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Nitin J. Karandikar, MD, PhD

Portrait
Dr. Richard G. Lynch Chair in Experimental Pathology
Chair and Department Executive Officer
Professor of Pathology

Contact Information

Office: C673 General Hospital
Iowa City, 52242
Phone: 319-384-9609

Education

MBBS, Bachelor of Medicine and Surgery, B.J. Medical College, University of Poona, India
MD, Pathology, B.J. Medical College, University of Poona, India
PhD, Immunology and Molecular Pathogenesis Graduate Program, Northwestern University Medical School

Internship, B.J. Medical College, University of Poona, India
Resident, Anatomic and Clinical Pathology, B.J. Medical College, University of Poona, India
Resident, Clinical Pathology, University of Texas Southwestern Medical Center, Dallas
Fellow, Hematopathology, University of Texas Southwestern Medical Center, Dallas
Post Doctoral Fellow, Research in Immunology, University of Texas Southwestern Medical Center

Licensure and Certifications

Hematology - American Board of Pathology
Clinical Pathology - American Board of Pathology

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Immunology, Interdisciplinary Graduate Program in Molecular and Cellular Biology

Publications

Itani, F. R., Sinha, S., Brate, A. A., Pewe, L. L., Gibson-Corley, K. N., Harty, J. T. & Karandikar, N. J. (2017). Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen. Scientific Reports, 7(1). DOI: 10.1038/s41598-017-01771-8.

Krasowski, M. D., Wilford, J. D., Howard, W., Dane, S., Davis, S. R., Karandikar, N. J., Blau, J. L. & Ford, B. (2016). Implementation of Epic Beaker clinical pathology at an academic medical center. J Pathol Informatics, 7, 7. DOI: 10.4103/2153-3539.175798.
[PubMed]

Steussy, B., Lekostaj, J., Qian, Q., Rosenthal, N., Holman, C. J., Syrbu, S., Darbro, B., Bossler, A. & Karandikar, N. J. (2016). Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman. Laboratory Medicine, 47(2), 155-157. DOI: 10.1093/labmed/lmw011.

Gibson-Corley, K. N., Boyden, A. W. & Karandikar, N. J. (2016). A method for histopathological study of the multifocal nature of spinal cord lesions in murine experimental autoimmune encephalomyelitis. Peer J.

Mohiuddin, I. H., Pillai, V., Baughman, E. J., Greenberg, B. M., Frohman, E. M., Crawford, M. P., Sinha, S. & Karandikar, N. J. (2016). Induction of regulatory T-cells from memory T-cells is perturbed during acute exacerbation of multiple sclerosis.. Clinical immunology (Orlando, Fla.). DOI: 10.1016/j.clim.2016.05.001.
[PubMed]

Sinha, S., Crawford, M. P., Ortega, S. B. & Karandikar, N. J. (2015). Multiparameter flow cytometric assays to quantify effector and regulatory T cell function in multiple sclerosis. J Mult Scler , 2(1), 130. DOI: 10.4172/2376-0389.1000130.
[PubMed]

Ortega, S. B., Kashi, V. P., Cunnasamy, K., Franco, J. & Karandikar, N. J. (2015). Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants. (Vols. 2). (6), pp. e170. Neurol Neuroimmunol Neuroinflamm. DOI: 10.1212/NXI.0000000000000170.
[PubMed]

Sinha, S., Boyden, A. W., Itani, F. R., Crawford, M. P. & Karandikar, N. J. (2015). CD8(+) T-cells as immune regulators of multiple sclerosis. Front Immunol, 6, 619. DOI: 10.3389/fimmun.2015.00619.
[PubMed]

Cunnusamy, K., Baughman, E. J., Franco, J., Ortega, S. B., Sinha, S., Chaudhary, P., Greenberg, B. M., Frohman, E. M. & Karandikar, N. J. (2014). Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells. Clinical Immunology, 152(May-June), 115-126.

Sinha, S., Itani, F. R. & Karandikar, N. J. (2014). Immune regulation of multiple sclerosis by CD8+ T cells.. Immunologic Research.

