Thomas H. Haugen, MD, PhD

Portrait
Director, Pathology and Laboratory Service, Veterans Administration Medical Center
Associate Professor of Pathology

Contact Information

Primary Office
113 Veterans Administration Medical Center
601 Highway 6 West
Iowa City, IA 52246
319-338-0581

Education

BA, Biochemistry, University of California, Berkeley, CA
PhD, Biochemistry, University of California, Davis, CA
MD, University of Iowa, Iowa City, IA
Resident, Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA
Fellow, Microbiology, University of Iowa Hospitals and Clinics, Iowa City, IA

Licensure and Certifications

Clinical Pathology - American Board of Pathology
Federal Licensing Examination (FLEX) - Federation of State Medical Boards

Education/Training Program Affiliations

Department of Pathology Graduate Program

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Research Summary

Regulation of human papillomavirus gene expression by viral and cellular factors.

Publications

Lace, M. J., Anson, J. R., Haugen, T. H., Dierdorf, J. M. & Turek, L. P. (2014). Interferon treatment of human keratinocytes harboring extrachromosomal, persistent HPV-16 plasmid genomes induces de novo viral integration. Carcinogenesis. PMID: 25416558.

Mathur, G., Haugen, T. H., Davis, S. L. & Krasowski, M. D. (2014). Streamlined sign-out of capillary protein electrophoresis using middleware and an open-source macro application. J Pathol Inform, 5(36). PMID: 25337433.

Dee, F. R., Haugen, T. H. & Kreiter, C. D. (2014). New web-based applications for mechanistic case diagramming. Med Educ Online. PMID: 25059836.

Lace, M. J., Turek, L. P., Anson, J. R. & Haugen, T. H. (2014). Analyzing the Human Papillomavirus (HPV) Life Cycle in Primary Keratinocytes with a Quantitative Colony-Forming Assay. Curr Protoc Microbiol, 14B.2.1-14B.2.13. PMID: 24789595.

Dee, F. R., Haugen, T. H. & Kreiter, C. D. (2014). New web-based applications for mechanistic case diagramming. Medical education online, 19, 24708. PMID: 25059836.

Lace, M. J., Ushikai, M., Yamakawa, Y., Anson, J. R., Ishiji, T., Turek, L. P. & Haugen, T. H. (2012). The truncated C-terminal E2 (E2-TR) protein of bovine papillomavirus (BPV) type-1 is a transactivator that modulates transcription in vivo and in vitro in a manner distinct from the E2-TA and E8^E2 gene products. Virology, 429(2), 99-111. PMID: 22551766.

Smith, E. M., Rubenstein, L. M., Haugen, T. H., Pawlita, M. & Turek, L. P. (2012). Complex etiology underlies risk and survival in head and neck cancer human papillomavirus, tobacco, and alcohol: a case for multifactor disease. Journal of Oncology, 2012, 571862. PMID: 22315596.

Lace, M. J., Anson, J. R., Klussmann, J. P., Wang, D. H., Smith, E. M., Haugen, T. H. & Turek, L. P. (2011). Human papillomavirus type 16 (HPV-16) genomes integrated in head and neck cancers and in HPV-16-immortalized human keratinocyte clones express chimeric virus-cell mRNAs similar to those found in cervical cancers. Journal of virology, 85(4), 1645-54. PMID: 21123375.

Kreiter, C. D., Haugen, T. H., Leaven, T., Goerdt, C., Rosenthal, N., McGaghie, W. C. & Dee, F. (2011). A report on the piloting of a novel computer-based medical case simulation for teaching and formative assessment of diagnostic laboratory testing. Medical education online, 16. PMID: 21249173.

Rubenstein, L. M., Smith, E. M., Pawlita, M., Haugen, T. H., Hamšíková, E. & Turek, L. P. (2011). Human papillomavirus serologic follow-up response and relationship to survival in head and neck cancer: a case-comparison study. Infectious agents and cancer, 6(1), 9. PMID: 21740566.

