Bradley Ford, MD, PhD

Portrait
Coordinator, Koontz Lecture Series
Medical Director, Clinical Microbiology
Program Director, Medical Microbiology Fellowship
Clinical Assistant Professor of Pathology

Contact Information

Primary Office: C606-B General Hospital
Iowa City, IA 52242
319-356-2990

Education

PhD, Medical Scientist Training Program, Stony Brook University, Stony Brook, NY
MD, Medical Scientist Training Program, Stony Brook School of Medicine, Stony Brook, NY

Resident, Laboratory and Genomic Medicine, Barnes Jewish Hospital, St. Louis, MO
Fellow, Medical and Public Health Microbiology, Barnes Jewish Hospital, St. Louis, MO
Postdoctoral Fellow, Molecular Microbiology, Washington University, St. Louis, MO

Licensure and Certifications

Diplomate in Clinical Pathology - American Board of Pathology

Research Summary

Dr. Ford's research focuses on development of new clinical testing methods using a variety of next generation platforms.

Publications

Hoff, B. M., Ford, D. C., Ince, D., Ernst, E. J., Livorsi, D. J., Heintz, B. H., Masse, V., Brownlee, M. J. & Ford, B. A. (2018). Implementation of a Mobile Clinical Decision Support Application to Augment Local Antimicrobial Stewardship. Journal of pathology informatics, 9, 10. PMID: 29692947.

Dunseth, C. D., Ford, B. A. & Krasowski, M. D. (2017). Traditional versus reverse syphilis algorithms: A comparison at a large academic medical center. Practical Laboratory Medicine, 8(2017), 52-59. DOI: 10/1016/j.plabm.2017.04.007.

Krasowski, M. D., Ford, B. A., Klutts, J. S., Jensen, C. S., Briggs, A. S., Robinson, R. A., Bruch, L. A. & Karandikar, N. J. (2017). Using Focused Laboratory Management and Quality Improvement Projects to Enhance Resident Training and Foster Scholarship. Academic pathology, 4, 2374289517722152. PMID: 28913416.

Ford, B. A. (2017). mecC-MRSA: Hiding in Plain Sight. Journal of clinical microbiology. PMID: 29118173.

Mathur, G., Yadav, K., Ford, B., Schafer, I., Basavaraju, S., Knust, B., Shieh, W., Hill, S., Locke, G., Quinlisk, P., Brown, S., Gibbons, A., Cannon, D., Kuehnert, M., Nichol, S., Rollin, P., Ströher, U. & Miller, R. (2017). High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus. Transplant Infectious Diseases, 4(19). PMID: 28423464.

Burghardt, E. L., Flenker, K. S., Clark, K. C., Miguel, J., Ince, D., Winokur, P., Ford, B. & McNamara, 2nd, J. O. (2016). Rapid, Culture-Free Detection of Staphylococcus aureus Bacteremia. PloS one, 11(6), e0157234. PMID: 27305148.

Ford, B. A. (2016). Identification of low-level vancomycin resistance in Staphylococcus aureus in the era of informatics. Journal of clinical microbiology. PMID: 26865694.

Krasowski, M. D., Wilford, J. D., Howard, W., Dane, S. K., Davis, S. R., Karandikar, N. J., Blau, J. L. & Ford, B. A. (2016). Implementation of Epic Beaker Clinical Pathology at an academic medical center. Journal of pathology informatics, 7, 7. PMID: 26955505.

Jarvis, C., Han, Z., Kalas, V., Klein, R., Pinkner, J. S., Ford, B., Binkley, J., Cusumano, C. K., Cusumano, Z., Mydock-McGrane, L., Hultgren, S. J. & Janetka, J. W. (2016). Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. ChemMedChem, 11(4), 367-73. PMID: 26812660.

Falcone, E. L., Petts, J. R., Fasano, M. B., Ford, B., Nauseef, W. M., Neves, J. F., Simões, M. J., Tierce, 4th, M. L., de la Morena, M. T., Greenberg, D. E., Zerbe, C. S., Zelazny, A. M. & Holland, S. M. (2016). Methylotroph Infections and Chronic Granulomatous Disease. Emerging infectious diseases, 22(3), 404-9. PMID: 26886412.

Marra, A. R., Edmond, M. B., Ford, B. A., Herwaldt, L. A., Algwizani, A. R. & Diekema, D. J. (2016). Failure of Risk-Adjustment by Test Method for C. difficile Laboratory-Identified Event Reporting. Infection control and hospital epidemiology, 1-3. PMID: 27745553.

