Xiangbing Meng, PhD

Portrait
Research Associate Professor of Obstetrics and Gynecology - Reproductive Science Research

Contact Information

Primary Office: 3234 MERF
Iowa City, IA 52242
319-335-8212

Education

BS, Biochemistry, Beijing Normal University, China
MS, Biochemistry and Molecular Biology, Beijing Normal University, China
PhD, Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Academy of Military Medicine, Beijing, China

Post Doctoral Fellow, Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio
Post Doctoral Fellow, Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, New Mexico

Research Summary

New prognosis biomarkers and potential therapeutic targets in gynecology; Synthetic lethal studies in gynecology; Mitotic Catastrophe induction in ovarian and endometrial cancer

Publications

Ebeid, K., Meng, X., Thiel, K. W., Do, A. V., Geary, S. M., Morris, A. S., Pham, E. L., Wongrakpanich, A., Chhonker, Y. S., Murry, D. J., Leslie, K. K. & Salem, A. K. (2018). Synthetically lethal nanoparticles for treatment of endometrial cancer. Nat Nanotechnol, 13(1), 72-81. PMID: 29203914.

Li, Y., Gonzalez Bosquet, J., Yang, S., Thiel, K. W., Leslie, K. K. & Meng, X. (2017). Role of MTDH in estrogen-regulated gene expression. (Vols. 40). (2), pp. 303-310. Int J Mol Med. PMID: 28627585.

Kavlashvilli, T., Jia, Y., Dai, D., Meng, X., Thiel, K. W., Leslie, K. K. & Yang, S. (2016). Inverse Relationship between Progesterone Receptor and Myc in Endometrial Cancer. PLoS One, 11(2), e0148912. PMID: 26859414.

Meng, X., Yang, S., Zhang, Y., Wang, X., Goodfellow, R. X., Jia, Y., Thiel, K. W., Reyes, H. D., Yang, B. & Leslie, K. K. (2015). Genetic Deficiency of Mtdh in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs. J Biol Chm, pii: jbc.M114.627653. PMID: 25787082.

Yang, S., Jia, Y., Liu, X., Winters, C., Wang, X., Zhang, Y., Devor, E. J., Hovey, A. M., Reyes, H. D., Xiao, X., Xu, Y., Dai, D., Meng, X., Thiel, K. W., Domann, F. E. & Leslie, K. K. (2014). Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer. Oncotarget, 5(20), 9783-97. PMID: 25229191.

Yang, S., Xiao, X., Liu, X., Jia, Y., Zhang, X., Devor, E. J., Meng, X., Thiel, K. W. & Leslie, K. K. (2014). Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells. Curr Pharm Des, 20(11), 1874-80. PMID: 23888956.

Meng, X., Yang, S., Wang, X., Jia, Y., Zhang, Y. & Leslie, K. K. (2014). Restoring sensitivity to cisplatin or TRAIL by targeting drug resistance master regulators in endometrial cancer.

Meng, X., Devor, E. J., Yang, S., Schickling, B. M. & Leslie, K. K. (2014). Role of MTDH, FOXM1 and microRNAs in Drug Resistance in Hepatocellular Carcinoma, Diseases. Diseases, 2(3), 209-225. DOI: 10.3390/diseases2030209.

Yang, S., Meng, X. (2014). Advances and Perspectives in the Treatment of High-Grade Serous Ovarian Cancer. Journal of Women's Health and Gynecology, 1, 1-3.

Meng, X., Dizon, D. S., Yang, S., Wang, X., Zhu, D., Thiel, T. K. & Leslie, K. K. (2013). Strategies for molecularly enhanced chemotherapy to achieve synthetic lethality in endometrial tumors with mutant p53. Obstet Gynecol Int 2013, 2013(828165). PMID: 24381593.

Yang, S., Leslie, K. K. & Meng, X. (2013). MTDH and FOXM1, Two Master Regulators in Gynecologic Cancer. Med J Obstet Gynecol, 1(2), 1009.

Meng, X., Thiel, K. W. & Leslie, K. K. (2013). Drug Resistance Mediated by MTDH/AEG-1/Lyric, Advances in Cancer Research, 1st Edition, AEG-1/MTDH/Lyric Implicated in Multiple Human Cancers. PMID: 23889990.

Meng, X., Yang, S., Zhu, D., Wang, X., Thiel, K. W. & Leslie, K. K. (2013). Strategies for Molecularly Enhanced Chemotherapy in Endometrial Tumors with Mutant p53 (Poster). 104th American Association for Cancer Research (AACR) Annual Meeting.

Meng, X., Laidler, L. L., Kosmacek, E. A., Yang, S., Xiong, Z., Zhu, D., Wang, X., Dai, D., Zhang, Y., Wang, X., Brachova, P., Albitar, L., Liu, D., Ianzini, F., Mackey, M. & Leslie, K. K. (2012). Induction of Mitotic Cell Death in Cancer Cells with Non-Functional p53: a New Therapeutic Strategy. Gynecol Oncol, 128(3), 461-9. PMID: 23146687.

