Sergei I. Syrbu, MD, PhD

Portrait
Clinical Professor, Hematopathology and Immunology
Medical Director, Immunopathology Laboratory
Clinical Professor of Pathology

Contact Information

Primary Office
6245 Roy Carver Pavilion
Iowa City, IA 52242
319-356-7372

Education

MD, State University of Medicine, Chishinau, Moldova
PhD, All Union Cardiology Research Center, Moscow, USSR
Postdoctoral Fellow, University of Connecticut Health Center
Resident, Pathology, University of Iowa Carver College of Medicine
Fellow, Hematopathology, University of Iowa Carver College of Medicine

Licensure and Certifications

State of Iowa Medical License - Iowa Board of Medicine
Hematology - American Board of Pathology
Anatomic and Clinical Pathology - American Board of Pathology

Research Summary

Interests Include: Cytologic and histomorphologic correlations of bone marrow and lymph node biopsies with immunohistochemistry and flow cytometric analysis in hematopoietic disorders and lymphomas. Development of new monoclonal antibodies and antigen retrieval procedures for immunohistochemical staining of formalin-fixed, paraffin embedded tissues.

Publications

Maurer, M. J., Ghesquières, H., Link, B. K., Jais, J. P., Habermann, T. M., Thompson, C. A., Haioun, C., Allmer, C., Johnston, P. B., Delarue, R., Micallef, I. N., Peyrade, F., Inwards, D. J., Ketterer, N., Farooq, U., Fitoussi, O., Macon, W. R., Molina, T. J., Syrbu, S., Feldman, A. L., Slager, S. L., Weiner, G. J., Ansell, S. M., Cerhan, J. R., Salles, G. A., Witzig, T. E., Tilly, H. & Nowakowski, G. S. (2018). Diagnosis-to-Treatment Interval Is an Important Clinical Factor in Newly Diagnosed Diffuse Large B-Cell Lymphoma and Has Implication for Bias in Clinical Trials. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 36(16), 1603-1610. PMID: 29672223.

Tracy, S. I., Habermann, T. M., Feldman, A. L., Maurer, M. J., Dogan, A., Perepu, U. S., Syrbu, S., Ansell, S. M., Thompson, C. A., Weiner, G. J., Nowakowski, G. S., Allmer, C., Slager, S. L., Witzig, T. E., Cerhan, J. R. & Link, B. K. (2017). Outcomes among US patients with diffuse large B cell lymphoma are independent of tumor Epstein Barr virus positivity or immunosuppression. Haematologica. PMID: 29170255.

Cerhan, J. R., Link, B. K., Habermann, T. M., Maurer, M. J., Feldman, A. L., Syrbu, S. I., Thompson, C. A., Farooq, U., Novak, A. J., Slager, S. L., Allmer, C., Lunde, J. J., Macon, W. R., Inwards, D. J., Johnston, P. B., Micallef INM,, Nowakowski, G. S., Ansell, S. M., Kay, N. E., Weiner, G. J. & Witzig, T. E. (2017). Cohort Profile: The Lymphoma Specialized Program of Research Excellence (SPORE) Molecular Epidemiology Resource (MER) Cohort Study. International journal of epidemiology. PMID: 29025017.

Farooq, U., Maurer, M. J., Thompson, C. A., Thanarajasingam, G., Inwards, D. J., Micallef, I., Macon, W., Syrbu, S., Lin, T., Lin, Y., Ansell, S. M., Nowakowski, G. S., Habermann, T. M., Cerhan, J. R. & Link, B. K. (2017). Clinical heterogeneity of diffuse large B cell lymphoma following failure of front-line immunochemotherapy. British journal of haematology. PMID: 28653407.

Lanzel, E., Syrbu, S. I., Hellstein, J. W., Stein, K. M., Welander, S. & Sousa Melo, S. L. (In Press). Destructive soft tissue mass in the maxilla/maxillary sinus. Oral Surg Oral Med Oral Pathol Oral Radiol. PMID: 28089462.

