Carol J. Holman, MD, PhD

Portrait
Medical Director of Hematopathology
Director, Hematopathology Fellowship Program
Director of Leukemia Pathology, Holden Comprehensive Cancer Center
Clinical Professor of Pathology

Contact Information

Primary Office
6229 Roy Carver Pavilion
Iowa City, IA 52242
319-356-3981

Education

PhD, Biochemistry, University of Illinois, Urbana-Champaign, IL
MD, University of Illinois, Urbana-Champaign, IL
Resident, Pathology, University of Minnesota
Fellow, Hematopathology, University of Minnesota

Licensure and Certifications

State of Iowa Medical License - Iowa Board of Medicine
Hematology - American Board of Pathology
Anatomic and Clinical Pathology - American Board of Pathology

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Research Summary

Dr. Holman has broad interests in many areas of hematopathology, including clinical diagnosis of patients with leukemia and lymphoma, as well as optimal laboratory testing for detection of minimal residual disease following therapy. She has research interests in the pathogenesis of Epstein-Barr virus infection and its role in a variety of diseases including post-transplant lymphoproliferative disorder, lymphomatoid granulomatosis, and infectious mononucleosis.

Publications

Gu, C., Holman, C., Sompallae, R., Jing, X., Tomasson, M., Hose, D., Seckinger, A., Zhan, F., Tricot, G., Goldschmidt, H., Yang, Y. & Janz, S. (2018). Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome. Blood cancer journal, 8(2), 22. PMID: 29449574.

Gupta, S., Karandikar, N. J., Ginader, T., Bellizzi, A. M. & Holman, C. J. (2018). Flow cytometric aberrancies in plasma cell myeloma and MGUS - correlation with laboratory parameters. Cytometry. Part B, Clinical cytometry. PMID: 29316245.

Rosean, T. R., Holman, C. J., Tompkins, V. S., Jing, X., Krasowski, M. D., Rose, J. S. & Janz, S. (2016). KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice. Blood Cancer Journal,(6:e), 398. PMID: 26918362.

Gu, C., Sompallae, R., Xu, H., Tompkins, V. S. & Holman, C. (2015). FOXM1 is a therapeutic target for high-risk multiple myeloma. Leukemia. PMID: 26648534.

Han, S. S., Tompkins, V. S., Son, D. J., Han, S., Yun, H., Kamberos, N. L., Dehoedt, C. L., Gu, C., Holman, C., Tricot, G., Zhan, F. & Janz, S. (2015). CDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myeloma. Experimental hematology & oncology, 4, 9. PMID: 25838973.

Rosean, T. R., Tompkins, V. S., Tricot, G., Holman, C. J., Olivier, A. K., Zhan, F. & Janz, S. (2014). Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma. Immunol ResEpub ahead of print. DOI: 10.1007/s12026-014-8528-x.

Jerath, N. U., Reddy, C. G., Moritani, T., Bruch, L. A., Holman, C. & Gutmann, L. A. (2014). A 47 year old woman with left shoulder pain after a fall. Neurology.

Hashem, H., Holman, C. & El Sheikh, A. (2014). Congenital dyserythropoietic anemia type 1 presenting as persistent pulmonary hypertension of the newborn with a unique course and skeletal manifestations. (Vols. 61). (8), pp. 1460-2. Pediatric Blood Cancer.

Kaplan, A., Samad, A., Dolan, M. M., Cioc, A. M., Holman, C. J., Schmechel, S. C. & Pambuccian, S. E. (2013). Follicular lymphoma transformed to "double-hit" B lymphoblastic lymphoma presenting in the peritoneal fluid. Diagnostic cytopathology, 41(11), 986-90. PMID: 22623514.

Mettler, T. N., Holman, C. J., McKenna, R. W. & Pambuccian, S. E. (2012). Plasmablastic myeloma in ascitic fluid. Diagnostic cytopathology, 40(9), 806-9. PMID: 21698783.

Holman, C. J., Karger, A. B., Mullan, B. D., Brundage, R. C. & Balfour, H. H. (2012). Quantitative Epstein-Barr virus shedding and its correlation with the risk of post-transplant lymphoproliferative disorder. Clinical Transplant, 26(5), 741-7. PMID: 22385033.

