Bradley Ford, PhD, MD

Portrait
Coordinator, Koontz Lecture Series
Medical Director, Clinical Microbiology
Program Director, Medical Microbiology Fellowship
Clinical Assistant Professor of Pathology

Contact Information

Primary Office: C606-B General Hospital
Iowa City, IA 52242
319-356-2990

Education

PhD, Medical Scientist Training Program, Stony Brook University, Stony Brook, NY
MD, Medical Scientist Training Program, Stony Brook School of Medicine, Stony Brook, NY

Resident, Laboratory and Genomic Medicine, Barnes Jewish Hospital, St. Louis, MO
Fellow, Medical and Public Health Microbiology, Barnes Jewish Hospital, St. Louis, MO
Post Doctoral Fellow, Molecular Microbiology, Washington University, St. Louis, MO

Licensure and Certifications

Diplomate in Clinical Pathology - American Board of Pathology

Research Summary

Dr. Ford's research focuses on development of new clinical testing methods using a variety of next generation platforms.

Publications

Mathur, G., Yadav, K., Ford, B., Schafer, I., Basavaraju, S., Knust, B., Shieh, W., Hill, S., Locke, G., Quinlisk, P., Brown, S., Gibbons, A., Cannon, D., Kuehnert, M., Nichol, S., Rollin, P., Ströher, U. & Miller, R. (2017). High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus. Transplant Infectious Diseases, 4(19). PMID: 28423464.

Ford, B. A. (2017). mecC-MRSA: Hiding in Plain Sight. Journal of clinical microbiology. PMID: 29118173.

Dunseth, C. D., Ford, B. A. & Krasowski, M. D. (2017). Traditional versus reverse syphilis algorithms: A comparison at a large academic medical center. Practical Laboratory Medicine, 8(2017), 52-59. DOI: 10/1016/j.plabm.2017.04.007.

Marra, A. R., Edmond, M. B., Ford, B. A., Herwaldt, L. A., Algwizani, A. R. & Diekema, D. J. (2016). Failure of Risk-Adjustment by Test Method for C. difficile Laboratory-Identified Event Reporting. Infection control and hospital epidemiology, 1-3. PMID: 27745553.

Krasowski, M. D., Wilford, J. D., Howard, W., Dane, S. K., Davis, S. R., Karandikar, N. J., Blau, J. L. & Ford, B. A. (2016). Implementation of Epic Beaker Clinical Pathology at an academic medical center. Journal of pathology informatics, 7, 7. PMID: 26955505.

Burghardt, E. L., Flenker, K. S., Clark, K. C., Miguel, J., Ince, D., Winokur, P., Ford, B. & McNamara, 2nd, J. O. (2016). Rapid, Culture-Free Detection of Staphylococcus aureus Bacteremia. PloS one, 11(6), e0157234. PMID: 27305148.

Ford, B. A. (2016). Identification of low-level vancomycin resistance in Staphylococcus aureus in the era of informatics. Journal of clinical microbiology. PMID: 26865694.

Jarvis, C., Han, Z., Kalas, V., Klein, R., Pinkner, J. S., Ford, B., Binkley, J., Cusumano, C. K., Cusumano, Z., Mydock-McGrane, L., Hultgren, S. J. & Janetka, J. W. (2016). Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. ChemMedChem, 11(4), 367-73. PMID: 26812660.

Morriss, F. H., Lindower, J. B., Bartlett, H. L., Atkins, D. L., Kim, J. O., Klein, J. M. & Ford, B. A. (2016). Neonatal Enterovirus Infection: Case Series of Clinical Sepsis and Positive Cerebrospinal Fluid Polymerase Chain Reaction Test with Myocarditis and Cerebral White Matter Injury Complications. AJP reports, 6(3), e344-e351. PMID: 27695644.

Arnold, A. R., Burnham, C. A., Ford, B. A., Lawhon, S. D., McAllister, S. K., Lonsway, D., Albrecht, V., Jerris, R. C., Rasheed, J. K., Limbago, B., Burd, E. M. & Westblade, L. F. (2016). Evaluation of an Immunochromatographic Assay for Rapid Detection of Penicillin-Binding Protein 2a in Human and Animal Staphylococcus intermedius Group, Staphylococcus lugdunensis, and Staphylococcus schleiferi Clinical Isolates. Journal of clinical microbiology, 54(3), 745-8. PMID: 26677248.