Maurer, M. J., Jais, J. P., Ghesquieres, H., Witzig, T. E., Hong, F., Haioun, C., Thompson, C. A., Thieblemont, C., Micallef, I. N., Porrata, L. F., Ribrag, V., Nowakowski, G. S., Gasanovas, O., Bologna, S., Morschhauser, F., Morrison, V. A., Peterson, B. A., Macon, W. R., Copie-Bergman, C., Feldman, A. & Syrbu, etal, S. I. (2015). Personalized risk prediction for event-free survival at 24 months in patients with diffuse large b-cell lymphoma. Am J Hematol.. PMID: 26492520.

Mir, M. A., Maurer, M. J., Ziesmer, S. C., Slager, S. L., Habermann, T., Macon, W. R., Link, B. K., Syrbu, S., Witzig, T., Friedberg, J. W., Press, O., LeBlanc, M., Novak, A. & Ansell, S. (2014). Elevated serum levels of IL-2R, IL-1RA and CXCL9 are associated with a poor prognosis in follicular lymphoma. BloodEpub ahead of print. PMID: 25422100.

Maurer, M. J., Ghesquiere, H., Jais, J. P., Witzig, T. E., Thompson, C. A., Delarue, R., Micallef, I. N., Peyrade, F., Macon, W. R., Molina, J. T., Ketterer, N., Syrbu, S. I., Fitoussi, O., Kurtin, P. J., Allmer, C., Nicolas-Virelizier, E., Slager, S. L., Habermann, T. M., Link, B. K., Salles, G., Tilly, H. & Cerhan, J. R. (2014). Event-Free Survival at 24 months Is a Robust End Point for Disease-Related Outcome in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy. J Clin Oncol. PMID: 24550425.

Wondergem, M. J., Herrmann, K., Syrbu, S. I., Zijlstra, J. M., Hoetjes, N., Hoekstra, O. S., Saskia, A. G., Cillessen, S., Moesbergen, L. M., Buck, A. K., Julie, M., Vose, J. V. & Juweid, M. E. (2014). 18F-Fluorothymidine Uptake Relative to cellular Proliferation in Follicular Lymphoma is Related to Error-Prone DNA Repair. (Vols. 4). (1), pp. 3. EJNMMI.

Tompkins, V. S., Han, S. S., Oliver, A., Syrbu, S., Bair, T., Button, A., Jacobus, L., Wang, Z., Lifton, S., Raychaudhuri, P., Morse III, H. C., Weiner, G., Link, B., Smith, B. J. & Janz, S. (2013). Identification of Candidate B-Lymphoma Genes by Cross-Species Gene Expression Profiling. PLos One, 8(10). PMID: 24130802.

Link, B. K., Maurer, M. J., Nowakowski, G. S., Ansell, S. M., Macon, W. R., Syrbu, S. I., Slager, S. L., Thompson, C. A., Inwards, D. I., Johnston, P. B., Colgan, J. P., Witzig, T. E., Habermann, T. M. & Cerhan, J. R. (2013). Rates and Outcomes of Follicular Lymphoma Transformation in the Immunochemotherapy Era: A Report From the University of Iowa/Mayo Clinic Specialized Program of Research Excellence Molecular Epidemiology Resource. J Clin Oncol. PMID: 23897955.

Fairley, J. A., Bream, M., Fullenkamp, C., Syrbu, S. I., Chen, M. & Messingham, K. (2013). Missing the target: Characterization of bullous pemphigoid patients who are negative using the BP180 enzyme-linked immunosorbant assay. (Vols. 68). (3), pp. 395-403. J Am Acad Dermatol. PMID: 23083837.

Maurer, M. J., 11 additional authors & Syrbu, S. I. (2013). An International Study to Create An IPI for The Event-Free Survival At 24 months (EFS24) Endpoint For DLBCL in The Immunochemotherapy Era. Blood, 122, 362.

Hoover, A. C., Anderson, C. M., Hoffman, H. T., Magalhaes-Silverman, M., Syrbu, S. I. & C, S. M. (2013). Laryngeal Chloroma Heralding Relapse of Acute Myeloid Leukemia. J Clin Oncol.

Lukas, M., Nystrom, L. M., Buckwalter IV, J. A., Syrbu, S. I. & Miller, B. J. (2013). Serum Protein Electrophoresis in the Evaluation of Lytic Bone Lesions. (Vols. 33). pp. 114-8. Iowa Orthop J. PMID: 24027470.

