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Marco M. Hefti, MD

Assistant Professor of Pathology

Contact Information

Primary Office
1027 Medical Laboratories (ML)


BA, Psychology, Cornell University
Other, Pre-medical, Columbia University
MD, Medicine, Mount Sinai School of Medicine
Resident, Surgery, Beth Israel Deaconess
Postdoctoral Fellow, Surgery/Pathology, Harvard Medical School
Resident, Anatomic Pathology, Beth Israel Deaconess
Chief Resident, Anatomic Pathology, Beth Israel Deaconess
Fellow, Neuropathology, Mount Sinai School of Medicine

Licensure and Certifications

Diplomate in Neuropathology - American Board of Pathology
Iowa Board of Medicine
Diplomate in Anatomic Pathology - American Board of Pathology

Research Summary

I am interested in the role of the tau protein in human brain development and in response to early-life hypoxic-ischemic injury, and in how this related to the development of age-related tauopathies such as Alzheimers disease.


Agostinelli, L. J., Mix, M. R., Hefti, M. M., Scammell, T. E. & Bassuk, A. G. (2021). Input-output connections of LJA5 prodynorphin neurons. J Comp Neurol, 529(3), 635-654. PMID: 32602558.

Lee, M. H., Perl, D. P., Nair, G., Li, W., Maric, D., Murray, H., Dodd, S. J., Koretsky, A. P., Watts, J. A., Cheung, V., Masliah, E., Horkayne-Szakaly, I., Jones, R., Stram, M. N., Moncur, J., Hefti, M., Folkerth, R. D. & Nath, A. (2020). Microvascular injury in the brains of patients with Covid-19. NEJM. PMID: 33378608.

Volk, L. E., Mavroudis, C. D., Ko, T., Hallowell, T., Delso, N., Roberts, A. L., Starr, J., Landis, W., Lin, Y., Hefti, M., Morgan, R. W., Melchior, R. W., Rosenthal, T. M., Chappell, A., Fisher, D., Dreher, M., Licht, D. J., Chen, J., Gaynor, J. W., Mascio, C. E. & Kilbaugh, T. J. (2020). Increased cerebral mitochondrial dysfunction and reactive oxygen species with cardiopulmonary bypass. Eur J Cardiothorac Surg. PMID: 33367535.

Langbehn, K. E., Carlson-Stadler, Z., van der Plas, E., Hefti, M. M., Dawson, J. D., Moser, D. J. & Nopoulos, P. C. (2020). DMPK mRNA Expression in Human Brain Tissue Throughout the Lifespan. Neurol Genet, 7(1), e537. PMID: 33575482.

Liu, G., Fiock, K. L., Levites, Y., Golde, T. E., Hefti, M. M. & Lee, G. (2020). Fyn depletion ameliorates tauP301L-induced neuropathology. Acta neuropathologica communications, 8(1), 108. PMID: 32665013.

Fiock, K. L., Smalley, M. E., Crary, J. F., Pasca, A. M. & Hefti, M. M. (2020). Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. eNeuro. PMID: 32393582.

Rettenmaier, L. A., Kirby, P. A., Reinking, B. E., Viaene, A. N. & Hefti, M. M. (2020). Neuropathology of Congenital Heart Disease in an Inpatient Autopsy Cohort 2000-2017. Journal of the American Heart Association, 9(7), e013575. PMID: 32200729.

Fiock, K. L., Smith, J. D., Crary, J. F. & Hefti, M. M. (2020). ├č-amyloid and tau pathology in the aging feline brain. Journal of Comparative Neurology, 528(1), 108-113. DOI: 10.1002/cne.24741.

Hefti, M. M., Kim, S., Bell, A. J., Betters, R. K., Fiock, K. L., Iida, M. A., Smalley, M. E., Farrell, K., Fowkes, M. E. & Crary, J. F. (2019). Tau Phosphorylation and Aggregation in the Developing Human Brain. Journal of neuropathology and experimental neurology, 78(10), 930-938. PMID: 31504677.