Kashi, V. P., Ortega, S. B. & Karandikar, N. J. (2014). Neuroantigen-specific autoregulatory CD8+ T cells inhibit autoimmune demyelination through modulation of dendritic cell function. (Vols. 9). (8) PLoS ONE. DOI: 10.1371/journal.pone.0105763.
[PubMed]

Rakheja, D., Chen, K. S., Liu, Y., Shukla, A. A., Schmid, V., Chang, T., Khokhar, S., Wickiser, J. E., Karandikar, N. J., Malter, J. S., Mendell, J. T. & Amatruda, J. F. (2014). Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumors. Nature Communications, 2, 4802. DOI: 10.1038/ncomms5802.
[PubMed]

Wang, L., Peters, J. M., Li, L., Karandikar, N. J., Koduru, P., Wang, H. Y. & Chen, W. (2014). Acute megakaryoblastic leukemia associated with trisomy 21 demonstrates a distinct immunophenotype. Cytometry B Clin Cytom. DOI: 10.1002/cytob.21198.
[PubMed]

Gutierrez, T., Mayeux, J. M., Ortega, S. B., Karandikar, N. J., Li, Q. Z., Rakheja, D., Zhou, X. J. & Satterthwaite, A. B. (2013). IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn(-/-) mice. European journal of immunology, 43(2), 382-93.
[PubMed]

Tyler, A. F., Mendoza, J. P., Firan, M. & Karandikar, N. J. (2013). CD8+T cells are required for glatiramer acetate therapy in autoimmune demyelinating disease. PLoS One, 8(6), e66772.
[PubMed]

Ayers, C. L., Mendoza, J. P., Sinha, S., Cunnusamy, K., Greenberg, B. M., Frohman, E. M. & Karandikar, N. J. (2013). Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis. Clinical Immunology, 147(2), 105-119.
[PubMed]

Ortega, S. B., Kashi, V. P., Tyler, A. F., Cunnusamy, K., Mendoza, J. P. & Karandikar, N. J. (2013). The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis. Journal of Immunology, 191(1), 117-26.
[PubMed]

Hoffhines, A. J., Karandikar, N. J., Fuda, F., Monaghan, S., Koduru, P. & Levenson, B. M. (2012). Greater incidence of cytogenetic aberrations in HIV-positive non-Hodgkin lymphoma. USCAP.

Olteanu, H., Harrington, A. M., Kroft, S. H., Karandikar, N. J. & Fuda, F. (2012). The prevalence of CD56 expression by flow cytometry in acute promyelocytic leukemia patients treated with All-Trans retinoic acid and anthracycline drug combinations. USCAP.

Kumar, K. R., Yates, S., Sarode, V. R., Karandikar, N. J. & Emmons, J. (2012). Flow cytometric aberrancies and clinical outcome in low grade, high proliferation index follicular lymphoma.

Castro-Silva, F. J., Fuda, F. S. & Karandikar, N. J. (2012). Increased bone marrow mast cells, dnumerated by multiparameter flow cytometry, are associated with myelodysplastic syndromes. USCAP.

Greenberg, B. M., Graves, D., Remington, G., Hardeman, P., Mann, M., Karandikar, N. J., Stuve, O., Monson, N. & Frohman, E. (2012). Rituximab dosing and monitoring strategies in neuromyelitis optica patients: Creating strategies for therapeutic success. Multiple sclerosis, 18(7), 1022-6.
[PubMed]

Morris, H. D., Karandikar, N. J., Balani, J., Fuda, F., Monaghan, S. & Emmons, J. (2012). A comparison of flow cytometry and cytologic evaluation.

Zaremba, C. M., Oliver, D., Cavalier, M., Fuda, F., Karandikar, N. J. & Chen, W. (2012). Distinct immunophenotype of early T-cell progenitors in T lymphoblastic leukemia/lymphoma may predict FMS-like tyrosine kinase 3 mutations. Annals of diagnostic pathology, 16(1), 16-20.
[PubMed]

Willis, J., Emmons, J., Karandikar, N. J. & Fuda, F. (2011). Utility of CD117 expression in the diagnosis of T/myeloid mixed phenotype acute leukemia. USCAP.