Tchobanu, L. M., Syrbu, S. I., Popovithi, M. I., Ivanova, V. M. & Gudumak, V. S. (2013). The immune-enzyme technique of detection of Ca2+ATPase of sarcoplasmic reticulum--a new biologic marker of acute cardiac infarction. Klin Lab Diagn,(5), 39-42.

Gabriel-Griggs, S., Bleile, M., Bell, A., Rosenthal, N. S. & Syrbu, S. I. (2012). Annexin A1 (ANXA1), Key Confirmatory Marker Discriminating Hairy Cell Leukemia from Variant Hairy Cell Leukemia and Other Morphologically Similar B-Cell Neoplasms. (Vols. 25). pp. 335A. Mod Pathol.

Perepu, U., Dogan, A., Maurer, M. J., Allmer, C., Thompson, C. A., Ansell, S. M., Syrbu, S. I., Slager, S. L., Witzig, T. E., Weiner, G. J., Habermann, T. M., Cerhan, J. R. & Link, B. K. (2012). EBV(+) Diffuse Large B Cell Lymphoma Is Infrequent in Upper Central United States and Lacks Unique Clinical Characteristics or Adverse Prognosis Compared to EBV (-) Counterparts: Results From University of Iowa/Mayo Clinic SPORE. (Vols. 120). pp. 1604. Blood.

Maurer, M. J., Ghesquieres, H., Witzig, T. E., Thompson, C. A., Micallef, N., Macon, W. R., Syrbu, S. I., Kurtin, P., Allmer, C., Gargi, T., Nicolas-Virelizier, E., Sebban, C., Slager, S. L., Habermann, T. M., Link, B. K. & Cerhan, J. R. (2012). Newly Diagnosed Diffuse Large B-Cell Lymphoma Patients Treated with Immunochemotherapy Who Are Alive and Progression Free 12 Months After Diagnosis Have a Subsequent Overall Survival Similar to That of the General Population. (Vols. 120). pp. 1540. Blood.

Jacobus, L. S., Lunde, J., Maurer, M. J., Dogan, A., Syrbu, S. I., Allmer, C., Novak, A. N., Cerhan, J. R., Nowakowski, G. S., Slager, S. L., Witzig, T. E., Thompson, C. A., Weiner, G. J., Haberman, T. M., Ansell, S. M. & Link, B. K. (2012). Non-Follicular Low Grade B-Cell Lymphomas: Patterns of Presentation and Management with Comparative Prognostic Utility of IPI and FLIPI. (Vols. 120). pp. 1563. Blood.

Link, B. K., Maurer, M. J., Nowakowski, G. S., Ansell, S. M., Macon, W. R., Syrbu, S. I., Slager, S. L., Thompson, C. A., Inwards, D. J., Johnston, P. B., Colgan, J. P., Witzig, T. E., Weiner, G. J., Habermann, T. M. & Cerhan, J. R. (2012). Rates and Outcomes of Follicular Lymphoma Transformation in the Rituximab Era: A Report From the University of Iowa/Mayo Clinic SPORE Molecular Epidemiology Resource. (Vols. 120). pp. 1546. Blood.

Naraev, B. G., Racila, E. V., Goodheart, M. J., Syrbu, S. I., O'Dorisio, T. M. & Halfdanarson, T. R. (2012). Status of DNA Repair and Cell Proliferation Markers in High Grade Neuroendocrine Carcinoma of the Uterine Cervix and Small Cell Carcinoma of the Lung. (Vols. 41). (2), pp. 339. Pancreas.

Fromm, J. R., Sabath, D. E., Wood, B. L., Savage, E., Syrbu, S. I. & Jensen, C. S. (2011). Diagnostic usefulness of flow cytometry for immunophenotyping classical Hodgkin lymphoma. Am J Clin Pathol, 136(1), 157-8; author reply 158. PMID: 21685044.

Maurer, M. J., Micallef, I. N., Cerhan, J. R., Katzmann, J. A., Link, B. K., Colgan, J. P., Habermann, T. M., Inwards, D. J., Markovic, S. N., Ansell, S. M., Porrata, L. F., Johnston, P. B., Nowakowski, G. S., Thompson, C. A., Gupta, M., Syrbu, S. I., Kurtin, P. J., Macon, W. R., Nikcevich, D. A. & Witzig, T. E. (2011). Elevated serum free light chains are associated with event-free and overall survival in two independent cohorts of patients with diffuse large B-cell lymphoma. J Clin Oncol, 29(12), 1620-6. PMID: 21383282.