Falcone, E. L., Petts, J. R., Fasano, M. B., Ford, B., Nauseef, W. M., Neves, J. F., Simões, M. J., Tierce, 4th, M. L., de la Morena, M. T., Greenberg, D. E., Zerbe, C. S., Zelazny, A. M. & Holland, S. M. (2016). Methylotroph Infections and Chronic Granulomatous Disease. Emerging infectious diseases, 22(3), 404-9. PMID: 26886412.

Ford, B. R., Schlueter, A. (2016). Culture of Blood and Cellular Therapy Products in Blood Banking. In A. L. Leber (Eds.) Clinical Microbiology Procedures Handbook. (4), pp. 13.3.5.1-13.3.5.6. Sterling, VA: American Society for Microbiology Press. DOI: 10.1128/9781555818814.ch13.3.

Ogrin, C., Ford, B. A., Stauffer, S. L., Krasowski, M. D. & Azar, A. E. (2015). Positive test for anti-thyroglobulin antibodies due to administration of immunoglobulin replacement therapy in a patient with thyroid cancer. Endocrine Practice. PMID: 26151422.

Krasowski, M. D., Schriever, A., Mathur, G., Blau, J. L., Stauffer, S. L. & Ford, B. A. (2015). Use of a data warehouse at an academic medical center for clinical pathology quality improvement, education, and research. Journal of pathology informatics, 6, 45. PMID: 26284156.

Westblade, L. F., Ranganath, S., Dunne, Jr., W. M., Burnham, C. D., Fader, R. & Ford, B. A. (2015). Infection with a chlorophyllic eukaryote after a traumatic freshwater injury. N Engl J Med, 372(10), 982-4. PMID: 25738686.

El-Herte, R. I., Schouweiler, K. E., Farah, R. S., Arbulu, R., Diekema, D. J., Wanat, K. A. & Ford, B. A. (2014). Phaeoacremonium parasiticum phaeohyphomycosis in a patient with systemic lupus erythematosus treated successfully with surgical debridement and voriconazole: A case report and review of the literature. IDCases, 1(4), 84-88. DOI: doi:10.1016/j.idcr.2014.10.004.

Westblade, L. F., Shams, F., Duong, S., Tariq, O., Bulbin, A., Klirsfeld, D., Sakaria, S., Ford, B. A., Burnham, C. D. & Ginocchio, C. D. (2014). Septic arthritis of a native knee joint due to corynebacterium striatum. J Clin Microbiol, JCM.02641-13. PMID: 24574280.

Guiton, P. S., Hannan, T. J., Ford, B., Caparon, M. G. & Hultgren, S. J. (2013). Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urirnary tract infections. Infection and immunity, 81(1), 329-39. PMID: 23132492.

Pence, M. A., Sharon, J., Tekippe, M., Pakalniskis, B. L., Ford, B. & Burnham, C. D. (2013). Two cases of Kerstersia gyiorum isolated from sites of chronic infection. Journal of Clinical Microbiology, 51(6), 2001-04. PMID: 23596236.

Ford, B., Burnham, C. A. (2013). Optimization of routine identification of clinically relevant gram-negative bacteria by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry and the bruker biotyper. Journal of clinical microbiology, 51(5), 1412-20. PMID: 23426923.

Storm, J. C., Ford, B. A. & Streit, J. A. (2013). Myocardial infection due to Fusobacterium necleatum. Diagn Microbiol Infec Dis, 77(4), 373-5. PMID: 24094834.

Brosnahan, A. J., Merriman, J. A., Salgado-Pabón, W., Ford, B. & Schlievert, P. M. (2013). Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. PLosONE, 8(4), e61255. PMID: 23613823.

Demarco, M. L., Ford, B. A. (2013). Beyond identification: emerging and future uses for MALDI-TOF mass spectrometry in the clinical microbiology laboratory. Clin Lab Med, 33(3), 611-628. PMID: 23931841.

Han, Z., Pinkner, J. S., Ford, B., Chorell, E., Crowley, J. M., Cusumano, C. K., Campbell, S., Henderson, J. P., Hultgren, S. J. & Janetka, J. W. (2012). Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides. Journal of medicinal chemistry, 55(8), 3945-59. PMID: 22449031.

Volkan, E., Ford, B., Pinkner, J. S., Dodson, K. W., Henderson, N. S., Thanassi, D. G., Waksman, G. & Hultgren, S. J. (2012). Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine. Proceedings of the National Academy of Sciences of the United States of America, 109(24), 9563-8. PMID: 22645361.