Smith, E. M., Rubenstein, L. M., Haugen, T. H., Hamsikova, E. & Turek, L. P. (2010). Tobacco and alcohol use increases the risk of both HPV-associated and HPV-independent head and neck cancers. Cancer causes & control: CCC, 21(9), 1369-78. PMID: 20401530.

Smith, E. M., Pawlita, M., Rubenstein, L. M., Haugen, T. H., Hamsikova, E. & Turek, L. P. (2010). Risk factors and survival by HPV-16 E6 and E7 antibody status in human papillomavirus positive head and neck cancer. International journal of cancer, 127(1), 111-7. PMID: 19876924.

Lace, M. J., Anson, J. R., Haugen, T. H. & Turek, L. P. (2010). Interferon regulatory factor (IRF)-2 activates the HPV-16 E6-E7 promoter in keratinocytes. Virology, 399(2), 270-9. PMID: 20129639.

Smith, E. M., Parker, M. A., Rubenstein, L. M., Haugen, T. H., Hamsikova, E. & Turek, L. P. (2010). Evidence for vertical transmission of HPV from mothers to infants. Infectious diseases in obstetrics and gynecology, 2010, 326369. PMID: 20300545.

Smith, E. M., Rubenstein, L. M., Hoffman, H., Haugen, T. H. & Turek, L. P. (2010). Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer. Infectious agents and cancer, 5, 4. PMID: 20181227.

Lace, M. J., Anson, J. R., Klingelhutz, A. J., Lee, J. H., Bossler, A. D., Haugen, T. H. & Turek, L. P. (2009). Human papillomavirus (HPV) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal HPVs. Journal of virology, 83(22), 11784-94. PMID: 19740985.

Lace, M. J., Yamakawa, Y., Ushikai, M., Anson, J. R., Haugen, T. H. & Turek, L. P. (2009). Cellular factor YY1 downregulates the human papillomavirus 16 E6/E7 promoter, P97, in vivo and in vitro from a negative element overlapping the transcription-initiation site. The Journal of general virology, 90(Pt 10), 2402-12. PMID: 19553391.

Bruch, L. A., De Young, B. R., Kreiter, C. D., Haugen, T. H., Leaven, T. C. & Dee, F. R. (2009). Competency assessment of residents in surgical pathology using virtual microscopy. Human pathology, 40(8), 1122-8. PMID: 19552936.

Lace, M. J., Anson, J. R., Klingelhutz, A. J., Harada, H., Taniguchi, T., Bossler, A. D., Haugen, T. H. & Turek, L. P. (2009). Interferon-beta treatment increases human papillomavirus early gene transcription and viral plasmid genome replication by activating interferon regulatory factor (IRF)-1. Carcinogenesis, 30(8), 1336-44. PMID: 19541854.

Lace, M. J., Isacson, C., Anson, J. R., Lorincz, A. T., Wilczynski, S. P., Haugen, T. H. & Turek, L. P. (2009). Upstream regulatory region alterations found in human papillomavirus type 16 (HPV-16) isolates from cervical carcinomas increase transcription, ori function, and HPV immortalization capacity in culture. Journal of virology, 83(15), 7457-66. PMID: 19458011.

Lace, M. J., Anson, J. R., Thomas, G. S., Turek, L. P. & Haugen, T. H. (2009). The E8E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes. DNA tumor virus meeting, Oxford, UK.

Haugen, T. H., Lace, M. J., Ishiji, T., Sameshima, A., Anson, J. R. & Turek, L. P. (2009). Cellular factors are required to activate bovine papillomavirus-1 early gene transcription and to establish viral plasmid persistence but are not required for cellular transformation. Virology, 389(2-Jan), 82-90. PMID: 19410271.

Lace, M. J., Anson, J. R., Turek, L. P. & Haugen, T. H. (2008). Functional mapping of the human papillomavirus type 16 E1 cistron. Journal of virology, 82(21), 10724-34. PMID: 18753208.

Lace, M. J., Anson, J. R., Thomas, G. S., Turek, L. P. & Haugen, T. H. (2008). The E8--E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes. Journal of virology, 82(21), 10841-53. PMID: 18753207.