Syrbu, S. I., COHEN, M. B. (2011). An enhanced antigen retrieval procedure for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue. In A. E. Kalyuzhny (Eds.) Signal Transduction Immunohistochemistry Methods and Protocols Series: Methods in Molecular Biology. pp. 101-110. Humana Press.

Savage, E. C., Vanderheyden, A. D., Bell, A. M., Syrbu, S. I. & Jensen, C. S. (2011). Independent diagnostic accuracy of flow cytometry obtained from fine-needle aspirates: a 10-year experience with 451 cases. Am J Clin Pathol, 135(2), 304-9. PMID: 21228371.

Syrbu, S. I., Cohen, M. B. (2011). An enhanced antigen-retrieval protocol for immunohistochemical staining of formalin-fixed, paraffin-embedded tissues. Methods in Molecular Biology (Clifton, N.J.), 717, 101-110. PMID: 21370027.

Nasr, M. R., Syrbu, S. I. (2011). CD15 expression in Hodgkin and Reed- Sternberg-like cells in lymph node: Pathologic significance and differential diagnosis. ASCP Check Sample, 46(1), 1-8.

Bleile, M. J., Syrbu, S. I. (2011). Diffuse Large B-cell Lymphoma, Plasmablastic Variant: Clinical Features and Pathologic Diagnosis. ASCP Check Sample, 46(3), 19-27.

Maurer, M. J., Cerhan, J. R., Katzmann, J. A., Dogan, A., Gupta, M., Macon, M. R., Syrbu, S. I., Link, B. K., Micallef, I. N. & Witzig, T. E. (2011). Elevated Monoclonal Free Light Chains Are a Serum Marker of ABC Type Diffuse Large B-Cell Lymphoma. (Vols. 118). pp. 1591. Blood.

Juweid, M., Syrbu, S. I. (2010). Error-prone DNA repair underlying somatic hypermutation/class-switch recombination (SHM/CSR) identified as major contributor of 18F-fluorothymidine (FLT) in low-grade follicular lymphoma (FL). Society of Nuclear Medicine Annual Meeting.

Juweid, M., Syrbu, S. I., Deyoung, B., O'Dorisio, M. & O'Dorisio, T. M. (2010). Discordant expression of proliferating cell nuclear antigen (PCNA) and Ki-67 Antigen in carcinoid and pancreatic neuroendocrine tumors (C&PET) likely indicates enhanced DNA repair. (Vols. 39). (2), pp. 279. Pancreas.

Maurer, M. J., Cerhan, J. R., Katzmann, J. A., Link, B. K., Colgan, J. P., Habermann, T. M., Inwards, D. J., Markovic, S. N., Ansell, S. M., Porrata, L. F., Johnston, P. B., Nowakowski, G. S., Thompson, C. A., Gupta, M., Syrbu, S. I., Kurtin, P., Macon, M. & Witzig, T. E. (2010). Elevatation of Serum Free Light Chains are Common in Lymphoma and Associated with Poor Event Free Survival and Overall Survival. (Vols. 116). pp. 4136. Blood.

Nasr, M. R., Rosenthal, N. S. & Syrbu, S. I. (2010). Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker. Am J Clin Pathol, 133(1), 41-8. PMID: 20023257.

Gerhan, J. R., Habermann, T. M., Maurer, M. J., Wooldridge, J. E., Ansell, S. M., Nowakowski, G. S., Micallef, I. N., Thompson, C. A., Wang, A. H., Macon, W. R., Syrbu, S. I., Slager, S. L., Witzig, T. E. & Link, B. K. (2010). Genetic Polymorphisms In Genes Involved In R-CHOP Metabolism and Event-Free and Overall Survival In Diffuse Large B-Cell Lymphoma. (Vols. 116). pp. 996. Blood.

Racila, E., Syrbu, S. I., Nasr, M. & Juweid, M. (2010). Thymidylate Synthase (TS) Expression In Diffuse Large B-Cell Lymphoma (DLBCL): Identification of a Potential Therapeutic Target. (Vols. 116). pp. 5107. Blood.