Meng, X., Zhu, D., Wang, X., Yang, S., Zhang, Y., Xiong, Z. & Leslie, K. K. (2012). Identification of a Novel Cytoplasmic Role for MDTH in Chemoresistance as a RNA Binding Protein (Poster). 103rd American Association for Cancer Research (AACR) Annual Meeting.

Meng, X., Zhu, D., Yang, S., Wang, X., Xiong, Z., Zhang, Y., Brachova, P. & Leslie, K. K. (2012). Cytoplasmic Metadherin (MTDH) Provides Survival Advantage Under Conditions of Stress by Acting as RNA-Binding Protein. The Journal of Biological Chemistry, 287(7), 4485-91. PMID: 22199357.

Meng, X., Brachova, P., Yang, S., Xiong, Z., Zhang, Y., Thiel, K. W. & Leslie, K. K. (2011). Knockdown of Metadherin Sensitizes Cell Death Receptor Ligand TRAIL and HDAC Inhibitor LBH589 Co-Treatment. PLoS One, 6(6), e20920.

Meng, X., Brachova, P., Yang, S., Xiong, Z., Zhang, Y. & Leslie, K. K. (2011). Knockdown of MTDH Increases Drug Sensitivity to HDAC Inhibitor and TRAIL Combination Treatment in Endometrial Cancer Cells (Poster). 102nd American Association for Cancer Research (AACR) Annual Meeting.

Yang, S., Xiao, X., Meng, X. & Leslie, K. K. (2011). A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors. PloS One, 6(10), e26343. PMID: 22039466.

Milhem, M. M., Knutson, T., Yang, S., Zhu, D., Wang, X., Leslie, K. K. & Meng, X. (2011). Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients. Journal of Cancer Science & Therapy, S5(4). PMID: 23543869.

Meng, X., Matlawska-Wasowska, K., Girodon, F., Mazel, T., Willman, C. L., Atlas, S., Chen, I. M., Harvey, R. C., Hunger, S. P., Ness, S. A., Winter, S. S. & Wilson, B. S. (2011). GSI-I (Z-LLNle-CHO) Inhibits Gamma-Secretase and the Proteosome to Trigger Cell Death in Precursor-B Acute Lymphoblastic Leukemia. Leukemia, 25(7), 1135-46. PMID: 21494254.

Meng, X., Laidler, L. L., Albitar, L., Holmes, A. A., Dai, D., Buekers, T. E., Bender, D. P. & Leslie, K. K. (2010). The Combination of Paclitaxel and Gefitinib (Iressa, ZD1839) Inhibits Endometrial Cancer Cells by Inducing Mitotic Catastrophe: Proof of Principle for Dual Therapy in Endometrial Cancer (Poster). 101st American Association for Cancer Research (AACR) Annual Meeting.

Meng, X., Martinez, M. A., Raymond-Stintz, M. A., Winter, S. S. & Wilson, B. S. (2009). IKK Inhibitor Bay 11-7082 Induces Necroptotic Cell Death in Precursor-B Acute Lymphoblastic Leukaemic Blasts. Br J Haematol, 148(3), 487-90.

Fan, J., Wray, J., Meng, X. & Shen, Z. (2009). BCCIP is Required for the Nuclear Localization of the p21 Protein. Cell Cycle, 8(18), 3019-24.

Meng, X., Winter, S. S., Martinez, A. M. & Wilson, B. S. (2009). IKK Inhibitor Bay 11-7082 Induces Necrotic Cell Death in Pre-B ALL Cells (Poster). 100th American Association for Cancer Research (AACR) Annual Meeting.

Wilson, B. S., Meng, X., Mazel, T., Willman, C., Atlas, A., Chen, I. M., Harvey, R. C., Hunger, S. P., Oliver, J. M. & Winter, S. S. (2008). Select y-Secretase Inhibitors Induce Apoptosis in Pre-B ALL Cells and Disrupt the Balance Between Constitutive Notch Signaling and Repression (Poster). 50th ASH Annual Meeting and Exposition.

Russell, T., Oliver, J. M., Wilson, B. S., Tarleton, C. A., Winter, S. S. & Meng, X. (2008). Differential Expression of Ikaros Isoforms in Monozygotic Twins with MLL-rearranged Precursor-B Acute Lymphoblastic Leukemia. Journal of Pediatric Hematology/Oncology, 30(12), 941-4. PMID: 19131787.

Lu, H., Yue, J., Meng, X., Nickoloff, J. & Shen, Z. (2007). BCCIP Regulates Homologous Recombination by Distinct Domains and Suppresses Spontaneous DNA Damage. Nucleic Acid Res, 35(21), 7160-70.

Meng, X., Yue, J., Liu, Z. & Shen, Z. (2007). Abrogation of the Transactivation Activity of p53 by BCCIP Down-Regulation. The Journal of Biological Chemistry, 282(3), 1570-6. PMID: 17135243.

Meng, X., Fan, J. & Shen, Z. (2007). Roles of BCCIP in Chromosome Stability and Cytokinesis. Oncogene, 26(43), 6253-60. PMID: 17452982.

