Deborah l. Segaloff, PhD

Portrait
Professor of Molecular Physiology and Biophysics
Professor of Obstetrics and Gynecology

Contact Information

Primary Office: 5-470 BSB
51 Newton Road
Iowa City, IA 52242
319-335-7850

Lab: 5-471 BSB
51 Newton Road
Iowa City, IA 52242
319-335-7832

Education

BS, Biochemistry, Pennsylvania State College
PhD, Biochemistry, Vanderbilt University

Fellow, Reproductive Sciences Training Grant
Post Doctoral Fellow, Endocrinology, Department of Medicine, Vanderbilt University
Post Doctoral Fellow, Foreign Researcher, INSERM
Fellow, Department of Pharmacology, Vanderbilt University

Education/Training Program Affiliations

Department of Molecular Physiology and Biophysics PhD, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Research Summary

My laboratory studies the LH and FSH receptors, collectively termed the gonadotropin receptors. These G protein-coupled receptors (GPCRs) are predominantly expressed in the ovaries and testes where they each play pivotal roles in female and male reproductive physiology, respectively. We have been interested in the mechanisms governing the proper folding and cell surface expression of the gonadotropin receptors and how these processes are disrupted by loss-of-function mutations causing receptor misfolding. Our studies have also focused on elucidating the mechanisms underlying cell surface receptor activation by hormone agonists and by activating mutations of the receptors. We have recently demonstrated that the LH and FSH receptors can physically associate with themselves and with each other to form dimers and higher ordered oligomers. These complexes form early in the biosynthetic pathway and are not correlated with the activation status of the receptor. Current studies are addressing the potential functional ramifications of gonadotropin receptor homo- and hetero- associations. In a separate line of investigation initiated recently, we are also examining potentially novel physiological roles for the LH and FSH receptors in several non-gonadal tissues.