John T. Harty, PhD

Portrait
Mark Stinski Chair in Microbial Immunology
Professor of Microbiology and Immunology
Professor of Pathology

Contact Information

Office: 3-530 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-335-9720

Lab: 3-501B Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
319-335-9919

Education

BS, Biology, University of Minnesota
PhD, Microbiology, University of Minnesota

Post Doctoral Fellow, Scripps Clinical and Research Foundation
Post Doctoral Fellow, Howard Hughes Medical Institute, University of Washington

Education/Training Program Affiliations

Biomedical Science Program, Department of Microbiology Graduate Program, Interdisciplinary Graduate Program in Immunology, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases

Research Summary

Research in the Harty laboratory is focused on understanding the dynamics of the T cell response, how effector and memory T cell differentiation are regulated, how memory T cell populations are maintained and how they can be generated and manipulated to enhance protective immunity. We then use this basic information to manipulate immune responses for optimal protection against Plasmodium infection of the liver and blood and Influenza virus infection of the lung.

The major approaches in the lab involve identification of new questions through sophisticated analyses of in vivo T cell responses to various pathogens or immunization regimens. These observations are then dissected at the cellular, biochemical and molecular levels to generate a comprehensive mechanistic view of T cell regulation. We recently initiated projects to use intravital 2-Photon imaging to further dissect immunity to infections of the liver, brain and lungs. Ultimately our goal is to provide fundamental insights that will inform vaccine design and therapeutic interventions for major human infectious diseases.

Current projects in the lab

1. Basic immunology and imaging of CD8 T cell immunity to liver-stage malaria

2. CD4 T cell and antibody mediated immunity to blood-stage malaria

3. Basic immunology and imaging of cerebral malaria

4. Tissue resident memory CD8 T cell dynamics and protection from influenza virus infection of the lung

5. Impact of repetitive influenza exposure on generation and persistence of protective CD8 T cells

6. Regulating memory CD8 T cell differentiation through inflammatory cytokines

Publications

Post, D. M., Slütter, B., Schilling, B., Chande, A. T., Rasmussen, J. A., Jones, B. D., D'Souza, A. K., Reinders, L. M., Harty, J. T., Gibson, B. W. & Apicella, M. A. (2017). Characterization of Inner and Outer Membrane Proteins from <i>Francisella tularensis</i> Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates. mBio, 8(5), e01592-17. PMID: 29018123.

Shan, Q., Zeng, Z., Xing, S., Li, F., Hartwig, S. M., Gullicksrud, J. A., Kurup, S. P., Van Braekel-Budimir, N., Su, Y., Martin, M. D., Varga, S. M., Taniuchi, I., Harty, J. T., Peng, W., Badovinac, V. P. & Xue, H. H. (2017). The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol, 18(8), 931-939. PMID: 28604718.

Van Braeckel-Budimir, N., Harty, J. T. (2017). Influenza induced lung Trm: Not all memories last forever. Immunol Cell Biol, 95(8), 651-655. PMID: 28405016.

Danahy, D. B., Anthony, S. M., Jensen, I. J., Hartwig, S. M., Shan, Q., Xue, H. H., Harty, J. T., Griffith, T. S. & Badovinac, V. P. (2017). Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells. PLoS Pathog, 13(9), e1006569. PMID: 28910403.

Kurup, S. P., Obeng-Adjei, N., Anthony, S. M., Traore, B., Doumbo, O. K., Butler, N. S., Crompton, P. D. & Harty, J. T. (2017). Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4. Nat Med, 23(10), 1220-1225. PMID: 28892065.

Shan, Q., Zeng, Z., Xing, S., Li, F., Hartwig, S. M., Gullicksrud, J. A., Kurup, S. P., Van Braeckel-Budimir, N., Su, Y., Martin, M. D., Varga, S. M., Taniuchi, I., Harty, J. T., Peng, W., Badovinac, V. P. & Xue, H. H. (2017). The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol, 18(8), 931-939. PMID: 28604718.

Gullicksrud, J. A., Li, F., Xing, S., Zeng, Z., Peng, W., Badovinac, V. P., Harty, J. T. & Xue, H. H. (2017). Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection. J Immunol, 199(3), 911-919. PMID: 28652395.

Urban, S. L., Doll, K. L. & Harty, J. T. (2017). Mechanisms of adaptive immunity to Plasmodium liver-stage infection: The known and unknown. In M. Mota , A. Rodriguez (Eds.) Malaria: immune response to infection and vaccination. pp. 27-46. Springer Press.

Huggins, M., Johnson, H. L., Jin, F., N'Songo, A., Hanson, L. M., LaFrance, S. J., Butler, N. S., Harty, J. T. & Johnson, A. J. (2017). Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria. Infect Immun, 85(5), e00985-16. PMID: 28264905.

Slütter, B., Van Braeckel-Budimir, N., Abboud, G., Varga, S. M., Salek-Ardakani, S. & Harty, J. T. (2017). Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity. Sci Immunol, 2(7), eaag2031. PMID: 28783666.

Itani, F. R., Sinha, S., Brate, A. A., Pewe, L. L., Gibson-Corley, K. N., Harty, J. T. & Karandikar, N. J. (2017). Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen. Sci Rep, 7(1), 1519. PMID: 28484224.

Van Braeckel-Budimir, N., Martin, M. D., Hartwig, S. M., Legge, K. L., Badovinac, V. P. & Harty, J. T. (2017). Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections. Front Immunol, 8, 40. PMID: 28191007.

Matte-Martone, C., Liu, J., Zhou, M., Chikina, M., Green, D. R., Harty, J. T. & Shlomchik, W. D. (2017). Differential requirements for myeloid leukemia IFN-? conditioning determine graft-versus-leukemia resistance and sensitivity. J Clin Invest, 127(7), 2765-2776. PMID: 28604385.