Thomas, D. L., Syrbu, S. I. & Graham, M. M. (2009). Epstein-Barr virus mimicking lymphoma on FDG-PET/CT. Clin Nucl Med, 34(12), 891-3. PMID: 20139824.

Muirhead, D., Stone, M. & Syrbu, S. I. (2009). The utility of PU 1 as an immunohistochemical marker for histiocytic and dendritic lesions of the skin. Am J Dermatopath, 31(5), 432-5. PMID: 19542915.

Juweid, M., Buck, A., Pronto, L. L., Mottaghy, F. M., Syrbu, S. I., Moller, P. & Vose, J. M. (2009). Association of increase in Thymidine uptake relative to tumor cell proliferation in indolent NHLs and DNA Repair. (Vols. 27). (15S), pp. 11116. J Clin Oncol.

Juweid, M., Syrbu, S. I., Bleile, M., Buck, A., Wondergem, M. & Vose, J. M. (2009). Association of increased thymidine uptake relative to tumor cell proliferation in low-grade follicular lymphoma and DNA repair. (Vols. 114). pp. 22. Blood.

Nasr, M. R., Rosenthal, N. S. & Syrbu, S. I. (2009). Expression profiling of transcription factors in B or T-lymphoblastic leukemia/lymphoma and Burkitt lymphoma: Utility of Pax-5 immunostaining as Pan-Pre-B-cell marker. (Vols. 22). pp. 279A. Mod Pathol.

Wehbe, A. M., Neppalli, N. & Syrbu, S. I. (2008). Diffuse follicle center lymphoma presents with high frequency of extranodal disease. (Vols. 26). pp. 19511. J Clin Oncol.

Maurer, M. J., Witzig, T. E., Macon, W. R., Syrbu, S. I., Cerhan, J. R., Allmer, C., Johnston, P. B., Link, B. K. & Habermann, T. M. (2008). Diffuse Large B-Cell Lymphoma (DLBCL) Patients with Composite Histology Have Improved Early Outcome Compared to De Novo DLBCL When Treated with R-CHOP. (Vols. 112). pp. 2819. Blood.

Qasem, S. A., COHEN, M. B. & Syrbu, S. I. (2007). Cyclin D1 and GATA3 expression correlate with estrogen receptor status in invasive breast carcinoma. (Vols. 131). (9), pp. 1448. Arch Pathol Lab Med.

Vanderheyden, A. D., Syrbu, S. I. & Jensen, C. S. (2007). Independent Diagnostic Accuracy of Flow Cytometry of Fine Needle Aspirates: A 10 year experience with 511 cases. (Vols. 21). pp. 86A. Mod Pathol.

Syrbu, S. I., Rokhlin, O. W. & COHEN, M. B. (2007). Novel monoclonal antibodies to human kappa and lambda immunoglobulin light chains suitable for immunohistochemical staining and direct immunofluorescence microscopy on formalin-fixed, paraffin-embedded (FFPE) tissues. (Vols. 20). pp. 261A. Mod Pathol.

Muirhead, D. M., Stone, M. & Syrbu, S. I. (2007). The utility of PU 1 as an immunohistochemical marker for histiocyte Lesions of the skin. (Vols. 20). pp. 96A. Mod Pathol.

McCune, R. C., Syrbu, S. I. & Vasef, M. A. (2006). Expression profiling of transcription factors Pax-5, Oct-1, Oct-2, BOB.1, and PU.1 in Hodgkin's and non-Hodgkin's lymphomas: a comparative study using high throughput tissue microarrays. Mod Pathol, 19(7), 1010-8. PMID: 16648862.

McCune, R. C., Syrbu, S. I. & Vasef, M. A. (2006). Transcription factor PU 1 is a useful marker in distinguishing nodular lymphocyte predominant Hodgkin lymphoma from classical Hodgkin lymphoma. (Vols. 18). pp. 241A. Mod Pathol.

Popovici, M., Syrbu, S. I., Cobet, V., Ivanov, V., Popovici, I. & Ciobanu, L. (2005). Serum determination of Ca2+-ATP-ase in the diagnosis of acute myocardial infarction. Arta Medicala, 2(11), 3-6.