Smith, E. M., Rubenstein, L. M., Ritchie, J. M., Lee, J. H., Haugen, T. H., Hamsikova, E. & Turek, L. P. (2008). Does pretreatment seropositivity to human papillomavirus have prognostic significance for head and neck cancers?. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17(8), 2087-96. PMID: 18708401.

Dee, F. R., Haugen, T. H., Wynn, P. A., Leaven, T. C., Kemp, J. D. & Cohen, M. B. (2008). A Web-based database for pathology faculty effort reporting. Human pathology, 39(4), 489-97. PMID: 18342660.

Smith, E. M., Wang, D., Rubenstein, L. M., Morris, W. A., Turek, L. P. & Haugen, T. H. (2008). Association between p53 and human papillomavirus in head and neck cancer survival. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17(2), 421-7. PMID: 18268127.

Smith, E. M., Wang, D., Kim, Y., Rubenstein, L. M., Lee, J. H., Haugen, T. H. & Turek, L. P. (2008). P16INK4a expression, human papillomavirus, and survival in head and neck cancer. Oral oncology, 44(2), 133-42. PMID: 17360226.

Cook, R. T., Schlueter, A. J., Coleman, R. A., Tygrett, L., Ballas, Z. K., Jerrells, T. R., Nashelsky, M. B., Ray, N. B., Haugen, T. H. & Waldschmidt, T. J. (2007). Thymocytes, pre-B cells, and organ changes in a mouse model of chronic ethanol ingestion--absence of subset-specific glucocorticoid-induced immune cell loss. Alcoholism, clinical and experimental research, 31(10), 1746-58. PMID: 17681030.

Smith, E. M., Swarnavel, S., Ritchie, J. M., Wang, D., Haugen, T. H. & Turek, L. P. (2007). Prevalence of human papillomavirus in the oral cavity/oropharynx in a large population of children and adolescents. The Pediatric infectious disease journal, 26(9), 836-40. PMID: 17721381.

Wahls, T., Haugen, T. H. & Cram, P. (2007). The continuing problem of missed test results in an integrated health system with an advanced electronic medical record. Joint Commission journal on quality and patient safety / Joint Commission Resources, 33(8), 485-92. PMID: 17724945.

Pyeon, D., Newton, M. A., Lambert, P. F., den Boon, J. A., Sengupta, S., Marsit, C. J., Woodworth, C. D., Connor, J. P., Haugen, T. H., Smith, E. M., Kelsey, K. T., Turek, L. P. & Ahlquist, P. (2007). Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer research, 67(10), 4605-19. PMID: 17510386.

Smith, E. M., Ritchie, J. M., Pawlita, M., Rubenstein, L. M., Haugen, T. H., Turek, L. P. & Hamsikova, E. (2007). Human papillomavirus seropositivity and risks of head and neck cancer. International journal of cancer - Journal international du cancer, 120(4), 825-32. PMID: 17131312.

Parker, T. M., Smith, E. M., Ritchie, J. M., Haugen, T. H., Vonka, V., Turek, L. P. & Hamsikova, E. (2006). Head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors. Oral oncology, 42(3), 288-96. PMID: 16324878.

Wang, D., Ritchie, J. M., Smith, E. M., Zhang, Z., Turek, L. P. & Haugen, T. H. (2005). Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14(3), 626-32. PMID: 15767341.

Smith, E. M., Johnson, S. R., Ritchie, J. M., Feddersen, D., Wang, D., Turek, L. P. & Haugen, T. H. (2004). Persistent HPV infection in postmenopausal age women. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 87(2), 131-7. PMID: 15491557.

Smith, E. M., Ritchie, J. M., Yankowitz, J., Wang, D., Turek, L. P. & Haugen, T. H. (2004). HPV prevalence and concordance in the cervix and oral cavity of pregnant women. Infectious diseases in obstetrics and gynecology, 12(2), 45-56. PMID: 15739817.

Smith, E. M., Ritchie, J. M., Summersgill, K. F., Hoffman, H. T., Wang, D. H., Haugen, T. H. & Turek, L. P. (2004). Human papillomavirus in oral exfoliated cells and risk of head and neck cancer. Journal of the National Cancer Institute, 96(6), 449-55. PMID: 15026470.

