J. Stacey Klutts, MD, PhD

Portrait
Chief, Pathology and Laboratory Service, Central Iowa VA Health Care System
Staff Pathologist, Iowa City VA Health Care System
Clinical Associate Professor of Pathology

Contact Information

Primary Office: BW23 Veterans Affairs Medical Center (113)
601 Highway 6 West
Iowa City, IA 52246
319-338-0581

Education

BS, Chemistry, Missouri State University, Springfield, MO
MD, University of Arkansas for Medical Sciences, Little Rock, AR
PhD, University of Arkansas for Medical Sciences, Little Rock, AR

Resident, Laboratory Medicine / Clinical Pathology, Washington University School of Medicine/Barnes-Jewish Hospital
Chief Resident, Laboratory Medicine, Washington University School of Medicine, St. Louis, MO

Licensure and Certifications

Diplomate, Clinical Pathology - American Board of Pathology
State of Iowa Medical License - Iowa Board of Medicine

Research Summary

Dr. Klutts' clinical responsibilities include many areas of Clinical Pathology, including Clinical Microbiology, Clinical Chemistry and General Clinical Laboratory Administration. His research interests include many areas, including the development and validation of testing for multi-drug resistant microorganisms, novel technologies for microbial detection in clinical labs, mechanisms of health care information delivery and developing methods for pathology resident physician evaluation.

Publications

Klein, D. M., Pham, K., Samy, L., Bluth, A., Nazi, K. M., Witry, M., Klutts, J. S., Grant, K. M., Gundlapalli, A. V., Kochersberger, G., Pfeiffer, L., Romero, S., Vetter, B. & Turvey, C. L. (2017). The Veteran-Initiated Electronic Care Coordination: A Multisite Initiative to Promote and Evaluate Consumer-Mediated Health Information Exchange. Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 23(4), 264-272. PMID: 27726644.

Turvey, C. L., Klein, D. M., Witry, M., Klutts, J. S., Hill, E. L., Alexander, B. & Nazi, K. M. (2016). Patient Education for Consumer-Mediated HIE. A Pilot Randomized Controlled Trial of the Department of Veterans Affairs Blue Button. Applied clinical informatics, 7(3), 765-76. PMID: 27484821.

Klutts, J. S., Guerin, L. A., Bruch, L. A., Firchau, D. J., Knudson, C. M., Rosenthal, N. S., Samuelson, M. I., Jensen, C. S., Delwiche, J. L. & Krasowski, M. D. (2015). Pathology Milestones: Assessing Clinical Competency by Committee. Academic pathology, 2(4), 2374289515614003. PMID: 28725752.

Schlichting, J. A., Mengeling, M. A., Makki, N. M., Malhotra, A., Halfdanarson, T. R., Klutts, J. S., Levy, B. T., Kaboli, P. J. & Charlton, M. E. (2015). Veterans' Continued Participation in an Annual Fecal Immunochemical Test Mailing Program for Colorectal Cancer Screening. J Am Board Fam Med, 28(4), 494-7. PMID: 26152441.

Samar, D., Kieler, J. B. & Klutts, J. S. (2015). Identification and deletion of Tft1, a predicted glycosyltransferase necessary for cell wall ß-1,3;1,4 glucan synthesis in aspergillus fumigatus. PLoS One, 10(2), e0117336. DOI: 10.1371/journal.pone.0117336.

Schlichting, J. A., Mengeling, M. A., Makki, N. M., Malhotra, A., Halfdanarson, T. R. & Klutts, J. S. (2014). Increasing colorectal cancer screening in an overdue population: Participation and cost impacts of adding telephone calls to a FIT mailing program. Journal of Community Health, 39(2), 239-47. PMID: 24499966.

Healthcare Associated Infection Consortium (2014). Strain types and antimicrobial resistance patterns of clostridium difficile isolates from the United States, 2011 to 2013. Antimicrobial Agents and Chemotherapy, 58(7), 4214-18. DOI: 10.1128/AAC.02775-13.

