Ling-Zhi Liu, MD, PhD

Portrait
Associate Professor of Pathology

Contact Information

Primary Office
108B Medical Research Center
25 S. Grand Avenue
Iowa City, IA 52242
319-353-4213

Education

MD, Internal Medicine, Shenyang Medical College
MS, China Medical University
PhD, Medical Science, China Medical University
Resident, The 3rd Military Medical University
Fellow, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Publications

Jiang, C. F., Li, D. M., Shi, Z. M., Wang, L., Liu, M. M., Ge, X., Liu, X., Qian, Y. C., Wen, Y. Y., Zhen, L. L., Lin, J., Liu, L. Z. & Jiang, B. H. (2016). Estrogen regulates miRNA expression: implication of estrogen receptor and miR-124/AKT2 in tumor growth and angiogenesis. Oncotarget, 7(24), 36940-36955. PMID: 27175587.

Wang, M., Ge, X., Zheng, J., Li, D., Liu, X., Wang, L., Jiang, C., Shi, Z., Qin, L., Liu, J., Yang, H., Liu, L. Z., He, J., Zhen, L. & Jiang, B. H. (2016). Role and mechanism of miR-222 in arsenic-transformed cells for inducing tumor growth. Oncotarget, 7(14), 17805-14. PMID: 26909602.

Wang, L., Jiang, C. F., Li, D. M., Ge, X., Shi, Z. M., Li, C. Y., Liu, X., Yin, Y., Zhen, L., Liu, L. Z. & Jiang, B. H. (2016). MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1. Oncotarget, 7(3), 2660-71. PMID: 26673620.

Zhao, P., Li, Q., Shi, Z., Li, C., Wang, L., Liu, X., Jiang, C., Qian, X., You, Y., Liu, N., Liu, L. Z., Ding, L. & Jiang, B. H. (2015). GSK-3ß regulates tumor growth and angiogenesis in human glioma cells. Oncotarget, 6(31), 31901-15. PMID: 26388612.

Xu, Q., Liu, L. Z., Yin, Y., He, J., Li, Q., Qian, X., You, Y., Lu, Z., Peiper, S. C., Shu, Y. & Jiang, B. H. (2015). Regulatory circuit of PKM2/NF-?B/miR-148a/152-modulated tumor angiogenesis and cancer progression. Oncogene, 34(43), 5482-93. PMID: 25703326.

Liu, L. Z., Ding, M., Zheng, J. Z., Zhu, Y., Fenderson, B. A., Li, B., Yu, J. J. & Jiang, B. H. (2015). Tungsten Carbide-Cobalt Nanoparticles Induce Reactive Oxygen Species, AKT, ERK, AP-1, NF-?B, VEGF, and Angiogenesis. Biological trace element research, 166(1), 57-65. PMID: 25893364.

He, J., Yu, J. J., Xu, Q., Wang, L., Zheng, J. Z., Liu, L. Z. & Jiang, B. H. (2015). Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy. Autophagy, 11(2), 373-84. PMID: 25650716.

Shi, Z., Chen, Q., Li, C., Wang, L., Qian, X., Jiang, C., Liu, X., Wang, X., Li, H., Kang, C., Jiang, T., Liu, L. Z., You, Y., Liu, N. & Jiang, B. H. (2014). MiR-124 governs glioma growth and angiogenesis and enhances chemosensitivity by targeting R-Ras and N-Ras. Neuro-oncology, 16(10), 1341-53. PMID: 24861879.

Wang, L., Shi, Z. M., Jiang, C. F., Liu, X., Chen, Q. D., Qian, X., Li, D. M., Ge, X., Wang, X. F., Liu, L. Z., You, Y. P., Liu, N. & Jiang, B. H. (2014). MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma. Oncotarget, 5(14), 5416-27. PMID: 24980823.

He, J., Wang, M., Jiang, Y., Chen, Q., Xu, S., Xu, Q., Jiang, B. H. & Liu, L. Z. (2014). Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1a/COX-2 pathway. Environmental health perspectives, 122(3), 255-61. PMID: 24413338.

Li, Q., Liu, X., Yin, Y., Zheng, J. T., Jiang, C. F., Wang, J., Shen, H., Li, C. Y., Wang, M., Liu, L. Z. & Jiang, B. H. (2014). Insulin regulates glucose consumption and lactate production through reactive oxygen species and pyruvate kinase M2. Oxidative medicine and cellular longevity, 2014, 504953. PMID: 24895527.

Li, Q., Fu, G. B., Zheng, J. T., He, J., Niu, X. B., Chen, Q. D., Yin, Y., Qian, X., Xu, Q., Wang, M., Sun, A. F., Shu, Y., Rui, H., Liu, L. Z. & Jiang, B. H. (2013). NADPH oxidase subunit p22(phox)-mediated reactive oxygen species contribute to angiogenesis and tumor growth through AKT and ERK1/2 signaling pathways in prostate cancer. Biochimica et biophysica acta, 1833(12), 3375-3385. PMID: 24113386.

