. A., Yang, B., Hunter, S. K. & Sigmund, C. D. (2009). Development and characterization of an Indoleamine 2,3-dioxygenase (IDO) deficient mouse model of preeclampsia. (Vols. 201). (6), pp. S276. American Journal of Obstetrics & Gynecology.

Santillan, M. K., Santillan, D. A., Sigmund, C. D. & Hunter, S. (2009). IDO and sFLT-1: A Potential Molecular Link Between the Immune System and Preeclampsia. (Vols. 199). (6), pp. S83. Am J Obstet Gynecol.

Santillan, M. K., Santillan, D. A., Sigmund, C. D. & Hunter, S. (2009). From molecules to medicine: A future cure for preeclampsia?. (Vols. 22). (9), pp. 531-541. Drug News Perspect. PMID: 20072730.

Santillan, M. K., Hunter, S. (2008). Preeclampsia/Eclampsia: An Immediate and Long Term Problem. (Vols. 29). (4), pp. 16. The Perinatal Letter.

Santillan, D., Santillan, M. & Hunter, S. (2007). Development of a novel non-dietary therapy for maternal phenylketonuria. (Vols. 197). (6, supplement), pp. S118. AJOG. DOI: http://dx.doi.org/10.1016/j.ajog.2007.10.409.

Santillan, M., Santillan, D., Gianopoulos, J., Mestril, R. & Koh, M. (2007). HSP60 and anti-HSP60 antibody are associated with intrapartum infection in preeclamptic mothers. (Vols. 197). (6, supplement), pp. S139. American Journal of Obstetrics & Gynecology. DOI: http://dx.doi.org/10.1016/j.ajog.2007.10.493.

Santillan, M. K., Santillan, D. A., Fleener, D., Hunter, S. & Yankowitz, J. (2007). Single Umbilical Artery: Does SIDE Matter?,. (Vols. 197). (6), pp. S56. AJOG.

Santillan, M., Besinger, R. E., Gianopoulos, J. G. & Mittendorf, R. (2005). An inverse correlation between umbilical cord blood ionized magnesium (IMG) and interleukin-6 (IL-6) levels could not be confirmed in the human. AJOG, 193(6), S183. DOI: http://dx.doi.org/10.1016/j.ajog.2005.10.741.

Santillan, M., Ero, M., Hoppnesteadt, D. A., Jeske, W., Herbert, J. M. & Fareed, J. (1997). Pharmacokinetics and pharmacodynamics of a novel glycoprotein IIb/IIIa antagonist, SR 121566A. Blood.

Eppsteiner, E. E., Santillan, M. K. & Stegmann, B. J. Influence of Infertility Diagnosis on Pregnancy Outcome in ART. POG, Article 1, 10.

Kempuraj, D., Ramasamy, T., Zaheer, S., Santillan, D., Santillan, M. & Zaheer, A. The Parkinsonian toxin 1 – methyl -4 – phenylpyridinium (MPP+), and proteins a-synuclein and glia maturation factor (GMF) activate mast cells and release proinflammatory mediators. (Vols. 30). San Diego, CA: MDS 19th International Congress of Parkinson's Disease and Movement Disorders.