Martin, M. D., Danahy, D. B., Hartwig, S. M., Harty, J. T. & Badovinac, V. P. (2017). Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice. Front Immunol, 8, 1527. PMID: 29213267.

Osborn, J. F., Mooster, J. L., Hobbs, S. J., Munks, M. W., Barry, C., Harty, J. T., Hill, A. B. & Nolz, J. C. (2017). Enzymatic synthesis of core 2 O-glycans governs the tissue-trafficking potential of memory CD8+ T cells. Sci Immunol, 2(16), eaan6049. PMID: 29030501.

Van Braeckel-Budimir, N., Gras, S., Ladell, K., Josephs, T. M., Pewe, L., Urban, S. L., Miners, K. L., Farenc, C., Price, D. A., Rossjohn, J. & Harty, J. T. (2017). A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene. Immunity, 47(5), 835-847. PMID: 29150238.

Van Braeckel-Budimir, N., Kurup, S. P. & Harty, J. T. (2016). Regulatory issues in immunity to liver and blood-stage malaria. Curr Opin Immunol, 42, 91-7. PMID: 27351448.

Vacaflores, A., Chapman, N. M., Harty, J. T., Richer, M. J. & Houtman, J. C. (2016). Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism. PLoS One, 11(6), e0157175. PMID: 27280403.

He, B., Xing, S., Chen, C., Gao, P., Teng, L., Shan, Q., Gullicksrud, J. A., Martin, M. D., Yu, S., Harty, J. T., Badovinac, V. P., Tan, K. & Xue, H. H. (2016). CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections. Immunity, 45(6), 1341-1354. PMID: 27986453.

Schaut, R. G., Lamb, I. M., Toepp, A. J., Scott, B., Mendes-Aguiar, C. O., Coutinho, J. F., Jeronimo, S. M., Wilson, M. E., Harty, J. T., Waldschmidt, T. J. & Petersen, C. A. (2016). Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis. J Immunol, 196(10), 4100-9. PMID: 27076677.

Doll, K. L., Pewe, L. L., Kurup, S. P. & Harty, J. T. (2016). Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses. J Immunol, 196(10), 4253-62. PMID: 27084099.

Kim, M. T., Kurup, S. P., Starbeck-Miller, G. R. & Harty, J. T. (2016). Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals. J Immunol, 197(5), 1754-61. PMID: 27439516.

Kim, M. T., Richer, M. J., Gross, B. P., Norian, L. A., Badovinac, V. P. & Harty, J. T. (2015). Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors. J Immunol, 195(9), 4537-44. PMID: 26408669.

Khan, S. H., Martin, M. D., Starbeck-Miller, G. R., Xue, H. H., Harty, J. T. & Badovinac, V. P. (2015). The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses. PLoS Pathog, 11(10), e1005199. PMID: 26431533.

Martin, M. D., Kim, M. T., Shan, Q., Sompallae, R., Xue, H. H., Harty, J. T. & Badovinac, V. P. (2015). Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection. PLoS Pathog, 11(10), e1005219. PMID: 26485703.

Starbeck-Miller, G. R., Harty, J. T. (2015). The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses. Adv Exp Med Biol, 850, 31-41. PMID: 26324344.

Peña Silva, R. A., Mitchell, I. J., Kung, D. K., Pewe, L. L., Granja, M. F., Harty, J. T., Faraci, F. M., Heistad, D. D. & Hasan, D. M. (2015). Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin. Neurosurgery, 77(4), 613-20. PMID: 26134597.

Banga, S., Coursen, J. D., Portugal, S., Tran, T. M., Hancox, L., Ongoiba, A., Traore, B., Doumbo, O. K., Huang, C. Y., Harty, J. T. & Crompton, P. D. (2015). Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans. PLoS One, 10(4), e0125090. PMID: 25919588.

Kurup, S. P., Harty, J. T. (2015). ?d T cells and immunity to human malaria in endemic regions. Ann Transl Med, 3(Suppl 1), S22. PMID: 26046068.

Richer, M. J., Pewe, L. L., Hancox, L. S., Hartwig, S. M., Varga, S. M. & Harty, J. T. (2015). Inflammatory IL-15 is required for optimal memory T cell responses. J Clin Invest, 125(9), 3477-90. PMID: 26241055.

Kim, M. T., Harty, J. T. (2014). Splenectomy Alters Distribution and Turnover but not Numbers or Protective Capacity of de novo Generated Memory CD8?T-Cells. Front Immunol, 5, 568. PMID: 25414706.

Brinkhoff, B., Ostroumov, D., Heemcke, J., Woller, N., Gürlevik, E., Manns, M. P., Longerich, T., Zender, L., Harty, J. T., Kubicka, S., Kühnel, F. & Wirth, T. C. (2014). Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers. Eur J Immunol, 44(4), 1213-24. PMID: 24338782.

Nolz, J. C., Harty, J. T. (2014). IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking. J Clin Invest, 124(3), 1013-26. PMID: 24509081.

Gorman, J. V., Starbeck-Miller, G., Pham, N. L., Traver, G. L., Rothman, P. B., Harty, J. T. & Colgan, J. D. (2014). Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection. J Immunol, 192(7), 3133-42. PMID: 24567532.

Starbeck-Miller, G. R., Badovinac, V. P., Barber, D. L. & Harty, J. T. (2014). Cutting Edge: Expression of Fc?RIIB Tempers Memory CD8 T Cell Function In Vivo. J Immunol, 192(1), 35-9. PMID: 24285839.