Ayers, C. L., Firan, M., Pillai, V., Lee, W. M. & Karandikar, N. J. (2011). Viral interactions with B-cells contribute to increased regulatory T-cells during chronic HCV infection. Viral immunology, 24(2), 119-29.
[PubMed]

Willis, J., Emmons, J., Karandikar, N. J. & Fuda, F. (2011). Cytochemical and/or immunohistochemical staining for myeloperoxidase are essential in the work-up of mixed phenotype acute leukemia. USCAP.

Biegler, B. W., Yan, S. X., Ortega, S. B., Tennakoon, D. K., Racke, M. K. & Karandikar, N. J. (2011). Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis. Journal of neuroimmunology, 234(2-Jan), 131-40.
[PubMed]

Baughman, E. J., Mendoza, J. P., Ortega, S. B., Ayers, C. L., Greenberg, B. M., Frohman, E. M. & Karandikar, N. J. (2011). Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis. Journal of autoimmunity, 36(2), 115-24.
[PubMed]

Rakheja, D., Konoplev, S., Su, M., Wheeler, D., Muzny, D. M., Ruvolo, V. R., Collins, R., Karandikar, N. J., Andreeff, M., Medeiros, L. J. & Chen, W. (2011). High incidence of IDH mutations in acute myeloid leukaemia with cuplike nuclei. British journal of haematology, 155(1), 125-8.
[PubMed]

Racke, M. K., Lovett-Racke, A. E. & Karandikar, N. J. (2010). The mechanism of action of glatiramer acetate treatment in multiple sclerosis. Neurology, 74 Suppl 1, S25-30.
[PubMed]

Pillai, V., Karandikar, N., Baughman, E., Mendoza, J. & Mohiuddin, I. (2010). Activation induced suppressive ability in human T cells revealed by a flow cytometric suppression assay. (Vols. 135). (Supplement), pp. S121. Clinical Immunology.

Qian, Y., Wei, C., Eun-Hyung Lee, F., Campbell, J., Halliley, J., Lee, J. A., Cai, J., Kong, Y. M., Sadat, E., Thomson, E., Dunn, P., Seegmiller, A. C., Karandikar, N. J., Tipton, C. M., Mosmann, T., Sanz, I. & Scheuermann, R. H. (2010). Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data. Cytometry. Part B, Clinical cytometry, 78 Suppl 1, S69-82.
[PubMed]

Olteanu, H., Karandikar, N. J., Eshoa, C. & Kroft, S. H. (2010). Laboratory findings in CD4(+) large granular lymphocytoses. International journal of laboratory hematology, 32(1 Pt 1), e9-16.
[PubMed]

Cubillas, R., Kintner, K., Phillips, F., Karandikar, N. J., Thiele, D. L. & Brown, G. R. (2010). Tumor necrosis factor receptor 1 expression is upregulated in dendritic cells in patients with chronic HCV who respond to therapy. Hepatitis research and treatment, 2010, 429243.
[PubMed]

Tirado, C. A., Chen, W., Valdez, F., Karandikar, N. J., Arbini, A., Acevedo, I., Garcia, R., Davila, O., Smart, R. L., Matthews, E., Kirk, A. & Collins, R. H. (2010). Unusual presentation of myeloid sarcoma in a case of acute promyelocytic leukemia with a cryptic PML-RARA rearrangement involving multiple sites including the atrium. Cancer genetics and cytogenetics, 200(1), 47-53.
[PubMed]

Harp, C. T., Ireland, S., Davis, L. S., Remington, G., Cassidy, B., Cravens, P. D., Stuve, O., Lovett-Racke, A. E., Eagar, T. N., Greenberg, B. M., Racke, M. K., Cowell, L. G., Karandikar, N. J., Frohman, E. M. & Monson, N. L. (2010). Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-? production in response to myelin basic protein and myelin oligodendrocyte glycoprotein. European journal of immunology, 40(10), 2942-56.
[PubMed]

Wang, H. Y., Fuda, F. S., Chen, W. & Karandikar, N. J. (2010). Notch1 in primary effusion lymphoma: a clinicopathological study. Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc, 23(6), 773-80.
[PubMed]

York, N. R., Mendoza, J. P., Ortega, S. B., Benagh, A., Tyler, A. F., Firan, M. & Karandikar, N. J. (2010). Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis. Journal of autoimmunity, 35(1), 33-44.
[PubMed]