Smith, E. M., Ritchie, J. M., Summersgill, K. F., Klussmann, J. P., Lee, J. H., Wang, D., Haugen, T. H. & Turek, L. P. (2004). Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. International journal of cancer. Journal international du cancer, 108(5), 766-72. PMID: 14696105.

Smith, E. M., Ritchie, J. M., Yankowitz, J., Swarnavel, S., Wang, D., Haugen, T. H. & Turek, L. P. (2004). Human papillomavirus prevalence and types in newborns and parents: concordance and modes of transmission. Sexually transmitted diseases, 31(1), 57-62. PMID: 14695959.

Smith, E. M., Haugen, T. H. & Turek, L. P. (2004). RESPONSE: Human Papillomavirus in Oral Exfoliated Cells and Risk of Head and Neck Cancer. J Natl Cancer Inst, 96, 1182-1186.

Ritchie, J. M., Smith, E. M., Summersgill, K. F., Hoffman, H. T., Wang, D., Klussmann, J. P., Turek, L. P. & Haugen, T. H. (2003). Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. International journal of cancer - Journal international du cancer, 104(3), 336-44. PMID: 12569557.

Smith, E. M., Ritchie, J. M., Levy, B. T., Zhang, W., Wang, D., Haugen, T. H. & Turek, L. P. (2003). Prevalence and persistence of human papillomavirus in postmenopausal age women. Cancer detection and prevention, 27(6), 472-80. PMID: 14642556.

Smith, E. M., Levy, B. T., Ritchie, J. M., Jia, J., Wang, D., Haugen, T. H. & Turek, L. P. (2002). Is use of hormone replacement therapy associated with increased detection of human papillomavirus and potential risk of HPV-related genital cancers?. European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP), 11(3), 295-305. PMID: 12131663.

Summersgill, K. F., Smith, E. M., Levy, B. T., Allen, J. M., Haugen, T. H. & Turek, L. P. (2001). Human papillomavirus in the oral cavities of children and adolescents. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 91(1), 62-9. PMID: 11174573.

Smith, E. M., Summersgill, K. F., Allen, J., Hoffman, H. T., McCulloch, T., Turek, L. P. & Haugen, T. H. (2000). Human papillomavirus and risk of laryngeal cancer. The Annals of otology, rhinology, and laryngology, 109(11), 1069-76. PMID: 11090000.

Kutza, J., Smith, E., Levy, B., Jian, J., Haugen, T. H. & Turek, L. (2000). Use of hormone replacement therapy (Hrt) And detection of human papillomavirus (Hpv) Dna in postmenopausal women. Annals of epidemiology, 10(7), 465-466. PMID: 11018386.

Summersgill, K. F., Smith, E. M., Kirchner, H. L., Haugen, T. H. & Turek, L. P. (2000). p53 polymorphism, human papillomavirus infection in the oral cavity, and oral cancer. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 90(3), 334-9. PMID: 10982955.

Smith, E. M., Hoffman, H. T., Summersgill, K. F., Kirchner, H. L., Turek, L. P. & Haugen, T. H. (1998). Human papillomavirus and risk of oral cancer. The Laryngoscope, 108(7), 1098-103. PMID: 9665264.

Smith, E. M., Johnson, S. R., Figuerres, E. J., Mendoza, M., Fedderson, D., Haugen, T. H. & Turek, L. P. (1997). The frequency of human papillomavirus detection in postmenopausal women on hormone replacement therapy. Gynecologic oncology, 65(3), 441-6. PMID: 9190973.

Bostik, P., Turek, L. P. & Haugen, T. H. (1997). Simple method for selective amplification of cDNA from a defined promoter. BioTechniques, 22(2), 300-2, 304, 306. PMID: 9043702.

Marshall, S. A., Jones, R. N., Wanger, A., Washington, J. A., Doern, G. V., Leber, A. L. & Haugen, T. H. (1996). Proposed MIC quality control guidelines for National Committee for Clinical Laboratory Standards susceptibility tests using seven veterinary antimicrobial agents: ceftiofur, enrofloxacin, florfenicol, penicillin G-novobiocin, pirlimycin, premafloxacin, and spectinomycin. Journal of clinical microbiology, 34(8), 2027-9. PMID: 8818906.