Van Braeckel-Budimir, N., Harty, J. T. (2014). CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model. Front Microbiol, 5, 272. PMID: 24936199.

Slütter, B., Harty, J. T. (2014). Instructing the instructor: tissue-resident T cells activate innate immunity. Cell Host Microbe, 16(4), 421-3. PMID: 25299324.

Doll, K. L., Harty, J. T. (2014). Correlates of protective immunity following whole sporozoite vaccination against malaria. Immunol Res, 59(1-3), 166-76. PMID: 24825778.

Kim, M. T., Harty, J. T. (2014). Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells. Front Immunol, 5, 295. PMID: 24995011.

Doll, K. L., Butler, N. S. & Harty, J. T. (2014). CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii. Vaccine, 32(4), 483-91. PMID: 24321740.

Starbeck-Miller, G. R., Xue, H. H. & Harty, J. T. (2014). IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo. J Exp Med, 211(1), 105-20. PMID: 24367005.

Fulton, R. B., Weiss, K. A., Pewe, L. L., Harty, J. T. & Varga, S. M. (2013). Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection. J Virol, 87(23), 12694-700. PMID: 24049171.

Cabrera, M., Pewe, L. L., Harty, J. T. & Frevert, U. (2013). In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice. PLoS One, 8(8), e70842. PMID: 23967119.

Slütter, B., Pewe, L. L., Lauer, P. & Harty, J. T. (2013). Cutting edge: rapid boosting of cross-reactive memory CD8 T cells broadens the protective capacity of the Flumist vaccine. J Immunol, 190(8), 3854-8. PMID: 23467935.

Doll, K. L., Butler, N. S. & Harty, J. T. (2013). Tracking the total CD8 T cell response following whole Plasmodium vaccination. Methods Mol Biol, 923, 493-504. PMID: 22990800.

Nolz, J. C., Harty, J. T. (2013). One bug or another: promiscuous T cells form lifelong memory. Immunity, 38(2), 207-8. PMID: 23438820.

Khanolkar, A., Williams, M. A. & Harty, J. T. (2013). Antigen experience shapes phenotype and function of memory Th1 cells. PLoS One, 8(6), e65234. PMID: 23762323.

Slütter, B., Pewe, L. L., Kaech, S. M. & Harty, J. T. (2013). Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. Immunity, 39(5), 939-48. PMID: 24238342.

Richer, M. J., Nolz, J. C. & Harty, J. T. (2013). Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling. Immunity, 38(1), 140-52. PMID: 23260194.

Butler, N. S., Vaughan, A. M., Harty, J. T. & Kappe, S. H. (2012). Whole parasite vaccination approaches for prevention of malaria infection. Trends Immunol, 33(5), 247-54. PMID: 22405559.

Schmidt, N. W., Khanolkar, A., Hancox, L., Heusel, J. W. & Harty, J. T. (2012). Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection. Eur J Immunol, 42(3), 629-40. PMID: 22161269.

Martin, M. D., Condotta, S. A., Harty, J. T. & Badovinac, V. (2012). Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo. J Immunol, 188(3), 1255-65. PMID: 22205031.

Condotta, S. A., Richer, M. J., Badovinac, V. & Harty, J. T. (2012). Probing CD8 T cell responses with Listeria monocytogenes infection. Adv Immunol, 113, 51-80. PMID: 22244579.

Pham, N. L., Badovinac, V. & Harty, J. T. (2012). Epitope specificity of memory CD8+ T cells dictates vaccination-induced mortality in LCMV-infected perforin-deficient mice. Eur J Immunol, 42(6), 1488-99. PMID: 22678903.

Nolz, J. C., Rai, D., Badovinac, V. P. & Harty, J. T. (2012). Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells. Proc Natl Acad Sci U S A, 109(16), 6199-204. PMID: 22474367.

Kashiwada, M., Pham, N. L., Pewe, L. L., Harty, J. T. & Rothman, P. B. (2011). NFIL3/E4BP4 is a key transcription factor for CD8a? dendritic cell development. Blood, 117(23), 6193-7. PMID: 21474667.

Nolz, J. C., Harty, J. T. (2011). Strategies and implications for prime-boost vaccination to generate memory CD8 T cells. Adv Exp Med Biol, 780, 69-83. PMID: 21842366.

Schmidt, N. W., Butler, N. S. & Harty, J. T. (2011). Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity. J Immunol, 186(10), 5873-84. PMID: 21460205.

Butler, N. S., Nolz, J. C. & Harty, J. T. (2011). Immunologic considerations for generating memory CD8 T cells through vaccination. Cell Microbiol, 13(7), 925-33. PMID: 21501363.

Schmidt, N. W., Harty, J. T. (2011). Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization. J Immunol, 186(7), 3836-40. PMID: 21357257.

Wirth, T. C., Martin, M. D., Starbeck-Miller, G., Harty, J. T. & Badovinac, V. (2011). Secondary CD8+ T-cell responses are controlled by systemic inflammation. Eur J Immunol, 41(5), 1321-33. PMID: 21425157.

Pham, N. L., Badovinac, V. & Harty, J. T. (2011). Differential role of "Signal 3" inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo. Front Immunol, 2, 4. PMID: 22566795.

Butler, N. S., Schmidt, N. W., Vaughan, A. M., Aly, A. S., Kappe, S. H. & Harty, J. T. (2011). Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host Microbe, 9(6), 451-62. PMID: 21669394.

Nolz, J. C., Harty, J. T. (2011). Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection. Immunity, 34(5), 781-93. PMID: 21549619.

Martin, M. D., Wirth, T. C., Lauer, P., Harty, J. T. & Badovinac, V. (2011). The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells. J Immunol, 187(6), 2923-31. PMID: 21832161.