Tirado, C. A., Valdez, F., Klesse, L., Karandikar, N. J., Uddin, N., Arbini, A., Fustino, N., Collins, R., Patel, S., Smart, R. L., Garcia, R., Doolittle, J. & Chen, W. (2010). Acute myeloid leukemia with inv(16) with CBFB-MYH11, 3'CBFB deletion, variant t(9;22) with BCR-ABL1, and del(7)(q22q32) in a pediatric patient: case report and literature review. Cancer genetics and cytogenetics, 200(1), 54-9.
[PubMed]

Seegmiller, A. C., Garcia, R., Huang, R., Maleki, A., Karandikar, N. J. & Chen, W. (2010). Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas. Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc, 23(7), 909-20.
[PubMed]

Maleki, A., Seegmiller, A. C., Uddin, N., Karandikar, N. J. & Chen, W. (2009). Bright CD38 expression is an indicator of MYC rearrangement. Leukemia & lymphoma, 50(6), 1054-7.
[PubMed]

Deisch, J., Fuda, F. B., Chen, W., Karandikar, N. J., Arbini, A. A., Zhou, X. J. & Wang, H. Y. (2009). Segmental tandem triplication of the MLL gene in an intravascular large B-cell lymphoma with multisystem involvement: a comprehensive morphologic, immunophenotypic, cytogenetic, and molecular cytogenetic antemortem study. Archives of pathology & laboratory medicine, 133(9), 1477-82.
[PubMed]

Seegmiller, A. C., Karandikar, N. J., Kroft, S. H., McKenna, R. W. & Xu, Y. (2009). Overexpression of CD7 in classical Hodgkin lymphoma-infiltrating T lymphocytes. Cytometry. Part B, Clinical cytometry, 76(3), 169-74.
[PubMed]

Chen, Y., Wu, H., Wang, S., Koito, H., Li, J., Ye, F., Hoang, J., Escobar, S. S., Gow, A., Arnett, H. A., Trapp, B. D., Karandikar, N. J., Hsieh, J. & Lu, Q. R. (2009). The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nature neuroscience, 12(11), 1398-406.
[PubMed]

Seegmiller, A. C., Kroft, S. H., Karandikar, N. J. & McKenna, R. W. (2009). Characterization of immunophenotypic aberrancies in 200 cases of B acute lymphoblastic leukemia. American journal of clinical pathology, 132(6), 940-9.
[PubMed]

Fuda, F. S., Karandikar, N. J. & Chen, W. (2009). Significant CD5 expression on normal stage 3 hematogones and mature B Lymphocytes in bone marrow. American journal of clinical pathology, 132(5), 733-7.
[PubMed]

Peters, J., Karandikar, N. J., Fuda, F., Wang, H. Y., Arbini, A. A. & Chen, W. (2008). Acute Megakaryoblastic Leukemia: Immunophenotypic Differences in Patients With and Without Down Syndrome. USCAP.

Kroft, S. H., Karandikar, N. J. (2008). Flow cytometric analysis of acute leukemias, myelodysplastic syndromes and myeloproliferative disorders.

del Pilar Martin, M., Cravens, P. D., Winger, R., Frohman, E. M., Racke, M. K., Eagar, T. N., Zamvil, S. S., Weber, M. S., Hemmer, B., Karandikar, N. J., Kleinschmidt-DeMasters, B. K. & Stüve, O. (2008). Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab. Archives of neurology, 65(12), 1596-603.
[PubMed]

Olteanu, H., Wang, H. Y., Chen, W., McKenna, R. W. & Karandikar, N. J. (2008). Immunophenotypic studies of monoclonal gammopathy of undetermined significance. BMC clinical pathology, 8, 13.
[PubMed]

Frohman, E. M., Eagar, T., Monson, N., Stuve, O. & Karandikar, N. J. (2008). Immunologic mechanisms of multiple sclerosis. Neuroimaging clinics of North America, 18(4), 577-88, ix.
[PubMed]

Pillai, V., Karandikar, N. J. (2008). Attack on the clones? Human FOXP3 detection by PCH101, 236A/E7, 206D, and 259D reveals 259D as the outlier with lower sensitivity. Blood, 111(1), 463-4; author reply 464-6.
[PubMed]