Syrbu, S. I., Jans, M. & Vasef, M. A. (2004). Expression profiling of transcription factors Pax-5, Oct1, Oct2, BOB.1, and PU.1 in classical Hodgkin and non-Hodgkin lymphomas: a comparative study using high throughout tissue microarrays. (Vols. 17). pp. 273A. Mod Pathol.

Syrbu, S. I., Popovici, M., Kobets, V., Ivanov, V., Popovici, I. & Ciobanu, L. (2003). The serum cardiac sarcoplasmic Ca-ATPase immunoassessment: a new diagnostic marker of acute myocardial infarction. (Vols. 24). pp. 299. Eur Heart J.

Rokhlin, O. W., Taghiyev, A. F., Guseva, N. V., Glover, R. A., Syrbu, S. I. & COHEN, M. B. (2002). TRAIL-DISC formation is androgen-dependent in the human prostatic carcinoma cell line LNCaP. Cancer Biology & Therapy, 1(6), 631-7. PMID: 12642685.

Weiner, R. E., Sasso, D. E., Gionfriddo, M. A., Thrall, R. S., Syrbu, S. I., Smilowitz, H. M. & Vento, J. (2001). Early detection of oleic acid-induced lung injury in rats using (111)In-labeled anti-rat intercellular adhesion molecule-1. J Nuclear Med, 42(7), 1109-15. PMID: 11438635.

Syrbu, S. I., Zafar, N. X. & Vaena, D. (2001). Lymphoma of the breast, morphologic and immunologic assessment. (Vols. 14). (1), pp. 180A. Modern Pathology.

Syrbu, S. I., Waterman, W. H., Molski, T. F., Nagarkatti, D., Hajjar, J. J. & Sha'afi, R. I. (1999). Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils. J Immunol, 162(4), 2334-40. PMID: 9973512.

Moraru, I. I., Syrbu, S. I., Zecevic, N., Hager, W. D., Watras, J. & Messineo, F. (1998). An antibody to annexin V blocks Ca(2+)-dependent ATPase activity of sarcoplasmic reticulum in human failing hearts. Ann NY Acad Sci, 853, 333-7. PMID: 10603973.

Moraru, I. I., Syrbu, S. I., Michaels, K., Kim, D. H., Malchoff, D. & Watras, J. (1998). Pressure overload induces overexpression of annexins II and V in aortic-banded rats. Ann NY Acad Sci, 853, 329-32. PMID: 10603972.

Weiner, R. E., Sasso, D. E., Gionfriddo, M. A., Syrbu, S. I., Smilowitz, H. M., Vento, J. & Thrall, R. S. (1998). Early detection of bleomycin-induced lung injury in rat using indium-111-labeled antibody directed against intercellular adhesion molecule-1. J Nucl Med, 39(4), 723-8. PMID: 9544689.

Cowan, A., Syrbu, S. I. (1998). Synthesis and intracellular trafficking of fertilin during guinea pig spermatogenesis. (Vols. 9). pp. 179a. Mol Biol Cell.

Syrbu, S. I., Popovici, M. I., Thrall, R. S. & Smilowitz, H. M. (1997). Role of inflammatory mediators in oleic acid induced acute lung injury. Curier Medical, 3, 36-40.

Sasso, D. E., Gionfriddo, M. A., Thrall, R. S., Syrbu, S. I., Smilowitz, H. M. & Weiner, R. E. (1996). Biodistribution of indium-111-labeled antibody directed against intercellular adhesion molecule-1. J Nucl Med, 37(4), 656-61. PMID: 8691262.

Syrbu, S. I., Thrall, R. S. & Smilowitz, H. M. (1996). Sequential appearance of inflammatory mediators in rat bronchoalveolar lavage fluid after oleic acid-induced lung injury. Exp Lung Res, 22(1), 33-49. PMID: 8838134.

Sasso, D., Gionfriddo, M. & Syrbu, S. I. (1995). Biodistribution of antibody directed against intercellular adhesion molecule-1 in normal rat. (Vols. 51). pp. A70. Am J Resp Crit Care Medicine.

Go, L., Watras, J., Harnick, S., Marx, S., Syrbu, S. I. & Marks, A. (1995). Chamber specific regulation of calcium ATPase messenger RNA and protein during human heart failure. (Vols. 92). pp. 132. Circulation.