Butler, N. S., Moebius, J., Pewe, L. L., Traore, B., Doumbo, O. K., Tygrett, L. T., Waldschmidt, T. J., Crompton, P. D. & Harty, J. T. (2011). Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nat Immunol, 13(2), 188-95. PMID: 22157630.

Nolz, J. C., Starbeck-Miller, G. R. & Harty, J. T. (2011). Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions. Immunotherapy, 3(10), 1223-33. PMID: 21995573.

Zhao, D. M., Yu, S., Zhou, X., Haring, J. S., Held, W., Badovinac, V., Harty, J. T. & Xue, H. (2010). Constitutive activation of Wnt signaling favors generation of memory CD8 T cells. J Immunol, 184(3), 1191-9. PMID: 20026746.

Schlub, T. E., Badovinac, V., Sabel, J. T., Harty, J. T. & Davenport, M. P. (2010). Predicting CD62L expression during the CD8+ T-cell response in vivo. Immunol Cell Biol, 88(2), 157-64. PMID: 19859082.

Butler, N. S., Harty, J. T. (2010). The role of inflammation in the generation and maintenance of memory T cells. Adv Exp Med Biol, 684, 42-56. PMID: 20795539.

Butler, N. S., Schmidt, N. W. & Harty, J. T. (2010). Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites. J Immunol, 184(5), 2528-38. PMID: 20097864.

Wirth, T. C., Harty, J. T. & Badovinac, V. (2010). Modulating numbers and phenotype of CD8+ T cells in secondary immune responses. Eur J Immunol, 40(7), 1916-26. PMID: 20411564.

Zhou, X., Yu, S., Zhao, D. M., Harty, J. T., Badovinac, V. & Xue, H. (2010). Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity, 33(2), 229-40. PMID: 20727791.

Pham, N. L., Pewe, L. L., Fleenor, C. J., Langlois, R. A., Legge, K. L., Badovinac, V. P. & Harty, J. T. (2010). Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly. Proc Natl Acad Sci U S A, 107(27), 12198-203. PMID: 20616089.

Schmidt, N. W., Butler, N. S., Badovinac, V. P. & Harty, J. T. (2010). Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites. PLoS Pathog, 6(7), e1000998. PMID: 20657824.

Wirth, T. C., Xue, H., Rai, D., Sabel, J. T., Bair, T., Harty, J. T. & Badovinac, V. (2010). Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation. Immunity, 33(1), 128-40. PMID: 20619696.

Khanolkar, A., Fulton, R. B., Epping, L. L., Pham, N. L., Tifrea, D., Varga, S. M. & Harty, J. T. (2010). T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts. J Immunol, 185(2), 1132-41. PMID: 20554960.

Haring, J. S., Harty, J. T. (2009). Interleukin-18-related genes are induced during the contraction phase but do not play major roles in regulating the dynamics or function of the T-cell response to Listeria monocytogenes infection. Infect Immun, 77(5), 1894-903. PMID: 19223481.

Wirth, T., Harty, J. T. (2009). Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection. Adv Exp Med Biol, 633, 71-80. PMID: 19209682.

Butler, N. S., Harty, J. T. (2009). A "memorable" NK cell discovery. Cell Res, 19(3), 277-8. PMID: 19252510.

Wirth, T. C., Badovinac, V., Zhao, L., Dailey, M. O. & Harty, J. T. (2009). Differentiation of central memory CD8 T cells is independent of CD62L-mediated trafficking to lymph nodes. J Immunol, 182(10), 6195-206. PMID: 19414773.

Wirth, T. C., Pham, N. L., Harty, J. T. & Badovinac, V. (2009). High initial frequency of TCR-transgenic CD8 T cells alters inflammation and pathogen clearance without affecting memory T cell function. Mol Immunol, 47(1), 71-8. PMID: 19195704.

Schmidt, N. W., Butler, N. S. & Harty, J. T. (2009). CD8 T cell immunity to Plasmodium permits generation of protective antibodies after repeated sporozoite challenge. Vaccine, 27(44), 6103-6. PMID: 19712771.

Pham, N. L., Badovinac, V. & Harty, J. T. (2009). A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation. J Immunol, 183(4), 2337-48. PMID: 19635915.

Rai, D., Pham, N. L., Harty, J. T. & Badovinac, V. (2009). Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts. J Immunol, 183(12), 7672-81. PMID: 19933864.

Khanolkar, A., Hartwig, S. M., Haag, B. A., Meyerholz, D., Epping, L. L., Haring, J. S., Varga, S. M. & Harty, J. T. (2009). Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome. J Virol, 83(18), 9258-72. PMID: 19570864.

Khanolkar, A., Hartwig, S. M., Haag, B. A., Meyerholz, D., Harty, J. T. & Varga, S. M. (2009). Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice. J Virol, 83(17), 8946-56. PMID: 19553337.

Reyes-Sandoval, A., Sridhar, S., Berthoud, T., Moore, A. C., Harty, J. T., Gilbert, S. C., Gao, G., Ertl, H. C., Wilson, J. C. & Hill, A. V. (2008). Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei. Eur J Immunol, 38(3), 732-41. PMID: 18266272.

Elzey, B. D., Schmidt, N. W., Crist, S. A., Kresowik, T. P., Harty, J. T., Nieswandt, B. & Ratliff, T. L. (2008). Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood, 111(7), 3684-91. PMID: 18256321.

Schmidt, N. W., Podyminogin, R. L., Butler, N. S., Badovinac, V. P., Tucker, B. J., Bahjat, K. S., Lauer, P., Reyes-Sandoval, A., Hutchings, C. L., Moore, A. C., Gilbert, S. C., Hill, A. V., Bartholomay, L. C. & Harty, J. T. (2008). Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria. Proc Natl Acad Sci U S A, 105(37), 14017-22. PMID: 18780790.