Morriss, F. H., Lindower, J. B., Bartlett, H. L., Atkins, D. L., Kim, J. O., Klein, J. M. & Ford, B. A. (2016). Neonatal Enterovirus Infection: Case Series of Clinical Sepsis and Positive Cerebrospinal Fluid Polymerase Chain Reaction Test with Myocarditis and Cerebral White Matter Injury Complications. AJP reports, 6(3), e344-e351. PMID: 27695644.

Arnold, A. R., Burnham, C. A., Ford, B. A., Lawhon, S. D., McAllister, S. K., Lonsway, D., Albrecht, V., Jerris, R. C., Rasheed, J. K., Limbago, B., Burd, E. M. & Westblade, L. F. (2016). Evaluation of an Immunochromatographic Assay for Rapid Detection of Penicillin-Binding Protein 2a in Human and Animal Staphylococcus intermedius Group, Staphylococcus lugdunensis, and Staphylococcus schleiferi Clinical Isolates. Journal of clinical microbiology, 54(3), 745-8. PMID: 26677248.

Ford, B. R., Schlueter, A. (2016). Culture of Blood and Cellular Therapy Products in Blood Banking. In A. L. Leber (Eds.) Clinical Microbiology Procedures Handbook. (4), pp. 13.3.5.1-13.3.5.6. Sterling, VA: American Society for Microbiology Press. DOI: 10.1128/9781555818814.ch13.3.

Krasowski, M. D., Schriever, A., Mathur, G., Blau, J. L., Stauffer, S. L. & Ford, B. A. (2015). Use of a data warehouse at an academic medical center for clinical pathology quality improvement, education, and research. Journal of pathology informatics, 6, 45. PMID: 26284156.

Westblade, L. F., Ranganath, S., Dunne, Jr., W. M., Burnham, C. D., Fader, R. & Ford, B. A. (2015). Infection with a chlorophyllic eukaryote after a traumatic freshwater injury. N Engl J Med, 372(10), 982-4. PMID: 25738686.

Ogrin, C., Ford, B. A., Stauffer, S. L., Krasowski, M. D. & Azar, A. E. (2015). Positive test for anti-thyroglobulin antibodies due to administration of immunoglobulin replacement therapy in a patient with thyroid cancer. Endocrine Practice. PMID: 26151422.

El-Herte, R. I., Schouweiler, K. E., Farah, R. S., Arbulu, R., Diekema, D. J., Wanat, K. A. & Ford, B. A. (2014). Phaeoacremonium parasiticum phaeohyphomycosis in a patient with systemic lupus erythematosus treated successfully with surgical debridement and voriconazole: A case report and review of the literature. IDCases, 1(4), 84-88. DOI: doi:10.1016/j.idcr.2014.10.004.

Westblade, L. F., Shams, F., Duong, S., Tariq, O., Bulbin, A., Klirsfeld, D., Sakaria, S., Ford, B. A., Burnham, C. D. & Ginocchio, C. D. (2014). Septic arthritis of a native knee joint due to corynebacterium striatum. J Clin Microbiol, JCM.02641-13. PMID: 24574280.

Guiton, P. S., Hannan, T. J., Ford, B., Caparon, M. G. & Hultgren, S. J. (2013). Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urirnary tract infections. Infection and immunity, 81(1), 329-39. PMID: 23132492.

Ford, B., Burnham, C. A. (2013). Optimization of routine identification of clinically relevant gram-negative bacteria by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry and the bruker biotyper. Journal of clinical microbiology, 51(5), 1412-20. PMID: 23426923.

Pence, M. A., Sharon, J., Tekippe, M., Pakalniskis, B. L., Ford, B. & Burnham, C. D. (2013). Two cases of Kerstersia gyiorum isolated from sites of chronic infection. Journal of Clinical Microbiology, 51(6), 2001-04. PMID: 23596236.

Storm, J. C., Ford, B. A. & Streit, J. A. (2013). Myocardial infection due to Fusobacterium necleatum. Diagn Microbiol Infec Dis, 77(4), 373-5. PMID: 24094834.

Brosnahan, A. J., Merriman, J. A., Salgado-Pabón, W., Ford, B. & Schlievert, P. M. (2013). Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. PLosONE, 8(4), e61255. PMID: 23613823.

Demarco, M. L., Ford, B. A. (2013). Beyond identification: emerging and future uses for MALDI-TOF mass spectrometry in the clinical microbiology laboratory. Clin Lab Med, 33(3), 611-628. PMID: 23931841.

Ford, B., Verger, D., Dodson, K., Volkan, E., Kostakioti, M., Elam, J., Pinkner, J., Waksman, G. & Hultgren, S. (2012). Structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket. Journal of bacteriology, 194(23), 6390-7. PMID: 23002225.

Dunne, W. M., Westblade, L. F. & Ford, B. (2012). Next-generation and whole-genome sequencing in the diagnostic clinical microbiology laboratory. European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology, 31(8), 1719-26. PMID: 22678348.