Qian, X., Zhao, P., Li, W., Shi, Z. M., Wang, L., Xu, Q., Wang, M., Liu, N., Liu, L. Z. & Jiang, B. H. (2013). MicroRNA-26a promotes tumor growth and angiogenesis in glioma by directly targeting prohibitin. CNS neuroscience & therapeutics, 19(10), 804-12. PMID: 23870455.

He, J., Qian, X., Carpenter, R., Xu, Q., Wang, L., Qi, Y., Wang, Z. X., Liu, L. Z. & Jiang, B. H. (2013). Repression of miR-143 mediates Cr (VI)-induced tumor angiogenesis via IGF-IR/IRS1/ERK/IL-8 pathway. Toxicological sciences : an official journal of the Society of Toxicology, 134(1), 26-38. PMID: 23748240.

Qian, X., Yu, J., Yin, Y., He, J., Wang, L., Li, Q., Zhang, L. Q., Li, C. Y., Shi, Z. M., Xu, Q., Li, W., Lai, L. H., Liu, L. Z. & Jiang, B. H. (2013). MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers. Cell cycle (Georgetown, Tex.), 12(9), 1385-94. PMID: 23574723.

Xu, Q., Jiang, Y., Yin, Y., Li, Q., He, J., Jing, Y., Qi, Y. T., Xu, Q., Li, W., Lu, B., Peiper, S. S., Jiang, B. H. & Liu, L. Z. (2013). A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. Journal of molecular cell biology, 5(1), 3-13. PMID: 22935141.

Yin, Y., Yan, Z. P., Lu, N. N., Xu, Q., He, J., Qian, X., Yu, J., Guan, X., Jiang, B. H. & Liu, L. Z. (2013). Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1. Biochimica et biophysica acta, 1829(2), 239-47. PMID: 23201159.

He, J., Jing, Y., Li, W., Qian, X., Xu, Q., Li, F. S., Liu, L. Z., Jiang, B. H. & Jiang, Y. (2013). Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis. PloS one, 8(2), e56647. PMID: 23437196.

He, J., Xu, Q., Jing, Y., Agani, F., Qian, X., Carpenter, R., Li, Q., Wang, X. R., Peiper, S. S., Lu, Z., Liu, L. Z. & Jiang, B. H. (2012). Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. EMBO reports, 13(12), 1116-22. PMID: 23146892.

Zou, C., Xu, Q., Mao, F., Li, D., Bian, C., Liu, L. Z., Jiang, Y., Chen, X., Qi, Y., Zhang, X., Wang, X., Sun, Q., Kung, H. F., Lin, M. C., Dress, A., Wardle, F., Jiang, B. H. & Lai, L. (2012). MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF. Cell cycle (Georgetown, Tex.), 11(11), 2137-45. PMID: 22592534.

Jing, Y., Liu, L. Z., Jiang, Y., Zhu, Y., Guo, N. L., Barnett, J., Rojanasakul, Y., Agani, F. & Jiang, B. H. (2012). Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells. Toxicological sciences : an official journal of the Society of Toxicology, 125(1), 10-9. PMID: 21984483.

Shi, Z. M., Wang, J., Yan, Z., You, Y. P., Li, C. Y., Qian, X., Yin, Y., Zhao, P., Wang, Y. Y., Wang, X. F., Li, M. N., Liu, L. Z., Liu, N. & Jiang, B. H. (2012). MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1. PloS one, 7(3), e32709. PMID: 22442669.

Xu, Q., Liu, L. Z., Qian, X., Chen, Q., Jiang, Y., Li, D., Lai, L. & Jiang, B. H. (2012). MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis. Nucleic acids research, 40(2), 761-74. PMID: 21917858.

He, J., Xu, Q., Wang, M., Li, C., Qian, X., Shi, Z., Liu, L. Z. & Jiang, B. H. (2012). Oral administration of apigenin inhibits metastasis through AKT/P70S6K1/MMP-9 pathway in orthotopic ovarian tumor model. International journal of molecular sciences, 13(6), 7271-82. PMID: 22837693.

Carpenter, R. L., Jiang, Y., Jing, Y., He, J., Rojanasakul, Y., Liu, L. Z. & Jiang, B. H. (2011). Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1. Biochemical and biophysical research communications, 414(3), 533-8. PMID: 21971544.

Lin, C. C., Liu, L. Z., Addison, J. B., Wonderlin, W. F., Ivanov, A. V. & Ruppert, J. M. (2011). A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Molecular and cellular biology, 31(12), 2513-27. PMID: 21518959.