Sasso, D., Gionfriddo, M., Syrbu, S. I., Smilowitz, H., Thrall, R. & Weiner, R. (1995). Early detection of lung injury using In-111 labeled anti-intercellular adhesion molecule-1 in rat model. (Vols. 36). pp. 159P. J Nucl Med.

Syrbu, S. I., Popovici, M. I. & Smilowitz, H. M. (1995). Endotoxin and TNF? induce upregulation of adhesion molecules on isolated myocardial cells. (C38) Curier Med.

Syrbu, S. I., Thrall, R. S., Wisniecki, P., Lifchez, S. & Smilowitz, H. M. (1995). Increased immunoreactive rat lung ICAM-1 in oleic acid-induced lung injury. Exp Lung Res, 21(4), 599-616. PMID: 7588446.

Syrbu, S. I., Smilowitz, H. M. (1995). Rapid increase in immunoreactive rat lung ICAM-1 following oleic acid-induced lung injury. (Vols. 51). pp. A766. Am J Resp Crit Care Medicine.

Syrbu, S. I., Smilowitz, H. M. (1995). Sequential appearance of inflammatory mediators in rat broncho-alveolar lavage fluid (BAL) after oleic acid (OA) induced lung injury. (Vols. 51). pp. A68. Am J Resp Crit Care Medicine.

Watras, J., Go, L. & Syrbu, S. I. (1995). Use of endomyocardial biopsies to analyze the sarcoplasmic reticulum calcium pump in patients with heart failure. (Vols. 92). pp. I698. Circulation.

Syrbu, S. I., Thrall, R. S., Wisniecki, P., Lifchez, S. & Smilowitz, H. M. (1994). Increased immunoreactive rat lung ICAM-1 in oleic acid induced lung injury. (Vols. 72). pp. 275S. Can J Physiol Pharmacol.

Syrbu, S. I., Popovich, M. i. & Loginov, V. A. (1992). Functional states and contents of ion transporting membrane proteins of red cells in hypertensive patients. pp. 107-116. Science (Chishinau, Moldova).

Popovici, M. I., Costin, S., Gudumac, V. & Syrbu, S. I. (1992). Molecular mechanisms of diastolic stiffness in cardiomyopathies. pp. 78. Materials of Vth Meeting of Balkan Medical Society. Constancsa (Romania).

Topal, V., Syrbu, S. I. (1991). Antioxidant treatment of patients with symmetrical lipomatosis (Madelung disease). Curier MEdical, 4, 12-15.

Popovich, M. I., Cobets, V. A., Kapelko, V. I. & Syrbu, S. I. (1991). Functional and energetic myocardial disorders at prolonged adrenergic stimulation and protective effect of taurine. pp. 74. Materials of IVth Soviet Symposium "Stress, Adaptations and Dysfunction". Chishinau.

Topal, V., Lysyi, L. T. & Syrbu, S. I. (1990). Hormonal metabolic disturbances in patients with symmetrical lipomathosis of the neck. Curier Medical, 5, 38-41.

Syrbu, S. I., Popovich, M. I., Golikov, M. & Kapelko, V. (1990). Myocardial dysfunction and metabolic disturbances induced by Adriamicine administration in rats. All Union Symposium of Physiology..

Syrbu, S. I., Popovich, M. I., Golikov, M. & Kapelko, V. (1990). Myocardial dysfunction and metabolic disturbances induced by Adriamicine administration in rats. (Vols. 3). pp. 103. J Physiology.

Levitsky, D. O., Benevolensky, D. S., Ikemoto, N., Syrbu, S. I. & Watras, J. (1989). Monoclonal antibodies to dog heart sarcoplasmic reticulum as markers of endoplasmic reticulum. J Mol Cell Cardiol, 21 Suppl 1, 55-8. PMID: 2543829.

Syrbu, S. I., Levitsky, D. O. & Popovici, M. i. (1989). Mechanism of inhibiting Ca uptake and ATPase activity of sarcoplasmic reticulum by monoclonal antibodies. In Achievements in cardiology.. pp. 149-163. Science (Chishinau, Moldova).

Syrbu, S. I., Popovich, M. I. & Levitsky, D. O. (1989). Production and characterization of monoclonal antibodies which inhibit the function of sarcoplasmicreticulum. (Vols. 21). pp. S32. J Mol Cell Cardiol.