Harper, M. M., Woll, A. W., Evans, L. P., Delcau, M., Akurathi, A., Hedberg-Buenz, A., Soukup, D. A., Boehme, N., Hefti, M. M., Dutca, L. M., Anderson, M. G. & Bassuk, A. G. (2019). Blast Preconditioning Protects Retinal Ganglion Cells and Reveals Targets for Prevention of Neurodegeneration Following Blast-Mediated Traumatic Brian Injury. Investigative ophthalmology & visual science, 60(13), 4159-4170. PMID: 31598627.

Seifert, A. C., Umphlett, M., Hefti, M., Fowkes, M. & Xu, J. (2019). Formalin tissue fixation biases myelin-sensitive MRI. Magnetic Resonance in Medicine, 82(4), 1504-1517. DOI: 10.1002/mrm.27821.

Persons, J. E., Hefti, M. M. & Nashelsky, M. B. (2019). Epidemiology of suicide in an Iowa cohort. Public health, 177, 128-134. PMID: 31563700.

Kim, Y., Liu, G., Leugers, C. J., Mueller, J. D., Francis, M. B., Hefti, M. M., Schneider, J. A. & Lee, G. (2019). Tau interacts with SHP2 in neuronal systems and in Alzheimer's disease brains. Journal of cell science, 132(14). PMID: 31201283.

Starks, R., Kirby, P., Ciliberto, M. & Hefti, M. M. (2018). Snyder-Robinson syndrome. Autopsy & case reports, 8(3), e2018031. PMID: 30237987.

Mavrommatis, M. A., Friedman, A. H., Fowkes, M. E. & Hefti, M. M. (2018). Aicardi syndrome in a 20-year-old female. American journal of ophthalmology case reports, 12, 61-64. PMID: 30238067.

Mavroudis, C. D., Karlsson, M., Ko, T., Hefti, M. M., Gentile, J. I., Morgan, R. W., Plyler, R., Mensah-Brown, K. G., Boorady, T. W., Melchior, R. W., Rosenthal, T. M., Shade, B. C., Schiavo, K. L., Nicolson, S. C., Spray, T. L., Sutton, R. M., Berg, R. A., Licht, D. J., Gaynor, J. W. & Kilbaugh, T. J. (2018). Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest in neonatal swine. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 54(1), 162-168. PMID: 29346537.

Chen, I. E., Tsankova, N. M., Hefti, M. M., Aggarwal, A., Doshi, A. H., Hormingo, A., Delman, B. N., Nael, K. (2018). Sequential Apparent Diffusion Coefficient for Assessment of Tumor Progression in Patients with Low-Grade Glioma. AJNR Am J Neuroradiol., 39(6), 1039-1046.. PMID: 29674411.

Hefti, M. M., Farrell, K., Kim, S., Bowles, K. R., Fowkes, M. E., Raj, T. & Crary, J. F. (2018). High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development. PloS one, 13(4), e0195771. PMID: 29634760.

Uzilov, A. V., Cheesman, K. C., Fink, M. Y., Newman, L. C., Pandya, C., Lalazar, Y., Hefti, M. M., Fowkes, M., Deikus, G., Lau, C. Y., Moe, A. S., Kinoshita, Y., Kasai, Y., Zweig, M., Gupta, A., Starcevic, D., Mahajan, M., Schadt, E. E., Post, K. D., Donovan, M. J., Sebra, R., Chen, R. & Geer, E. B. (2017). Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma. Cold Spring Harbor molecular case studies, 3(3), a001602. PMID: 28487882.

Mente, K., Kim, S. A., Grunseich, C., Hefti, M. M., Crary, J. F., Danek, A., Karp, B. I. & Walker, R. H. (2017). Hippocampal sclerosis and mesial temporal lobe epilepsy in chorea-acanthocytosis: A case with clinical, pathologic, and genetic evaluation. Neuropathology and applied neurobiology. PMID: 28398599.

Ledderose, C., Hefti, M. M., Chen, Y., Bao, Y., Seier, T., Li, L., Woehrle, T., Zhang, J. & Junger, W. G. (2016). Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic signalling, 12(4), 673-685. PMID: 27577957.