Gailey, M. P., Klutts, J. & Jensen, C. S. (2013). Fine needle aspiration of histoplasmosis in the era of endoscopic ultrasound (EUS) and endobronchial ultrasound (EBUS). Can Cytopath, 121(9), 508-17. PMID: 23677891.

Baselski, V., Klutts, J. S., Baselski, V. & Klutts, J. S. (2013). Quantitative cultures of bronchoscopically obtained specimens should be performed for optimal management of ventilator-associated pneumonia. Journal of clinical microbiology, 51(3), 740-4. PMID: 23284021.

Heiss, C., Skowyra, M. L., Liu, H., Klutts, J., Wang, Z., Williams, M., Srikanta, D., Beverly, S. M., Azadi, P. & Doering, T. L. (2013). Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans. J. Biol. Chem., 288, 10994-11003.

Colpan, A., Johnston, B., Porter, S., Clabots, C., Anway, R., Thao, L., Kuskowski, M. A., Tchesnokova, V., Sokurenko, E. V., Johnson, J. R., Allen, B. L., Baracco, G. J., Bedimo, R., Bessesen, M., Bonomo, R. A., Brecher, S. M., Brown, S. T., Castellino, L., Desai, A. S., Fernau, F., Fisher, M. A., Fleckenstein, J., Fleming, C. S., Fries, N. J., Kan, V. L., Kauffman, C. A., Klutts, S., Ohl, M., Russo, T., Swiatlo, A. & Swiatlo, E. (2013). Escherichia coli sequence type 131 (ST131) subclone h30 as an emergent multidrug-resistant pathogen among US Veterans. Clinical Infectious Diseases, 57(9), 1256-1265. DOI: 10.1093/cid/cit503.

Kieler, J. B., Duong, K. L., Moye-Rowley, W. S. & Klutts, J. S. (2013). Targeted gene deletion in Aspergillus fumigatus using microbial machinery and a recyclable marker. J Microbiol Methods, 95(3), 373-8. PMID: 24161898.

Baselski, V., Klutts, J. (2013). Point-Counterpoint: Quantitative cultures of bronchoscopically obtained specimens should be performed for optimal management in patients with ventilator associated pneumonia. Journal of clinical microbiology, 51(3), 740-44. PMID: 23284021.

Charlton, M. E., Mengeling, M. A., Halfdanarson, T. R., Makki, N. M., Malhotra, A., Klutts, S. J., Levy, B. T. & Kaboli, P. J. (2013). Evaluation of a home-based colorectal cancer screening intervention in a rural state. Journal of Rural Health, 30(3), 322-32. PMID: 24164375.

Paul, S., Klutts, J. S. & Moye-Rowley, W. S. (2012). Analysis of promoter function in Aspergillus fumigatus. Eukaryotic cell, 11(9), 1167-77. PMID: 22843562.

Kieler, J. B., Duong, K. l. & Klutts, J. (2012). Amylases and cell wall synthesis in Aspergillus fumigatus. Keystone Conference: Fungal Pathogens: From Basic Biology to Drug Discovery. Santa Fe, NM.

Samar, D., Mecklenburg, E. W., Kieler, J. B. & Klutts, J. (2011). Agrobacterium mediated transformation and splinkerette PCR for the development and characterization of an Aspergillus fumigatus cell wall mutant library. American Society of Microbiology General Meeting. New Orleans, LA.

Klutts, J., Robinson-Dunn, B. (2011). A Critical Appraisal of the Role of the Clinical Microbiology Laboratory in Diagnosis of Invasive Fungal Infections. Journal of clinical microbiology, 49(9), S39-S42.

Mecklenburg, E. W., Klutts, J. (2010). Utilization of a Novel Transformation and Screening Protocol to Generate an Aspergillus fumigatus Cell Wall Mutant Library. American Society of Microbiology General Meeting - San Diego, CA.

Duong, K. L., Klutts, J. (2010). The Role of Amylases in Aspergillus fumigatus cell wall synthesis. American Society of Microbiology General Meeting - San Diego, CA.

Heiss, C., Klutts, J., Wang, Z., Doering, T. L. & Azadi, P. (2009). The structure of Cryptococcus neoformans galactoxylomannan contains beta-D-glucuronic acid. Carbohydrate research, 344(7), 915-20. PMID: 19345342.