Xue, H., Jing, X., Bollenbacher-Reilley, J., Zhao, D. M., Haring, J. S., Yang, B., Liu, C., Bishop, G. A., Harty, J. T. & Leonard, W. J. (2008). Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function. Mol Cell Biol, 28(13), 4300-9. PMID: 18426908.

Stojakovic, M., Salazar-Fontana, L. I., Tatari-Calderone, Z., Badovinac, V., Santori, F. R., Kovalovsky, D., Sant'Angelo, D., Harty, J. T. & Vukmanovic, S. (2008). Adaptable TCR avidity thresholds for negative selection. J Immunol, 181(10), 6770-8. PMID: 18981094.

Haring, J. S., Jing, X., Bollenbacher-Reilley, J., Xue, H., Leonard, W. J. & Harty, J. T. (2008). Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection. J Immunol, 180(5), 2855-62. PMID: 18292507.

Harty, J. T., Badovinac, V. (2008). Shaping and reshaping CD8+ T-cell memory. Nat Rev Immunol, 8(2), 107-19. PMID: 18219309.

Humphreys, T. D., Khanolkar, A., Badovinac, V. & Harty, J. T. (2008). Generation and maintenance of Listeria-specific CD8+ T cell responses in perforin-deficient mice chronically infected with LCMV. Virology, 370(2), 310-22. PMID: 17936870.

Harty, J. T. (2007). Dynamics of the CD8 T-cell response revealed by Listeria monocytogenes infection. In K. A. Brogden , F. C. Minion , N. Cornick , T. B. Stanton , Q. Zhang , L. K. Nolan , M. J. Wannemuehler (Eds.) Virulence mechanisms of bacterial pathogens. (4th edition), pp. 315-326. ASM Press.

Messingham, K. A., Harty, J. T. (2007). Adaptive immunity to Listeria monocytogenes. In H. Goldfine , H. Shen (Eds.) Listeria monocytogenes, Pathogenesis and Host Response. pp. 225-50. Springer Science + Business Media, LLC.

Santori, F. R., Popmihajlov, Z., Badovinac, V., Smith, C., Radoja, S., Harty, J. T. & Vukmanovic, S. (2007). TCR beta chain that forms peptide-independent alloreactive TCR transfers reduced reactivity with irrelevant peptide/MHC complex. J Immunol, 178(10), 6109-14. PMID: 17475836.

Khanolkar, A., Badovinac, V. & Harty, J. T. (2007). CD8 T cell memory development: CD4 T cell help is appreciated. Immunol Res, 39(1-3), 94-104. PMID: 17917058.

Badovinac, V., Harty, J. T. (2007). Manipulating the rate of memory CD8+ T cell generation after acute infection. J Immunol, 179(1), 53-63. PMID: 17579021.

Reyes-Sandoval, A., Harty, J. T. & Todryk, S. M. (2007). Viral vector vaccines make memory T cells against malaria. Immunology, 121(2), 158-65. PMID: 17462077.

Messingham, K. A., Badovinac, V., Jabbari, A. & Harty, J. T. (2007). A role for IFN-gamma from antigen-specific CD8+ T cells in protective immunity to Listeria monocytogenes. J Immunol, 179(4), 2457-66. PMID: 17675507.

Badovinac, V. P., Haring, J. S. & Harty, J. T. (2007). Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. Immunity, 26(6), 827-41. PMID: 17555991.

Badovinac, V., Harty, J. T. (2006). Programming, demarcating, and manipulating CD8+ T-cell memory. Immunol Rev, 211, 67-80. PMID: 16824118.

Jabbari, A., Harty, J. T. (2006). Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype. J Exp Med, 203(4), 919-32. PMID: 16567385.

Jabbari, A., Harty, J. T. (2006). Simultaneous assessment of antigen-stimulated cytokine production and memory subset composition of memory CD8 T cells. J Immunol Methods, 313(1-2), 161-8. PMID: 16762359.

Porter, B. B., Harty, J. T. (2006). The onset of CD8+-T-cell contraction is influenced by the peak of Listeria monocytogenes infection and antigen display. Infect Immun, 74(3), 1528-36. PMID: 16495523.

Hamilton, S. E., Badovinac, V., Khanolkar, A. & Harty, J. T. (2006). Listeriolysin O-deficient Listeria monocytogenes as a vaccine delivery vehicle: antigen-specific CD8 T cell priming and protective immunity. J Immunol, 177(6), 4012-20. PMID: 16951364.

Jabbari, A., Legge, K. & Harty, J. T. (2006). T cell conditioning explains early disappearance of the memory CD8 T cell response to infection. J Immunol, 177(5), 3012-8. PMID: 16920937.

Haring, J. S., Badovinac, V. & Harty, J. T. (2006). Inflaming the CD8+ T cell response. Immunity, 25(1), 19-29. PMID: 16860754.

Haring, J. S., Harty, J. T. (2006). Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor. Infect Immun, 74(11), 6252-63. PMID: 16966404.

Badovinac, V., Messingham, K. A., Griffith, T. S. & Harty, J. T. (2006). TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells. J Immunol, 177(2), 999-1006. PMID: 16818756.

Jabbari, A., Harty, J. T. (2006). The generation and modulation of antigen-specific memory CD8 T cell responses. J Leukoc Biol, 80(1), 16-23. PMID: 16684891.

Corbin, G. A., Harty, J. T. (2005). T cells undergo rapid ON/OFF but not ON/OFF/ON cycling of cytokine production in response to antigen. J Immunol, 174(2), 718-26. PMID: 15634891.