Wang, H. Y., Karandikar, N. J., Payne, D., Maleki, A., Schultz, B. A., Collins, R. & McKenna, R. W. (2008). A 3-way collision tumor of the upper respiratory tract: a composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma. Human pathology, 39(5), 781-7.
[PubMed]

Maftoun-Banankhah, S., Maleki, A., Karandikar, N. J., Arbini, A. A., Fuda, F. S., Wang, H. Y. & Chen, W. (2008). Multiparameter flow cytometric analysis reveals low percentage of bone marrow hematogones in myelodysplastic syndromes. American journal of clinical pathology, 129(2), 300-8.
[PubMed]

Wang, H., Xu, Y., McKenna, R. W. & Karandikar, N. J. (2007). Acute myeloid leukemias with a CD34(-)/HLA-DR(-) immunophenotype encompass a wide range of morphologic subtypes. USCAP.

Seegmiller, A. C., Xu, Y., McKenna, R. W. & Karandikar, N. J. (2007). Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma. American journal of clinical pathology, 127(2), 176-81.
[PubMed]

Pillai, V., Ortega, S. B., Wang, C. K. & Karandikar, N. J. (2007). Transient regulatory T-cells: a state attained by all activated human T-cells. Clinical immunology (Orlando, Fla.), 123(1), 18-29.
[PubMed]

Chen, W., Karandikar, N. J., McKenna, R. W. & Kroft, S. H. (2007). Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience. American journal of clinical pathology, 127(1), 39-46.
[PubMed]

Karandikar, N. J., Seegmiller, A. C. & McKenna, R. W. (2007). Eleven-parameter flow cytometry of lymphoma-infiltrating T lymphocytes: Expansion of memory and suppressor/regulatory T cells.

Pillai, V., Karandikar, N. J. (2007). Human regulatory T cells: a unique, stable thymic subset or a reversible peripheral state of differentiation?. Immunology letters, 114(1), 15-Sep.
[PubMed]

Averill, L., Lee, W. M. & Karandikar, N. J. (2007). Differential dysfunction in dendritic cell subsets during chronic HCV infection. Clinical immunology (Orlando, Fla.), 123(1), 40-9.
[PubMed]

Sathe, A., Ortega, S. B., Mundy, D. I., Collins, R. H. & Karandikar, N. J. (2007). In vitro methotrexate as a practical approach to selective allodepletion. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 13(6), 644-54.
[PubMed]

Pillai, V., Lee, W. M., Thiele, D. L. & Karandikar, N. J. (2007). Clinical responders to antiviral therapy of chronic HCV infection show elevated antiviral CD4+ and CD8+ T-cell responses. Journal of viral hepatitis, 14(5), 318-29.
[PubMed]

Wang, H. Y., Wilson, K. S., McKenna, R. W., Xu, Y. & Karandikar, N. J. (2007). An extranodal nasal natural killer/T-cell lymphoma with isochromosome 7q10 as the sole cytogenetic aberration was initially diagnosed via bone marrow biopsy. Archives of pathology & laboratory medicine, 131(11), 1709-14.
[PubMed]

Fuda, F. S., McKenna, R. W. & Karandikar, N. J. (2006). All Cases of Precursor T Acute Lymphoblastic Leukemia/Lymphoma (T-ALL) Exhibit Multiple Immunophenotypic Aberrancies. USCAP.

Chenault, C. B., Karandikar, N. J., Xu, Y., Dowell, J., Amirkhan, R. & McKenna, R. W. (2006). Langerhans Cell Histiocytosis (LCH) in Acute Leukemia and MDS in Adult Patients. USCAP.