Kieler, J. B., Klutts, J. (2009). A Glucosyltransferase in Aspergillus fumigatus with a Potential Role in Cell Wall Synthesis. American Society of Microbiology General Meeting - Philadelphia, PA.

Klutts, J., Ford, B. A., Perez, N. R. & Gronowski, A. M. (2009). Evidence-based approach for interpretation of Epstein-Barr virus serological patterns. Journal of clinical microbiology, 47(10), 3204-10. PMID: 19656988.

Reilly, M. C., Levery, S. B., Castle, S. A., Klutts, J. & Doering, T. L. (2009). A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans. The Journal of biological chemistry, 284(52), 36118-27. PMID: 19864415.

Castle, S. A., Owuor, E. A., Thompson, S. H., Garnsey, M. R., Klutts, J., Doering, T. L. & Levery, S. B. (2008). Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids. Eukaryotic cell, 7(9), 1611-5. PMID: 18676952.

Klutts, J., Wu, A. H., Smith, A., Yen-Lieberman, B. & Gronowski, A. M. (2008). Diagnostic performance of a new automated heterophile antibody test in adults and children. Diagnostic microbiology and infectious disease, 61(3), 351-3. PMID: 18420370.

Kieler, J. B., Klutts, J. (2008). A Novel Glucosyltransferase in Aspergillus fumigatus—New Implications for Cell Wall Synthesis. Interscience Conference on Antimicrobial Agents and Chemotherapy/Infectious Diseases Society of America. Washington, D.C.

Klutts, J., Doering, T. L. (2008). Cryptococcal xylosyltransferase 1 (Cxt1p) from Cryptococcus neoformans plays a direct role in the synthesis of capsule polysaccharides. The Journal of biological chemistry, 283(21), 14327-34. PMID: 18347023.

Klutts, J., Levery, S. B. & Doering, T. L. (2007). A beta-1,2-xylosyltransferase from Cryptococcus neoformans defines a new family of glycosyltransferases. The Journal of biological chemistry, 282(24), 17890-9. PMID: 17430900.

Klutts, J. (2007). Hot, Tired and Lumpy - A Case of Classical EBV-Related Mononucleosis. In M. G. Scott , A. M. Gronowski , C. S. Eby (Eds.) Tietz Applied Laboratory Medicine, 2nd Edition. John Wiley & Sons, Inc., Hoboken, NJ.

Scott, M. G., LeGrys, V. A. & Klutts, J. (2007). Electrolytes and Blood Gases. In C. A. Burtis , E. R. Ashwood & D. E. Bruns (Eds.) Tietz Fundamentals of Clinical Chemistry, 6th Edition. pp. pp 431-49. Elsevier, Philadelphia, PA.

Klutts, J., Scott, M. G. (2007). Disorders of Water, Electrolyte, and Acid-Base Metabolism. In C. A. Burtis , E. R. Ashwood , D. E. Bruns (Eds.) Tietz Fundamentals of Clinical Chemistry, 6th Edition. pp. pp 655-74. Elsevier, Philadelphia, PA.

Klutts, J., Levery, S. B. & Doering, T. L. (2006). Xylosyltransferases and Capsule Biosynthesis in Cryptococcus neoformans. Academy of Clinical Laboratory Physicians and Scientists (ACLPS) Annual Meeting. Chicago, IL.

Klutts, J., Levery, S. B. & Doering, T. L. (2006). Xylosyltransferases and Capsule Biosynthesis in Cryptococcus neoformans. American Society for Microbiology, General Meeting. Orlando, FL.

Klutts, J., Yoneda, A., Reilly, M. C., Bose, I. & Doering, T. L. (2006). Glycosyltransferases and their products: cryptococcal variations on fungal themes. FEMS yeast research, 6(4), 499-512. PMID: 16696646.

Scott, M. G., LeGrys, V. A. & Klutts, J. (2005). Electrolytes and Blood Gases. In E. R. Ashwood , D. E. Bruns (Eds.) Tietz Fundamentals of Clinical Chemistry, 4th Edition. pp. pp 983-1015. Elsevier, Philadelphia, PA.