Gleason, M. K., Lenvik, T. R., McCullar, V., Felices, M., O'Brien, M. S., Cooley, S. A., Verneris, M. R., Cichocki, F., Holman, C. J., Panoskaltsis-Mortari, A., Niki, T., Hirashima, M., Blazar, B. R. & Miller, J. S. (2012). Tim-3 enhances interferon gamma production in response to galectin-9 human natural killer cells. Blood, 119(13), 3064-72. PMID: 22323453.

Holman, C. J., McKenna, R. W. (2012). "Aplastic Anemia". In Case Studies in Hematology and Coagulation: A New ASCP CaseSet. ASCP Press.

Holman, C. J., McKenna, R. W. (2012). "Aplastic anemia" in: Case Studies in Hematology and Coagulation: A New ASCP CaseSet. In G. Gulati (Eds.) I. ASCP Press.

Holman, C. J. (2012). "Bone marrow aplasia after liver transplant". R. Novickas (Eds.) ASCP Press.

Holman, C. J., Nguyen, P., Singleton, T. & McKenna, R. (2011). "Mycosis fungoides tumor stage, with a cytotoxic T-cell phenotype". In (Workshop Case No. 291) in Workshop Books, Session One. The Society for Haematopathology and European Association for Haematopathology.

Wudhikarn, K., Holman, C. J., Linan, M., Blaes, A. H., Dunitz, J. M., Hertz, M. E. & Peterson, B. A. (2011). Post-transplant lymphoproliferative disorders in lung transplant recipients: 20-yr experience at the University of Minnesota. Clinical Transplant, 25(5), 705-13. PMID: 21077949.

Romain, C. A., Balfour, Jr, H. H., Vezina, H. E. & Holman, C. J. (2010). A method for evaluating antiviral drug susceptibility of Epstein-Barr virus. Virus Adapt Treatment, 2, 1-7.

Dunning, K. K., Wudhikarn, K., Safo, A. O., Holman, C. J., McKenna, R. W. & Pambuccian, S. E. (2009). Adrenal extranodal NK/T-cell lymphoma diagnosed by fine-needle aspiration and cerebrospinal fluid cytology and immunophenotyping: a case report. Diagn Cytopathol, 37(9), 686-95. PMID: 19373919.

Wudhikarn, K., Holman, C. J., Blaes, A. H., Dunitz, J. M., Hertz, M. I. & Peterson, B. A. (2009). Post transplant lymphoproliferative disorders (PTDL) after lung transplantation: comparison of patients with early versus late disease. (Vols. 114). (22), pp. 1518. Blood.

Budde, A. M., Romain, C. A., Balfour, Jr, H. H. & Holman, C. J. (2008). Epstein-Barr virus (EBV) LMP-1 gene sequence variation to track transmission of EBV infection. (Vols. 130). pp. 477. Am J Clin Pathol.

Balfour, H. H., Hokanson, K. M., Schacherer, R. M., Fietzer, C. M., Schmeling, D. O., Holman, C. J., Vezina, H. E. & Brundage, R. C. (2007). A virologic pilot study of valacyclovir in infectious mononucleosis. Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology, 39(1), 16-21. PMID: 17369082.

Holman, C. J., Webb, C. H., Hokanson, K. M., Schmeling, D. O., Cook, M. E., Romain, C. A. & Balfour, Jr, H. H. (2006). Epstein-Barr virus (EBV) shedding patterns in acute and chronic infection. (Vols. 126). pp. 461-2. Am J Clin Pathol.

Balfour, H. H., Holman, C. J., Hokanson, K. M., Lelonek, M. M., Giesbrecht, J. E., White, D. R., Schmeling, D. O., Webb, C. H., Cavert, W., Wang, D. H. & Brundage, R. C. (2005). A prospective clinical study of Epstein-Barr virus and host interactions during acute infectious mononucleosis. The Journal of Infectious diseases, 192(9), 1505-12. PMID: 16206064.