Tennakoon, D. K., Mehta, R. S., Ortega, S. B., Bhoj, V., Racke, M. K. & Karandikar, N. J. (2006). Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis. Journal of immunology (Baltimore, Md. : 1950), 176(11), 7119-29.
[PubMed]

Chen, W., Kesler, M. V., Karandikar, N. J., McKenna, R. W. & Kroft, S. H. (2006). Flow cytometric features of angioimmunoblastic T-cell lymphoma. Cytometry. Part B, Clinical cytometry, 70(3), 142-8.
[PubMed]

Biegler, B. W., Yan, S. X., Ortega, S. B., Tennakoon, D. K., Racke, M. K. & Karandikar, N. J. (2006). Glatiramer acetate (GA) therapy induces a focused, oligoclonal CD8+ T-cell repertoire in multiple sclerosis. Journal of neuroimmunology, 180(2-Jan), 159-71.
[PubMed]

Xu, Y., McKenna, R. W., Wilson, K. S., Karandikar, N. J., Schultz, R. A. & Kroft, S. H. (2006). Immunophenotypic identification of acute myeloid leukemia with monocytic differentiation. Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 20(7), 1321-4.
[PubMed]

Olteanu, H., Karandikar, N. J., McKenna, R. W. & Xu, Y. (2006). Differential usefulness of various markers in the flow cytometric detection of paroxysmal nocturnal hemoglobinuria in blood and bone marrow. American journal of clinical pathology, 126(5), 781-8.
[PubMed]

Ratts, R. B., Lovett-Racke, A. E., Choy, J., Northrop, S. C., Hussain, R. Z., Karandikar, N. J. & Racke, M. K. (2006). CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate. Journal of neuroimmunology, 178(2-Jan), 117-29.
[PubMed]

Ratts, R. B., Karandikar, N. J., Hussain, R. Z., Choy, J., Northrop, S. C., Lovett-Racke, A. E. & Racke, M. K. (2006). Phenotypic characterization of autoreactive T cells in multiple sclerosis. Journal of neuroimmunology, 178(2-Jan), 100-10.
[PubMed]

Fuda, F. S., Kroft, S. H., Alfardan, J. M., Xu, Y., McKenna, R. W. & Karandikar, N. J. (2005). Myeloperoxidase expression differentiates leukemic from non-leukemic blasts. (18), pp. 230A-230A 1068 Suppl. 1. Modern Pathology.

Karandikar, N. J., Racke, M. K. (2005). Glatiramer acetate therapy: The plot thickens. (62), pp. 858-9. Archives of Neurology.

Xu, Y., McKenna, R. W., Karandikar, N. J., Pildain, A. J. & Kroft, S. H. (2005). Flow cytometric analysis of monocytes as a tool for distinguishing chronic myelomonocytic leukemia from reactive monocytosis. American journal of clinical pathology, 124(5), 799-806.
[PubMed]

Frohman, E. M., Filippi, M., Stuve, O., Waxman, S. G., Corboy, J., Phillips, J. T., Lucchinetti, C., Wilken, J., Karandikar, N. J., Hemmer, B., Monson, N., De Keyser, J., Hartung, H., Steinman, L., Oksenberg, J. R., Cree, B. A., Hauser, S. & Racke, M. K. (2005). Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions. Archives of neurology, 62(9), 1345-56.
[PubMed]

Frohman, E. M., Filippi, M., Stuve, O., Waxman, S. G., Corboy, J., Phillips, J. T., Lucchinetti, C., Wilken, J. & Karandikar, N. J. (2005). Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions. Archives of Neurology,(62), 1345-56.

Alfardan, J. M., Kroft, S. H., Fuda, F. S., Xu, Y., McKenna, R. W. & Karandikar, N. J. (2005). Immunophenotypic comparison of peripheral blood stem cells, normal bone marrow blasts and leukemic myeloid blasts. (18), pp. 220A 1025 Suppl. 1. Modern Pathology.

Kroft, S. H., Asplund, S. L., McKenna, R. W. & Karandikar, N. J. (2004). Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients. British journal of haematology, 126(2), 209-12.
[PubMed]

Karandikar, N. J., Kroft, S. H., Yegappan, S., Rogers, B. B., Aquino, V. M., Lee, K. M., Kumar, V., Guenaga, F. J., Jaffe, E. S., Douek, D. C. & McKenna, R. W. (2004). Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis. Blood, 104(7), 2007-9.
[PubMed]

Eagar, T. N., Turley, D. M., Padilla, J., Karandikar, N. J., Tan, L., Bluestone, J. A. & Miller, S. D. (2004). CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance. Journal of immunology (Baltimore, Md. : 1950), 172(12), 7442-50.
[PubMed]