Lu, H., Guo, X., Meng, X., Liu, J., Allen, C., Wray, J., Nickoloff, J. A. & Shen, Z. (2005). The BRCA2-Interacting Protein BCCIP Functions in RAD51 and BRCA2 Focus Formation and Homologous Recombinational Repair. Molecular and Cellular Biology, 25(5), 1949-57. PMID: 15713648.

Meng, X., Lu, H. & Shen, Z. (2004). Radiation-Induced G1/S Checkpoint Activation: Roles of BCCIP on p21 Expression and Intracellular Distribution (Poster). Radiation Research Society 51st Annual Meeting, St. Louis, MO.

Meng, X., Lu, H. & Shen, Z. (2004). Radiation-Induced G1/S Checkpoint Activation: Roles of BRAC2 in BCCIP-Dependent Regulation of p21 Expression (Poster). Radiation Biology and Cancer: From Molecular Responses to the Clinic, AACR Special Conference in Cancer Research, Dana Point, CA.

Meng, X., Yuan, Y., Maestas, A. & Shen, Z. (2004). Recovery from DNA Damage-Induced G2 Arrest Requires Actin-Binding Protein Filamin-Actin-Binding Protein 280. The Journal of Biological Chemistry, 279(7), 6098-6105. PMID: 14660646.

Meng, X., Lu, H. & Shen, Z. (2004). BCCIP Functions Through p53 to Regulate the Expression of p21Waf1/Cip1. Cell Cycle (Georgetown, Tex.), 3(11), 1457-62. PMID: 15539944.

Meng, X., Liu, J. & Shen, Z. (2004). Inhibition of G1 to S Cell Cycle Progression by BCCIPß. Cell Cycle (Georgetown, Tex.), 3(3), 343-8. PMID: 14726710.

Meng, X., Liu, J. & Shen, Z. (2003). Genomic Structure of the Human BCCIP Gene and Its Expression in Cancer. Gene, 302(2-Jan), 139-46. PMID: 12527204.

Meng, X., Shen, Z. (2002). Interaction of BCCIP with PCNA and Transcription Factors (Talk). Program & Abstracts of Radiation Research Society & North American Hyperthermia Society.

Meng, X., Guo, X., Liu, J. & Shen, Z. (2002). Functional Characterization of BCCIP, a BRCA2-Interacting Protein (Poster). Era of Hope, The Department of Defense Breast Cancer Research Program Meeting.

Liu, J., Meng, X. & Shen, Z. (2002). Association of Human RAD52 Protein with Transcription Factors. Biochemical and Biophysical Research Communications, 297(5), 1191-6. PMID: 12372413.

Meng, X., Sun, Z. (1999). Roles of p21 and Gadd45 in Human Cellular Spindle Checkpoint Regulation. Bulletin of the Academy of Military Medical Sciences, 23(2), 160-163.

Meng, X., Mao, J., Song, Y. & Sun, Z. (1999). The Role of ATM in DNA Damage Response to Ionizing Radiation (Poster). International Symposium on Biology of Cancer Prevention and Treatment, China.

Meng, X., Dong, Y. & Sun, Z. (1999). p21, Gadd45 Transcription Activated by p53 Take Roles in DNA Damage Surveillance in Diverse Ways. Science in China (Series C), 42(4), 428-434.

Meng, X., Dong, Y. & Sun, Z. (1999). ATM Plays a Role in DNA Damage Signal Transduction by Catalyzing Proteins Phosphorylation. Chinese Science Bulletin, 44(19), 1790-1794.

Meng, X., Sun, Z. (1999). Molecular Mechanism of Enhancement of Cellular Radiosensitivity by Wortmannin. Chinese Journal of Biochemistry and Molecular Biology, 15(4), 613-619.

Meng, X., Dong, Y. & Sun, Z. (1999). Gadd45 transcription activated by p53 take roles in DNA damage surveillance in diverse ways. SCIENCE IN CHINA(Series C), 42(4), 428-434.

Meng, X., Gong, B., Mao, J., Dong, Y. & Sun, Z. (1999). LD-PCR Amplification Full Length cDNA of ATM. Bulletin of the Academy of Military Medical Sciences, 23(2), 160.

Meng, X., Sun, Z. (1998). Effects of Wortmannin and 3-AB on G2 Delay and MPF Transient Failure to Dephosphorylation Induced by Radiation. Chinese Science Bulletin, 43(18), 1550-1555.

Meng, X., Ye, C. (1996). Multiple Roles of p21 in Cellular Proliferation Regulation. Progress of Biochemistry and Biophysics, 23(3), 224-228.

Meng, X., Wei, Q. (1994). Endogenous Substrates of Calcineurin (CaN) in Mice Brains. Chinese Science Bulletin, 39(12), 1750-1754.

Meng, X., Wei, Q. (1994). Proteins Phosphorylation and Dephosphorylation in Ischemia and Normal Mice Brains. Chinese Journal of Biochemistry, 10(6), 717-721.

Meng, X., Wei, Q. (1993). Calmodulin Binding Proteins in Ischemia and Control Mice Brains. Chinese Science Bulletin, 38(15), 2083-2087.