Volkan, E., Ford, B., Pinkner, J. S., Dodson, K. W., Henderson, N. S., Thanassi, D. G., Waksman, G. & Hultgren, S. J. (2012). Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine. Proceedings of the National Academy of Sciences of the United States of America, 109(24), 9563-8. PMID: 22645361.

Shu, Q., Crick, S. L., Pinkner, J. S., Ford, B., Hultgren, S. J. & Frieden, C. (2012). The E. coli CsgB nucleator of curli assembles to ß-sheet oligomers that alter the CsgA fibrillization mechanism. Proceedings of the National Academy of Sciences of the United States of America, 109(17), 6502-7. PMID: 22493266.

Han, Z., Pinkner, J. S., Ford, B., Chorell, E., Crowley, J. M., Cusumano, C. K., Campbell, S., Henderson, J. P., Hultgren, S. J. & Janetka, J. W. (2012). Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides. Journal of medicinal chemistry, 55(8), 3945-59. PMID: 22449031.

Phan, G., Remaut, H., Wang, T., Allen, W. J., Pirker, K. F., Lebedev, A., Henderson, N. S., Geibel, S., Volkan, E., Yan, J., Kunze, M. B., Pinkner, J. S., Ford, B., Kay, C. W., Li, H., Hultgren, S. J., Thanassi, D. G. & Waksman, G. (2011). Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature, 474(7349), 49-53. PMID: 21637253.

Cusumano, C. K., Pinkner, J. S., Han, Z., Greene, S. E., Ford, B., Crowley, J. R., Henderson, J. P., Janetka, J. W. & Hultgren, S. J. (2011). Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Science translational medicine, 3(109), 109. PMID: 22089451.

Ford, B., Han, Z., Pinkner, J. S., Obermann, R., Nolan, W., Wildman, S. A., Hobbs, D., Ellenberger, T., Cusumano, C. K., Hultgren, S. J. & Janetka, J. W. (2010). Structure-based drug design and optimization of mannoside bacterial FimH antagonists. Journal of medicinal chemistry, 53(12), 4779-92. PMID: 20507142.

Ford, B., Rêgo, A. T., Ragan, T. J., Pinkner, J., Dodson, K., Driscoll, P. C., Hultgren, S. & Waksman, G. (2010). Structural homology between the C-terminal domain of the PapC usher and its plug. Journal of bacteriology, 192(7), 1824-31. PMID: 20118254.

Ford, B., Eby, C. S., Scott, M. G. & Coyne, D. W. (2010). Intra-individual variability in serum hepcidin precludes its use as a marker of iron status in hemodialysis patients. Kidney international, 78(8), 769-73. PMID: 20668427.

Ford, B., Boykevisch, S., Zhao, C., Kunzelmann, S., Bar-Sagi, D., Herrmann, C. & Nassar, N. (2009). Characterization of a Ras mutant with identical GDP- and GTP-bound structures. Biochemistry, 48(48), 11449-57. PMID: 19883123.

Klutts, J. S., Ford, B., Perez, N. R. & Gronowski, A. M. (2009). Evidence-based approach for interpretation of Epstein-Barr virus serological patterns. Journal of clinical microbiology, 47(10), 3204-10. PMID: 19656988.

Ford, B., Coyne, D. W., Eby, C. S. & Scott, M. G. (2009). Variability of ferritin measurements in chronic kidney disease; implications for iron management. Kidney international, 75(1), 104-10. PMID: 18843257.

Ferguson, A. M., Ford, B. & Gronowski, A. M. (2008). Method validation for cerebral spinal fluid human chorionic gonadotropin measurement with the Advia Centaur. Clinical chemistry, 54(8), 1408-9. PMID: 18664453.

Mikhailik, A., Ford, B., Keller, J., Chen, Y., Nassar, N. & Carpino, N. (2007). A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling. Molecular cell, 27(3), 486-97. PMID: 17679096.

Kleinman, H., Ford, B., Keller, J., Carpino, N. & Nassar, N. (2006). Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1. Acta crystallographica - Section F, Structural biology and crystallization communications, 62(Pt 3), 218-20. PMID: 16511305.

Ford, B., Hornak, V., Kleinman, H. & Nassar, N. (2006). Structure of a transient intermediate for GTP hydrolysis by ras. Structure (London, England : 1993), 14(3), 427-36. PMID: 16531227.

Ford, B., Skowronek, K., Boykevisch, S., Bar-Sagi, D. & Nassar, N. (2005). Structure of the G60A mutant of RAS: implications for the dominant negative effect. The Journal of biological chemistry, 280(27), 25697-705. PMID: 15878843.