Holman, C. J., Gulbahce, E. H., McKeon, D. M., van Burik, J., Balfour, Jr, H. H. & Pambuccian, S. E. (2005). BK virus infection in symptomatic immunosuppressed patients: Comparison of urine cytology and semi-quantative PCR. (Vols. 129). pp. 556. Arch Pathol Lab Med.

(2003). CD10 and other markers in the diagnosis of hepatobiliary tumors. 92nd Annual Meeting of the United States and Canadian Academy of Pathology (USCAP). Washington, DC..

Holman, C. J., van Burik, J. A., Hinrichs, S. H. & Balfour Jr, H. H. (2003). Specific detection of human BK polyomavirus in urine samples of immunocompromised patients. Clinical Diagn Lab Immunol, 10(1), 66-9. PMID: 12522041.

Bailey, T. J., Neppalli, V., Holman, C. J., Dolan, M., Hirsch, B. & Brown, C. A. (2003). The prevalence of mutations in the ATP binding site of BCR-ABL among patients with chronic myeloid leukemia. (Vols. 120). pp. 284-5. Am J Clin Pathol.

Julin, J. E., van Burik, J. H., Krivit, W., Webb, C., Holman, C. J., Clark, H. B. & Balfour, H. H. (2002). Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient. Transpl Infect Dis, 4, 201-6. PMID: 12535263.

Holman, C. J., van Burik, J. H., Hinrichs, S. & Balfour, Jr., H. H. (2001). A semi-quantitive PCR assay for detection of BK virus in immunocompromised hosts. 17th Annual Clinical Virology Symposium, Clearwater Beach, FL.

Holman, C. J., Van Burik, J. H., Hinrichs, S. & Balfour, Jr., H. H. (2001). A semi-quantitive PCR assay for detection of BK virus in immunocompromised hosts. (Vols. 116). pp. 282. Am J Clin Pathol.

Holman, C. J., Crosson, J. C. (2000). Routine blood typing results as initial indicator of Common Variable Immunodeficiency. (Vols. 114). pp. 315. Am J Clin Pathol.

Manning, T. C., Holman, C. J., Brodnicki, T. C., Parke, E. A., Speir, J. A., Garcia, K. C., Teyton, L., Wilson, I. A. & Kranz, D. M. (1998). Alanine scanning mutagenesis of an aß T cell receptor: mapping the energy of antigen recognition. Immunity, 8(4), 413-25. PMID: 9586632.

Holman, C. J., Manning, T. C., Schodin, B. A. & Kranz, D. M. (1996). A residue in the center of peptide QL9 affects binding to both L9 and the T cell receptor. Journal of Immunology, 157(10), 4478-85. PMID: 8906825.

Schleuter, C., Manning, T., Brodnicki, T. & Kranz, D. (1996). Identification of peptide and T cell receptor residues involved in the interaction of CTL 2C and QL9/Ld. ASBMB/ASIP/AAI Joint Meeting New Orleans, LA.

Schodin, B. A., Holman, C. J. & Kranz, D. M. (1996). Binding properties and solubility of single-chain T cell receptors expressed in E coli. Molecular Immunology, 33(9), 819-29. PMID: 8811077.

Holman, C. J., Schodin, B. A., Tetin, S. Y. & Kranz, D. M. (1996). Specificity and binding properties of a single-chain T cell receptor. J Mol Biology, 256(5), 859-69. PMID: 8601837.

Schleuter, C. J., Kranz, D. M. (1995). Characterization of a single chain T cell receptor - peptide/MHC binding interaction. International Congress of ImmunologySan Francisco, CA.

Hawrylak, N., Ghosh, P., Broadus, J., Holman, C. J., Greenough, W. T. & Lauterbur, P. C. (1993). Nuclear magnetic resonance (NMR) imaging of iron oxide-labeled neural transplants. Exp Neurology, 121(2), 181-92. PMID: 8339769.

Roth, M. E., Tjoa, B. A., Holman, C. J., Wilson, E. R., Lunn, B. C. & Kranz, D. M. (1992). Sequence diversity of T cell receptor a chain transcripts from Balb/c thymus. Mol Immunology, 29, 1447-55. PMID: 8339769.