Hefti, M. M., Kinney, H. C., Cryan, J. B., Haas, E. A., Chadwick, A. E., Trachtenberg, F. L., Armstrong, D. D., Grafe, M. & Krous, H. F. (2016). Response to Letter to the Editor from Ackerman MJ, et al. (Vols. 12). (2), pp. 232-5. Forensic science, medicine, and pathology. PMID: 27022985.

Hefti, M. M., Trachtenberg, F. L., Haynes, R. L., Hassett, C., Volpe, J. J. & Kinney, H. C. (2016). A Century of Germinal Matrix Intraventricular Hemorrhage in Autopsied Premature Infants: A Historical Account. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 19(2), 108-14. PMID: 26372101.

Hefti, M. M., Cryan, J. B., Haas, E. A., Chadwick, A. E., Crandall, L. A., Trachtenberg, F. L., Armstrong, D. D., Grafe, M., Krous, H. F. & Kinney, H. C. (2016). Hippocampal malformation associated with sudden death in early childhood: a neuropathologic study: Part 2 of the investigations of the San Diego SUDC Research Project. Forensic science, medicine, and pathology, 12(1), 14-25. PMID: 26782962.

Hefti, M. M., Kinney, H. C., Cryan, J. B., Haas, E. A., Chadwick, A. E., Crandall, L. A., Trachtenberg, F. L., Armstrong, D. D., Grafe, M. & Krous, H. F. (2016). Sudden unexpected death in early childhood: general observations in a series of 151 cases: Part 1 of the investigations of the San Diego SUDC Research Project. Forensic science, medicine, and pathology, 12(1), 4-13. PMID: 26782961.

Hefti, M. M., Tsankova, N. M. (2016). Epigenetic Dysregulation in Brain Tumors and Neurodevelopment. In D. H. Yasui , J. Peedicayil , D. R. Grayson (Eds.) Neuropsychiatric Disorders and Epigenetics. pp. 261-271. Elsevier.

Hefti, M. M., Hu, R., Knoblauch, N. W., Collins, L. C., Haibe-Kains, B., Tamimi, R. M. & Beck, A. H. (2013). Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. Breast cancer research : BCR, 15(4), R68. PMID: 23971947.

Beck, A. H., Knoblauch, N. W., Hefti, M. M., Kaplan, J., Schnitt, S. J., Culhane, A. C., Schroeder, M. S., Risch, T., Quackenbush, J. & Haibe-Kains, B. (2013). Significance analysis of prognostic signatures. PLoS computational biology, 9(1), e1002875. PMID: 23365551.

Sarpel, U., Hefti, M. M., Wisnievsky, J. P., Roayaie, S., Schwartz, M. E. & Labow, D. M. (2009). Outcome for patients treated with laparoscopic versus open resection of hepatocellular carcinoma: case-matched analysis. Annals of surgical oncology, 16(6), 1572-7. PMID: 19259738.

Hefti, M. M., Chessin, D. B., Harpaz, N. H., Steinhagen, R. M. & Ullman, T. A. (2009). Severity of inflammation as a predictor of colectomy in patients with chronic ulcerative colitis. Diseases of the colon and rectum, 52(2), 193-7. PMID: 19279411.

Martens, T. P., See, F., Schuster, M. D., Sondermeijer, H. P., Hefti, M. M., Zannettino, A., Gronthos, S., Seki, T. & Itescu, S. (2006). Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium. Nature clinical practice. Cardiovascular medicine, 3 Suppl 1, S18-22. PMID: 16501624.

Martens, T. P., Morgan, J. A., Hefti, M. M., Brunacci, D. A., Cheema, F. H., Kesava, S. K., Xydas, S., Dang, N. C., Vigilance, D. W., Kohmoto, T., Gorenstein, L. A., Smith, Jr, C. R. & Argenziano, M. (2005). Adhesiolysis is facilitated by robotic technology in reoperative cardiac surgery. The Annals of thoracic surgery, 80(3), 1103-5. PMID: 16122499.

Martens, T. P., Hefti, M. M., Kalimi, R., Smith, C. R. & Argenziano, M. (2004). Robot-assisted off-pump minimally invasive reoperative coronary artery bypass grafting: case report. The heart surgery forum, 7(6), E533-4. PMID: 15769680.