Crawford, M. P., Yan, S. X., Ortega, S. B., Mehta, R. S., Hewitt, R. E., Price, D. A., Stastny, P., Douek, D. C., Koup, R. A., Racke, M. K. & Karandikar, N. J. (2004). High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood, 103(11), 4222-31.
[PubMed]

Rawal, A., Sarode, R., Curtis, B. R., Karandikar, N. J., Friedman, K. & Rogers, Z. R. (2004). Acquired Glanzmann's thrombasthenia as part of multiple-autoantibody syndrome in a pediatric heart transplant patient. The Journal of pediatrics, 144(5), 672-4.
[PubMed]

Brenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., Roederer, M., Douek, D. C. & Koup, R. A. (2003). Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood, 101(7), 2711-20.
[PubMed]

Karandikar, N. J., Crawford, M. P., Yan, X., Ratts, R. B., Brenchley, J. M., Ambrozak, D. R., Lovett-Racke, A. E., Frohman, E. M., Stastny, P., Douek, D. C., Koup, R. A. & Racke, M. K. (2002). Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis. The Journal of clinical investigation, 109(5), 641-9.
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Racke, M. K., Lovett-Racke, A. E. & Karandikar, N. J. (2002). Myelin-reactive T cells and their regulation in multiple sclerosis. Neuroscience News,(4), 29-38.

Douek, D. C., Betts, M. R., Brenchley, J. M., Hill, B. J., Ambrozak, D. R., Ngai, K. L., Karandikar, N. J., Casazza, J. P. & Koup, R. A. (2002). A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape. Journal of immunology (Baltimore, Md. : 1950), 168(6), 3099-104.
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Karandikar, N. J., Hotchkiss, E. C., Mckenna, R. W. & Kroft, S. H. (2002). Transient stress lymphocytosis: an immunophenotypic characterization of the most common cause of newly identified adult lymphocytosis in a tertiary hospital. American journal of clinical pathology, 117(5), 819-25.
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Eagar, T. N., Karandikar, N. J., Bluestone, J. A. & Miller, S. D. (2002). The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. European journal of immunology, 32(4), 972-81.
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Karandikar, N. J., Aquino, D. B., McKenna, R. W. & Kroft, S. H. (2001). Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome. An immunophenotypic analysis. American journal of clinical pathology, 116(2), 204-10.
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Karandikar, N. J., Eagar, T. N., Vanderlugt, C. L., Bluestone, J. A. & Miller, S. D. (2000). CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 109(2), 173-80.
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Karandikar, N. J., Vanderlugt, C. L., Eagar, T., Tan, L., Bluestone, J. A. & Miller, S. D. (1998). Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950), 161(1), 192-9.
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Karandikar, N. J., Vanderlugt, C. L., Bluestone, J. A. & Miller, S. D. (1998). Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease. Journal of neuroimmunology, 89(2-Jan), 10-18.
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Vanderlugt, C. L., Karandikar, N. J., Lenschow, D. J., Dal Canto, M. C., Bluestone, J. A. & Miller, S. D. (1997). Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE. Journal of neuroimmunology, 79(2), 113-8.
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McRae, B. L., Karandikar, N. J. & Miller, S. D. (1997). Degenerate antigen recognition by CD4+ effector T cells in experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 75(2-Jan), 156-62.
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Miller, S. D., Vanderlugt, C. L. & Karandikar, N. J. (1997). B7-CD28/CTLA-4 costimulatory pathways in the intrinsic and induced regulation of CD4 T cell-mediated autoimmune diseases. Immune Regulatory Pathways in Autoimmune and Neuroimmunologic Diseases..

Karandikar, N. J., Vanderlugt, C. L., Walunas, T. L., Miller, S. D. & Bluestone, J. A. (1996). CTLA-4: a negative regulator of autoimmune disease. The Journal of experimental medicine, 184(2), 783-8.
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Miller, S. D., Vanderlugt, C. L., Lenschow, D. J., Pope, J. G., Karandikar, N. J., Dal Canto, M. C. & Bluestone, J. A. (1995). Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity, 3(6), 739-45.
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