Shu, Q., Crick, S. L., Pinkner, J. S., Ford, B., Hultgren, S. J. & Frieden, C. (2012). The E. coli CsgB nucleator of curli assembles to ß-sheet oligomers that alter the CsgA fibrillization mechanism. Proceedings of the National Academy of Sciences of the United States of America, 109(17), 6502-7. PMID: 22493266.

Dunne, W. M., Westblade, L. F. & Ford, B. (2012). Next-generation and whole-genome sequencing in the diagnostic clinical microbiology laboratory. European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology, 31(8), 1719-26. PMID: 22678348.

Ford, B., Verger, D., Dodson, K., Volkan, E., Kostakioti, M., Elam, J., Pinkner, J., Waksman, G. & Hultgren, S. (2012). Structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket. Journal of bacteriology, 194(23), 6390-7. PMID: 23002225.

Phan, G., Remaut, H., Wang, T., Allen, W. J., Pirker, K. F., Lebedev, A., Henderson, N. S., Geibel, S., Volkan, E., Yan, J., Kunze, M. B., Pinkner, J. S., Ford, B., Kay, C. W., Li, H., Hultgren, S. J., Thanassi, D. G. & Waksman, G. (2011). Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature, 474(7349), 49-53. PMID: 21637253.

Cusumano, C. K., Pinkner, J. S., Han, Z., Greene, S. E., Ford, B., Crowley, J. R., Henderson, J. P., Janetka, J. W. & Hultgren, S. J. (2011). Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Science translational medicine, 3(109), 109. PMID: 22089451.

Ford, B., Han, Z., Pinkner, J. S., Obermann, R., Nolan, W., Wildman, S. A., Hobbs, D., Ellenberger, T., Cusumano, C. K., Hultgren, S. J. & Janetka, J. W. (2010). Structure-based drug design and optimization of mannoside bacterial FimH antagonists. Journal of medicinal chemistry, 53(12), 4779-92. PMID: 20507142.

Ford, B., Eby, C. S., Scott, M. G. & Coyne, D. W. (2010). Intra-individual variability in serum hepcidin precludes its use as a marker of iron status in hemodialysis patients. Kidney international, 78(8), 769-73. PMID: 20668427.

Ford, B., Rêgo, A. T., Ragan, T. J., Pinkner, J., Dodson, K., Driscoll, P. C., Hultgren, S. & Waksman, G. (2010). Structural homology between the C-terminal domain of the PapC usher and its plug. Journal of bacteriology, 192(7), 1824-31. PMID: 20118254.

Klutts, J. S., Ford, B., Perez, N. R. & Gronowski, A. M. (2009). Evidence-based approach for interpretation of Epstein-Barr virus serological patterns. Journal of clinical microbiology, 47(10), 3204-10. PMID: 19656988.

Ford, B., Boykevisch, S., Zhao, C., Kunzelmann, S., Bar-Sagi, D., Herrmann, C. & Nassar, N. (2009). Characterization of a Ras mutant with identical GDP- and GTP-bound structures. Biochemistry, 48(48), 11449-57. PMID: 19883123.

Ford, B., Coyne, D. W., Eby, C. S. & Scott, M. G. (2009). Variability of ferritin measurements in chronic kidney disease; implications for iron management. Kidney international, 75(1), 104-10. PMID: 18843257.

Ferguson, A. M., Ford, B. & Gronowski, A. M. (2008). Method validation for cerebral spinal fluid human chorionic gonadotropin measurement with the Advia Centaur. Clinical chemistry, 54(8), 1408-9. PMID: 18664453.

Mikhailik, A., Ford, B., Keller, J., Chen, Y., Nassar, N. & Carpino, N. (2007). A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling. Molecular cell, 27(3), 486-97. PMID: 17679096.

Kleinman, H., Ford, B., Keller, J., Carpino, N. & Nassar, N. (2006). Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1. Acta crystallographica - Section F, Structural biology and crystallization communications, 62(Pt 3), 218-20. PMID: 16511305.

Ford, B., Hornak, V., Kleinman, H. & Nassar, N. (2006). Structure of a transient intermediate for GTP hydrolysis by ras. Structure (London, England : 1993), 14(3), 427-36. PMID: 16531227.

Ford, B., Skowronek, K., Boykevisch, S., Bar-Sagi, D. & Nassar, N. (2005). Structure of the G60A mutant of RAS: implications for the dominant negative effect. The Journal of biological chemistry, 280(27), 25697-705. PMID: 15878843.