Brovkovich, V. M., Syrbu, S. I., benevolensky, D. S. & Levitsky, D. O. (1988). Effect of total ischemia on the function of cardiac sarcoplasmic reticulum. pp. 13a. International Symposium on Hypoxia (Berlin):.

Syrbu, S. I., Popovici, M. I. (1988). Functional states of Ca pump system of cardiac muscle during prolonged administration of pesticides. In Actual Problems of Cardiovascular Pathology in Moldova. pp. 120-125. Science (Chishinau, Moldova).

Levitsky, D. O., Benevolensky, D. S. & Syrbu, S. I. (1988). Monoclonal antibodies to Ca ATPase as a tool for studying structure and function of sarcoplasmic reticulum. (Vols. Suppl IV). pp. S81. Ind. J. Heart Res.

Syrbu, S. I., Levitsky, D. P. & Cherepakhin, V. V. (1988). Monoclonal antibodies to Ca ATPase as a tool for studying structure and function of sarcoplasmic reticulum. In Actual Problems of Cardiovascular Pathology in Moldova. pp. 83-95. Science (Chishinau, Moldova).

Levitsky, D. O., Syrbu, S. I. & Benevolensky, D. S. (1988). Studies of the structure and function of sarcoplasmic reticulum using monoclonal antibodies against Ca ATPase. pp. P4.4.44. IVth International Congress of Cell Biology (Monreal)..

Levitsky, D. O., Syrbu, S. I., Cherepakhin, V. V. & Rokhlin, O. V. (1987). Monoclonal antibodies to dog heart sarcoplasmic reticulum. Application of the mAbs for studies of the structure and function of Ca2+-pumps. Biomedica biochimica acta, 46(9), S382-7. PMID: 2449184.

Levitsky, D. O., Syrbu, S. I., Cherepakhin, V. V. & Rokhlin, O. V. (1987). Monoclonal antibodies to dog heart sarcoplasmic reticulum. Antibodies that inhibit Ca2+-pump systems of cardiac and skeletal muscles. Eur J Biochem, 164(2), 477-84. PMID: 2436908.

Levitsky, D. O., Brovkovich, V. M. & Syrbu, S. I. (1987). Mechanisms of the damage of sarcoplasmic reticulum calcium pump in ischemic myocardium. (Vols. 19). pp. S213. J Mol Cell Cardiol.

Syrbu, S. I., Cherepakhin, V. V., Rokhlin, O. W. & Levitsky, D. O. (1987). Monoclonal antibodies to Ca ATPase of cardiac sarcoplasmic reticulum inhibiting Ca pump activity and differentiating fast and slow muscles. (Vols. 19). pp. S43. J Mol Cell Cardiol.

Suhoplechev, S., Loginov, V. S. & Syrbu, S. I. (1986). Binding of monoclonal antibodies against Ca ATPase with red cells membrane of hypertensive patients. 4th Soviet Congress of Cardiology (Moscow).

Syrbu, S. I., Sakharova, A. A. & Cherepakhin, V. V. (1986). Monoclonal antibodies against Ca ATPase that discriminate slow and fast muscles. pp. 309-310. Materials of III Symposium of Soviet Section of the ISHR (Baku).

Levitsky, D. O., Syrbu, S. I., Cherepakhin, V. V., Rokhlin, O. W. & Popovich, M. I. (1986). Monoclonal antibodies to sarcoplasmic reticulum membranes that inhibit Ca2+ transport, and Ca2+ ATPase activity. Biologich Membr, 3, 101-106.

Syrbu, S. I., Levitsky, D. O. & Levchenko, T. S. (1986). Production of monoclonal antibodies to dog heart sarcoplasmic reticulum. pp. 309-310. Materials of Vth Soviet Congress of Biochemistry(Kiev).

Popovich, M. I., Gerasimova, T. S. & Syrbu, S. I. (1984). High energy phosphates and myocardial contractile function after prolonged administration of pesticides in rats. Materials of All Union Symposium "Stress and Adaptation" (Moscow).

Popovich, M. I., Gerasimova, T. S., Syrbu, S. I. & Severin, V. V. (1983). Biochemical and physiological alteration of myocardium in rats treated by pesticides. Materials of International Symposium of Soviet Section of the ISHR (Tashkent).