Johnson, D. M., Doern, G. V., Haugen, T. H., Hindler, J., Washington, J. A. & Jones, R. N. (1996). Comparative activity of twelve beta-lactam drugs tested against penicillin-resistant Streptococcus pneumoniae from five medical centers: effects of serum protein and capsular material on potency and spectrum as measured by reference tests. Diagnostic microbiology and infectious disease, 25(3), 137-41. PMID: 8902410.

Souza, I. E., Nicholson, D., Matthey, S., Alden, B., Haugen, T. H., Trigg, M. E. & Bale, J. F. (1995). Rapid epidemiologic characterization of cytomegalovirus strains from pediatric bone marrow transplant patients. Infection control and hospital epidemiology: the official journal of the Society of Hospital Epidemiologists of America, 16(7), 399-404. PMID: 7673645.

Sommersgill, K. E., Smith, E. M., Hoffman, H. T., Ricks, J., Haugen, T. H. & Turek, L. P. (1995). The frequency of HPV in the oral cavity of a healthy adult population. 14th International Papillomavirus Workshop.

Ushikai, M., Lace, M. J., Yamakawa, Y., Kono, M., Anson, J., Ishiji, T., Parkkinen, S., Wicker, N., Valentine, M. E., Davidson, I., Turek, L. P. & Haugen, T. H. (1994). Trans activation by the full-length E2 proteins of human papillomavirus type 16 and bovine papillomavirus type 1 in vitro and in vivo: cooperation with activation domains of cellular transcription factors. J Virol, 68(10), 6655-66. PMID: 8083999.

Souza, I. E., Nicholson, D., Matthey, S., Alden, B. & Haugen, T. H. (1994). Detection of human cytomegalovirus in peripheral blood leukocytes by the polymerase chain reaction and a nonradioactive probe. Diagnostic microbiology and infectious disease, 20(1), 13-9. PMID: 7867293.

Smith, E. M., Pignatari, S. S., Gray, S. D., Haugen, T. H. & Turek, L. P. (1993). Human papillomavirus infection in papillomas and nondiseased respiratory sites of patients with recurrent respiratory papillomatosis using the polymerase chain reaction. Archives of otolaryngology -- head & neck surgery, 119(5), 554-7. PMID: 8387317.

Haugen, T. H., Alden, B., Matthey, S. & Nicholson, D. (1993). Restriction enzyme fragment length polymorphisms of amplified herpes simplex virus type-1 DNA provide epidemiologic information. Diagnostic microbiology and infectious disease, 17(2), 129-33. PMID: 7902227.

Perl, T. M., Haugen, T. H., Pfaller, M. A., Hollis, R., Lakeman, A. D., Whitley, R. J., Nicholson, D., Hunter, G. A. & Wenzel, R. P. (1992). Transmission of herpes simplex virus type 1 infection in an intensive care unit. Annals of internal medicine, 117(7), 584-6. PMID: 1524332.

Ishiji, T., Lace, M. J., Parkkinen, S., Anderson, R. D., Haugen, T. H., Cripe, T. P., Xiao, J. H., Davidson, I., Chambon, P. & Turek, L. P. (1992). Transcriptional enhancer factor (TEF)-1 and its cell-specific co-activator activate human papillomavirus-16 E6 and E7 oncogene transcription in keratinocytes and cervical carcinoma cells. The EMBO journal, 11(6), 2271-81. PMID: 1318197.

Cripe, T. P., Alderborn, A., Anderson, R. D., Parkkinen, S., Bergman, P., Haugen, T. H., Pettersson, U. & Turek, L. P. (1990). Transcriptional activation of the human papillomavirus-16 P97 promoter by an 88-nucleotide enhancer containing distinct cell-dependent and AP-1-responsive modules. The New biologist, 2(5), 450-63. PMID: 1963084.