Klutts, J., Scott, M. G. (2005). Physiology and Disorders of Water, Electrolytes, and Acid-Base Metabolism. In E. R. Ashwood , C. A. Burtis (Eds.) Tietz Fundamentals of Clinical Chemistry, 4th Edition. pp. pp 1747-76. Elsevier, Philadelphia, PA.

Klutts, J., Levery, S. B. & Doering, T. L. (2005). A Beta-1,2 Xylosyltransferase from Cryptococcus neoformans. American Society for Microbiology General Meeting. Atlanta, GA.

Klutts, J., Levery, S. B. & Doering, T. L. (2005). A Beta-1,2 Xylosyltransferase from Cryptococcus neoformans. ACLPS Annual Meeting, Pittsburg, PA.

Klutts, J., Levery, S. B. & Doering, T. L. (2005). A Beta-1,2 Xylosyltransferase from Cryptococcus neoformans. International Meeting of Cryptococcus and Cryptococcosis (ICCC), Biennial Meeting. Boston, MA.

Klutts, J., Levery, S. B. & Doering, T. L. (2005). A Beta-1,2 Xylosyltransferase from Cryptococcus neoformans. Gordon Conference on Glycobiology. Ventura, VA.

Klutts, J., Levery, S. B. & Doering, T. L. (2005). A Beta-1,2 Xylosyltransferase from Cryptococcus neoformans. Annual Meeting of the Society for Glycobiology. Boston, MA.

Klutts, J., Doering, T. L. (2004). Purification and Characterization of a Xylosyltransferase from Cryptococcus neoformans. American Society for Microbiology, General Meeting. New Orleans, LA.

Klutts, J., Liao, R. S., Dunne, W. M. & Gronowski, A. M. (2004). Evaluation of the Bio-Plex 2200 Multi-Analyte System for Detection of Antibodies to Epstein-Barr Virus. ACLPS Annual Meeting. Denver, CO.

Klutts, J., Liao, R. S., Dunne, W. M. & Gronowski, A. M. (2004). Evaluation of a multiplexed bead assay for assessment of Epstein-Barr virus immunologic status. Journal of clinical microbiology, 42(11), 4996-5000. PMID: 15528686.

Griffith, C. L., Klutts, J., Zhang, L., Levery, S. B. & Doering, T. L. (2004). UDP-glucose dehydrogenase plays multiple roles in the biology of the pathogenic fungus Cryptococcus neoformans. The Journal of biological chemistry, 279(49), 51669-76. PMID: 15383535.

Klutts, J., Eby, C. (2003). Evaluation of a Micro-particle Agglutination Assay for the Diagnosis of Heparin-Induced Thrombocytopenia. ACLPS Annual Meeting. Tucson, AZ.

Klutts, J., Dunne, W. M. (2003). Detection of Gram-Positive and Gram-Negative Bacteria in Platelet Products Using an Acridine Orange Staining Technique. ACLPS Annual Meeting. Tucson, AZ.

Klutts, J., Pastuszak, I., Edavana, V. K., Thampi, P., Pan, Y. T., Abraham, E. C., Carroll, J. D. & Elbein, A. D. (2003). Purification, cloning, expression, and properties of mycobacterial trehalose-phosphate phosphatase. The Journal of biological chemistry, 278(4), 2093-100. PMID: 12417583.

Klutts, J., Pan, Y. T. & Elbein, A. D. (2002). The Purification and characterization of a Trehalose-phosphate Phosphatase from Mycobacterium smegmatis. ACLPS Annual Meeting. New York, NY.

Klutts, J., Hatanaka, K., Pan, Y. T. & Elbein, A. D. (2002). Biosynthesis of d-arabinose in Mycobacterium smegmatis: specific labeling from d-glucose. Archives of biochemistry and biophysics, 398(2), 229-39. PMID: 11831854.

Klutts, J. (2002). The Biosynthesis of D-Arabinose and D-Trehalose in Mycobacterium smegmatis, PhD Dissertation-University of Arkansas for Medical Sciences.