Haring, J. S., Corbin, G. A. & Harty, J. T. (2005). Dynamic regulation of IFN-gamma signaling in antigen-specific CD8+ T cells responding to infection. J Immunol, 174(11), 6791-802. PMID: 15905520.

Jabbari, A., Harty, J. T. (2005). Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation. J Immunol, 175(8), 4829-33. PMID: 16210583.

Badovinac, V. P., Messingham, K. A., Jabbari, A., Haring, J. S. & Harty, J. T. (2005). Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination. Nat Med, 11(7), 748-56. PMID: 15951824.

Haring, J. S., Badovinac, V., Olson, M. R., Varga, S. M. & Harty, J. T. (2005). In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor. J Immunol, 175(5), 3117-22. PMID: 16116201.

Hamilton, S. E., Porter, B. B., Messingham, K. A., Badovinac, V. & Harty, J. T. (2004). MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response. Nat Immunol, 5(2), 159-68. PMID: 14745446.

Tvinnereim, A. R., Hamilton, S. E. & Harty, J. T. (2004). Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens. J Immunol, 173(3), 1994-2002. PMID: 15265934.

Corbin, G. A., Harty, J. T. (2004). Duration of infection and antigen display have minimal influence on the kinetics of the CD4+ T cell response to Listeria monocytogenes infection. J Immunol, 173(9), 5679-87. PMID: 15494519.

Badovinac, V., Porter, B. B. & Harty, J. T. (2004). CD8+ T cell contraction is controlled by early inflammation. Nat Immunol, 5(8), 809-17. PMID: 15247915.

Badovinac, V., Harty, J. T. (2003). Memory lanes. Nat Immunol, 4(3), 212-3. PMID: 12605228.

Messingham, K. A., Badovinac, V. & Harty, J. T. (2003). Deficient anti-listerial immunity in the absence of perforin can be restored by increasing memory CD8+ T cell numbers. J Immunol, 171(8), 4254-62. PMID: 14530349.

Badovinac, V., Hamilton, S. E. & Harty, J. T. (2003). Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice. Immunity, 18(4), 463-74. PMID: 12705850.

Badovinac, V., Messingham, K. A., Hamilton, S. E. & Harty, J. T. (2003). Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host. J Immunol, 170(10), 4933-42. PMID: 12734336.

Badovinac, V., Harty, J. T. (2002). CD8(+) T-cell homeostasis after infection: setting the 'curve'. Microbes Infect, 4(4), 441-7. PMID: 11932195.

Tvinnereim, A. R., Hamilton, S. E. & Harty, J. T. (2002). CD8(+)-T-cell response to secreted and nonsecreted antigens delivered by recombinant Listeria monocytogenes during secondary infection. Infect Immun, 70(1), 153-62. PMID: 11748177.

Badovinac, V., Porter, B. B. & Harty, J. T. (2002). Programmed contraction of CD8(+) T cells after infection. Nat Immunol, 3(7), 619-26. PMID: 12055624.

Harty, J. T., Badovinac, V. (2002). Influence of effector molecules on the CD8(+) T cell response to infection. Curr Opin Immunol, 14(3), 360-5. PMID: 11973135.

Hamilton, S. E., Harty, J. T. (2002). Quantitation of CD8+ T cell expansion, memory, and protective immunity after immunization with peptide-coated dendritic cells. J Immunol, 169(9), 4936-44. PMID: 12391206.

Badovinac, V., Harty, J. T. (2001). Detection and analysis of antigen-specific CD8+ T cells. Immunol Res, 24(3), 325-32. PMID: 11817329.

Wilson, R. L., Tvinnereim, A. R., Jones, B. D. & Harty, J. T. (2001). Identification of Listeria monocytogenes in vivo-induced genes by fluorescence-activated cell sorting. Infect Immun, 69(8), 5016-24. PMID: 11447181.

Hamilton, S. E., Tvinnereim, A. R. & Harty, J. T. (2001). Listeria monocytogenes infection overcomes the requirement for CD40 ligand in exogenous antigen presentation to CD8(+) T cells. J Immunol, 167(10), 5603-9. PMID: 11698431.

Badovinac, V., Harty, J. T. (2000). Intracellular staining for TNF and IFN-gamma detects different frequencies of antigen-specific CD8(+) T cells. J Immunol Methods, 238(1-2), 107-17. PMID: 10758241.

Harty, J. T., Tvinnereim, A. R. & White, D. W. (2000). CD8+ T cell effector mechanisms in resistance to infection. Annu Rev Immunol, 18, 275-308. PMID: 10837060.

Tvinnereim, A. R., Harty, J. T. (2000). CD8(+) T-cell priming against a nonsecreted Listeria monocytogenes antigen is independent of the antimicrobial activities of gamma interferon. Infect Immun, 68(4), 2196-204. PMID: 10722620.

Wilson, R. L., White, D. W. & Harty, J. T. (2000). Transient expression of bacterial gene fragments in eukaryotic cells: implications for CD8(+) T cell epitope analysis. J Immunol Methods, 234(1-2), 137-47. PMID: 10669778.

Myung, P. S., Clements, J. L., White, D. W., Malik, Z. A., Cowdery, J. S., Allen, L. H., Harty, J. T., Kusner, D. J. & Koretzky, G. A. (2000). In vitro and in vivo macrophage function can occur independently of SLP-76. Int Immunol, 12(6), 887-97. PMID: 10837416.

Badovinac, V., Tvinnereim, A. R. & Harty, J. T. (2000). Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science, 290(5495), 1354-8. PMID: 11082062.