Liu, L. Z., Li, C., Chen, Q., Jing, Y., Carpenter, R., Jiang, Y., Kung, H. F., Lai, L. & Jiang, B. H. (2011). MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1a expression. PloS one, 6(4), e19139. PMID: 21544242.

Li, D., Zhao, Y., Liu, C., Chen, X., Qi, Y., Jiang, Y., Zou, C., Zhang, X., Liu, S., Wang, X., Zhao, D., Sun, Q., Zeng, Z., Dress, A., Lin, M. C., Kung, H. F., Rui, H., Liu, L. Z., Mao, F., Jiang, B. H. & Lai, L. (2011). Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 17(7), 1722-30. PMID: 21350001.

Liu, L. Z., Jiang, Y., Carpenter, R. L., Jing, Y., Peiper, S. C. & Jiang, B. H. (2011). Role and mechanism of arsenic in regulating angiogenesis. PloS one, 6(6), e20858. PMID: 21687637.

Bian, C. X., Shi, Z., Meng, Q., Jiang, Y., Liu, L. Z. & Jiang, B. H. (2010). P70S6K 1 regulation of angiogenesis through VEGF and HIF-1alpha expression. Biochemical and biophysical research communications, 398(3), 395-9. PMID: 20599538.

Zhao, P., Meng, Q., Liu, L. Z., You, Y. P., Liu, N. & Jiang, B. H. (2010). Regulation of survivin by PI3K/Akt/p70S6K1 pathway. Biochemical and biophysical research communications, 395(2), 219-24. PMID: 20361940.

Jiang, B. H., Liu, L. Z. (2009). PI3K/PTEN signaling in angiogenesis and tumorigenesis. Advances in cancer research, 102, 19-65. PMID: 19595306.

Liu, L. Z., Zheng, J. Z., Wang, X. R. & Jiang, B. H. (2008). Endothelial p70 S6 kinase 1 in regulating tumor angiogenesis. Cancer research, 68(19), 8183-8. PMID: 18829578.

Jiang, B. H., Liu, L. Z. (2008). Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 11(3), 63-76. PMID: 18440854.

Jiang, B. H., Liu, L. Z. (2008). AKT signaling in regulating angiogenesis. Current cancer drug targets, 8(1), 19-26. PMID: 18288940.

Jiang, B. H., Liu, L. Z. (2008). PI3K/PTEN signaling in tumorigenesis and angiogenesis. Biochimica et biophysica acta, 1784(1), 150-8. PMID: 17964232.

Fang, J., Ding, M., Yang, L., Liu, L. Z. & Jiang, B. H. (2007). PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis. Cellular signalling, 19(12), 2487-97. PMID: 17826033.

Xia, C., Meng, Q., Liu, L. Z., Rojanasakul, Y., Wang, X. R. & Jiang, B. H. (2007). Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer research, 67(22), 10823-30. PMID: 18006827.

Liu, L. Z., Zhou, X. D., Qian, G., Shi, X., Fang, J. & Jiang, B. H. (2007). AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. Cancer research, 67(13), 6325-32. PMID: 17616691.

Cao, Z., Liu, L. Z., Dixon, D. A., Zheng, J. Z., Chandran, B. & Jiang, B. H. (2007). Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. Cellular signalling, 19(7), 1542-53. PMID: 17341442.

Zhong, X. S., Liu, L. Z., Skinner, H. D., Cao, Z., Ding, M. & Jiang, B. H. (2007). Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells. Biochemical and biophysical research communications, 358(1), 92-8. PMID: 17470361.

Li, Z. D., Liu, L. Z., Shi, X., Fang, J. & Jiang, B. H. (2007). Benzo[a]pyrene-3,6-dione inhibited VEGF expression through inducing HIF-1alpha degradation. Biochemical and biophysical research communications, 357(2), 517-23. PMID: 17442277.

Fang, J., Zhou, Q., Liu, L. Z., Xia, C., Hu, X., Shi, X. & Jiang, B. H. (2007). Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Carcinogenesis, 28(4), 858-64. PMID: 17071632.

Zhou, Q., Liu, L. Z., Fu, B., Hu, X., Shi, X., Fang, J. & Jiang, B. H. (2007). Reactive oxygen species regulate insulin-induced VEGF and HIF-1alpha expression through the activation of p70S6K1 in human prostate cancer cells. Carcinogenesis, 28(1), 28-37. PMID: 16774940.

Jiang, B. H., Liu, L. Z., Schafer, R., Flynn, D. C. & Barnett, J. B. (2006). A novel role for 3, 4-dichloropropionanilide (DCPA) in the inhibition of prostate cancer cell migration, proliferation, and hypoxia-inducible factor 1alpha expression. BMC cancer, 6, 204. PMID: 16884534.