Cripe, T. P., Alderborn, A., Haugen, T. H., Anderson, R. D., Parkkinen, S., Pettersson, U. & Turek, L. P. (1990). The binding of a member of the NF-1 protein family is critical but not sufficient for keratinocyte-dependent activation of the HPV-16 E6-E7 gene promoter, P97. P. M. Howley , T. R. Broker (Eds.) pp. 455-462. Papillomaviruses - Proceedings of the UCLA Symposium, Taos, NM, March 11-18, 1989, Wiley-Liss New York.

Haugen, T. H., Turek, L. P., Mercurio, F. M., Cripe, T. P., Olson, B. J., Anderson, R. D., Seidl, D., Karin, M. & Schiller, J. (1988). Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain. The EMBO journal, 7(13), 4245-53. PMID: 2854060.

Cripe, T. P., Haugen, T. H., Turk, J. P., Tabatabai, F., Schmid, P. G., Dürst, M., Gissmann, L., Roman, A. & Turek, L. P. (1987). Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis. The EMBO journal, 6(12), 3745-53. PMID: 2448139.

Haugen, T. H., Cripe, T. P., Karin, M. & Turek, L. P. (1987). A bovine papilloma virus E2 gene function trans-activates the major early viral promoter. Cancer Cells - Papilloma Viruses, CSH Press, Cold Spring Harbor, NY, 5, 39-46.

Seeberger, R., Haugen, T. H., Turek, L. P. & Pfister, H. (1987). An enhancer of human papillomavirus 8 is trans-activated by the bovine papillomavirus 1 E2-function. Cancer Cells - Papilloma Viruses, CSH Press, Cold Spring Harbor, NY, 5, 33-38.

Haugen, T. H., Cripe, T. P., Ginder, G. D., Karin, M. & Turek, L. P. (1987). Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene. The EMBO journal, 6(1), 145-52. PMID: 3034572.

Turek, L. P., Haugen, T. H. (1987). Transforming and regulatory functions of bovine papilloma virus-1. L. Gissman , L. Koss , K. Syrjanen (Eds.) pp. 410-442. Springer, New York and Berlin.

Hanley, J. M., Haugen, T. H. & Heath, E. C. (1983). Biosynthesis and processing of rat haptoglobin. The Journal of biological chemistry, 258(12), 7858-69. PMID: 6863267.

Haugen, T. H., Hanley, J. M. & Heath, E. C. (1981). Haptoglobin - A novel mode of biosynthesis of a liver secretory glycoprotein. The Journal of biological chemistry, 256(3), 1055-7. PMID: 7451486.

Haugen, T. H., Heath, E. C. (1979). De novo biosynthesis of an enzymatically active precursor form of bovine pancreatic RNase. Proceedings of the National Academy of Sciences of the United States of America, 76(6), 2689-93. PMID: 288056.

Heath, E. C., Brinkley, S. A., Das, R. C. & Haugen, T. H. (1979). Biosynthesis and processing of glycoproteins. In T. R. Russel , K. Brew , H. Fabor & J. Schultz (Eds.) From Gene to Protein: Information Transfer in Normal and Abnormal Cells. pp. 379-406. Academic Press, Inc. (London).

Haugen, T. H., Preiss, J. (1979). Biosynthesis of bacterial glycogen - The nature of the binding of substrates and effectors to ADP-glucose synthase. The Journal of biological chemistry, 254(1), 127-36. PMID: 363717.

Haugen, T. H., Ishaque, A. & Preiss, J. (1976). Biosynthesis of bacterial glycogen - Characterization of the subunit structure of Escherichia coli B glucose-1-phosphate adenylyltransferase (EC 2.7.7.27). The Journal of biological chemistry, 251(24), 7880-5. PMID: 826540.

Haugen, T. H., Ishaque, A. & Preiss, J. (1976). ADPGlucose pyrophosphorylase: evidence for a lysine residue at the activator site of the Escherichia coli B enzyme. Biochemical and biophysical research communications, 69(2), 346-53. PMID: 773375.

Haugen, T. H., Ishaque, A., Chatterjee, A. K. & Preiss, J. (1974). Purification of Escherichia coli ADPglucose pyrophosphorylase by affinity chromatography. FEBS letters, 42(2), 205-8. PMID: 4369095.