Badovinac, V., Harty, J. T. (2000). Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma. J Immunol, 164(12), 6444-52. PMID: 10843700.

Badovinac, V., Corbin, G. A. & Harty, J. T. (2000). Cutting edge: OFF cycling of TNF production by antigen-specific CD8+ T cells is antigen independent. J Immunol, 165(10), 5387-91. PMID: 11067887.

White, D. W., Badovinac, V., Fan, X. & Harty, J. T. (2000). Adaptive immunity against Listeria monocytogenes in the absence of type I tumor necrosis factor receptor p55. Infect Immun, 68(8), 4470-6. PMID: 10899844.

White, D. W., Badovinac, V., Kollias, G. & Harty, J. T. (2000). Cutting edge: antilisterial activity of CD8+ T cells derived from TNF-deficient and TNF/perforin double-deficient mice. J Immunol, 165(1), 5-9. PMID: 10861027.

Grandea, A. G., Golovina, T. N., Hamilton, S. E., Sriram, V., Spies, T., Brutkiewicz, R. R., Harty, J. T., Eisenlohr, L. C. & Van Kaer, L. (2000). Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice. Immunity, 13(2), 213-22. PMID: 10981964.

White, D. W., MacNeil, A., Busch, D. H., Pilip, I. M., Pamer, E. G. & Harty, J. T. (1999). Perforin-deficient CD8+ T cells: in vivo priming and antigen-specific immunity against Listeria monocytogenes. J Immunol, 162(2), 980-8. PMID: 9916723.

Harty, J. T., White, D. (1999). A knockout approach to understanding CD8+ cell effector mechanisms in adaptive immunity to Listeria monocytogenes. Immunobiology, 201(2), 196-204. PMID: 10631568.

Harty, J. T., Bevan, M. J. (1999). Responses of CD8(+) T cells to intracellular bacteria. Curr Opin Immunol, 11(1), 89-93. PMID: 10047532.

Harty, J. T. (1998). Immunity to Listeria monocytogenes infection of the liver. In I. N. Crispe (Eds.) T lymphocytes in the liver: immunobiology, pathology and host defense. pp. 139-62. John Wiley and Sons, Inc., New York, NY.

White, D. W., Harty, J. T. (1998). Perforin-deficient CD8+ T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha. J Immunol, 160(2), 898-905. PMID: 9551927.

Jensen, V. B., Harty, J. T. & Jones, B. D. (1998). Interactions of the invasive pathogens Salmonella typhimurium, Listeria monocytogenes, and Shigella flexneri with M cells and murine Peyer's patches. Infect Immun, 66(8), 3758-66. PMID: 9673259.

Shen, H., Miller, J. F., Fan, X., Kolwyck, D., Ahmed, R. & Harty, J. T. (1998). Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity. Cell, 92(4), 535-45. PMID: 9491894.

Krieg, A. M., Love-Homan, L., Yi, A. K. & Harty, J. T. (1998). CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J Immunol, 161(5), 2428-34. PMID: 9725240.

Harty, J. T., Lenz, L. L. & Bevan, M. J. (1996). Primary and secondary immune responses to Listeria monocytogenes. Curr Opin Immunol, 8(4), 526-30. PMID: 8794012.

Harty, J. T., Bevan, M. J. (1996). CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes. Infect Immun, 64(9), 3632-40. PMID: 8751910.

White, D. W., Wilson, R. L. & Harty, J. T. (1996). CD8+ T cells in intracellular bacterial infections of mice. Res Immunol, 147(8-9), 519-24. PMID: 9127883.

Harty, J. T., Pamer, E. G. (1995). CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection. J Immunol, 154(9), 4642-50. PMID: 7722316.

Anderson, G. W., Even, C., Rowland, R. R., Palmer, G. A., Harty, J. T. & Plagemann, P. G. (1995). C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age. J Neurovirol, 1(3-4), 244-52. PMID: 9222362.

Harty, J. T., Bevan, M. J. (1995). Specific immunity to Listeria monocytogenes in the absence of IFN gamma. Immunity, 3(1), 109-17. PMID: 7621071.

Vukmanovic, S., Stella, G., King, P. D., Dyall, R., Hogquist, K. A., Harty, J. T., Nikolic-Zugic, J. & Bevan, M. J. (1994). A positively selecting thymic epithelial cell line lacks costimulatory activity. J Immunol, 152(8), 3814-23. PMID: 7511660.

Contag, C. H., Harty, J. T. & Plagemann, P. G. (1992). Pathogenesis of age-dependent poliomyelitis, viral and immunological factors contributing to fatal paralysis. In R. P. Roos (Eds.) Molecular Neurobiology, Pathogenesis of Viral CNS Infections. pp. 377-415. Humana Press, Inc..

Plagemann, P. G., Harty, J. T. & Even, C. (1992). Mode of neutralization of lactate dehydrogenase-elevating virus by polyclonal and monoclonal antibodies. Arch Virol, 123(1-2), 89-100. PMID: 1372497.

Harty, J. T., Bevan, M. J. (1992). CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo. J Exp Med, 175(6), 1531-8. PMID: 1375265.

Harty, J. T., Schreiber, R. D. & Bevan, M. J. (1992). CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion. Proc Natl Acad Sci U S A, 89(23), 11612-6. PMID: 1360672.

Staskus, K. A., Retzel, E. F., Lewis, E. D., Silsby, J. L., Cyr, S. S., Rank, J. M., Wietgrefe, S. W., Haase, A. T., Cook, R., Fast, D., Geiser, P. T., Harty, J. T., Kong, S. H., Lahti, C. J., Neufeld, T. P., Porter, T. E., Shoop, E. & Zachow, K. R. (1991). Isolation of replication-competent molecular clones of visna virus. Virology, 181(1), 228-40. PMID: 1847257.

Kuo, L. L., Harty, J. T., Erickson, L., Palmer, G. A. & Plagemann, P. G. (1991). A nested set of eight RNAs is formed in macrophages infected with lactate dehydrogenase-elevating virus. J Virol, 65(9), 5118-23. PMID: 1870216.

Pamer, E. G., Harty, J. T. & Bevan, M. J. (1991). Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature, 353(6347), 852-5. PMID: 1719425.

Harty, J. T., Plagemann, P. G. (1990). Monoclonal antibody protection from age-dependent poliomyelitis: implications regarding the pathogenesis of lactate dehydrogenase-elevating virus. J Virol, 64(12), 6257-62. PMID: 2243393.

Li, X., Hu, B., Harty, J. T., Even, C. & Plagemann, P. G. (1990). Polyclonal B cell activation of IgG2a and IgG2b production by infection of mice with lactate dehydrogenase-elevating virus Is partly dependent on CD4+ lymphocytes. Viral Immunol, 3(4), 273-88. PMID: 2076177.

Contag, C. H., Harty, J. T. & Plagemann, P. G. (1989). Dual virus etiology of age-dependent poliomyelitis of mice. A potential model for human motor neuron diseases. Microb Pathog, 6(6), 391-401. PMID: 2549329.

Onyekaba, C. O., Harty, J. T. & Plagemann, P. G. (1989). Extensive cytocidal replication of lactate dehydrogenase-elevating virus in cultured peritoneal macrophages from 1-2-week-old mice. Virus Res, 14(4), 327-38. PMID: 2623946.

Chan, S. P., Onyekaba, C. O., Harty, J. T. & Plagemann, P. G. (1989). Persistent infection of mice by lactate dehydrogenase-elevating virus: transient virus replication in macrophages of the spleen. Virus Res, 14(4), 317-26. PMID: 2623945.

Onyekaba, C. O., Harty, J. T., Even, C., Hu, B. G. & Plagemann, P. G. (1989). Persistent infection of mice by lactate dehydrogenase-elevating virus: effects of immunosuppression on virus replication and antiviral immune responses. Virus Res, 14(4), 297-315. PMID: 2623944.

Harty, J. T., Plagemann, P. G. (1988). Formalin inactivation of the lactate dehydrogenase-elevating virus reveals a major neutralizing epitope not recognized during natural infection. J Virol, 62(9), 3210-6. PMID: 2457113.

Harty, J. T., Chan, S. P., Contag, C. H. & Plagemann, P. G. (1987). Protection of C58 mice from lactate dehydrogenase-elevating virus-induced motor neuron disease by non-neutralizing antiviral antibodies without interference with virus replication. J Neuroimmunol, 15(2), 195-206. PMID: 3034974.

Harty, J. T., Chan, S. P. & Plagemann, P. G. (1987). Characteristics of monoclonal antibodies to the lactate dehydrogenase-elevating virus. Intervirology, 27(1), 53-60. PMID: 3610572.

Cafruny, W. A., Chan, S. P., Harty, J. T., Yousefi, S., Kowalchyk, K., McDonald, D., Foreman, B., Budweg, G. & Plagemann, P. G. (1986). Antibody response of mice to lactate dehydrogenase-elevating virus during infection and immunization with inactivated virus. Virus Res, 5(4), 357-75. PMID: 3022497.

Hanto, D. W., Harty, J. T., Hoffman, R. A. & Simmons, R. L. (1986). Evidence that secondary mixed leukocyte culture supernatant mediates changes in cellular recruitment, blood flow, and vascular permeability. Transplantation, 42(6), 621-7. PMID: 2947359.

Harty, J. T., So, S. K., Keller, G. A., Hoffman, R., Ascher, N. L. & Simmons, R. L. (1985). Immunospecific lymphocyte-mediated injury of isolated hepatocytes. Transplant Proc, 17, 606-7.

Hanto, D. W., Harty, J. T., Hoffman, R. A. & Simmons, R. L. (1985). Soluble mediators generated by allogeneic stimulation increased lymphocyte recruitment, regional blood flow, and vascular permeability in vitro. Transplant Proc, 17, 578-81.

Keller, G. A., West, M. A., Harty, J. T., Cerra, F. B. & Simmons, R. L. (1985). Modulation of hepatocyte protein synthesis during co-cultivation with macrophage-rich peritoneal cells in vitro. Arch Surg, 120(2), 180-6. PMID: 3977588.

Keller, G. A., Barke, R., Harty, J. T., Humphrey, E. & Simmons, R. L. (1985). Decreased hepatic glutathione levels in septic shock. Predisposition of hepatocytes to oxidative stress: an experimental approach. Arch Surg, 120(8), 941-5. PMID: 3893390.

Keller, G. A., West, M. A., Harty, J. T., Wilkes, L. A., Cerra, F. B. & Simmons, R. L. (1985). Modulation of hepatocyte protein synthesis by endotoxin-activated Kupffer cells. III. Evidence for the role of a monokine similar to but not identical with interleukin-1. Ann Surg, 201(4), 436-43. PMID: 3883925.

Hanto, D. W., Harty, J. T. & Simmons, R. L. (1983). Lymphocyte recruitment properties of regional lymph node or spleen cells during skin allograft rejection. Transplantation, 36(5), 578-81. PMID: 6356522.

Hanto, D. W., Harty, J. T., Hoffman, R. & Simmons, R. L. (1983). Cyclosporine suppression of lymphocyte recruitment, regional blood flow, and vascular permeability at sites of allogeneic cellular interactions. Surgery, 94(2), 218-24. PMID: 6879440.